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Clinical Trials and Studies

As a Center of Research Translation, the Center for Musculoskeletal Research, URMC Orthopaedics and Rehabilitation, and UR Rheumatology are committed to increasing the diversity and efficacy of treatments and procedures available to our patients from the Rochester, NY region. We conduct state-of-the-art translational studies to better understand disease processes and clinical trials in multi-site efforts that are national in scope.

URMC is one of the first institutions nationwide with funding from the National Institutes of Health to establish the University of Rochester Clinical & Translational Science Institute (UR CTSI). The UR CTSI is to lead the emerging field of clinical and translational research to more quickly advance treatments to patients. We are also developing educational programs to train clinicians and biomedical scientists in the conduct of translational research and clinical trials.

All open clinical trials, sponsored clinical studies, and other studies are listed below.

Table of principal investigators with associated study names, RSRB or IRB numbers, and sponsors.
Principal Investigator RSRB # or IRB # Study Title Sponsor
Anolik 22559 Immunological Assay Development NIH
Anolik 55411 AMP Collaboration: Cellular Dynamics at the Synovium Bone Interface in RA  
Awad  STUDY00004840 A Microphysiological System of Tendon Inflammation and Fibrosis for Drug Screening and Efficacy NIH
Baumhauer 62579 Evaluation of the PROMIS Computerized Adaptive Tests in Foot and Ankle Patients  
Baumhauer 68138 Evaluation of the PROMIS Computerized Adaptive Tests in Orthopaedic Injection Patients  
Baumhauer 69111 Using Patient-Reported Outcomes (PRO) in Clinical Care: Analyses of PRO Collected with UR VOICE  
Baumhauer 70382 Using Patient Reported Outcome Measures to Evaluate Health Care by Census Block Group  
Baumhauer 3118 Determination of the Minimum Clinically Important Difference (MCID) and Patient Acceptable Symptomatic State (PASS) using PROMIS Following Orthopedic Procedures  
Boyce 72856 Histologic Osteoporosis in Patients Receiving Total Hip Arthroplasty  
Buckley 48660 Regenerative capacity and mechanical properties of tendinopathic and healthy human tendons of the foot and ankle ex-vivo NIH
Carmody (Tyler) 55998 A Randomized Trial to Assess Patient Quality of Life and Function after Alternative Surgeries for Pathologic Fractures of the Femur Memorial Sloan Kettering Cancer Center
Carmody 73583 Coned Hemi Pelvic Replacement-Compassionate Care Case  
Cole 73355 Effect of CHAMPP Intervention on Injury Prevention, Performance, and Academic Outcomes in a Cohort of Inner-City and Suburban School Adolescent Athletes  
Cook STUDY00003390 Prediction of skeletal maturity using pelvic radiographs – a simplified scale  
Cook STUDY00003486 LLD Measurement using Scoliometer  
Daiss 46924 Whole Blood Samples and Nasal Swabs for Measurement of Ongoing Humoral Immune Response in Patients with Acute and Chronic Staphylococcus aureus Infections  
DelSignore STUDY00000084 Suture Suspension Technique for Addressing Basal Joint Arthritis  
DiGiovanni 72073 Orthopaedic Surgery Skills Acquisition: Where, How, and From Whom Residents Are Learning  
DiGiovanni 73064 The Refinement and Reorganization of an Orthopaedics Sub-Internship Curriculum at the University of Rochester  
Drinkwater 50069 Birmingham Hip Resurfacing (BHR) System Post Approval Study - A Prospective, Multi-Centered Study of the BHR Smith & Nephew
Eliseev 52621 Expansion and Characterization of Mesenchymal Stem Cells from Human Bone Marrow  
