Yi-Fen Lee Lab

Yi-Fen Lee

Yi-Fen Lee

Dr. Yi-Fen Lee

Associate Professor of Urology

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Email: Yifen_Lee@urmc.rochester.edu

Dr. Yi-Fen Lee Publications (PDF files are available when you click individual publication)

  1. Lee, Yi-Fen. Purification of Human Progesterone Receptor," M.S. Thesis, Dept. of Biology, Tunghai University, Taiwan, 1988.

  2. Bao B.-Y., Ting, H.-J.,Y-C Hu, and Lee, Y.-F., Androgen signaling is required in vitamin D mediated growth inhibition in prostate cancer cells. Oncogene, 23(19): 3350-3360, 2004.

  3. Lee, Y.-F., Ting, H.-J and Bao B.-Y. Vitamin D and prostate cancer. In Prostate cancer basic mechanisms and therapeutic approaches, World Scientific Publishing Company Pte Ltd, Singapore, 277-292. 2005.

  4. Ting H.-J., Bao B.-Y, and Lee, Y.-F., Androgen Receptor Coregulators Mediate the Suppressive Effect of Androgen Signals on Vitamin D receptor Activity. Endocrine 26(1): 1-10, 2005.

  5. Bao B.-Y., Yeh, S.-D., and Lee, Y.-F., 1 alpha25-dihydroxyvitamin D3 inhibits prostate cancer cell invasion via modulation of selective protease. Carcinogenesis, 27(1): 32-42, 2006.

  6. Bao B.-Y., Yao, J., and Lee, Y.-F., 1_ alpha 25-dihydroxyvitamin D3 suppresses interluekin-8-mediated prostate cancer cell angiogenesis. Carcinogenesis, 27 (9):1883-1893, 2006.

  7. Ting, H.-J Hsu, J., Bao B.-Y., and Lee, Y.-F., Docetaxel-Induced growth Inhibition and apoptosis in androgen independent prostate cancer cells are enhanced by 1__a,25-Dihydroxyvitamin D3. Cancer letters 247, 122-129, 2007.

  8. Chen, T.-C., Persons, K.S., Zheng S., Mathieu, J., Holick, M. F., Lee, Y.-F., Bao B., Arai, M. A., and Kittala, A., Evaluation of C-2-substituted 19-nor-1alpha,25-dihydroxyvitamin D(3) analogs as therapeutic agents for prostate cancer. J. of Steroid biochemistry & Molecular Biology 103:717-720, 2007.

  9. Ting, H.-J Hsu, J., Bao B.-Y., Reeder, J., Messing, E., and Lee, Y.-F., Increased Expression of Corepressors in Aggressive Androgen-Independent Prostate Cancer Cells Results in Loss of 1a,25-Dihydroxyvitamin D3 Responsiveness. Molecular Cancer Research 5(9): 967-980, 2007.

  10. Bao B.-Y., Ting H.-J, Hsu J., and Lee, Y.-F., Protective role of 1a, 25-dihydroxyvitamin D3 against oxidative stress in non-malignant human prostate epithelial cells. International J. of Cancer, 15: 122(12):2699-2706. 2008. PMID: 18348143.

  1. Chang C, Sofia L, Ideta R, Lee Y, Yeh S, Silva S, Burbach P. Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. Proc.Natl. Acad. Sci. USA 91:6040-6044, 1994.

  2. Ideta R, Yeh SY, Lee Y, Adachi K, Su C, Chang C. Gene expression of the androgen repressed rat TR2 orphan receptor: a member of steroid receptor superfamily. Endocrine 3:277-283, 1995.

  3. Lee, Y.-F., Lee H-J, Burbach P, Chang C. Suppression of SV40 gene expression by human TR4 orphan receptors: a member of nuclear receptor superfamily. J Biol Chem, 270: 30129-30133, 1995.

  4. Lee, Y.-F., Pan H-J, Burbach P, Morkin E. and Chang C. Identification of direct-repeat 4 as a positive regulatory element for the human TR4 orphan receptor: A modulator for thyroid hormone target gene. J Biol Chem, 272: 12215-12220 1996.

