URMC / Center for Musculoskeletal Research / Clinical Trials and Studies

Clinical Trials and Studies

As a Center of Research Translation, the Center for Musculoskeletal Research, URMC Orthopaedics and Rehabilitation, and UR Rheumatology are committed to increasing the diversity and efficacy of treatments and procedures available to our patients from the Rochester, NY region. We conduct state-of-the-art translational studies to better understand disease processes and clinical trials in multi-site efforts that are national in scope.

URMC is one of the first institutions nationwide with funding from the National Institutes of Health to establish the University of Rochester Clinical & Translational Science Institute (UR CTSI). The UR CTSI is to lead the emerging field of clinical and translational research to more quickly advance treatments to patients. We are also developing educational programs to train clinicians and biomedical scientists in the conduct of translational research and clinical trials.

All open clinical trials, sponsored clinical studies, and other studies are listed below.

Table of principal investigators with associated study names, RSRB or IRB numbers, and sponsors.
Principal Investigator	RSRB # or IRB #	Study Title	Sponsor
Anolik	22559	Immunological Assay Development	NIH
Anolik	55411	AMP Collaboration: Cellular Dynamics at the Synovium Bone Interface in RA
Awad	STUDY00004840	A Microphysiological System of Tendon Inflammation and Fibrosis for Drug Screening and Efficacy	NIH
Baumhauer	62579	Evaluation of the PROMIS Computerized Adaptive Tests in Foot and Ankle Patients
Baumhauer	68138	Evaluation of the PROMIS Computerized Adaptive Tests in Orthopaedic Injection Patients
Baumhauer	69111	Using Patient-Reported Outcomes (PRO) in Clinical Care: Analyses of PRO Collected with UR VOICE
Baumhauer	70382	Using Patient Reported Outcome Measures to Evaluate Health Care by Census Block Group
Baumhauer	3118	Determination of the Minimum Clinically Important Difference (MCID) and Patient Acceptable Symptomatic State (PASS) using PROMIS Following Orthopedic Procedures
Boyce	72856	Histologic Osteoporosis in Patients Receiving Total Hip Arthroplasty
Buckley	48660	Regenerative capacity and mechanical properties of tendinopathic and healthy human tendons of the foot and ankle ex-vivo	NIH
Carmody (Tyler)	55998	A Randomized Trial to Assess Patient Quality of Life and Function after Alternative Surgeries for Pathologic Fractures of the Femur	Memorial Sloan Kettering Cancer Center
Carmody	73583	Coned Hemi Pelvic Replacement-Compassionate Care Case
Cole	73355	Effect of CHAMPP Intervention on Injury Prevention, Performance, and Academic Outcomes in a Cohort of Inner-City and Suburban School Adolescent Athletes
Cook	STUDY00003390	Prediction of skeletal maturity using pelvic radiographs – a simplified scale
Cook	STUDY00003486	LLD Measurement using Scoliometer
Daiss	46924	Whole Blood Samples and Nasal Swabs for Measurement of Ongoing Humoral Immune Response in Patients with Acute and Chronic Staphylococcus aureus Infections
DelSignore	STUDY00000084	Suture Suspension Technique for Addressing Basal Joint Arthritis
DiGiovanni	72073	Orthopaedic Surgery Skills Acquisition: Where, How, and From Whom Residents Are Learning
DiGiovanni	73064	The Refinement and Reorganization of an Orthopaedics Sub-Internship Curriculum at the University of Rochester
Drinkwater	50069	Birmingham Hip Resurfacing (BHR) System Post Approval Study - A Prospective, Multi-Centered Study of the BHR	Smith & Nephew
Eliseev	52621	Expansion and Characterization of Mesenchymal Stem Cells from Human Bone Marrow
