Our lab works at the interface of medicine and engineering, with an emphasis on precisely controlling biomaterial functionality and architecture to treat diseases, control cell behavior, or answer fundamental biological questions. In particular, we are focusing on two avenues: synthetic hydrogels with tunable degradation and mechanical properties as a synthetic extracellular matrix analogue for the culture and delivery of cells for regenerative medicine approaches and polymers formed using reversible-addition fragmentation chain transfer polymerization (RAFT), a controlled, living polymerization strategy, designed with drug delivery applications in mind. Our overall hypothesis is that by using bottom-up approaches, we can design ‘smart’ materials with distinct capabilities, such as controlling cell behavior or overcoming delivery barriers.
- Dynamic manipulation of hydrogels to control cell behavior: a review. Tissue Eng Part B Rev. 19, 455-69. (2013 Dec 01).
- TOF-SIMS 3D Imaging of Native and Non-Native Species within HeLa Cells. Anal Chem. 85, 10869-77. (2013 Nov 19).
- The effect of mesenchymal stem cells delivered via hydrogel-based tissue engineered periosteum on bone allograft healing. Biomaterials. 34, 8887-98. (2013 Nov 01).