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Additional Journal Club Articles

Stem Cells in Musculoskeletal Biology

August 23, 2018 - "Deletion of the Transcription Factor PGC-1α in Mice Negatively Regulates Bone Mass" View in Calcified Tissue International

August 9, 2018 - "The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation" View in Science Direct

July 26, 2018 - "PGC-1a Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ" View in Cell

July 12, 2018 - "Understanding metabolic changes in aging bone marrow"

June 28, 2018 - "Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations"

June 14, 2018 - "Quiescence of human muscle stem cells is favored by culture on natural biopolymeric films" View in PubMed

May 31, 2018 - "Chromatin dynamics regulate mesenchymal stem cell lineage specification and differentiation to osteogenesis" View in Science Direct

May 17, 2018 - "Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia" View in Science Direct

May 3, 2018 - "Tyrosine kinase Fyn promotes osteoarthritis by activating the β-catenin pathway" View in British Medical Journals 

April 19, 2018 - "Mitochondrial Dysfunction Is an Acute Response of Articular Chondrocytes to Mechanical Injury" View in Journal of Orthopaedic Research

April 5, 2018 - "Vhl deletion in osteoblasts boosts cellular glycolysis and improves global glucose metabolism" View in The Journal of Clinical Investigation

March 22, 2018 - "Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis" View in Nature

February 22, 2018 - "Gpr177, a Novel Locus for Bone Mineral Density and Osteoporosis, Regulates Osteogenesis and Chondrogenesis in Skeletal Development" View in PubMed

February 8, 2018 - "Transcriptional Profiling of Quiescent Muscle Stem Cells In Vivo" View in Cell

January 11, 2018 - "Regulatory elements driving the expression of skeletal lineage reporters differ during bone development and adulthood" View article in The Bone Journal

January 25, 2018 - "Ontogenic Identification and Analysis of Mesenchymal Stromal Cell Populations during Mouse Limb and Long Bone Development" View article in PubMed

December 14, 2017 - "Exposure to a youthful circulation rejuvenates bone repair through modulation of b-catenin"

November 30, 2017 - "Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression" View article in Diabetes Journal

October 16, 2017 - "Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy" View article in Nature

September 21, 2017 - "Heypothalamic stem cells control ageing speed partly through exosomal miRNAs" View article in Nature

August 24, 2017 - "Correction of a pathogenic gene mutation in human embryos" View article in Nature

August 10, 2017 - "Modulation of oxidative phosphorylation and redox homeostasis in mitochondrial NDUFS4 deficiency via mesenchymal stem cells" View article in Stem Cell Research & Therapy

July 13, 2017 - "Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy" View article in Cell

June 29, 2017 - "Postnatal Calvarial Skeletal Stem Cells Expressing PRX1 Reside Exclusively in the Calvarial Sutures and Are Required for Bone Regeneration" View article in PubMed

June 15, 2017 - "Leptin-receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis" View article in Nature

May 4, 2017 - "MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells" View article in Nature

April 20, 2017 - "Adipocyte Accumulation in Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration" View article in Science Direct

March 30, 2017 - "Tumor-homing cytotoxic human induced neural stem cells for cancer therapy" View article in Science Translational Medicine

March 16, 2017 - "Tumor-homing cytotoxic human induced neural stem cells for cancer therapy" View article in Science Translational Medicine

March 2, 2017 - " Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells in Vivo" View article in Cell Stem Cell

February 16, 2017 - "Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate" View article in Science Direct

February 2, 2017 - "Wnt/β-catenin signaling in osteoblasts regulates global energy metabolism" View article in Science Direct

January 17, 2017 - "Oxidative status predicts quality in human mesenchymal stem cells" View article in BioMed Central 

November 10, 2016 - "The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are independent and Mechanistically Distinct" View article in PubMed

October 27, 2016 - "Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response" View article in Cell

October 13, 2016 - "Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs)" View article here

September 29, 2016 - "NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice" View article in Science

August 25, 2016 - "Transcriptome sequencing wide functional analysis of human mesenchymal stem cells in response to TLR4 ligand" View article in Nature

August 11, 2016 - "Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells" View article in PubMed

July 28, 2016 - "Asymmetric division of clonal muscle stem cells coordinates muscle regeneration in vivo" View article in PubMed

July 14, 2016 - "No Identical "Mesenchymal Stem Cells" at Different Times and Sites: Human Committed Progenitors of Distinct Origin and Differentiation Potential Are Incorporated as Adventitial Cells in Microvessels" View article in Cell

June 2, 2016 - "Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program" View article in Science Direct

May 5, 2016 -  "Mitotic History reveals distinct stem cell populations and their contributions to hematopoiesis"

