Feldon Lab

Steven E. Feldon, MD - Chairman

  • Chairman - Department of Ophthalmology (SMD, Primary Administrative)
  • Professor - Department of Ophthalmology (SMD, Primary Appointment)
  • Professor - Department of Center for Visual Science (RC)
  • Board Certified Specialty | American Board of Ophthalmology
  • MBA | Business Or Commerce | Univ of Southern California (1997)
  • MD | Medicine | Einstein College Medicine (1973)

Research Overview

Multidisciplinary collaborations are a key to the successful enhancement of eye health. The University of Rochester Medical Center and the Flaum Eye Institute provide an ideal environment for this work.

Graves' Disease

One example of current multidisciplinary investigations is the Graves’ disease collaboration between Steven E. Feldon, M.D., an orbital disease specialist, and Richard Phipps, Ph.D., a researcher who specializes in the study of the biology of fibroblasts (connective tissue cells involved in thyroid eye disease).

Many Graves’ disease patients—especially women who smoke—will develop thyroid eye disease, a condition that causes disfiguring bulging eyes, corneal drying, optic nerve inflammation, blurry vision, and even blindness. An inflammatory process associated with the disease induces structural cells behind the eye called fibroblasts to make too much connective tissue protein. The fibroblasts also convert into fat-like cells. The combination of excessive connective tissue and accumulating fatty tissue pushes the eye out of the eye socket, causing disfigurement, double vision, and vision loss.

Recent Publications

Showing 5 of 86 journal articles.

S Feldon; L Levin: R Scherer; A Arnold; SM Chung: L Johnson; G Kosmorsky; S Newman; J Katz; P Langenberg; PD Wilson; SE Kelman; K Kickersin. "Development and Validation of a Computerized Expert System for Evaluation of Automated Visual Feilds From the Ischemic Optic Neuopathy Decompression Trial." Biomedical Central Ophthalmology. 2006; .

Baglole CJ; Ray DM; Bernstein SH; Feldon SE; Smith TJ; Sime PJ; Phipps RP. "More than structural cells, fibroblasts create and orchestrate the tumor microenvironment." Immunological investigations. 2006; 35(3-4):297-325.

Feldon SE; O'loughlin CW; Ray DM; Landskroner-Eiger S; Seweryniak KE; Phipps RP. "Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes." The American journal of pathology.. 2006; 169(4):1183-93.

S Feldon; DJ Park; CW O'Loughlin; VT Nguyen; S Landskroner-Eiger; D Chang; TH Thatcher; RP Phipps. "Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves' ophthalmopathy". IOVS. 2005; 46: 3913-21.

Baglole CJ; Reddy SY; Pollock SJ; Feldon SE; Sime PJ; Smith TJ; Phipps RP. "Isolation and phenotypic characterization of lung fibroblasts." Methods in molecular medicine. 2005; 117():115-27.

More articles...

Contact

Steven E. Feldon, M.D.
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave., Box 659
Rochester, NY 14642

Office: (585) 273-3937
Fax: (585) 506-0292
Office locaton: 3-3041
Steven_Feldon@urmc.
rochester.edu