Bone Loss Research
The Schwarz laboratory focuses on finding solutions to bone loss due to conditions such as rheumatoid arthritis, infections, tumors that spread to bone, and bone destruction near the implants used in reconstructive surgery. Several genes are known to turn on the healing process in bone. Dr. Schwarz's group loads these genes into harmless virus particles. The particles are coated onto experimental bone implants to deliver therapeutic genes to the area of reconstruction, thus improving bone healing. The cartilage that lines joints in mice can be encouraged to heal more completely when virus particles deliver therapeutic genes too. An additional interest of Dr. Schwarz's lab is the use of magnetic resonance imaging (MRI) and high resolution computed tomography (CT) scans to visualize the formation of new blood vessels as patients heal.
Selected Journal Covers
- Anti-Glucosaminidase IgG in Sera as a Biomarker of Host Immunity Against Staphylococcus aureus in Orthopaedic Surgery Patients. J Bone Joint Surg Am. 95, e1711-9. (2013 Nov 20).
- Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice. Genesis. 51, 667-75. (2013 Sep 01).
- Anti-oxidation treatment of ultra high molecular weight polyethylene components to decrease periprosthetic osteolysis: evaluation of osteolytic and osteogenic properties of wear debris particles in a murine calvaria model. Curr Rheumatol Rep. 15, 325. (2013 May 01).