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Research Opportunities by Investigative Approach:Molecular Biology and Genetics |
Protein Structure and Function |
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Sequencing of the human genome has now defined the diversity and scope of cellular protein expression. The next challenge is to define the structure and function of the many proteins newly identified by this exciting advance. The many roles of proteins are incredibly diverse. Proteins fulfill a structural role in the cell, acting as scaffolding in the formation of tissues and organs. Enzymes are the molecular machines that catalyze the synthesis of new compounds, modify the function of others, and ultimately participate in the degradation and recycling of all cellular components. Proteins participate in the crosstalk between cells, tissues and organs as signaling molecules or as chaperones for these molecules. Others transport nutrients throughout the body and participate in a complex yet precise control of metabolism. Proteins are essential components of normal cellular function. It is not difficult to see how defects in protein structure, function, or abundance could be the molecular mechanism that leads to abnormal human physiology (pathology) or human disease. Challenging opportunities are available in several labs within our program to study structure and function of proteins involved in lipid metabolism, blood coagulation, cancer metastasis, RNA processing, and steroid hormone action. Faculty investigating protein structure and function: Chawnshang
Chang |
Illustrations courtesy of Dr. Philip Fay |
