Principal Investigator
Contact
Benoit Lab
University of Rochester
work
Goergen Hall 324
Rochester
NY
14627-0168
Therapeutic Biomaterials
Benoit Lab, 2011
Our lab works at the interface of medicine and engineering, with an emphasis on precisely controlling biomaterial functionality and architecture to treat diseases, control cell behavior, or answer fundamental biological questions. In particular, we are focusing on two avenues: synthetic hydrogels with tunable degradation and mechanical properties as a synthetic extracellular matrix analogue for the culture and delivery of cells for regenerative medicine approaches and polymers formed using reversible-addition fragmentation chain transfer polymerization (RAFT), a controlled, living polymerization strategy, designed with drug delivery applications in mind. Our overall hypothesis is that by using bottom-up approaches, we can design ‘smart’ materials with distinct capabilities, such as controlling cell behavior or overcoming delivery barriers.
Latest News
Recent Publications
- (2012 Jan 17). Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures. J Cell Biochem. In press.
- (2011 Jul 11). Synthesis of folate-functionalized RAFT polymers for targeted siRNA delivery. Biomacromolecules. 12, 2708-14.
- (2010 Apr 05). pH-responsive polymeric sirna carriers sensitize multidrug resistant ovarian cancer cells to doxorubicin via knockdown of polo-like kinase 1. Mol Pharm. 7, 442-55.