April 7, 2016 - "Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation" View article in PubMed

March 10, 2016 - "Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation" View article in Science Direct

February 25, 2016 - "A predictive computational framework for direct reprogramming between human cell types" View article in Nature

February 11, 2016 - "Distinct EMT programs control normal mammary stem cells and tumor-initiating cells" View article in PubMed

January 28, 2016 - "Direct measurement of local oxygen concentration in the bone marrow of live animals" View article in PubMed

December 3, 2015 - "Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs" View article in PubMed

November 19, 2015 - "Multiparameter Analysis of Human Bone Marrow Stromal Cells Identifies Distinct Immunomodulatory and Differentiation-Competent Subtypes" View article in PubMed

November 5, 2015 - "Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging" View article in PubMed

September 10, 2015 - "CD49f Acts as an Inflammation Sensor to Regulate Differentiation, Adhesion, and Migration of Human Mesenchymal Stem Cells" View article in PubMed

August 27, 2015 - "Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness" View article in PubMed

August 13, 2015 - "Establishing criteria for human mensenchymal stem cell potency" View article in PubMed

July 30, 2015 - "Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation" View article in PubMed

June 25, 2015 - "Systemic infusion of mesenchymal stem cells improves cell-based bone regeneration via upregulation of regulatory T cells" View article in PubMed

June 4, 2015 - "ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency" View article in PubMed

May 7, 2015 - "Establishment of bone marrow and hematopoietic niches in vivo by reversion of chondrocyte differentiation of human b one marrow stromal cells" View article in PubMed

April 23, 2015 - "Identification and specification of the mouse skeletal stem cell" View article in PubMed

April 9, 2015 - "In Vivo therapeutic potential of mesenchymal stromal cells depends on the source and the isolation procedure" View article in PubMed

March 12, 2015 - "DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway" View article in PubMed

February 26, 2015 - "Gremlin 1 identifies a skeletal stem cell with bone, cartilage and reticular stromal potential" View article in PubMed

February 12, 2015 - "The NAD-dependent deacetylase SIRT2 is required for programmed necrosis" View article in PubMed

Osteoarthritis, Fracture Healing and the Impact of Diabetes on the Skeleton

October 26, 2017 - "Regional Differences Between Perisynovial and Infrapatellar Adipose Tissue Depots and Their Response to Class II and Class III Obesity in Patients with Osteoarthritis." View article in PubMed

August 31, 2017 - "Knee osteoarthritis has doubled in prevalence since the mid-20th century." View article in PubMed

August 17, 2017- "Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs" View article in PubMed

August 10,2017 - "Mechanoresponsive stem cells to target cancer metastases through biophysical cues" View article in PubMed

August 3, 2017 - "Impact Insertion of Osteochondral Grafts: Interference Fit and Central Graft Reduction Affect Biomechanics and Cartilage Damage" View article in PubMed

July 20, 2017 - "Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells" View article in PubMed

July 13, 2017 - "Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis" View article in PubMed

June 29, 2017 - "Beyond Sequencing: Population Analysis in an Era of Mass Spe" View webinar

June 22, 2017 - "FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging." View article in PubMed

June 15, 2017 - "Joint morphogenetic cells in the adult mammalian synovium" View article in PubMed

June 8, 2017 - "Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties" View article in Nature

June 1, 2017 - "Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug." View article in PubMed

May 11, 2017 - "Exogenous fibroblast growth factor 9 attenuates cartilage degradation and aggravates osteophyte formation in post-traumatic osteoarthritis" View article in PubMed

May 4, 2017 - "Post-Traumatic Osteoarthritis in Mice Following Mechanical Injury to the Synovial Joint" View article in PubMed

April 27, 2017 - "Differences in sensitivity to microstructure between cyclic - and impact-based microindentation of the human cortical bone." View article in PubMed

March 30, 2017 - "Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice." View article in PubMed

March 9, 2017 - "Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease" View article in PubMed

February 16, 2017 - "Assessment of collagen quality associated with non-enzymatic cross-links in human bone using Fourier-transform infrared imagining" View article in PubMed

February 9, 2017 - "Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity" View article in PubMed

February 2, 2017 - "Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage" View article in Arthritis & Rheumatology

January 19, 2017 - "Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes." View article in PubMed

January 5, 2017 - "Early, focal changes in cartilage cellularity and structure following surgically induced meniscal destabilization in the mouse." View article in PubMed

December 15, 2016 - "Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury" View article here

October 6, 2016 - "Hyperelastic "bone": A highly, versatile, growth factor-free, osteogenerative, scalable, and surgically friendly biomaterial" View article here

September 8, 2016 - "Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage"  View article here