  5. Lee H-J, Lee, Y.-F., and Chang, C. Identification the human aldolase A gene as the first induced target for the TR2 orphan receptor, a member of the steroid hormone receptor superfamily. Biochem. Biophys. Res. Commun. 235, 205-211 1997.

  6. Lee, Y.-F., Burbach P, Chang C. Negative feedback control the retinoids-RAR/RXR pathways by human TR4 orphan receptors: a member of steroid hormone receptor superfamily. J Biol Chem, 273:13437-13443 1998.

  7. Lee, Y.-F., Young, W-J, Smith, S.M., and Chang, C Bi-directional regulation of the human TR2 and TR4 orphan receptor with the ciliary neurotrophic factor (CNTF) signaling pathway. J Biol Chem, 273:20877-20885 1998.

  8. Lee, Y.-F., Lee H-J, and Chang C., Identification of the histamine H1 receptor gene as a differentially repressed target of the human TR2 orphan receptor. Molecular and Cellular Biochemistry 194:199-207, 1999.

  9. Inui, S, Lee, Y.-F., Haake, A. R., Goldsmith, L. A., and Chang, C. Induction of TR4 orphan receptor by retinoic acid in human HaCat keratinocytes. J. Invest. Dermatol 112: 426-431, 1999.

  10. Lee, Y.-F., Young W-J, Lin W.-J., Shyr, C.-R., and Chang, C Differential regulation of DR3-vitamin D3 and DR4-thyroid hormone signaling pathways by the human TR4 orphan receptor. J Biol Chem, 274: 16198-16205, 1999.

  11. Lee, Y.-F., Shyr, C.-R., Thin, T. H., Lin W.-J., and Chang, C Convergence of two repressors through heterodimer formation of androgen receptor and TR4 orphan receptor: A new signaling pathway in the steroind receptor suprfamily. Proc.Natl. Acad. Sci. USA, 96:14724-14729, 1999.

  12. Lee H-J, Lee, Y.-F., and Chang C TR4 Orphan Receptor Represses the Human Steroid 21-Hydroxylase Gene Expression through the Monomeric AGGTCA Motif. Biochem Biophys Res Commun.3;285 (5):1361-8, 2001.

  13. Lee, Y.-F., Lee, H.-J., and Chang, C Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily. J. of Steroid biochemistry & Molecular Biology 1728:1-17, 2002.

  14. Lee Y-F., Lin W.-J., Huang J., Messing, E., Chan F., and Chang, C. Non-Androgen receptor mediated antiandrogen action: Activation of MAP kinase pathway by hydroxyflutamide in androgen receptor negative prostate cancer cells. Cancer Res. 21: 6039-6044, 2002.

  15. Ohtsu, H., Xiao, Z., Ishida, J., Nagai, M., Wang, H.-K., Itokawa, H., Su, C.-Y., Shih, C., Chiang, T., Chang, E., Lee, Y., Tsai, M.Y., Chang, C., and Lee, K.-H. Antitumor agents. 217. curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents. J. Med. Chem. 45, 5037-5042, 2002.

  16. Inui Shigeki, Lee, Y.-F., Chang E. and Shyr C.-R., Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptor and a specific ligand mediated-peroxisome proliferator-activated receptor a (PPARa) in human HaCaT Keratinocytes. J of Dermatological Science. 31(1):65-71, 2003.

  17. Lin, W.-J., Li, J., Lee, Y.-F., Altuwaijri, S., Ou, J. H., and Chang, C Suppression of Hepatitis B virus corepromoter by the nuclear orphan receptor TR4. J. Biol. Chem 278:9353-9360, 2003.

  18. Kim E, Xie S., Yeh, S.-D., Lee, Y.-F., Collins, L. Hu Y-C., Shyr C.-R., Mu X.-M., Lin N.-C., Chen Y.-T., Wang, P.-H. and Chang, C. Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster. J Biol Chem, 278: 46919-46926. 2003.