Flemister	STUDY00003715	Radiographic Outcomes After Flexible Flatfoot Reconstruction and Spring Ligament Reconstruction with a Fibertape device
Flemister	67864	Modulation of Insertional Achilles Tendinopathy by Multiaxial Mechanical Strains	NIH
Ginnetti	60948	Comparison of Validated Hip Outcome Scores to PROMIS CAT in Patients Undergoing Total Hip and Knee Arthroplasty
Ginnetti	STUDY0000489	Worse than Death EQ-5D Derived Utility Scores Amongst COVID-19 Total Joint Arthroplasty Case Cancellations at an Academic Medical Center in New York State
Ginnetti	STUDY00004981	Patient Perspectives and Perceptions of Routine Postoperative Total Joint Arthroplasty Encounters
Ginnetti	STUDY00004866	Patient Perspectives of Robotic Assisted Total Joint Arthroplasty
Ginnetti	STUDY00004388	The Clinical Impact of GIAN’s HealthCart Mobile Application in Patients with Symptomatic Hip and Knee Osteoarthritis
Ginnetti	3254	Surgical Approach on THA Outcomes
Ginnetti	STUDY00004741	Time Driven Activity Based Costing of Total Joint Arthroplasty Physician Billing Processes at an Academic Medical Center
Ginnetti	66743	Acetabular Screw Fixation
Giordano	46161	Clinical Outcomes for Subjects with Borderline Acetabular Dysplasia Before and After Hip Preservation Surgery
Giordano	56194	Comparison of Validated Hip Outcome Scores to PROMIS CAT in Patients Undergoing Hip Arthroscopy
Giordano	57374	Accuracy of Intra-Articular Anesthetic Hip Injection as Predictor of Hip Arthroscopy Outcome
Giordano	69306	Surgeons’ Accuracy of Predicting Patient-Reported Outcome and Satisfaction Scores in Patients Undergoing Hip Arthroscopy
Giordano	72558	Gene Expression in Femoroacetabular Impingement and Osteoarthritis: Evaluating Markers of Inflammation and Bone Metabolism	Goldstein
Gorczyca	50934	Limit of Threshold of Subchondral Bone Within the Humeral Head at Which Locked Screw Fixation Fails in the Operative Treatment of Proximal Humerus Fractures
Gorczyca	69635	Peri-Operative Anemia in Geriatric Hip Fractures Determining Expected Change in Hemoglobin and Hematocrit in the Peri-Operative Period
Gorczyca	70470	Femoral Neck Fractures in Patients with End Stage Renal Disease Undergoing Hemodialysis: A comparison of outcomes, morbidity and mortality of hemiarthroplasty vs. cannulated screw fixation
Gorczyca	STUDY00004199	Outcomes of Pelvic Ring Injuries Associated with Traumatic Urologic Injury
Gorczyca	STUDY00003156	ABOS Knowledge, Skills, and Behavior
Hammert	50425	Lymphedema Following Elective Hand and Wrist Surgery in Women who are Post Axillary Lymph Node Dissection: A Prospective Clinical Trial
Hammert	54202	Comparison of the MHQ, Boston Carpal Tunnel Syndrome Scale, and PROMIS Physical Function, Upper Extremity and Pain CAT Instruments in Carpal Tunnel Syndrome
Hammert	57511	A Multicenter, Prospective, Randomized, Subject and Evaluator Blinded Comparative Study of Nerve Cuffs and Avance Nerve Graft Evaluation Recovery Outcomes for the Repair of Nerve Discontinuities
Hammert	60764	Hand Division PROMIS Outcomes Analysis
Hammert	STUDY00004266	Osteoporosis Screening with Computer Learning and Bone Density	Goldstein
Hammert	70952	A Prospective Study to Evaluate the Safety and Effectiveness of Cartiva® Synthetic Cartilage Implant (SCI) for CMC in the Treatment of First Carpometacarpal Joint Osteoarthritis as Compared to a Ligament Reconstruction Tendon Interposition
Hammert	STUDY00004499	Hand Division Outcomes Analysis
Hammert	STUDY00003512	M-CHIQ Carpal Tunnel Review
Hammert	STUDY00003298	Determining Factors that Predict Eventual Surgical Treatment for Thumb Carpometacarpal Arthritis and Assessing Effect of Surgical Treatment on Patient-Reported Outcomes.
