Clinical Trials As a Center of Research Translation, the Center for Musculoskeletal Research, URMC Orthopaedics and Rehabilitation, and UR Rheumatology are committed to increasing the diversity and efficacy of treatments and procedures available to our patients from the Rochester, NY region. We conduct state-of-the-art translational studies to better understand disease processes and clinical trials in multi-site efforts that are national in scope. URMC is one of the first institutions nationwide with funding from the National Institutes of Health to establish the University of Rochester Clinical and Translational Science Institute (CTSI). The CTSI is to lead the emerging field of clinical and translational research to more quickly advance treatments to patients. We are also developing educational programs to train clinicians and biomedical scientists in the conduct of translational research and clinical trials. Read about our clinical trials below. Principal Investigator RSRB#/WIRB# Official Title Sponsor ClinicalTrials.gov# Anolik Pending A Pilot, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Study to Evaluate Efficacy, Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Pharmacogenetics of CC-220 in Subjects with Systemic Lupus Erythematosus Celgene Corporation NCT02185040 Anolik 24715 A Partially Blinded, Randomized Multi-Center, Phase IV Trial to Evaluate Mechamism of Action of Anti-TNF Agents in Rheumatoid Arthritis (ARA06) NIH NIAID Autoimmunity Centers of Excellence NCT00837434 Anandarajah 20101481 A Phase 3, Multi-center, Randomized, Double-Blind, Placebo-Controlled, Paraellel-Group, Efficacy and Safety Study of Two Doses of Apremilast (CC-10004) In Subjects with Active Psoriatic Arthritis Celgene Corporation NCT01212757 Anandarajah 20131480 A Phase 3, Randomized, Double-blind, Placebo-controlled Study of The Efficacy and Safety of 2 Doses of Tofacitinib (Cp-690,550) or Adalimumab in Subjects with Active Psoriatic Arthritis Pfizer, Inc. NCT01877668 Coca 39964 A Randomized, Double-Blind, Placebo-controlled Phase II Clinical Trial of Baminercept, a Lymphotoxin-beta Receptor Fusion Protein, for the Treatment of Primary Sjögren's Syndrome (ASJ02) NIH NIAID NCT01552681 Looney 49397 T and B Cell Responses Across Autoimmune Diseases (SRA01) NIH NIAID Autoimmunity Centers of Excellence NTC01947036 Looney 48772 An Investigator-Initiated, Phase II, Randomized, Withdrawal Study of Mycophenolate Mofetil (MMF) in Patients with Stable, Quiescent Systemic Lupus Erythematosus (SLE) NIH NIAID Autoimmunity Centers of Excellence NCT01946880 Ritchlin 55799 A Randomized, Double-Blind, Placebo-controlled Phase 3 Study to Evaluate the Efficacy, Safety and Effect on Radiographic Progression of Brodalumab in Subjects With Psoriatic Arthritis: AMVISION-1 Amgen, Inc. NCT02029495 Ritchlin 39346 A Randomized, Double-blinded, Placebot-controlled Multiple-dose Study with an Open Label Extension to Evaluate the Safety and Efficacy of AMG 827 in Subjects with Psoriatic Arthritis Amgen, Inc. NCT01516957 Ritchlin 53086 DC-STAMP and TRAF3: Regulators of Osteoclastogenesis and Biomarkers in Psoriatic Arthritis NIH NCATS CTSA NCT02413749 Ritchlin 53131 Serum, Cellular and Imaging Markers of Arthritis in Psoriasis Patients Rheumatology Research Foundation NCT2413801 Ritchlin 13959 Microarray Analysis of Peripheral Blood and Tissues of Patients with Immune Mediated Inflammatory Diseases Centocor, Inc. NCT00462072 Ritchlin 32368 Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) as a Severity and Response Biomarker in Psoriatic Arthritis National Psoriasis Foundation NCT01123265 Ritchlin 35995 The Morphologic and Functional Relationship Between the Draining PLN and Synovial Inflammation in the Knee Joints of RA Patients Before and After Anti-TNF or B Cell Depletion Therapy NIH NIAID P01 NCT01083563 Ritchlin 27553 The Effect of Certolizumab on Lower Extremity Lymph Flow in Rheumatoid Arthritis UCB, Inc. NCT01098201 Ritchlin 39665 Prospective Validation of Soluble Biomarkers as Predictors of Structural Damage in Rheumatoid Arthritis Canadian Research and Education in Arthritis NCT01476956 Schwarz 15198 Vascular CT Assessment of Structural Autograft and Allograft Healing NIH NIAMS P50 CORT NCT00594776 White/Looney 31281 A Randomized, Double-Blind, Placebo-Controlled, Phase II Multicenter Trial of a Monoclonal Antibody to DS20 (Rituximab) for the Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH) NIH NIAID Autoimmunity Centers of Excellence NCT01086540 Please also see a list of our Sponsored Clinical Studies.