Flemister STUDY00003715 Radiographic Outcomes After Flexible Flatfoot Reconstruction and Spring Ligament Reconstruction with a Fibertape device   
Flemister 67864 Modulation of Insertional Achilles Tendinopathy by Multiaxial Mechanical Strains NIH
Ginnetti 60948 Comparison of Validated Hip Outcome Scores to PROMIS CAT in Patients Undergoing Total Hip and Knee Arthroplasty  
Ginnetti STUDY0000489 Worse than Death EQ-5D Derived Utility Scores Amongst COVID-19 Total Joint Arthroplasty Case Cancellations at an Academic Medical Center in New York State  
Ginnetti STUDY00004981 Patient Perspectives and Perceptions of Routine Postoperative Total Joint Arthroplasty Encounters  
Ginnetti STUDY00004866 Patient Perspectives of Robotic Assisted Total Joint Arthroplasty  
Ginnetti STUDY00004388 The Clinical Impact of GIAN’s HealthCart Mobile Application in Patients with Symptomatic Hip and Knee Osteoarthritis  
Ginnetti 3254 Surgical Approach on THA Outcomes  
Ginnetti STUDY00004741 Time Driven Activity Based Costing of Total Joint Arthroplasty Physician Billing Processes at an Academic Medical Center  
Ginnetti 66743 Acetabular Screw Fixation  
Giordano 46161 Clinical Outcomes for Subjects with Borderline Acetabular Dysplasia Before and After Hip Preservation Surgery  
Giordano 56194 Comparison of Validated Hip Outcome Scores to PROMIS CAT in Patients Undergoing Hip Arthroscopy  
Giordano 57374 Accuracy of Intra-Articular Anesthetic Hip Injection as Predictor of Hip Arthroscopy Outcome   
Giordano 69306 Surgeons’ Accuracy of Predicting Patient-Reported Outcome and Satisfaction Scores in Patients Undergoing Hip Arthroscopy  
Giordano 72558 Gene Expression in Femoroacetabular Impingement and Osteoarthritis: Evaluating Markers of Inflammation and Bone Metabolism Goldstein
Gorczyca 50934 Limit of Threshold of Subchondral Bone Within the Humeral Head at Which Locked Screw Fixation Fails in the Operative Treatment of Proximal Humerus Fractures  
Gorczyca 69635 Peri-Operative Anemia in Geriatric Hip Fractures Determining Expected Change in Hemoglobin and Hematocrit in the Peri-Operative Period  
Gorczyca 70470 Femoral Neck Fractures in Patients with End Stage Renal Disease Undergoing Hemodialysis: A comparison of outcomes, morbidity and mortality of hemiarthroplasty vs. cannulated screw fixation  
Gorczyca STUDY00004199 Outcomes of Pelvic Ring Injuries Associated with Traumatic Urologic Injury  
Gorczyca STUDY00003156 ABOS Knowledge, Skills, and Behavior   
Hammert 50425 Lymphedema Following Elective Hand and Wrist Surgery in Women who are Post Axillary Lymph Node Dissection: A Prospective Clinical Trial  
Hammert 54202 Comparison of the MHQ, Boston Carpal Tunnel Syndrome Scale, and PROMIS Physical Function, Upper Extremity and Pain CAT Instruments in Carpal Tunnel Syndrome  
Hammert 57511 A Multicenter, Prospective, Randomized, Subject and Evaluator Blinded Comparative Study of Nerve Cuffs and Avance Nerve Graft Evaluation Recovery Outcomes for the Repair of Nerve Discontinuities  
Hammert 60764 Hand Division PROMIS Outcomes Analysis  
Hammert STUDY00004266 Osteoporosis Screening with Computer Learning and Bone Density Goldstein
Hammert 70952 A Prospective Study to Evaluate the Safety and Effectiveness of Cartiva® Synthetic Cartilage Implant (SCI) for CMC in the Treatment of First Carpometacarpal Joint Osteoarthritis as Compared to a Ligament Reconstruction Tendon Interposition  
Hammert STUDY00004499 Hand Division Outcomes Analysis   
Hammert STUDY00003512 M-CHIQ Carpal Tunnel Review  
Hammert STUDY00003298 Determining Factors that Predict Eventual Surgical Treatment for Thumb Carpometacarpal Arthritis and Assessing Effect of Surgical Treatment on Patient-Reported Outcomes.  
