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Journal Clubs

The CMSR offers several Journal Clubs that are designed to be an integral component of graduate and post-doctoral training and education in the basic biomedical sciences. The Journal Clubs aim to provide trainees with a strong foundation and a broad grasp of current research questions and methodologies throughout the musculoskeletal biology field. The most recent advances in the fundamentals of osteoblast, osteoclast, and chondrocyte biology and the molecular mechanisms of musculoskeletal development and disease are presented and discussed.

The presenter(s) at each Journal Club meeting is a student or fellow and the paper to be discussed (not more than 6 months past publication) is chosen by the trainee in consultation with their faculty mentor. The paper is made available to all members of the CMSR a week in advance. During the meeting, the presenter(s) is responsible for providing enough background to bring the group up to speed on the specific topic and then moderates the group’s discussion of each figure and how it contributes to the overall conclusion(s) of the study. At least one faculty mentor is present at the meeting to observe and contribute if any clarification is necessary. Besides familiarizing the group with current literature, participants learn how to critically evaluate a study and envision novel experiments that might better address the hypothesis in question.

STEM CELLS in MUSCULOSKELETAL BIOLOGY
Zoom, 11:30 am - 12:30 pm (Every Other Thursday)

July 23, 2020 - Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis

July 2, 2020 - Dexamethasone Promotes Mesenchymal Stem Cell Apoptosis and Inhibits Osteogenesis by Disrupting Mitochondrial Dynamics

June 25, 2020 - PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission

June 11, 2020 - ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection

May 28, 2020 - Notch signaling drives synovial fibroblast identity and arthritis pathology

May 14, 2020 - Diet-Induced Metabolic Dysregulation in Female Mice Causes Osteopenia in Adult Offspring

April 30, 2020 - Adenosine A2A receptor (A2AR) stimulation enhances mitochondrial metabolism and mitigates reactive oxygen species-mediated mitochondrial injury

April 16, 2020 - NIPA2 regulates osteoblast function by modulating mitophagy in type 2 diabetes osteoporosis

April 2, 2020 - Perivascular osteoprogenitors are associated with transcortical channels of long bones​

February 6, 2020 - Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization​

January 30, 2020 - A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering​

January 9, 2020 - Glutamine Links Obesity to Inflammation in Human White Adipose Tissue

December 19, 2019 - Sinusoidal Electromagnetic Fields Increase Peak Bone Mass in Rats by Activating Wnt10b/β-Catenin in Primary Cilia of Osteoblasts

December 12, 2019 - "Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer"

November 14, 2019 - "Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin"

October 31, 2019 - "Molecular architecture of lineage allocation and tissue organization in early mouse embryo"

October 17, 2019 - "Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects"

October 10, 2019 - "Mediation of the Acute Stress Response by the Skeleton"

September 5, 2019 - "17β-Estradiol Directly Lowers Mitochondrial Membrane Microviscosity and Improves Bioenergetic Function in Skeletal Muscle"

August 22, 2019 - "Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate"

August 8, 2019 - "Transcriptional profiling of intramembranous and endochondral ossification after fracture in mice"

View more articles of the Stem Cells in Musculoskeletal Biology Journal Club

BONE MARROW MICROENVIRONMENT 
Zoom, 4:00 pm - 5:00 pm (Every Thursday)

July 30, 2020 - Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling​

July 23, 2020 - Repolarizing heterogeneous leukemia-associated macrophages with more M1 characteristics eliminates their pro-leukemic effects

July 16, 2020 - Inflammation-driven activation of JAK/STAT signaling reversibly accelerates acute myeloid leukemia in vitro​

June 18, 2020 - PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

June 11, 2020 - Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner

June 4, 2020 - Codelivery of Ponatinib and SAR302503 by Active Bone-Targeted Polymeric Micelles for the Treatment of Therapy-Resistant Chronic Myeloid Leukemia

May 28, 2020 - Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia

May 14, 2020 - Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

May 7, 2020 - Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

April 30, 2020 - Mesenchymal stem cells suppress leukemia via macrophage- mediated functional restoration of bone marrow microenvironment

April 23, 2020 - Erythropoietin inhibits osteoblast function in myelodysplastic syndromes via the canonical Wnt pathway

April 16, 2020 - Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche

CARTILAGE
Zoom, (Every Other Monday)

August 10, 2020 - A proteomic atlas of senescence-associated secretomes for aging biomarker development

July 27, 2020 - Hypoxia impacts human MSC response to substrate stiffness during chondrogenic differentiation

July 13, 2020 - Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis

June 15, 2020 - Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2

June 1, 2020 - Senescence cell–associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers

May 11, 2020 - Identification of Chondrocyte Genes and Signaling Pathways in Response to Acute Joint Inflammation

April 27, 2020 - Inhibition of TET1 prevents the development of osteoarthritis and reveals the 5hmC landscape that orchestrates pathogenesis

April 13, 2020 - Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation

March 30, 2020 - Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk

March 9, 2020 - Lipid availability determines fate of skeletal progenitor cells via SOX9

BONE BIOLOGY
Zoom, 2:00 pm - 3:00 pm (Every Other Wednesday)

July 8, 2020 - High-Dose TGF-β1 Impairs Mesenchymal Stem Cell-Mediated Bone Regeneration via Bmp2 Inhibition

June 24, 2020 - TGF-b type 2 receptor–mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis

June 10, 2020 - ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

May 27, 2020 - Blockade of only TGF-b 1 and 2 is sufficient to enhance the efficacy of vaccine and PD-1 checkpoint blockade immunotherapy

May 13, 2020 - Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine

April 29, 2020 - Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin

April 15, 2020 - TGF-β Signaling in Cellular Senescence and Aging-Related Pathology

April 1, 2020 - Cells exhibiting strong p16-INK4a promoter activation in vivo display features of senescence

March 11, 2020 - Periosteal cells are a major source of soft callus in bone fracture

February 26, 2020 - M1 macrophages accelerate renal glomerular endothelial cell senescence through reactive oxygen species accumulation in streptozotocin-induced diabetic mice

February 12, 2020 - Senolytics improve physical function and increase lifespan in old age

January 29, 2020 - Senolytic therapies for healthy longevity

January 15, 2020 - An Essential Role for Senescent Cells in Optimal Wound Healing
through Secretion of PDGF-AA​

OSTEOARTHRITIS, FRACTURE HEALING AND THE IMPACT OF DIABETES ON THE SKELETON

February 8, 2018 - "Germinal Center B Cells Are Essential for Collagen - Induced Arthritis"

January 24, 2018 - "Nanoindentation modulus of murine cartilage: a sensitive indicator of the initiation and progression of post-traumatic osteoarthritis"

January 11, 2018 - "Inflammatory cytokines stabilize SOXC transcription factors to mediate the transformation of fibroblast - like synoviocytes in arthritic disease"

January 4, 2018 - "Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes"

November 30, 2017 - "Intermittent Fasting Promotes Wite Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota"

November 9, 2017 - "Effects of local delivery of BMP2, zoledronate and their combination on bone microarchitecture, biomechanics and bone turnover in osteoporotic rabbits"

November 2, 2017 - "Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression"

View more articles of the Osteoarthritis, Fracture Healing and the Impact of Diabetes on The Skeleton Journal Club