Hammert	STUDY00001450 (69331)	Computer Learning for Osteoporosis Screening
Jonason	42321	Inhibition of Osteoarthritic Articular Chondroctye Maturation by Teriparatide and The Influence of Type 2 Diabetes on Osteoarthritis Progression
Jonason	71804	Inflammation-Mediated Mineralization of the Meniscus in OA Pathogenesis	NIH P30
Jonason	STUDY00004402	Chondrocyte DNA Double-Strand Breaks in the Pathogenesis of Osteoarthritis	NIH
Judd	STUDY00004474	The Effect of Timing of Preoperative Hemodialysis on the Outcomes of Hip Fractures patients with Chronic Kidney Disease
Judd	64534	Comparison of Short Term Outcomes for Patients on Novel Oral Anticoagulation to Those Being Treated with Traditional Oral Anticoagulant or No Anticoagulation at the Time of Hip Fracture
Judd	3100	Comparison of Hip Hemiarthroplasty Outcomes Based on Surgical Approach
Judd	64894	Prospective, Randomized, Double-Blinded, Controlled Multi-Center Clinical Trial Evaluating the Use of Non-Invasive CMF Bone Stimulation as Adjunct to Surgical Treatment of Ankle Fractures
Kenney	STUDY00004882	Longitudinal Outcomes after Dome High Tibial Osteotomy: up to 20 years follow-up
Ketonis	72116	Establishment of a Murine Model of Pyogenic Flexor Tenosynovitis and Investigation of Novel Treatment Strategies	NIH
Ketonis	STUDY00003239	Non-invasive assessment of the ulnar nerve around the elbow and diagnosis of cubital tunnel using machine learning	Goldstein
Ketz	41701	Complications Following Treatment for Hip Fractures
Ketz	60775	Fibular Length and its Importance among Patients Undergoing Operative Fixation of Ankle Fractures
Ketz	60987	Computed Tomography of Ankle Fractures Changes, Surgical Approach and Fixation Strategy for the Posterior Malleolus
Ketz	61574	Unplanned Readmissions following Hip and Knee Arthroplasty Surgery
Ketz	63803	Obesity and Morbid Obesity as an Independent Predictor of Poor Outcome Following Lower Extremity Long Bone Fracture
Ketz	66343	Failure after Extensor Mechanism Repair
Ketz	70461	Ankle Stability and Comparison of Intraoperative Stress Views
Ketz	71903	Does Primary Closure of Pin-Sites Following Removal of External Fixator Increase Risk of Infection
Ketz	STUDY00004341	Proximal Humerus Fractures: Non-Operative Versus Operative Treatment
Ketz	STUDY00003566	From Injury to the O.R.: Iatrogenic Interval Displacement of Fractures
Ketz	STUDY00004417	A retrospective study of PROMIS outcomes in hammer toes fixed with an intramedullary device compared to K wire fixation
Ketz	STUDY00003626	posterior tibialis tendon transfer for foot-drop secondary to a traumatic injury to their common peroneal nerve
Ketz	STUDY00003907	Patient Outcomes after Undergoing Staged Treatment for Calcaneus Fractures
Ketz	67423	The Treatment of Talar Head Fractures-Background and Technical Tips
Ketz	67345	Flexor Hallicus Longus Tendon Transfer for the Treatment of Posterior Ankle Wounds
Loiselle	54231	Evaluating the Effects of Type 2 Diabetes on Insulin Responsiveness in Human Tendon and Synovial Sheets
Loiselle	70644	Non-Invasive Ultrasound Assessment of Tendon Healing
Maloney	STUDY00004103	Observational Analysis of Elbow & Shoulder Mechanics of Baseball Pitchers Using Novel Wearable Sensor Technology through a full Season of Game Play
Maloney	STUDY00003949	Long-Term Outcomes of Corticosteroid Injections versus Iontophoresis for Treatment of Lateral Epicondylitis
Maloney	60825	Clinical Outcomes of Superior Capsule Reconstruction for Irreparable Rotator Cuff Tears
Mannava	STUDY00005121	Workers’ Compensation Arthroscopic Rotator Cuff Repair PROMIS Outcomes Study
Mannava	STUDY00004814	Patient Reported Outcomes after PRP Injections
Mannava	STUDY00004932	The Impact of Depression on Rehabilitation Compliance After Rotator Cuff Repair
