Journal Clubs

The CMSR offers several Journal Clubs that are designed to be an integral component of graduate and post-doctoral training and education in the basic biomedical sciences. The Journal Clubs aim to provide trainees with a strong foundation and a broad grasp of current research questions and methodologies throughout the musculoskeletal biology field. The most recent advances in the fundamentals of osteoblast, osteoclast, and chondrocyte biology and the molecular mechanisms of musculoskeletal development and disease are presented and discussed.

The presenter(s) at each Journal Club meeting is a student or fellow and the paper to be discussed (not more than 6 months past publication) is chosen by the trainee in consultation with their faculty mentor. The paper is made available to all members of the CMSR a week in advance. During the meeting, the presenter(s) is responsible for providing enough background to bring the group up to speed on the specific topic and then moderates the group’s discussion of each figure and how it contributes to the overall conclusion(s) of the study. At least one faculty mentor is present at the meeting to observe and contribute if any clarification is necessary. Besides familiarizing the group with current literature, participants learn how to critically evaluate a study and envision novel experiments that might better address the hypothesis in question.

MESENCHYMAL STEM CELL
Room 1-8527, 1:00 pm - 3:00 pm (Every Other Thursday)

July 30, 2015 - "Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation" View article in PubMed

June 25, 2015 - "Systemic infusion of mesenchymal stem cells improves cell-based bone regeneration via upregulation of regulatory T cells" View article in PubMed

June 4, 2015 - "ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency" View article in PubMedi

May 7, 2015 - "Establishment of bone marrow and hematopoietic niches in vivo by reversion of chondrocyte differentiation of human b one marrow stromal cells" View article in PubMed

April 23, 2015 - "Identification and specification of the mouse skeletal stem cell" View article in PubMed

April 9, 2015 - "In Vivo therapeutic potential of mesenchymal stromal cells depends on the source and the isolation procedure" View article in PubMed

March 12, 2015 - "DNA methyltransferase 3a regulates osteoclast differentitation by coupling to an S-adenosylmethionine-producing metabolic pathway" View article in PubMed

February 26, 2015 - "Gremlin 1 identifies a skeletal stem cell with bone, cartilage and reticular stromal potential" View article in PubMed

February 12, 2015 - "The NAD-dependent deacetylase SIRT2 is required for programmed necrosis" View article in PubMed

OSTOARTHRITIS, FRACTURE HEALING AND THE IMPACT OF DIABETES ON THE SKELETON
Room 1-8527, 8:30 am - 9:30 am (Every Thursday)

July 30, 2015 - "The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment" View article in PubMed

July 23, 2015 - "IKKB in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5" View article in PubMed

July 16, 2015 - "Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation" View article in PubMed

June 4, 2015 - "Response of knee fibrocartilage to joint destabilization" View article in PubMed

May 28, 2015 - "Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients" View article in PubMed

May 19, 2015 - "Ex vivo non-invasive assessment of cell viability and proliferation in bio-engineered whole organ constructs" View article in PubMed

April 2, 2015 - "Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity" View article in PubMed

March 19, 2015 - "Airflow accelerates bovine and human articular cartilage drying and chondrocyte death" View article in PubMed

February 5, 2015 - "PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis" View article in PubMed

December 4, 2014 - "Rapid, automated imaging of mouse articular cartilage by microCT for early detection of osteoarthritis and finite element modelling of joint mechanics" View article in PubMed

November 20, 2014 (Plato Schwartz Library) "Effects of CD14 Macrophages and Proinflammatory Cytokines on Chondrogenesis in Osteoarthritic Synovium-Derived Stem Cells" View article in PubMed

November 13, 2014 (Plato Schwartz Library) "Inhibition of TGF-B signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis" View article in PubMed

October 23, 2014 - "Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes" View article in PubMed

Upcoming Speakers

July 29 , 2015
8:30 am - 9:30 am
Neuman Room (Rm 1-6823)

Bentley Hunt - Micropatterning endothelial cells for vascularized tissue engineered periosteum