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URMC / Center for Musculoskeletal Research / Clinical Trials
 

Clinical Trials

As a Center of Research Translation, the Center for Musculoskeletal Research, URMC Orthopaedics and Rehabilitation, and UR Rheumatology are committed to increasing the diversity and efficacy of treatments and procedures available to our patients from the Rochester, NY region. We conduct state-of-the-art translational studies to better understand disease processes and clinical trials in multi-site efforts that are national in scope.

URMC is one of the first institutions nationwide with funding from the National Institutes of Health to establish the University of Rochester Clinical and Translational Science Institute (CTSI). The CTSI is to lead the emerging field of clinical and translational research to more quickly advance treatments to patients. We are also developing educational programs to train clinicians and biomedical scientists in the conduct of translational research and clinical trials.

Read about our clinical trials below.

Principal Investigator RSRB # or IRB # Study Title Sponsor
Anolik 22559 Immunological Assay Development  
Anolik 55411 AMP Collaboration: Cellular Dynamics at the Synovium Bone Interface in RA  
Baumhauer 58661 Patient-Reported Outcomes of Novel Forefoot Surgical Techniques  
Baumhauer 62579 Evaluation of the PROMIS Computerized Adaptive Tests in Foot and Ankle Patients  
Baumhauer 67010 A Multi-Center, Randomized, Pivotal Study Evaluating AMPLEX® Compared To Autogenous Bone Graft in Subjects Indicated for Arthrodesis Surgery Involving the Hindfoot or Ankle  
Baumhauer 67609 The Effects of Knee Scooter Usage on Lower Extremity Venous Flow  
Baumhauer 68138 Evaluation of the PROMIS Computerized Adaptive Tests in Orthopaedic Injection Patients  
Baumhauer 69111 Using Patient-Reported Outcomes (PRO) in Clinical Care: Analyses of PRO Collected with UR VOICE  
Baumhauer 70382 Using Patient Reported Outcome Measures to Evaluate Health Care by Census Block Group  
Baumhauer 65891 A Prospective, Controlled, Multi-Center, Post-Approval Trial to Evaluate the Long-term Safety and Effectiveness of AUGMENT® Bone Graft Compared to Autologous Bone Graft as a Bone Regeneration Device in Foot and Ankle Fusions  
Baumhauer 73150 Evaluating the Impact of PROMIS Use on Clinician and Group Consumer Assessment of Healthcare Providers and Systems (CG-CAHPS) Survey Results  
Baumhauer 3118 Determination of the Minimum Clinically Important Difference (MCID) and Patient Acceptable Symptomatic State (PASS) using PROMIS Following Orthopedic Procedures  
Boyce 72856 Histologic Osteoporosis in Patients Receiving Total Hip Arthroplasty  
Buckley 48660 Regenerative capacity and mechanical properties of tendinopathic and healthy human tendons of the foot and ankle ex-vivo NIH
Carmody 63775 Evaluation of PROMIS Compared to MSTS/TESS in the Reporting of Musculoskeletal Oncology Outcomes  
Carmody (Tyler) 55998 A Randomized Trial to Assess Patient Quality of Life and Function after Alternative Surgeries for Pathologic Fractures of the Femur Memorial Sloan Kettering Cancer Center
Carmody 73583 Coned Hemi Pelvic Replacement-Compassionate Care Case  
Cole 73355 Effect of CHAMPP Intervention on Injury Prevention, Performance, and Academic Outcomes in a Cohort of Inner-City and Suburban School Adolescent Athletes  
Daiss 46924 Whole Blood Samples and Nasal Swabs for Measurement of Ongoing Humoral Immune Response in Patients with Acute and Chronic Staphylococcus aureus Infections  
DiGiovanni 67341 Does the Presence and Treatment of Osteochondral Defects Affect Outcomes Following Dorsal Cheilectomy for Grade 1-3 Hallux Rigidus   
DiGiovanni 72073 Orthopaedic Surgery Skills Acquisition: Where, How, and From Whom Residents Are Learning  
