Journal Clubs

 

The CMSR offers several Journal Clubs that are designed to be an integral component of graduate and post-doctoral training and education in the basic biomedical sciences. The Journal Clubs aim to provide trainees with a strong foundation and a broad grasp of current research questions and methodologies throughout the musculoskeletal biology field. The most recent advances in the fundamentals of osteoblast, osteoclast, and chondrocyte biology and the molecular mechanisms of musculoskeletal development and disease are presented and discussed.

The presenter(s) at each Journal Club meeting is a student or fellow and the paper to be discussed (not more than 6 months past publication) is chosen by the trainee in consultation with their faculty mentor. The paper is made available to all members of the CMSR a week in advance. During the meeting, the presenter(s) is responsible for providing enough background to bring the group up to speed on the specific topic and then moderates the group’s discussion of each figure and how it contributes to the overall conclusion(s) of the study. At least one faculty mentor is present at the meeting to observe and contribute if any clarification is necessary. Besides familiarizing the group with current literature, participants learn how to critically evaluate a study and envision novel experiments that might better address the hypothesis in question.

MESENCHYMAL STEM CELL
Room 1-8527, 1:30 pm - 3:00 pm (Every Other Thursday)


October 9, 2014 - "WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentation" View article in PubMed

OSTOARTHRITIS, FRACTURE HEALING AND THE IMPACT OF DIABETES ON THE SKELETON
Room 1-8527, 11:30 am - 12:30 pm (Every Thursday)


October 2, 2014
- "Induction of an inflammatory and prodegradative phenotype in autologous fibroblast-like synoviocytes by the infrapatellar fat pad from patients with knee osteoarthritis". View article in PubMed

September 17, 2014 - "Diabetes irreversibly depletes bone marrow-derived mesenchymal progenitor cell subpopulations". View article in PubMed

August 21, 2014 - "A novel disease-modifying osteoarthritis drug candiate targeting Runx1". View article in PubMed

August 14, 2014 - "A multifunctional streptococcal collagen-mimetic protein coating prevents bacterial adhesion and promotes osteoid formation on titanium." View article in PubMed

August 7, 2014 - "Aging and oxidative stress reduce the response of human articular chondrocytes to insulin-like growth factor-1 and osteogenic protein-1." View article in PubMed

July 10, 2014 - "Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination." View article in PubMed

June 19, 2014 - "Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin." View artilce in PubMed

June 12, 2014 - "B cells promote obesity-associated periodontitis and oral pathogen-associated inflammation." View Article in PubMed

May 15, 2014 - "Quantitative imaging of murine osteoarthritic cartilage by phase-contrast micro-computed tomography." View Artilce in PubMed

May 8, 2014 - "Early response of mouse joint tissue to noninvasive knee injury suggests treatment targets." View article in PubMed

April 24, 2014 - "Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NfkB-Opa-1 signaling pathway." View article in PubMed

April 17, 2014 - "Bone-specific insulin reistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation." View article in PubMed

April 3, 2014 - "Macro- to microscale strain transfer in fibrous tissues is heterogeneous and tissue-specific." View article in PubMed

March 6, 2014 - "Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis." View article in PubMed

February 27, 2014 - "Contrast-enhanced CT with a high-affinity cationic contrast agent for imaging ex vivo bovine, intact ex vivo rabbit, and in vivo rabbit cartilage." View article in PubMed

February 20, 2014 - "Anti-inflammatory effects of cell-based therapy with tyrosine hydroxylase-positive catecholaminergic cells in experimental arthritis." View article in PubMed

February 13, 2014 - "FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes." View article in PubMed

February 6, 2014 - "WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentitation." View article in PubMed

January 30, 2014 - "Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis." View article in PubMed

January 23, 2014 - "Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria." View article in PubMed

January 16, 2014 - "Interplay between FGF21 and insulin action in the liver regulates metabolism." View article in PubMed

January 9, 2014 - "Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo." View article in PubMed

 

 

Upcoming Speakers

Neuman Room

Wednesday, October 15, 2014
8:00 am - 9:30 am

Margaret Thomas - MSC derived exosomes for treatment of tendon injuries - implications from an in vitro study

Sarah Catheline - Coordinate dysregulation of SOX9 and RUNX2 during the development of osteoarthritis

Tim Rutkowski - The Notch target genes, Hes1 and Hes5, regulate early chondrogenesis and chondrocyte maturation by modulating Sox9 expression