Additional Journal Club Articles
Stem Cells in Musculoskeletal Biology
December 19, 2019 - Sinusoidal Electromagnetic Fields Increase Peak Bone Mass in Rats by Activating Wnt10b/β-Catenin in Primary Cilia of Osteoblasts
December 12, 2019 - "Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer"
November 14, 2019 - "Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin"
October 31, 2019 - "Molecular architecture of lineage allocation and tissue organization in early mouse embryo"
October 17, 2019 - "Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects"
October 10, 2019 - "Mediation of the Acute Stress Response by the Skeleton"
September 5, 2019 - "17β-Estradiol Directly Lowers Mitochondrial Membrane Microviscosity and Improves Bioenergetic Function in Skeletal Muscle"
August 22, 2019 - "Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate"
August 8, 2019 - "Transcriptional profiling of intramembranous and endochondral ossification after fracture in mice"
July 25, 2019 - "Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping"
July 11, 2019 - "The bone marrow microenvironment at single-cell resolution"
June 27, 2019 - "Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility"
June 13, 2019 - "The extracellular domain of epithelial cell adhesion molecule (EpCAM) enhances multipotency of mesenchymal stem cells through EGFR–LIN28–LET7 signaling"
May 23, 2019 - "L-Carnitine Reduces Oxidative Stress and Promotes Cells Differentiation and Bone Matrix Proteins Expression in Human Osteoblast-Like Cells"
May 2, 2019 - "Changes in characteristics of periodontal ligament stem cells in spheroid culture"
April 18, 2019 - "Curcumin pretreatment protects against hypoxia/reoxgenation injury via improvement of mitochondrial function, destabilization of HIF-1α and activation of Epac1-Akt pathway in rat bone marrow mesenchymal stem cells"
April 4, 2019 - "A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate"
March 28, 2019 - "Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells"
March 7, 2019 - "Periarticuar mesenchymal progenitors initiate and contribute to secondary ossification center formation during mouse long bone development"
February 21, 2019 - "A Novel Single Pulsed Electromagnetic Field Stimulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells and Bone Repair"
February 7, 2019 - "Gain Fat—Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis"
January 24, 2019 - "Mesenchymal Stem Cells Shift Mitochondrial Dynamics and Enhance Oxidative Phosphorylation in Recipient Cells"
January 10, 2019 - "Simvastatin alleviates bone resorption in apical periodontitis possibly by inhibition of mitophagy-related osteoblast apoptosis"
December 13, 2018 - "Glucose metabolism induced by Bmp signaling is essential for murine skeletal development"
November 29, 2018 - "Human tissue-specific MSCs demonstrate differential mitochondria transfer abilities that may determine their regenerative abilities"
November 15, 2018 - "Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation"
November 1, 2018 - "Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease"
October 18, 2018 - "A dual role of cholesterol in osteogenic differentiation of bone marrow stromal cells"
October 4, 2018 - "Identification of the Human Skeletal Stem Cell"
September 20, 2018 - "Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming"
August 23, 2018 - "Deletion of the Transcription Factor PGC-1α in Mice Negatively Regulates Bone Mass" View in Calcified Tissue International
August 9, 2018 - "The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation" View in Science Direct
July 26, 2018 - "PGC-1a Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ" View in Cell
July 12, 2018 - "Understanding metabolic changes in aging bone marrow"
June 28, 2018 - "Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations"
June 14, 2018 - "Quiescence of human muscle stem cells is favored by culture on natural biopolymeric films" View in PubMed
May 31, 2018 - "Chromatin dynamics regulate mesenchymal stem cell lineage specification and differentiation to osteogenesis" View in Science Direct
May 17, 2018 - "Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia" View in Science Direct
May 3, 2018 - "Tyrosine kinase Fyn promotes osteoarthritis by activating the β-catenin pathway" View in British Medical Journals
April 19, 2018 - "Mitochondrial Dysfunction Is an Acute Response of Articular Chondrocytes to Mechanical Injury" View in Journal of Orthopaedic Research
April 5, 2018 - "Vhl deletion in osteoblasts boosts cellular glycolysis and improves global glucose metabolism" View in The Journal of Clinical Investigation
March 22, 2018 - "Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis" View in Nature
February 22, 2018 - "Gpr177, a Novel Locus for Bone Mineral Density and Osteoporosis, Regulates Osteogenesis and Chondrogenesis in Skeletal Development" View in PubMed
February 8, 2018 - "Transcriptional Profiling of Quiescent Muscle Stem Cells In Vivo" View in Cell
January 11, 2018 - "Regulatory elements driving the expression of skeletal lineage reporters differ during bone development and adulthood" View article in The Bone Journal