Drinkwater 50069 Birmingham Hip Resurfacing (BHR) System Post Approval Study - A Prospective, Multi-Centered Study of the BHR Smith & Nephew
Drinkwater 66340 Patient Reported Outcomes in Bundled Payment Total Joint Arthroplasty  
Eliseev 52621 Expansion and Characterization of Mesenchymal Stem Cells from Human Bone Marrow  
Everett 62907 PROMIS Scores and Outcomes in Spine Patients  
Flemister 50040 Comparison of tendon characteristics, plantar flexor strength and self-reported function in people with achilles tendinopathy before and after an isometric exercise intervention  
Flemister 67864 Modulation of Insertional Achilles Tendinopathy by Multiaxial Mechanical Strains NIH
Ginnetti 60948 Comparison of Validated Hip Outcome Scores to PROMIS CAT in Patients Undergoing Total Hip and Knee Arthroplasty  
Giordano 46161 Clinical Outcomes for Subjects with Borderline Acetabular Dysplasia Before and After Hip Preservation Surgery  
Giordano 56194 Comparison of Validated Hip Outcome Scores to PROMIS CAT in Patients Undergoing Hip Arthroscopy  
Giordano 57374 Accuracy of Intra-Articular Anesthetic Hip Injection as Predictor of Hip Arthroscopy Outcome   
Giordano 69306 Surgeons’ Accuracy of Predicting Patient-Reported Outcome and Satisfaction Scores in Patients Undergoing Hip Arthroscopy  
Giordano 72558 Gene Expression in Femoroacetabular Impingement and Osteoarthritis: Evaluating Markers of Inflammation and Bone Metabolism  
Goldblatt 53365 Operating Room Traffic  
Gorczyca 50934 Limit of Threshold of Subchondral Bone Within the Humeral Head at Which Locked Screw Fixation Fails in the Operative Treatment of Proximal Humerus Fractures  
Gorczyca 69635 Peri-Operative Anemia in Geriatric Hip Fractures Determining Expected Change in Hemoglobin and Hematocrit in the Peri-Operative Period  
Gorczyca 70470 Femoral Neck Fractures in Patients with End Stage Renal Disease Undergoing Hemodialysis: A comparison of outcomes, morbidity and mortality of hemiarthroplasty vs. cannulated screw fixation  
Hammert 50425 Lymphedema Following Elective Hand and Wrist Surgery in Women who are Post Axillary Lymph Node Dissection: A Prospective Clinical Trial  
Hammert 54202 Comparison of the MHQ, Boston Carpal Tunnel Syndrome Scale, and PROMIS Physical Function, Upper Extremity and Pain CAT Instruments in Carpal Tunnel Syndrome  
Hammert 57511 A Multicenter, Prospective, Randomized, Subject and Evaluator Blinded Comparative Study of Nerve Cuffs and Avance Nerve Graft Evaluation Recovery Outcomes for the Repair of Nerve Discontinuities  
Hammert 60764 Hand Division PROMIS Outcomes Analysis  
Hammert 69331 Computer Learning for Osteoporosis Screening  
Hammert 70952 A Prospective Study to Evaluate the Safety and Effectiveness of Cartiva® Synthetic Cartilage Implant (SCI) for CMC in the Treatment of First Carpometacarpal Joint Osteoarthritis as Compared to a Ligament Reconstruction Tendon Interposition  
Jonason 42321 Inhibition of Osteoarthritic Articular Chondroctye Maturation by Teriparatide and The Influence of Type 2 Diabetes on Osteoarthritis Progression  
Jonason 71804 Inflammation-Mediated Mineralization of the Meniscus in OA Pathogenesis NIH P30
Judd 60819 Outcomes of Isolated Fractures of the Ulnar Shaft in Adults  
Judd 64534 Comparison of Short Term Outcomes for Patients on Novel Oral Anticoagulation to Those Being Treated with Traditional Oral Anticoagulant or No Anticoagulation at the Time of Hip Fracture  
Judd 3100 Comparison of Hip Hemiarthroplasty Outcomes Based on Surgical Approach  
Judd 64894 Prospective, Randomized, Double-Blinded, Controlled Multi-Center Clinical Trial Evaluating the Use of Non-Invasive CMF Bone Stimulation as Adjunct to Surgical Treatment of Ankle Fractures   