Hammert STUDY00001450 (69331) Computer Learning for Osteoporosis Screening  
Jonason 42321 Inhibition of Osteoarthritic Articular Chondroctye Maturation by Teriparatide and The Influence of Type 2 Diabetes on Osteoarthritis Progression  
Jonason 71804 Inflammation-Mediated Mineralization of the Meniscus in OA Pathogenesis NIH P30
Jonason STUDY00004402 Chondrocyte DNA Double-Strand Breaks in the Pathogenesis of Osteoarthritis NIH
Judd STUDY00004474 The Effect of Timing of Preoperative Hemodialysis on the Outcomes of Hip Fractures patients with Chronic Kidney Disease  
Judd 64534 Comparison of Short Term Outcomes for Patients on Novel Oral Anticoagulation to Those Being Treated with Traditional Oral Anticoagulant or No Anticoagulation at the Time of Hip Fracture  
Judd 3100 Comparison of Hip Hemiarthroplasty Outcomes Based on Surgical Approach  
Judd 64894 Prospective, Randomized, Double-Blinded, Controlled Multi-Center Clinical Trial Evaluating the Use of Non-Invasive CMF Bone Stimulation as Adjunct to Surgical Treatment of Ankle Fractures   
Kenney STUDY00004882 Longitudinal Outcomes after Dome High Tibial Osteotomy: up to 20 years follow-up  
Ketonis 72116 Establishment of a Murine Model of Pyogenic Flexor Tenosynovitis and Investigation of Novel Treatment Strategies NIH
Ketonis STUDY00003239 Non-invasive assessment of the ulnar nerve around the elbow and diagnosis of cubital tunnel using machine learning Goldstein
Ketz 41701 Complications Following Treatment for Hip Fractures  
Ketz 60775   Fibular Length and its Importance among Patients Undergoing Operative Fixation of Ankle Fractures   
Ketz 60987 Computed Tomography of Ankle Fractures Changes, Surgical Approach and Fixation Strategy for the Posterior Malleolus  
Ketz 61574 Unplanned Readmissions following Hip and Knee Arthroplasty Surgery  
Ketz 63803 Obesity and Morbid Obesity as an Independent Predictor of Poor Outcome Following Lower Extremity Long Bone Fracture  
Ketz 66343 Failure after Extensor Mechanism Repair  
Ketz 70461 Ankle Stability and Comparison of Intraoperative Stress Views  
Ketz 71903 Does Primary Closure of Pin-Sites Following Removal of External Fixator Increase Risk of Infection  
Ketz STUDY00004341 Proximal Humerus Fractures: Non-Operative Versus Operative Treatment  
Ketz STUDY00003566 From Injury to the O.R.: Iatrogenic Interval Displacement of Fractures  
Ketz STUDY00004417 A retrospective study of PROMIS outcomes in hammer toes fixed with an intramedullary device compared to K wire fixation   
Ketz STUDY00003626 posterior tibialis tendon transfer for foot-drop secondary to a traumatic injury to their common peroneal nerve  
Ketz STUDY00003907 Patient Outcomes after Undergoing Staged Treatment for Calcaneus Fractures  
Ketz 67423 The Treatment of Talar Head Fractures-Background and Technical Tips  
Ketz 67345 Flexor Hallicus Longus Tendon Transfer for the Treatment of Posterior Ankle Wounds  
Loiselle 54231 Evaluating the Effects of Type 2 Diabetes on Insulin Responsiveness in Human Tendon and Synovial Sheets  
Loiselle 70644 Non-Invasive Ultrasound Assessment of Tendon Healing  
Maloney STUDY00004103 Observational Analysis of Elbow & Shoulder
Mechanics of Baseball Pitchers Using Novel
Wearable Sensor Technology through a full Season of Game Play 
Maloney STUDY00003949 Long-Term Outcomes of Corticosteroid Injections versus Iontophoresis for Treatment of Lateral Epicondylitis   
Maloney 60825 Clinical Outcomes of Superior Capsule Reconstruction for Irreparable Rotator Cuff Tears  
Mannava STUDY00005121 Workers’ Compensation Arthroscopic Rotator Cuff Repair PROMIS Outcomes Study   
Mannava STUDY00004814 Patient Reported Outcomes after PRP Injections  
Mannava STUDY00004932 The Impact of Depression on Rehabilitation Compliance After Rotator Cuff Repair  