  19. Mu X., Lee, Y.-F., Liu N.-C., Chen Y-T., Kim E., Shyr. C.-R., and Chang C. Targeted inactivation of testicular nuclear orphan receptor-4 (TR4) delays and disrupts late Meiotic prophase and subsequent meiotic divisions of spermatogenesis. Molecular and Cellular Biology 24:5887-5899. 2004.

  20. Lee Y.-F., Collins L, Heinlein CA, Liu NC, Chen YT, Chen Y, Shyr CR, Meshul CK, Uno H, Lardy H, Chou S, Platt KA and Chang C ?rowth retardation and abnormal female maternity in mice lacking testicular orphan nuclear receptor 4? Proc.Natl. Acad. Sci. USA, 101: 15058-15063. 2004.

  21. Lee, Y.-F., and Chang, C. Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor. Biochem Biophys Res Commun 323: 876-883. 2004.

  22. Lee, Y.-F. Chuang, K.-H., Lin, W.-J., Chu, C. Y., Altuwaijri, S., Yvonne Wan Y.-J., and Chang, C., 9-cis-Retinoic Acid Inhibits Androgen Receptor Activity through Activation of Retinoid X Receptor. Mol. Endocrinol., 19: 1200 - 1212. 2005.

  23. Lee, Y.-F., Wang C.-P., Chang, C., and Lee H.-J. Transactivation of the proximal promoter of human oxytocin gene by TR4 orphan receptor. Biochem Biophys Res Commun 351: 204-208. 2006.

  24. Zhang, Y., Chen, Y.-T., Xie, S., Wang, L., Lee, Y.-F., Chang, S.-S., and Chang C., Loss of Testicular Orphan Receptor 4 Impairs Normal Myelination in Mouse Forebrain, Mol. Endocrinol. 2007 Soi:10.1210.

  25. Liu, N.-C., Lin, W-J., Kim, E., Collins, L. L. Lin, H.-Y., Yu, I-C., Sparks, J. D., Chen, L-M., Chang, C., and Lee, Y.-F., Loss of TR4 Orphan Receptor Reduces Phosphoenolpyruvate Carboxykinase-mediated Gluconeogenesis. Diabetes; 56:2901-2909, 2007.

  26. Chen LM, Wang RS, Lee YF, Liu NC, Chang YJ, Wu CC, Xie S, Hung YC, Chang C. Subfertility with Defective Folliculogenesis in Female Mice Lacking TR4 Orphan Nuclear Receptor. Mol Endocrinol. 22(4):858-867, 2008.PMID: 18174360.

  27. Lee Y.-F., Cai, Y., Li, G., Liu, S., Bao,B.Y., Huang, J., Hsu, C., and Chang, C.A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor. International J. of Cancer 15: 123 (1): 195-201, 2008. PMID: 18386814.

  28. Lee Y.-F., Li G., Liu S., Cai Y, Xie S., Liu N.-C., Bao, B.-Y., Chen Z., and Chang C., Oxidative Stress Stimulates TR4 Orphan Receptor through Forkhead Transcription Factor FOXO3a. Endocrinology 149(7):3490-9, 2008. PMC2453090

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Contact

Yi-Fen Lee
University of Rochester
Box 656
601 Elmwood Ave.
Rochester, NY 14642
Office: 1-6526
+1-585-275-9702
yifen_lee@URMC.rochester.edu

Other PIs' Emails

 
Chawnshang Chang, Ph.D.

 

Chawnshang Chang, Ph.D.
Shu-Yuan Yeh, Ph.D.

Shuyuan Yeh, Ph.D.
Miyamoto Icon

Hiroshi Miyamoto, MD. Ph.D.
Soo OK Lee, Ph.D.

Soo OK Lee, Ph.D.
HeuiJu Ting

HueiJu Ting, Ph.D.
JeffLin's Photo Wen-Jye Lin, Ph.D