Ketonis 72116 Establishment of a Murine Model of Pyogenic Flexor Tenosynovitis and Investigation of Novel Treatment Strategies NIH
Ketz 41701 Complications Following Treatment for Hip Fractures  
Ketz 54438 Predictive Factors in Trochanteric Fixation cutout: Which Radiographic and Surgical Patterns Make a Difference?  
Ketz 60775   Fibular Length and its Importance among Patients Undergoing Operative Fixation of Ankle Fractures   
Ketz 60987 Computed Tomography of Ankle Fractures Changes, Surgical Approach and Fixation Strategy for the Posterior Malleolus  
Ketz 61574 Unplanned Readmissions following Hip and Knee Arthroplasty Surgery  
Ketz 63803 Obesity and Morbid Obesity as an Independent Predictor of Poor Outcome Following Lower Extremity Long Bone Fracture  
Ketz 66343 Failure after Extensor Mechanism Repair  
Ketz 70461 Ankle Stability and Comparison of Intraoperative Stress Views  
Ketz 71903 Does Primary Closure of Pin-Sites Following Removal of External Fixator Increase Risk of Infection  
Loiselle 54231 Evaluating the Effects of Type 2 Diabetes on Insulin Responsiveness in Human Tendon and Synovial Sheets  
Loiselle 70644 Non-Invasive Ultrasound Assessment of Tendon Healing  
Maloney 42524 Correlation of vascular and anatomical response with structural and clinical outcome: a pilot study in patients who have undergone rotator cuff repair surgery NIH P30
Maloney 59168 Comparison of Validated Knee Outcome Scores to the PROMIS CAT  
Maloney 60825 Clinical Outcomes of Superior Capsule Reconstruction for Irreparable Rotator Cuff Tears  
Maloney 61137 The VENUS (Verifying the Effectiveness of the NUsurface System) Active Implants
Mesfin 47517 Regulating Angiogenic and Osteoblastic Pathways in Metastatic Renal Cell Cancer to Bone R30
Mesfin 50144 Evaluation of Infection Following Vancomycin Application  
Mesfin 53083 Anabolic and Catabolic Marker Expression in Human Intervertebral Disc Specimen  
Mesfin 53644 Outcomes Following Surgical and Non-Surgical Management of Hyperostotic Spine Fractures  
Mesfin 54543 Investigating the role of Tracheal Traction Exercises (TTE) in reducing dysphagia following anterior cervical surgery Goldstein
Mesfin 59360 Prevalence of cervical spine conditions in Patients Undergoing CT of the Cervical Spine and lumbar spine conditions in patients undergoing CT of the abdomen/pelvis   
Mesfin 59379 Outcomes of Operative and Non-Operative Management of Lumbar Fractures: Long-Term  Follow Up  
Mesfin 62221 Complications in Halo Implications  
Mesfin 62665 Spinal Cord Injury Patients: Outcomes and Complications   
Mesfin 63350 Feasibility of Occipital Condyle Screws  
Mesfin 63580 Primary Tumors of the Spine: Outcomes and Complications    
Mesfin 64309 Complications of Surgical Microscope-Assisted Procedures  
Mesfin 67541 Metastatic Tumor Research and Outcome Network (MTRON): A Multicenter Prospective Registry for the Management of Metastatic Spine Tumors  AO Foundation
Mesfin 73657 Long-Term radiographic and clinical outcomes in patients undergoing un-instrumented fusion for spinal deformity  
Mitten 73612 Using Natural Language Processing to Identify Carpal Tunnel Patients from Provider Notes  
Myers 70380 Use of a Machine Learning Algorithm to Predict Discharge Location in Primary Total Joint Arthroplasty  
Nicandri 58828 A Pilot Study Using PROMIS to Assess the Health and Well-Being of Orthopaedic Residents  
Nicandri 68012 Establishing Proficiency Benchmarks for Orthopaedic Surgery Trainees Using the Fundamentals of Arthroscopic Surgery Training (FAST) Workstation  
Nicandri 51422 Does the FAST Program Demonstrate Transfer Validity OREF
Oh 57719 Clinical Applicability of Using Circulating Antibody-Secreting Cells and Microbiome Analysis for Assessments of Treatment Response and Prognosis of Active Infections in Diabetic Foot Ulcer Goldstein