McDowell STUDY00003331  Outcomes of Surgical Intervention to Treat Femoral Metastases   
Mesfin 47517 Regulating Angiogenic and Osteoblastic Pathways in Metastatic Renal Cell Cancer to Bone R30
Mesfin 50144 Evaluation of Infection Following Vancomycin Application  
Mesfin 53083 Anabolic and Catabolic Marker Expression in Human Intervertebral Disc Specimen  
Mesfin 53644 Outcomes Following Surgical and Non-Surgical Management of Hyperostotic Spine Fractures  
Mesfin 54543 Investigating the role of Tracheal Traction Exercises (TTE) in reducing dysphagia following anterior cervical surgery Goldstein
Mesfin 59360 Prevalence of cervical spine conditions in Patients Undergoing CT of the Cervical Spine and lumbar spine conditions in patients undergoing CT of the abdomen/pelvis   
Mesfin 59379 Outcomes of Operative and Non-Operative Management of Lumbar Fractures: Long-Term  Follow Up  
Mesfin 62665 Spinal Cord Injury Patients: Outcomes and Complications   
Mesfin 63350 Feasibility of Occipital Condyle Screws  
Mesfin 63580 Primary Tumors of the Spine: Outcomes and Complications    
Mesfin 64309 Complications of Surgical Microscope-Assisted Procedures  
Mesfin 67541 Metastatic Tumor Research and Outcome Network (MTRON): A Multicenter Prospective Registry for the Management of Metastatic Spine Tumors  AO Foundation
Mesfin 73657 Long-Term radiographic and clinical outcomes in patients undergoing un-instrumented fusion for spinal deformity  
Mesfin STUDY00004067 (72904) Patient Interactions with Physician Review Websites  
Mesfin STUDY00000340 (40854) Long-Term Pulmonary Function in Operative Compared to Non-Operatively Treated Idiopathic Scoliosis  
Mesfin STUDY00003882 Surgical Management of Cervical Ossification of the Posterior Longitudinal Ligament (OPLL): Outcomes and Complications  
Mesfin STUDY00004300 Surgical Management of Synovial Cysts  
Mesfin STUDY00004797 Understanding Usage of Intraoperative Neuromonitoring in Cervical and Thoracolumbar Spine Surgery and Patient Outcomes  
Mesfin STUDY00004913 Academic Characteristics of Orthopedic Division Chiefs and Division Chiefs’ opinion regarding the Impact of COVID in their practice  
Mesfin STUDY00004790 Thoracic Cage Injuries: Prevalence and Correlation of Sternal Fractures Accompanying Thoracic Spinal Fractures  
Mesfin STUDY00004749 Impact of Preoperative Depression on Survey Results in an Outpatient Setting  
Molinari STUDY00003466 Case Series on Dropped Head Syndrome  
Myers STUDY00004121 Machine Learning (ML) Using Large Scale Administrative Data to Predict 90-day Complications and Readmissions After THA and TKA at the University of Rochester Goldstein
Nelson 3293 Anesthetic Burden in Casting  
Nelson STUDY00000177 (28880) The Treatment of Progressive Early Onset Spinal  Deformities: A Multi-Center Outcome Study PSSG
Nelson WIRB20172069 Setting Scoliosis Straight Surgeon Performance Program SSSF
Nicandri 58828 A Pilot Study Using PROMIS to Assess the Health and Well-Being of Orthopaedic Residents  
Nicandri 68012 Establishing Proficiency Benchmarks for Orthopaedic Surgery Trainees Using the Fundamentals of Arthroscopic Surgery Training (FAST) Workstation  
Nicandri 51422 Does the FAST Program Demonstrate Transfer Validity OREF
Oh 57719 Clinical Applicability of Using Circulating Antibody-Secreting Cells and Microbiome Analysis for Assessments of Treatment Response and Prognosis of Active Infections in Diabetic Foot Ulcer Goldstein
Oh 61239 Elucidating Staphylococcus aureus Deformation, Migration and Persistence Within the Canalicular System of Human Bone in Osteomyelitis  
Oh STUDY00003255 Immunoassay for Diagnosis and Tracking Treatment Response in 
Orthopaedic Infections
Oh STUDY00003644  Investigating Patient-Reported Outcomes Measurement Information System (PROMIS) for Neuropathic Pain Identification  
