 |
M.D. (1980)
Medical College of Wisconsin
Ph.D. (1987)
University of Michigan
|
Eric
K. Richfield
Associate Professor of Pathology & Laboratory Medicine, Neurology and the Center for Aging and Developmental Biology
Primary Appointment:
Pathology & Laboratory Medicine
GEBS Cluster Affiliation:
NS
- Neuroscience
|
Research:
Neurodegenerative Disorders
Clinical Interests:
Neurodegenerative Diseases, Tissue Banking, Molecular Diagnosis of Tissue Samples |
Contact Information:
E-Mail: Eric_Richfield@urmc.rochester.edu |
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, New York 14642
|
Medical Center 1-7423
Phone: (716) 275-3202
Fax: (716) 273-1027 |
|
Research
Overview
|
| Our lab is interested in using both postmortem
human tissue and animal models to study neurodegenerative diseases,
including Huntington's disease, Parkinson's disease, and Alzheimer's
disease. Techniques including histochemistry, immunocytochemistry,
receptor autoradiography, and in situ hybridization histochemistry
are used to identify and study specific neuronal and glial changes
occurring in these different disorders. Postmortem human tissue
is used to identify the specific sequence and pattern of neuronal
vulnerability in the different diseases. Animal models are then
used to reproduce these diseases in order to gain further understanding
of the mechanisms involved in neuronal death and to develop
interventions to prevent neuronal death. |
|
Recent Publications
|
- McCoy, L., Richfield, E.K. (1996)
- Chronic treatment with typical and atypical antipsychotics
increase the AMPA-preferring form of the AMPA receptor in
rat brain. European J. Pharmacol. 318: 41-45.
- Richfield, E.K., Maguire, K., Cox, C., Gilmore, J., Voorn,
P. (1995)
- Reduced expression of preproenkephalin in striatal neurons
from Huntington's disease patients. Ann. Neurol. 37: 335-343.
- Kazee, A.M., Cox, C., Richfield, E.K. (1995)
- Substantia nigra lesions in Alzheimer's disease and normal
aging. Alzheimer's Dis. Assoc. Disorders 9:61-67.
- Richfield, E.K., Maguire, K., Cox, C., Vonkeman, H.,
Voorn, P. (1995)
- Preferential loss of preproenkephalin versus preprotachykinin
striatal neurons from Huntington's disease patients. Ann.
Neurol. 38: 852-861.
- Pokora, M.J., Richfield, E.K., Cory-Slechta, D.A. (1996)
- Preferential vulnerability of nucleus accumbens dopamine
binding sites to low level lead exposure: Time course of
effects and interactions with chronic dopamine agonist treatments.
J. Neurochem. 67: 1540-1550.
- Voorn, P., Brady, L.S., Berendse, H.W., Richfield, E.K.
(1996)
- Densitometrical analysis of opioid receptor ligand binding
in the human ventral striatum. I. Distribution of µ
opioid receptor defines shell and core of the ventral straitum.
Neurosci. 75: 777-792.
|
Back to Pathology & Laboratory Medicine
|
