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URMC  » Center for Musculoskeletal Research » Seminars

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Journal Clubs

 

The CMSR offers several Journal Clubs that are designed to be an integral component of graduate and post-doctoral training and education in the basic biomedical sciences. The Journal Clubs aim to provide trainees with a strong foundation and a broad grasp of current research questions and methodologies throughout the musculoskeletal biology field. The most recent advances in the fundamentals of osteoblast, osteoclast, and chondrocyte biology and the molecular mechanisms of musculoskeletal development and disease are presented and discussed.

The presenter(s) at each Journal Club meeting is a student or fellow and the paper to be discussed (not more than 6 months past publication) is chosen by the trainee in consultation with their faculty mentor. The paper is made available to all members of the CMSR a week in advance. During the meeting, the presenter(s) is responsible for providing enough background to bring the group up to speed on the specific topic and then moderates the group’s discussion of each figure and how it contributes to the overall conclusion(s) of the study. At least one faculty mentor is present at the meeting to observe and contribute if any clarification is necessary. Besides familiarizing the group with current literature, participants learn how to critically evaluate a study and envision novel experiments that might better address the hypothesis in question.

SIGNALING AND THE SKELETON
Room 1-8527, 1:00pm-2:00pm (First Friday of the Month)

February 8, 2013, 1:00pm-3:00 pm, Room 1-8527 "TAK1 is Essential for Osteoclast Differentiation and is an Important Modulator of Cell Death by Apoptosis and Necroptosis" View article in PubMed
December 5, 2012 1:00pm - 3:00 pm Room 1-8527 "Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation" View article in PubMed
October 5, 2012 1:00pm - 3:00 pm, Room 1-8527 "Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration" View article in PubMed
September 7, 2012 - "A Stem Cell-Based Approach to Cartilage Repair" View article in PubMed

NOTCH SIGNALING, SKELETAL DEVELOPMENT AND DISEASE
Room 1-8527, 9:30am-10:30am (Last Friday of the Month)

OSTOARTHRITIS, FRACTURE HEALING AND THE IMPACT OF DIABETES ON THE SKELETON
Room 1-8527, 12:30pm-1:30pm (Every Thursday)

April 11, 2013 - "Bone morphogenetic protein signaling in joint homeostasis and disease" View article in PubMed; "Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation" View article in PubMed

April 18, 2013 - "DNA methylome signature in rheumatoid arthritis" View article in PubMed

April 25, 2013 - "Dkk1 promotes angiogenic responses and cartilage matrix proteinase secretion in synovial fibroblasts from osteoarthritic joints" View article in PubMed

May 2, 2013 - "A Wnt/B-catenin negative feedback loop inhibits interleukin-1-induced matrix metalloproteinase expression in human articular chondrocytes" View article in PubMed

May 9, 2013 - "Efficacy and Tolerability of Advanced Glycation End-Products Inhibitor in Osteoarthritis: A Randomized, Double-Blind, Pacebo-controlled Study" View article in PubMed

May 16, 2013 - "The transcription factor Jdp2 controls bone homeostatsis and antibacterial immunity by regulating osteoclast and neutrophil differentation" View article in PubMed

May 30, 2013 - "Adiponectin Regulates Bone Mass via Opposite Central and Peripheral Mechanisms through Fox01" View article in PubMed

June 6, 2013 - "Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice" View article in PubMed

June 13, 2013 -"Initial responses of articular tissues in a murine high-fat diet-induced osteoarhritis model: pivotal role of the IPFP as a cytokine fountain" View article in PubMed

TENDON AND CARTILAGE MECHANOBIOLOGY AND TISSUE ENGINEERING
Room 1-8527, 12:30pm-1:30pm (Last Monday of the Month)