Honors & News
November 17, 2014
Four individually accomplished investigators, in four labs, are working toward one goal. The URMC is increasing collaboration among its scientists in order to move biomedical research further, faster. In the process, it's winning support from the National Institutes of Health.
Deborah J. Fowell, PhD, is very familiar with Leishmania major, a particularly nasty parasite that infects the skin of twelve million people around the world, including more than seven hundred US soldiers who returned from Iraq with
Baghdad boil.David J. Topham, PhD, is well known for all things-influenza. MinSoo Kim, PhD, is pretty handy at turning living T-cells different colors with beams of light. And James F. Miller, PhD, likes to sit in on cross-talk between T-cells and the molecules that help push them into action.
October 9, 2014
A diverse team of immunologists, engineers and critical care clinicians at the University of Rochester Medical Center received $4 million from the National Institutes of Health to study sepsis, an over-the-top immune response to an infection that leads to organ failure and death in about one third of patients. Beyond administering antibiotics, fluids and other supportive measures, physicians have no specific treatment to stop the syndrome, which is the most expensive condition treated in U.S. hospitals, according to the Agency for Healthcare Research and Quality.
August 11, 2014
Yelena Lerman Selected as Recipient for the 2014 International Endotoxin and Innate Immunity Society (IEIIS) Young Investigator Award
Yelena Lerman, a graduate student in Pharmacology and Physiology and member of the Minsoo Kim Lab, has been selected as a recipient for the 2014 International Endotoxin and Innate Immunity Society (IEIIS) Young Investigator Award for her abstract, titled: "Massive neutrophil extravasation during sepsis and TLR2-induced cytokine production are regulated by integrin a3ß1." As an awardee Yelena will give an oral presentation Thursday, October 23rd at the SLB IEIIS Joint Meeting in Salt Lake City, UT.
August 4, 2014
Brandon Walling Accepted into Howard Hughes Medical Institute Med-into-Grad Fellowship
Brandon Walling, an IMV graduate student in the Minsoo Kim Lab, has been accepted into the Howard Hughes Medical Institute Med-into-Grad Fellowship in Cardiovascular Science.
In 2005, HHMI launched the Med into Grad (MIG) Initiative to address the growing gap between basic biology and medicine. The Institute recognized that biomedical scientists could benefit from additional training to help them translate biological knowledge into effective medical treatments and diagnostics. MIG training includes the fundamentals of pathobiology, an introduction to how medicine is practiced, and a survey of the problems and challenges faced by medical practitioners.
HHMI has held two MIG Initiative competitions, awarding $26 million in grants to 25 graduate institutions. This funding has enabled them to initiate or enhance existing programs designed to help students obtain the skills necessary to partner with clinician-scientists in the application of emerging biological knowledge to medical practice. These programs train students to recognize and capitalize on translational opportunities that may arise from their research and, in some cases, may influence the direction of their future investigations.
July 18, 2014
Since the early days of Kodak, Xerox, and Bausch & Lomb, Rochester-area innovators have been making astounding discoveries in optics and imaging. Researchers at the University of Rochester are beginning a major study that will add to the region's imaging expertise, while also advancing global understanding of how the body's immune system works.
The National Institutes of Health (NIH) has awarded a five-year, $9 million Research Program Project Grant (PO1) to scientists in the School of Medicine and Dentistry to adapt and develop cutting-edge imaging techniques, allowing them to view the immune system while it is fighting infection and disease.
June 23, 2014
Yelena Lerman Recieves Medical Faculty Council Travel Award
Yelena Lerman is the recipient of the Medical Faculty Council Travel Award in Basic Science Research for Spring 2014. Yelena is in her sixth year of the Pharamacology PhD program under the mentorship of Dr. Minsoo Kim in the Department of Microbiology & Immunology. Yelena gave an oral and poster presentation of her work on
Exacerbated tissue homing of neutrophils during sepsis and TLR2-induced cytokine production are regulated by integrin a3b1at the American Association of Immunologists (AAI) meeting in May 2014. Her work evaluated the surface expression kinetics of b1 and b3 integrin heterodimers on neutrophils during sepsis in both mice and humans. She showed that only integrin a3b1 is significantly upregulated during sepsis. Previous studies suggested a role for IL-10 as a regulator of the transition from mild sepsis to irreversible septic shock. Thus, sepsis progression could be modulated by altering IL-10 release and α3β1 upregulation.
May 15, 2014
Tara Capece Receives Trainee Poster Award at 2014 AAI Meeting
Graduate student, Tara Capece received the Trainee Poster Award at the 2014 AAI Immunology Conference for her work,
Regulation of the integrin LFA-1 in T cell activation.
Tara is currently working on LFA-1 in T cell activation and migration in Dr. Minsoo Kim's lab. The Kim lab is focused on understanding how T cells and neutrophils home to and migrate within tissues.
May 10, 2014
Yelena Lerman Receives Trainee Abstract Award at 2014 AAI Meeting
April 23, 2014
Young-min Hyun Receives 2014 AAI Early Career Faculty Travel Grant
Young-min Hyun, a research assistant professor in Minsoo Kim's lab, has received the 2014 AAI Early Career Faculty Travel Grant. Hyun's research focuses on leukocytes migration from blood vessel to inflamed tissue through endothelial cell layer and basement membrane.
April 5, 2014
Yuexin Xu Receives HHMI Translational Medicine Award
Yuexin Xu, a graduate student in Minsoo Kim's lab, has received the HHMI translational medicine award at the University of Rochester Annual Poster Competition 2014 for her work
Optogenetic control of chemokine receptor signal and T-cell migration.