Oh 61239 Elucidating Staphylococcus aureus Deformation, Migration and Persistence Within the Canalicular System of Human Bone in Osteomyelitis  
Oh 69536 Clinical and Radiographic Outcomes of Deltoid-Spring Ligament Reconstruction in Adult Acquired Flatfoot Deformity  
Oh 73524 Clinical Outcomes of Syme's and Chopart's Amputations in Adult Diabetic Foot Ulcer Infection Patients  
Puzas 51759 Environmental Exposures and Endocrine Function: A Pilot Study EHSC
Ricciardi 67686 What is the association between perioperative serum 25-Hydroxyvitamin D3 levels and early readmission rates after hemiarthroplasty or total hip arthroplasty for femoral neck fracture  
Ricciardi 68592 What are preoperative predictors of 90-day readmission and 1-year mortality after hemiarthroplasty or total hip arthroplasty for femoral neck fracture in a comprehensive geriatric fracture care model  
Rizzone 58797 Sports Specialization and the Risk of Sports-Related Injury in Athletes  
Rizzone 66925 Serum Levels and Stress Fractures AMSSM
Rizzone 67018 Assessment of patellar tendon characteristics in children Strong Children's Research Center
Rizzone 68651 Outcomes of Overuse Injuries in a Sports Medicine Clinic  
Rizzone 72520 Outcomes of Dry Needling in Lower Extremity  
Rizzone 72858 Female Perspectives on Sports Bras  
Rizzone 67879 Evaluation of the PROMIS Computerized Adaptive Tests in Concussion Patients  
Rubery 65202 Morphology of the Pediatric Occiput and Cervical Spine: A CT-Based Study   
Rubery 3049 Evaluation of UR Wellness Workplace Health Program Outcomes  
Rubery 62787 Evaluation of the PROMIS in Patients with Spinal Deformities and Spine Tumors   
Sanders 44587 Bracing in Adolescent Idiopathic Scoliosis II University of Iowa
Sanders 52336 Cost Analysis of Casting vs. Growing Rods  
Sanders 57501 Long-Term Follow-up of Early Onset Scoliosis Patients Treated with EDF Casting  
Sanders 63122 Spinal and Vetebral Dimension Charts: Precise and Accurate Characterization for Decision-Support CHU St. Justine
Sanders 68642 Deep Learning of Skeletal Maturity Radiograph Staging  
Sanders 40854 Long-Term Pulmonary Function in Operative Compared to Non-Operatively Treated Idiopathic Scoliosis  
Sanders 45895 Minimize Implants Maximize Outcomes University of Minnesota
Sanders 28880 The Treatment of Progressive Early Onset Spinal  Deformities: A Multi-Center Outcome Study  
Soles 61705 Bilateral Total Hip Arthroplasty: Comparing Financial and Surgical Outcomes of Simultaneous versus Staged Intervention  
Speech 38136 Retrospective Review of Electrodiagnostic Evaluations of Patients with Possible Cubital and Carpal Tunnel Syndrome  
Thirukumaran 66116 Health Services Research for Investigating Determinants and Outcomes of orthopaedic care  
Thirukumaran 67863 Big Data Methods for Surveillance of Post-Operative Complications in Orthopaedics  
Thirukumaran 69386 Impact of Bundeled Payment Reforms on Racial and Socioeconomic Disparaties in Hip and Knee Replacement Surgeries  
Voloshin 59175 Comparison of Validated Shoulder Outcome Scores to PROMIS CAT in Patients Undergoing Shoulder Arthroplasty  
Voloshin 61949   Evaluation of the PROMIS Computerized Adaptive Tests in Shoulder Patients   
Voloshin 69763 Reconstruction of the Anterior Rotator Cable via Long Head of Biceps Imbrication: A Surgical Technique Description and Case Series  
Voloshin 71615 Mid-Term Radiographic and Clinical Outcomes for Second Generation Trabecular MetalTM Glenoid Components in Total Shoulder Arthroplasty Zimmer Biomet Inc.
Zuscik 51569 Assessment of Knee Osteoarthritis in Osteoporosis Patients Prescribed Forteo  
Zuscik 65996 Evaluating Teriparatide as a Chondroregenerative Therapy in Human Ostroarthritis Hansjorg Wyss Award

 

Please also see a list of our Sponsored Clinical Studies.