January 25, 2018 - "Ontogenic Identification and Analysis of Mesenchymal Stromal Cell Populations during Mouse Limb and Long Bone Development" View article in PubMed
December 14, 2017 - "Exposure to a youthful circulation rejuvenates bone repair through modulation of b-catenin"
November 30, 2017 - "Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression" View article in Diabetes Journal
October 16, 2017 - "Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy" View article in Nature
September 21, 2017 - "Heypothalamic stem cells control ageing speed partly through exosomal miRNAs" View article in Nature
August 24, 2017 - "Correction of a pathogenic gene mutation in human embryos" View article in Nature
August 10, 2017 - "Modulation of oxidative phosphorylation and redox homeostasis in mitochondrial NDUFS4 deficiency via mesenchymal stem cells" View article in Stem Cell Research & Therapy
July 13, 2017 - "Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy" View article in Cell
June 29, 2017 - "Postnatal Calvarial Skeletal Stem Cells Expressing PRX1 Reside Exclusively in the Calvarial Sutures and Are Required for Bone Regeneration" View article in PubMed
June 15, 2017 - "Leptin-receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis" View article in Nature
May 4, 2017 - "MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells" View article in Nature
April 20, 2017 - "Adipocyte Accumulation in Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration" View article in Science Direct
March 30, 2017 - "Tumor-homing cytotoxic human induced neural stem cells for cancer therapy" View article in Science Translational Medicine
March 16, 2017 - "Tumor-homing cytotoxic human induced neural stem cells for cancer therapy" View article in Science Translational Medicine
March 2, 2017 - " Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells in Vivo" View article in Cell Stem Cell
February 16, 2017 - "Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate" View article in Science Direct
February 2, 2017 - "Wnt/β-catenin signaling in osteoblasts regulates global energy metabolism" View article in Science Direct
January 17, 2017 - "Oxidative status predicts quality in human mesenchymal stem cells" View article in BioMed Central
November 10, 2016 - "The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are independent and Mechanistically Distinct" View article in PubMed
October 27, 2016 - "Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response" View article in Cell
October 13, 2016 - "Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs)" View article here
September 29, 2016 - "NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice" View article in Science
August 25, 2016 - "Transcriptome sequencing wide functional analysis of human mesenchymal stem cells in response to TLR4 ligand" View article in Nature
August 11, 2016 - "Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells" View article in PubMed
July 28, 2016 - "Asymmetric division of clonal muscle stem cells coordinates muscle regeneration in vivo" View article in PubMed
July 14, 2016 - "No Identical "Mesenchymal Stem Cells" at Different Times and Sites: Human Committed Progenitors of Distinct Origin and Differentiation Potential Are Incorporated as Adventitial Cells in Microvessels" View article in Cell
June 2, 2016 - "Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program" View article in Science Direct
May 5, 2016 - "Mitotic History reveals distinct stem cell populations and their contributions to hematopoiesis"
April 7, 2016 - "Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation" View article in PubMed
March 10, 2016 - "Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation" View article in Science Direct
February 25, 2016 - "A predictive computational framework for direct reprogramming between human cell types" View article in Nature
February 11, 2016 - "Distinct EMT programs control normal mammary stem cells and tumor-initiating cells" View article in PubMed
January 28, 2016 - "Direct measurement of local oxygen concentration in the bone marrow of live animals" View article in PubMed
December 3, 2015 - "Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs" View article in PubMed
November 19, 2015 - "Multiparameter Analysis of Human Bone Marrow Stromal Cells Identifies Distinct Immunomodulatory and Differentiation-Competent Subtypes" View article in PubMed
November 5, 2015 - "Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging" View article in PubMed
September 10, 2015 - "CD49f Acts as an Inflammation Sensor to Regulate Differentiation, Adhesion, and Migration of Human Mesenchymal Stem Cells" View article in PubMed
August 27, 2015 - "Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness" View article in PubMed
August 13, 2015 - "Establishing criteria for human mensenchymal stem cell potency" View article in PubMed
July 30, 2015 - "Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation" View article in PubMed
June 25, 2015 - "Systemic infusion of mesenchymal stem cells improves cell-based bone regeneration via upregulation of regulatory T cells" View article in PubMed
June 4, 2015 - "ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency" View article in PubMed
