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  • May 7, 2015

    Understanding the Enemy Within that Causes Brain Damage after Cardiac Arrest

    A new $1.7 million grant will bring together a team of researchers to study – an ultimately thwart – the chain reaction that occurs in the body after cardiac arrest that can ultimately lead to brain damage and death.

    While the biological sequence of events is triggered by cardiac arrest, the death and disability associated with this event is the result of a broader systemic injury caused the initial loss of blood flow and subsequent tissue inflammation once blood circulation is restored, said University of Rochester Medical Center neurologist Marc Halterman, M.D., Ph.D., the principal investigator of the study. In fact, it is the cumulative effect of this systemic injury on the brain, and not the heart – that ultimately leads to mortality in the disorder.

  • April 27, 2015

    Anolik Elected to American Society for Clinical Investigation

    Dr. Jennifer Anolik with MSTP Director, Dr. Kerry O'Banion

    Jennifer H. Anolik, M.D., Ph.D., associate professor of Medicine in the Division of Allergy/Immunology and Rheumatology, was named a member of the American Society for Clinical Investigation, one of the nation’s oldest and most respected medical honor societies. Anolik, who runs URMC’s Lupus Clinic and Program, was nominated for her work conducting translational and basic science research on lupus and rheumatoid arthritis. She joins 18 other Medical Center faculty members who have been inducted into the Society in the past. Anolik is a former URMC MSTP (M.D., '96) and Biochemistry (Ph.D., '94) student. During her time in the program, she conducted research with Robert Bambara, Ph.D. and Russell Hilf, Ph.D..

    Anolik’s research focuses on the role of B cells in systemic autoimmune disease through synergistic and innovative approaches in translational immunology and animal models. It has fundamentally contributed to the understanding of how and why B cell targeted therapies can be efficacious in subsets of lupus and rheumatoid arthritis patients and established these therapies as a major advance in the field of immunologic disease. Her work has broad implications for other autoimmune diseases such as vasculitis and diabetes, as well immunologic diseases like malignancy and immune deficiency.

    Under Anolik’s leadership, URMC was one of 11 research groups across the country recently chosen by the National Institutes of Health to join the NIH Accelerating Medicines Partnership in Rheumatoid Arthritis and Lupus Network, a partnership between the NIH, biopharmaceutical companies, advocacy organizations and academic scientists to more rapidly identify promising drug targets and develop new treatments for patients with these conditions. Anolik’s team was selected for this highly competitive award based on the novelty of their translational research proposal coupled with the unique collaboration between Orthopaedics and Rheumatology at URMC.

    Read the entire press release.

  • April 3, 2015

    Study Finds New Genetic Clues to Pediatric Seizure Disorders

    Researchers have identified a new genetic mutation at the heart of a severe and potentially deadly seizure disorder found in infants and young children. The finding, which was reported today in the American Journal of Human Genetics, may help scientists unravel the complex biological mechanism behind these diseases.

    These findings allow us to open up what was, up to this point, a black box and more fully understand the biological pathways associated with these disorders and why some individuals do not respond to treatment, said Alex Paciorkowski, M.D., an assistant professor of Neurology at the University of Rochester Medical Center (URMC) and lead author of the study.

    Once the mutation was identified, the researchers worked with neurobiologists in the lab of Marc Halterman, M.D., Ph.D. in the URMC Center for Neural Development and Disease, and were able to identify the downstream impact of the mutation, namely that it regulated another gene that has been associated with severe seizures called myocyte-specific enhancer factor 2C (MEF2C).

  • March 13, 2015

    Irina Lerman Attends Endocrine Society's Annual Meeting & Expo

    Current MD/PhD student, Irina Lerman attended the Endocrine Society's Annual Meeting & Expo in March 2015, held in San Diego. She was invited to compete in the Presidential Poster Competition for her first-authored top-scoring abstract, titled Neutrophil elastase potentiates human prostate cancer growth in mouse models. She is a first year graduate student in Dr. Steve Hammes' lab.

    The Endocrine Society's Annual Meeting Steering Committee (AMSC) is an annual meeting incorporating current endocrine topics, speakers from around the world, and new and innovative formats that will incorporate basic research, clinical investigation, and clinical practice, with a goal of providing a venue for bridging the gaps in science and practice. The ENDO 2016 meeting in Boston, will celebrate the Centennial of the Endocrine Society.

  • February 23, 2015

    SMD Ranks 12th Nationally in New Model to Evaluate Academic Physicians/Medical Schools

    The School of Medicine and Dentistry placed 12th nationally in a new ranking designed to evaluate medical schools' production of academic physicians who advance medicine through basic, clinical, translational and implementation science research. The new model, detailed in Academic Medicine, the journal of the Association of American Medical Colleges, analyzes publications, grants, clinical trials and awards or honors for medical school graduates to arrive at a ranking that the authors argue is based on more relevant and objective criteria than those that dominate the current ranking systems.

    The well-known yearly analysis performed by U.S. News & World Report has become the main tool to compare U.S. medical schools, but these rankings of research medical schools rely heavily on subjective and premedical student performance measures, including assessment scores from medical school deans, undergraduate grade point averages and school acceptance rates. Although U.S. News' research schools rankings incorporate total NIH funding and NIH dollars-per-faculty-member, these factors account for just 15 percent of the total score. (SMD was #34 in the 2015 U.S. News rankings; the 2016 rankings are due out next month.)

  • February 1, 2015

    MSTP Announces 40th Anniversary Celebration!

    Edward M. Eddy Rubin

    The Medical Scientist Training Program (MSTP) is excited to announce a celebration of the 40th anniversary of the MSTP NIH training grant on Friday, October 9, 2015.

    The keynote speaker will be an MSTP alumni from the Class of 1980: Edward Rubin, MD, PhD, Director, DOE Joint Genome Institute.

    Edward M. Eddy Rubin is an internationally-known geneticist and medical researcher at the Lawrence Berkeley National Laboratory in Berkeley, California, where he became head of the Genomic Sciences Division in 1998. In 2002 he assumed the directorship of the DOE Joint Genome Institute (JGI) to lead the JGI ’s involvement in the Human Genome Project (HGP).

    For more information and schedule of events for the day, please visit the MSTP 40th Anniversary page.

  • February 1, 2015

    MSTP Monthly Social Event: Curling

    MSTP Students at the Rochester Curling Club

    This past Saturday, January 31, the MSTP students visited the Rochester Curling Club for their monthly social event. Many of the current MSTP students attended the event including, Kyle Koster, Andrew Shubin, Andrew Cox, Aisha Seibert, Drew and Liz Scoles, Scott Friedland, and Kevin Makino.

    Dating back to medieval Scotland, Curling is an Olympic sport (since 1998) in which players slide stones on a sheet of ice towards a target area which is segmented into four concentric circles. The sport has become increasingly popular with over 1.5 million curlers across the world.

    Below are some photos and videos of the event. Please join us for our next social event!

    Andrew Shubin and Kyle Koster

    Aisha Seibert

    Drew and Liz Scoles with Scott Friedland and Kevin Makino