September 1,2016 - "Defining the consequences of genetic variation on a proteome-wide scale" View article in PubMed

August 25, 2016 - "Interaction of HIF1α and β-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice" View article here

August 18, 2016 - "Peptide - siRNA nanocomplexes targeting NF - kB subunit p65 suppress nascent experimental arthritis" View article in JCI

August 11,2016 - "Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis" View article in JCI

August 4,2016 - "Genome-wide associate study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility gene" View article in Science Direct

July 28, 2016 - "Reduction of friction by recombinant human proteoglycan 4 in IL-1α stimulated bovine cartilage explantsView article in Pubmed

July 21, 2016 - "Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest" View pdf article here

July 14, 2016 - "Network Analysis Implicates Alpha-Synuclein (Snca) in the Regulation of Ovariectomy-Induced Bone Loss" View article in PubMed

July 7, 2016 - "Protein related to DAN and cerberus (PRDC) inhibits osteoblastic differentiation and its suppression promotes osteogenesis in vitro." View article in PubMed

June 30, 2016 - "CCL20/CCR6 Signaling Regulates Bone Mass Accrual in Mice" View pdf article here

June 23, 2016 - "Sepsis- Induced Osteoblast Ablation Causes Immunodeficiency"

June 2, 2016 - "Bone marrow lesions detected by specific combination of MRI sequences are associated with severity of osteochondral degeneration" View article in PubMed

May 26, 2016 - "A predictive computational framework for direct reprogramming between human cell types." View article in PubMed

May 12, 2016 - "Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis." View article in PubMed

May 5, 2016 - "NOTCH signaling in skeletal progenitors is critical for fracture repair." View article in PubMed

April 28, 2016 - "Sex steroid deficiency-associated bone loss in microbiota dependent and prevented by probiotics." View article in PubMed

April 21, 2016 - "Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis" View article in PubMed

February 25, 2016 - "Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term" View article in PubMed

February 11, 2016 - "Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro" View article in PubMed

February 4, 2016 - "Fibrin accumulation secondary to loss of plasmin-mediated fibrinolysis drives inflammatory osteoporosis in mice" View article in PubMed 

January 28, 2016 - "Vitamin D prevents articular cartilage erosion by regulating collagen II turnover through TGF-B1 in ovariectomized rats" View article in PubMed

December 17, 2015 - "Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density" View article in PubMed

December 10, 2015 - "The alarmins S100A8/A9 induce canonical Wnt signaling in murine knee joints; implications for osteoarthritis" View article in PubMed 

October 22, 2015 - "Chronic superantigen exposure induces systemic inflammation, elevated bloodstream endotoxin and abnormal glucose tolerance in rabbits: possible role in diabetes" View article in PubMed

October 15, 2015 - "Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture" View article in PubMed

October 1, 2015 - " Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation" View article in PubMed 

September 24, 2015 - "Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice" View article in PubMed

September 17, 2015 - "Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis" View article in PubMed

September 10, 2015 - "Intermittent Parathryoid Hormone Enhances Cancellous Osseointegration of a Novel Murine tibial Implant" View article in PubMed

September 3, 2015 - "Intermittent PTHrP (1-34) exposure augments chondrogenesis and reduces hypertrophy of mesenchymal stromal cells" View article in PubMed

August 27, 2015 - "PTH [1-34]-induced alterations of the subchondral bone provoke early osteoarthritis" View article in PubMed

August 20, 2015 - "Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification" View article in PubMed

July 30, 2015 - "The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment" View article in PubMed

July 23, 2015 - "IKKB in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5" View article in PubMed

July 16, 2015 - "Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation" View article in PubMed

June 4, 2015 - "Response of knee fibrocartilage to joint destabilization" View article in PubMed

May 28, 2015 - "Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients" View article in PubMed

May 19, 2015 - "Ex vivo non-invasive assessment of cell viability and proliferation in bio-engineered whole organ constructs" View article in PubMed

April 2, 2015 - "Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity" View article in PubMed

March 19, 2015 - "Airflow accelerates bovine and human articular cartilage drying and chondrocyte death" View article in PubMed

February 5, 2015 - "PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis" View article in PubMed

December 4, 2014 - "Rapid, automated imaging of mouse articular cartilage by microCT for early detection of osteoarthritis and finite element modelling of joint mechanics" View article in PubMed

November 20, 2014 (Plato Schwartz Library) - "Effects of CD14 Macrophages and Proinflammatory Cytokines on Chondrogenesis in Osteoarthritic Synovium-Derived Stem Cells" View article in PubMed

November 13, 2014 (Plato Schwartz Library) - "Inhibition of TGF-B signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis" View article in PubMed

October 23, 2014 - "Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes" View article in PubMed