McDowell	STUDY00003331	Outcomes of Surgical Intervention to Treat Femoral Metastases
Mesfin	47517	Regulating Angiogenic and Osteoblastic Pathways in Metastatic Renal Cell Cancer to Bone	R30
Mesfin	50144	Evaluation of Infection Following Vancomycin Application
Mesfin	53083	Anabolic and Catabolic Marker Expression in Human Intervertebral Disc Specimen
Mesfin	53644	Outcomes Following Surgical and Non-Surgical Management of Hyperostotic Spine Fractures
Mesfin	54543	Investigating the role of Tracheal Traction Exercises (TTE) in reducing dysphagia following anterior cervical surgery	Goldstein
Mesfin	59360	Prevalence of cervical spine conditions in Patients Undergoing CT of the Cervical Spine and lumbar spine conditions in patients undergoing CT of the abdomen/pelvis
Mesfin	59379	Outcomes of Operative and Non-Operative Management of Lumbar Fractures: Long-Term Follow Up
Mesfin	62665	Spinal Cord Injury Patients: Outcomes and Complications
Mesfin	63350	Feasibility of Occipital Condyle Screws
Mesfin	63580	Primary Tumors of the Spine: Outcomes and Complications
Mesfin	64309	Complications of Surgical Microscope-Assisted Procedures
Mesfin	67541	Metastatic Tumor Research and Outcome Network (MTRON): A Multicenter Prospective Registry for the Management of Metastatic Spine Tumors	AO Foundation
Mesfin	73657	Long-Term radiographic and clinical outcomes in patients undergoing un-instrumented fusion for spinal deformity
Mesfin	STUDY00004067 (72904)	Patient Interactions with Physician Review Websites
Mesfin	STUDY00000340 (40854)	Long-Term Pulmonary Function in Operative Compared to Non-Operatively Treated Idiopathic Scoliosis
Mesfin	STUDY00003882	Surgical Management of Cervical Ossification of the Posterior Longitudinal Ligament (OPLL): Outcomes and Complications
Mesfin	STUDY00004300	Surgical Management of Synovial Cysts
Mesfin	STUDY00004797	Understanding Usage of Intraoperative Neuromonitoring in Cervical and Thoracolumbar Spine Surgery and Patient Outcomes
Mesfin	STUDY00004913	Academic Characteristics of Orthopedic Division Chiefs and Division Chiefs’ opinion regarding the Impact of COVID in their practice
Mesfin	STUDY00004790	Thoracic Cage Injuries: Prevalence and Correlation of Sternal Fractures Accompanying Thoracic Spinal Fractures
Mesfin	STUDY00004749	Impact of Preoperative Depression on Survey Results in an Outpatient Setting
Molinari	STUDY00003466	Case Series on Dropped Head Syndrome
Myers	STUDY00004121	Machine Learning (ML) Using Large Scale Administrative Data to Predict 90-day Complications and Readmissions After THA and TKA at the University of Rochester	Goldstein
Nelson	3293	Anesthetic Burden in Casting
Nelson	STUDY00000177 (28880)	The Treatment of Progressive Early Onset Spinal Deformities: A Multi-Center Outcome Study	PSSG
Nelson	WIRB20172069	Setting Scoliosis Straight Surgeon Performance Program	SSSF
Nicandri	58828	A Pilot Study Using PROMIS to Assess the Health and Well-Being of Orthopaedic Residents
Nicandri	68012	Establishing Proficiency Benchmarks for Orthopaedic Surgery Trainees Using the Fundamentals of Arthroscopic Surgery Training (FAST) Workstation
Nicandri	51422	Does the FAST Program Demonstrate Transfer Validity	OREF
Oh	57719	Clinical Applicability of Using Circulating Antibody-Secreting Cells and Microbiome Analysis for Assessments of Treatment Response and Prognosis of Active Infections in Diabetic Foot Ulcer	Goldstein
Oh	61239	Elucidating Staphylococcus aureus Deformation, Migration and Persistence Within the Canalicular System of Human Bone in Osteomyelitis
Oh	STUDY00003255	Immunoassay for Diagnosis and Tracking Treatment Response in Orthopaedic Infections
Oh	STUDY00003644	Investigating Patient-Reported Outcomes Measurement Information System (PROMIS) for Neuropathic Pain Identification