January 12, 2014
Tara Capece Awarded NIH/NIAID F31 Ruth L. Kirschstein Predoctoral Fellowship
Tara Capece, MS/MPH was awarded an NIH/NIAID F31 Ruth L. Kirschstein Predoctoral Fellowship for the grant titled: Regulation of the integrin LFA-1 during T cell migration and activation. Tara, a fourth-year doctoral candidate in , Minsoo Kim's lab, was awarded a two and a half year fellowship from the National Institute of Allergy and Infectious Disease to investigate how the integrin LFA-1 is modulated by chemokine signals and T cell receptor signals to serve different functions, as the former induces cell migration while the later mediated stable cell-to-cell contact. Answering these questions will provide novel insight for vaccine and immunomodulatory drug design.
October 21, 2013
CVBI Students Receive Young Investigator Award at NYIC
The Kim lab Understanding how T cells and neutrophils home to and migrate within tissues is a major focus of our research, and the Elliott lab understand the signaling pathways that regulate how phagocytes locate and engulf apoptotic cells and how this process impacts the immune system in normal and disease states.
August 15, 2013
Tara Capece and Patrick Murphy Appointed to Immunology Training Grant
July 2, 2013
CVBI Postdoctoral Fellow Receives Vaccine Fellowship Award
Milan Popovic, a post-doctoral fellow in Minsoo Kim's Lab, was awarded the 2013 Rochester Vaccine Fellowship award. Selection for the fellowship was a unanimous decision by three independent reviewers who praised Milan for his outstanding achievement in vaccine-related research.
May 1, 2013
Tara Capece Wins Second Place at Graduate Student Society Poster Competition
Tara Capece, a CVBI student in Minsoo Kim lab, won Second Place at the Graduate Student Society Poster Competition in recognition of outstanding presentation of thesis work The competition was held in the Sarah Flaum Atrium in April and involved students from all graduate programs at the University of Rochester Medical Center. Congratulations Tara!
January 8, 2013
The World Intellectual Property Organization (Wipo) has published a patent entitled,
Photoactivatable Receptors and Their Usesby CVBI associate professor Minsoo Kim. The patent abstract states, Provided herein is a chimeric photoactivatable polypeptide comprising an opsin membrane receptor, wherein an intracellular domain of the opsin membrane receptor is replaced with a corresponding intracellular domain of a chemokine receptor, a sphingosine-1-phosphate receptor or an ATP receptor and uses thereof. Further provided are methods of treating cancer, injury of the nervous system, autoimmune disease, and graft rejection comprising administering to the subject a cell that expresses the chimeric photoactivatable polypeptide and exposing the cell to a visible light source.
March 23, 2012
Lynne Maquat Named 2012 Batsheva de Rothschild FellowProfessor of Biochemistry & Biophysics and Director for the Center for RNA Biology, Lynne Maquat, Ph.D., has been named a 2012 Batsheva de Rothschild Fellow of the Israel Academy of Sciences and Humanities. Batsheva de Rothschild (1914-1999) was a biologist, trained at the Sorbonne, Paris and at Columbia University, New York. She worked for a while at the Pasteur Institute in Paris.
The Batsheva Fund was established as a private endowment fund, first in New York City and afterwards, in 1965, in Israel. In 1993 she generously transferred the fund to the Israel Academy of Sciences and Humanities. In 1958 she became the only one ever, from her legendary family, to settle in Israel and became active in public life. Science and the arts were the two loves of this exceptional woman. In 1989 she was awarded the prestigious Israel Prize for her many contributions to Israeli society, among them the founding of Israel's Batsheva and Bat Dor Dance Companies. The Batsheva Fund's purpose is to further Science in Israel for the people of Israel.
January 6, 2011
As any weekend warrior knows, an errant elbow or a missed ball can put a crimp in an afternoon of fun. The bruising and swelling are painfully obvious, but the processes occurring under the skin remain full of mystery. What is known is that leukocytes, or white blood cells, mobilize to protect injured body tissue from infection. What is not understood is why some leukocytes - but not others - are attracted to damaged tissue.
The response begins when leukocytes travel through blood vessels near the site of the injury and stop. Eight out of ten white blood cells will eventually continue traveling through the blood vessel, while the other two cells will actually enter the tissue to begin fighting against infection. Thanks to a $9.2 million grant from the National Institutes of Health, a research team led by Richard Waugh (Waugh Lab), Chairman of the Biomedical Engineering Department at the University of Rochester, is trying to find the reasons.
The project team includes: Minsoo Kim (Kim Lab) and Ingrid Sarelius of the University of Rochester; Michael King and Moonsoo Jin of Cornell University; Daniel Hammer of the University of Pennsylvania; and Micah Dembo of Boston University.
January 14, 2008
Researchers have found a way to selectively block the ability of white blood cells to
crawltoward the sites of injury and infection when such mobility drives disease, according to a study published today in The Journal of Experimental Medicine. The results suggest a new treatment approach for autoimmune diseases like rheumatoid arthritis, lupus and multiple sclerosis, and for conditions made worse by misplaced inflammation, like atherosclerosis, stroke and transplant rejection, researchers said.
There are many cases where it would be incredibly useful to precisely block integrin activation, and thus T cell migration,said Minsoo Kim, Ph.D., assistant professor of Microbiology and Immunology within the David H. Smith Center for Vaccine Biology and Immunology at the Medical Center, and lead author of the article.
Good examples include when our immune system attacks our own cells, or rejects a lifesaving transplant or clogs our blood vessels by mistake. The problem is that past, system-wide attempts that block all integrin activation, like the multiple sclerosis drug Tysabri, shut down not only unwanted inflammation in one locale, but also vital immune defenses elsewhere, leaving patients vulnerable to infection.
- Sepsis lethality through exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is dependent on integrin α3β1. Blood. In press. (2014 Oct 02).
- Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model. Neurobiol Aging. 35, 1286-92. (2014 Jun 01).