May 7, 2015 - "Establishment of bone marrow and hematopoietic niches in vivo by reversion of chondrocyte differentiation of human b one marrow stromal cells" View article in PubMed
April 23, 2015 - "Identification and specification of the mouse skeletal stem cell" View article in PubMed
April 9, 2015 - "In Vivo therapeutic potential of mesenchymal stromal cells depends on the source and the isolation procedure" View article in PubMed
March 12, 2015 - "DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway" View article in PubMed
February 26, 2015 - "Gremlin 1 identifies a skeletal stem cell with bone, cartilage and reticular stromal potential" View article in PubMed
February 12, 2015 - "The NAD-dependent deacetylase SIRT2 is required for programmed necrosis" View article in PubMed
Osteoarthritis, Fracture Healing and the Impact of Diabetes on the Skeleton
February 8, 2018 - "Germinal Center B Cells Are Essential for Collagen - Induced Arthritis"
January 24, 2018 - "Nanoindentation modulus of murine cartilage: a sensitive indicator of the initiation and progression of post-traumatic osteoarthritis"
January 11, 2018 - "Inflammatory cytokines stabilize SOXC transcription factors to mediate the transformation of fibroblast - like synoviocytes in arthritic disease"
January 4, 2018 - "Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes"
November 30, 2017 - "Intermittent Fasting Promotes Wite Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota"
November 9, 2017 - "Effects of local delivery of BMP2, zoledronate and their combination on bone microarchitecture, biomechanics and bone turnover in osteoporotic rabbits"
November 2, 2017 - "Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression"
October 26, 2017 - "Regional Differences Between Perisynovial and Infrapatellar Adipose Tissue Depots and Their Response to Class II and Class III Obesity in Patients with Osteoarthritis." View article in PubMed
August 31, 2017 - "Knee osteoarthritis has doubled in prevalence since the mid-20th century." View article in PubMed
August 17, 2017- "Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs" View article in PubMed
August 10,2017 - "Mechanoresponsive stem cells to target cancer metastases through biophysical cues" View article in PubMed
August 3, 2017 - "Impact Insertion of Osteochondral Grafts: Interference Fit and Central Graft Reduction Affect Biomechanics and Cartilage Damage" View article in PubMed
July 20, 2017 - "Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells" View article in PubMed
July 13, 2017 - "Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis" View article in PubMed
June 29, 2017 - "Beyond Sequencing: Population Analysis in an Era of Mass Spe" View webinar
June 22, 2017 - "FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging." View article in PubMed
June 15, 2017 - "Joint morphogenetic cells in the adult mammalian synovium" View article in PubMed
June 8, 2017 - "Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties" View article in Nature
June 1, 2017 - "Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug." View article in PubMed
May 11, 2017 - "Exogenous fibroblast growth factor 9 attenuates cartilage degradation and aggravates osteophyte formation in post-traumatic osteoarthritis" View article in PubMed
May 4, 2017 - "Post-Traumatic Osteoarthritis in Mice Following Mechanical Injury to the Synovial Joint" View article in PubMed
April 27, 2017 - "Differences in sensitivity to microstructure between cyclic - and impact-based microindentation of the human cortical bone." View article in PubMed
March 30, 2017 - "Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice." View article in PubMed
March 9, 2017 - "Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease" View article in PubMed
February 16, 2017 - "Assessment of collagen quality associated with non-enzymatic cross-links in human bone using Fourier-transform infrared imagining" View article in PubMed
February 9, 2017 - "Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity" View article in PubMed
February 2, 2017 - "Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage" View article in Arthritis & Rheumatology
January 19, 2017 - "Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes." View article in PubMed
January 5, 2017 - "Early, focal changes in cartilage cellularity and structure following surgically induced meniscal destabilization in the mouse." View article in PubMed
December 15, 2016 - "Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury" View article here
October 6, 2016 - "Hyperelastic "bone": A highly, versatile, growth factor-free, osteogenerative, scalable, and surgically friendly biomaterial" View article here
September 8, 2016 - "Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage" View article here
September 1,2016 - "Defining the consequences of genetic variation on a proteome-wide scale" View article in PubMed
August 25, 2016 - "Interaction of HIF1α and β-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice" View article here
August 18, 2016 - "Peptide - siRNA nanocomplexes targeting NF - kB subunit p65 suppress nascent experimental arthritis" View article in JCI