Oh	STUDY00004278	Clinical Outcomes of a Synthetic Cartilage Implant Hemiarthroplasty vs First Metatarsophalangeal Joint Arthrodesis in Hallux Rigidus Using Patient Reported Outcomes Measurement Information System
Oh	STUDY00003593	Use of Vancomycin Powder in Patients Undergoing Surgical Treatment for Diabetic Foot Infection
Ricciardi	STUDY00003836	Analyzing Recommended Smoking Cessation Compliance in Total Joint Arthroplasty Patients
Ricciardi	68592	What are preoperative predictors of 90-day readmission and 1-year mortality after hemiarthroplasty or total hip arthroplasty for femoral neck fracture in a comprehensive geriatric fracture care model
Rizzone	58797	Sports Specialization and the Risk of Sports-Related Injury in Athletes
Rizzone	66925	Serum Levels and Stress Fractures	AMSSM
Rizzone	67018	Assessment of patellar tendon characteristics in children	Strong Children's Research Center
Rizzone	68651	Outcomes of Overuse Injuries in a Sports Medicine Clinic
Rizzone	72520	Outcomes of Dry Needling in Lower Extremity
Rizzone	72858	Female Perspectives on Sports Bras
Rizzone	STUDY00004977	Bone Stress Injury Case Review
Rizzone	STUDY00003503	Playing Surface Material and Acute Knee Pathology in High School Athletes: A Prospective Cohort Study of the NATION Data
Rizzone	STUDY000004453	Visibility of NCAA Institutional Policy Statements for Transgender Athletes
Rizzone	STUDY00004508	Stakeholders’ Perceptions and Experiences with ACL Injury Prevention in Kids (SPEAK)	AMSSM
Rizzone	STUDY00004848	Improving Long-Term Activity Levels and Health Outcomes in At-Risk, Underrepresented Adolescent Females through Implementation of a Teacher-Student Physical Activity Program	P30
Rubery	65202	Morphology of the Pediatric Occiput and Cervical Spine: A CT-Based Study
Rubery	STUDY00003049	Evaluation of UR Wellness Workplace Health Program Outcomes
Rubery	62787	Evaluation of the PROMIS in Patients with Spinal Deformities and Spine Tumors
Soles	61705	Bilateral Total Hip Arthroplasty: Comparing Financial and Surgical Outcomes of Simultaneous versus Staged Intervention
Soles	STUDY00004196	Anatomic reduction of the Sacroiliac Joint and Posterior Pelvic Ring: Does Quality of Reduction Affect Clinical Outcomes?
Speech	38136	Retrospective Review of Electrodiagnostic Evaluations of Patients with Possible Cubital and Carpal Tunnel Syndrome
Thirukumaran	66116	Health Services Research for Investigating Determinants and Outcomes of orthopaedic care
Thirukumaran	67863	Big Data Methods for Surveillance of Post-Operative Complications in Orthopaedics
Thirukumaran	69386	Impact of Bundeled Payment Reforms on Racial and Socioeconomic Disparaties in Hip and Knee Replacement Surgeries
Voloshin	59175	Comparison of Validated Shoulder Outcome Scores to PROMIS CAT in Patients Undergoing Shoulder Arthroplasty
Voloshin	STUDY00003714	Evaluation of the PROMIS Computerized Adaptive Tests in Shoulder Patients
Voloshin	69763	Reconstruction of the Anterior Rotator Cable via Long Head of Biceps Imbrication: A Surgical Technique Description and Case Series
Voloshin	71615	Mid-Term Radiographic and Clinical Outcomes for Second Generation Trabecular MetalTM Glenoid Components in Total Shoulder Arthroplasty	Zimmer Biomet Inc.
Voloshin	STUDY00003162	Mid-term Radiographic and Clinical Outcomes for Uncemented Second Generation Trabecular Metal Glenoid Components in Total Shoulder Arthroplasty (II)
Voloshin	STUDY00003895	Should Internal Rotation be Restricted after Reverse Total Shoulder Arthroplasty	Goldstein
Wilbur	STUDY00004432	Dupuytrens Disease
Wilbur	STUDY00003463	NSAIDs vs. Opioids
Wilbur	STUDY00004149	Digit Widget in Dupuytren's
Zuscik	65996	Evaluating Teriparatide as a Chondroregenerative Therapy in Human Ostroarthritis	Hansjorg Wyss Award