Oh STUDY00004278 Clinical Outcomes of a Synthetic Cartilage Implant
Hemiarthroplasty vs First Metatarsophalangeal Joint Arthrodesis in Hallux Rigidus Using Patient Reported Outcomes Measurement  Information System 
Oh STUDY00003593 Use of Vancomycin Powder in Patients Undergoing Surgical Treatment for Diabetic Foot Infection  
Ricciardi STUDY00003836 Analyzing Recommended Smoking Cessation Compliance in Total Joint Arthroplasty Patients  
Ricciardi 68592 What are preoperative predictors of 90-day readmission and 1-year mortality after hemiarthroplasty or total hip arthroplasty for femoral neck fracture in a comprehensive geriatric fracture care model  
Rizzone 58797 Sports Specialization and the Risk of Sports-Related Injury in Athletes  
Rizzone 66925 Serum Levels and Stress Fractures AMSSM
Rizzone 67018 Assessment of patellar tendon characteristics in children Strong Children's Research Center
Rizzone 68651 Outcomes of Overuse Injuries in a Sports Medicine Clinic  
Rizzone 72520 Outcomes of Dry Needling in Lower Extremity  
Rizzone 72858 Female Perspectives on Sports Bras  
Rizzone STUDY00004977 Bone Stress Injury Case Review  
Rizzone STUDY00003503 Playing Surface Material and Acute Knee Pathology in High School Athletes: A Prospective Cohort Study of the NATION Data  
Rizzone STUDY000004453 Visibility of NCAA Institutional Policy Statements for Transgender Athletes  
Rizzone STUDY00004508 Stakeholders’ Perceptions and Experiences with ACL Injury Prevention in Kids (SPEAK) AMSSM
Rizzone STUDY00004848 Improving Long-Term Activity Levels and Health Outcomes in At-Risk, Underrepresented Adolescent Females through Implementation of a Teacher-Student Physical Activity Program P30
Rubery 65202 Morphology of the Pediatric Occiput and Cervical Spine: A CT-Based Study   
Rubery STUDY00003049 Evaluation of UR Wellness Workplace Health Program Outcomes  
Rubery 62787 Evaluation of the PROMIS in Patients with Spinal Deformities and Spine Tumors   
Soles 61705 Bilateral Total Hip Arthroplasty: Comparing Financial and Surgical Outcomes of Simultaneous versus Staged Intervention  
Soles STUDY00004196 Anatomic reduction of the Sacroiliac Joint and Posterior Pelvic Ring: Does Quality of Reduction Affect Clinical Outcomes?  
Speech 38136 Retrospective Review of Electrodiagnostic Evaluations of Patients with Possible Cubital and Carpal Tunnel Syndrome  
Thirukumaran 66116 Health Services Research for Investigating Determinants and Outcomes of orthopaedic care  
Thirukumaran 67863 Big Data Methods for Surveillance of Post-Operative Complications in Orthopaedics  
Thirukumaran 69386 Impact of Bundeled Payment Reforms on Racial and Socioeconomic Disparaties in Hip and Knee Replacement Surgeries  
Voloshin 59175 Comparison of Validated Shoulder Outcome Scores to PROMIS CAT in Patients Undergoing Shoulder Arthroplasty  
Voloshin STUDY00003714  Evaluation of the PROMIS Computerized Adaptive Tests in Shoulder Patients   
Voloshin 69763 Reconstruction of the Anterior Rotator Cable via Long Head of Biceps Imbrication: A Surgical Technique Description and Case Series  
Voloshin 71615 Mid-Term Radiographic and Clinical Outcomes for Second Generation Trabecular MetalTM Glenoid Components in Total Shoulder Arthroplasty Zimmer Biomet Inc.
Voloshin STUDY00003162 Mid-term Radiographic and Clinical Outcomes for Uncemented Second Generation Trabecular Metal Glenoid Components in Total Shoulder Arthroplasty (II)  
Voloshin STUDY00003895 Should Internal Rotation be Restricted after Reverse Total Shoulder Arthroplasty Goldstein
Wilbur STUDY00004432 Dupuytrens Disease  
Wilbur STUDY00003463 NSAIDs vs. Opioids  
Wilbur STUDY00004149 Digit Widget in Dupuytren's  
Zuscik 65996 Evaluating Teriparatide as a Chondroregenerative Therapy in Human Ostroarthritis Hansjorg Wyss Award