Welcome to the Benoit Lab
Our lab works at the interface of medicine and engineering, with an emphasis on precisely controlling biomaterial functionality and architecture to treat diseases, control cell behavior, or answer fundamental biological questions. In particular, we are focusing on two avenues: synthetic hydrogels with tunable degradation and mechanical properties as a synthetic extracellular matrix analogue for the culture and delivery of cells for regenerative medicine approaches and polymers formed using reversible-addition fragmentation chain transfer polymerization (RAFT), a controlled, living polymerization strategy, designed with drug delivery applications in mind. Our overall hypothesis is that by using bottom-up approaches, we can design ‘smart’ materials with distinct capabilities, such as controlling cell behavior or overcoming delivery barriers.
Current Research Projects
- Enzymatically-responsive pro-angiogenic peptide-releasing poly(ethylene glycol) hydrogels promote vascularization in vivo.J Control Release. 217, 191-201. (2015 Nov 10).
- Agonism of Wnt-β-catenin signalling promotes mesenchymal stem cell (MSC) expansion.J Tissue Eng Regen Med. 9, E13-26. (2015 Nov 01).
- Drug Release: Temporally Tunable, Enzymatically Responsive Delivery of Proangiogenic Peptides from Poly(ethylene glycol) Hydrogels (Adv. Healthcare Mater. 13/2015).Adv Healthc Mater. 4, 2001. (2015 Sep 01).