August 11,2016 - "Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis" View article in JCI
August 4,2016 - "Genome-wide associate study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility gene" View article in Science Direct
July 28, 2016 - "Reduction of friction by recombinant human proteoglycan 4 in IL-1α stimulated bovine cartilage explants" View article in Pubmed
July 21, 2016 - "Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest" View pdf article here
July 14, 2016 - "Network Analysis Implicates Alpha-Synuclein (Snca) in the Regulation of Ovariectomy-Induced Bone Loss" View article in PubMed
July 7, 2016 - "Protein related to DAN and cerberus (PRDC) inhibits osteoblastic differentiation and its suppression promotes osteogenesis in vitro." View article in PubMed
June 30, 2016 - "CCL20/CCR6 Signaling Regulates Bone Mass Accrual in Mice" View pdf article here
June 23, 2016 - "Sepsis- Induced Osteoblast Ablation Causes Immunodeficiency"
June 2, 2016 - "Bone marrow lesions detected by specific combination of MRI sequences are associated with severity of osteochondral degeneration" View article in PubMed
May 26, 2016 - "A predictive computational framework for direct reprogramming between human cell types." View article in PubMed
May 12, 2016 - "Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis." View article in PubMed
May 5, 2016 - "NOTCH signaling in skeletal progenitors is critical for fracture repair." View article in PubMed
April 28, 2016 - "Sex steroid deficiency-associated bone loss in microbiota dependent and prevented by probiotics." View article in PubMed
April 21, 2016 - "Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis" View article in PubMed
February 25, 2016 - "Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term" View article in PubMed
February 11, 2016 - "Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro" View article in PubMed
February 4, 2016 - "Fibrin accumulation secondary to loss of plasmin-mediated fibrinolysis drives inflammatory osteoporosis in mice" View article in PubMed
January 28, 2016 - "Vitamin D prevents articular cartilage erosion by regulating collagen II turnover through TGF-B1 in ovariectomized rats" View article in PubMed
December 17, 2015 - "Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density" View article in PubMed
December 10, 2015 - "The alarmins S100A8/A9 induce canonical Wnt signaling in murine knee joints; implications for osteoarthritis" View article in PubMed
October 22, 2015 - "Chronic superantigen exposure induces systemic inflammation, elevated bloodstream endotoxin and abnormal glucose tolerance in rabbits: possible role in diabetes" View article in PubMed
October 15, 2015 - "Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture" View article in PubMed
October 1, 2015 - " Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation" View article in PubMed
September 24, 2015 - "Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice" View article in PubMed
September 17, 2015 - "Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis" View article in PubMed
September 10, 2015 - "Intermittent Parathryoid Hormone Enhances Cancellous Osseointegration of a Novel Murine tibial Implant" View article in PubMed
September 3, 2015 - "Intermittent PTHrP (1-34) exposure augments chondrogenesis and reduces hypertrophy of mesenchymal stromal cells" View article in PubMed
August 27, 2015 - "PTH [1-34]-induced alterations of the subchondral bone provoke early osteoarthritis" View article in PubMed
August 20, 2015 - "Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification" View article in PubMed
July 30, 2015 - "The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment" View article in PubMed
July 23, 2015 - "IKKB in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5" View article in PubMed
July 16, 2015 - "Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation" View article in PubMed
June 4, 2015 - "Response of knee fibrocartilage to joint destabilization" View article in PubMed
May 28, 2015 - "Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients" View article in PubMed
May 19, 2015 - "Ex vivo non-invasive assessment of cell viability and proliferation in bio-engineered whole organ constructs" View article in PubMed
April 2, 2015 - "Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity" View article in PubMed
March 19, 2015 - "Airflow accelerates bovine and human articular cartilage drying and chondrocyte death" View article in PubMed
February 5, 2015 - "PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis" View article in PubMed
December 4, 2014 - "Rapid, automated imaging of mouse articular cartilage by microCT for early detection of osteoarthritis and finite element modelling of joint mechanics" View article in PubMed
November 20, 2014 (Plato Schwartz Library) - "Effects of CD14 Macrophages and Proinflammatory Cytokines on Chondrogenesis in Osteoarthritic Synovium-Derived Stem Cells" View article in PubMed
November 13, 2014 (Plato Schwartz Library) - "Inhibition of TGF-B signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis" View article in PubMed
October 23, 2014 - "Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes" View article in PubMed