Bone Loss Research
The Schwarz laboratory focuses on finding solutions to bone loss due to conditions such as rheumatoid arthritis, infections, tumors that spread to bone, and bone destruction near the implants used in reconstructive surgery. Several genes are known to turn on the healing process in bone. Dr. Schwarz's group loads these genes into harmless virus particles. The particles are coated onto experimental bone implants to deliver therapeutic genes to the area of reconstruction, thus improving bone healing. The cartilage that lines joints in mice can be encouraged to heal more completely when virus particles deliver therapeutic genes too. An additional interest of Dr. Schwarz's lab is the use of magnetic resonance imaging (MRI) and high resolution computed tomography (CT) scans to visualize the formation of new blood vessels as patients heal.
Selected Journal Covers
- Anti-oxidation treatment of ultra high molecular weight polyethylene components to decrease periprosthetic osteolysis: evaluation of osteolytic and osteogenic properties of wear debris particles in a murine calvaria model. Curr Rheumatol Rep. 15, 325. (2013 May 01).
- PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis. J Bone Miner Res. 28, 586-97. (2013 Mar 01).
- Bone fragility beyond strength and mineral density: Raman spectroscopy predicts femoral fracture toughness in a murine model of rheumatoid arthritis. J Biomech. 46, 723-30. (2013 Feb 22).