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Journal Clubs

The CMSR offers several Journal Clubs that are designed to be an integral component of graduate and post-doctoral training and education in the basic biomedical sciences. The Journal Clubs aim to provide trainees with a strong foundation and a broad grasp of current research questions and methodologies throughout the musculoskeletal biology field. The most recent advances in the fundamentals of osteoblast, osteoclast, and chondrocyte biology and the molecular mechanisms of musculoskeletal development and disease are presented and discussed.

The presenter(s) at each Journal Club meeting is a student or fellow and the paper to be discussed (not more than 6 months past publication) is chosen by the trainee in consultation with their faculty mentor. The paper is made available to all members of the CMSR a week in advance. During the meeting, the presenter(s) is responsible for providing enough background to bring the group up to speed on the specific topic and then moderates the group’s discussion of each figure and how it contributes to the overall conclusion(s) of the study. At least one faculty mentor is present at the meeting to observe and contribute if any clarification is necessary. Besides familiarizing the group with current literature, participants learn how to critically evaluate a study and envision novel experiments that might better address the hypothesis in question.

Room 1-8527, 1:00 pm - 3:00 pm (Every Other Thursday)


October 13, 2016 - "Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs)" View article here

September 29, 2016 - "NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice" View article in Science

August 25, 2016 - "Transcriptome sequencing wide functional analysis of human mesenchymal stem cells in response to TLR4 ligand" View article in Nature

August 11, 2016 - "Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells" View article in PubMed

July 28, 2016 - "Asymmetric division of clonal muscle stem cells coordinates muscle regeneration in vivo" View article in PubMed

July 14, 2016 - "No Identical "Mesenchymal Stem Cells" at Different Times and Sites: Human Committed Progenitors of Distinct Origin and Differentiation Potential Are Incorporated as Adventitial Cells in Microvessels" View article in Cell

June 2, 2016 - "Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program" View article in Science Direct

May 5, 2016"Mitotic History reveals distinct stem cell populations and their contributions to hematopoiesis" View article in Cell

April 7, 2016 - "Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation" View article in PubMed

March 10, 2016 - "Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation" View article in Science Direct

February 25, 2016 - "A predictive computational framework for direct reprogramming between human cell types" View article in Nature

February 11, 2016 - "Distinct EMT programs control normal mammary stem cells and tumor-initiating cells" View article in PubMed

January 28, 2016 - "Direct measurement of local oxygen concentration in the bone marrow of live animals" View article in PubMed

December 3, 2015 - "Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs" View article in PubMed

November 19, 2015 - "Multiparameter Analysis of Human Bone Marrow Stromal Cells Identifies Distinct Immunomodulatory and Differentiation-Competent Subtypes" View article in PubMed

November 5, 2015 - "Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging" View article in PubMed

September 10, 2015 - "CD49f Acts as an Inflammation Sensor to Regulate Differentiation, Adhesion, and Migration of Human Mesenchymal Stem Cells" View article in PubMed

August 27, 2015 - "Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness" View article in PubMed

August 13, 2015 - "Establishing criteria for human mensenchymal stem cell potency" View article in PubMed

July 30, 2015 - "Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation" View article in PubMed

June 25, 2015 - "Systemic infusion of mesenchymal stem cells improves cell-based bone regeneration via upregulation of regulatory T cells" View article in PubMed

View more articles of the Mesenchymal Stem Cell Journal Club

Room 1-8527, 8:30 am - 9:30 am (Every Thursday)


October 6, 2016 - "Hyperelastic "bone": A highly, versatile, growth factor-free, osteogenerative, scalable, and surgically friendly biomaterial" View article here

September 8, 2016 - "Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage"  View article here

September 1,2016 - "Defining the consequences of genetic variation on a proteome-wide scale" View article in PubMed

August 25, 2016 - "Interaction of HIF1α and β-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice" View article here

August 18, 2016 - "Peptide - siRNA nanocomplexes targeting NF - kB subunit p65 suppress nascent experimental arthritis" View article in JCI

August 11,2016 - "Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis" View article in JCI

August 4,2016 - "Genome-wide associate study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility gene" View article in Science Direct

July 28, 2016 - "Reduction of friction by recombinant human proteoglycan 4 in IL-1α stimulated bovine cartilage explantsView article in Pubmed

July 21, 2016 - "Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest" View pdf article here

July 14, 2016 - "Network Analysis Implicates Alpha-Synuclein (Snca) in the Regulation of Ovariectomy-Induced Bone Loss" View article in PubMed

July 7, 2016 - "Protein related to DAN and cerberus (PRDC) inhibits osteoblastic differentiation and its suppression promotes osteogenesis in vitro." View article in PubMed

June 30, 2016 - "CCL20/CCR6 Signaling Regulates Bone Mass Accrual in Mice" View pdf article here

June 23, 2016 - "Sepsis- Induced Osteoblast Ablation Causes Immunodeficiency" View pdf article here

June 2, 2016 - "Bone marrow lesions detected by specific combination of MRI sequences are associated with severity of osteochondral degeneration" View article in PubMed

May 26, 2016 - "A predictive computational framework for direct reprogramming between human cell types." View article in PubMed

May 12, 2016 - "Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis." View article in PubMed

May 5, 2016 - "NOTCH signaling in skeletal progenitors is critical for fracture repair." View article in PubMed

April 28, 2016 - "Sex steroid deficiency-associated bone loss in microbiota dependent and prevented by probiotics." View article in PubMed

April 21, 2016 - "Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis" View article in PubMed

February 25, 2016 - "Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term" View article in PubMed

February 11, 2016 - "Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro" View article in PubMed

February 4, 2016 - "Fibrin accumulation secondary to loss of plasmin-mediated fibrinolysis drives inflammatory osteoporosis in mice" View article in PubMed

January 28, 2016 - "Vitamin D prevents articular cartilage erosion by regulating collagen II turnover through TGF-B1 in ovariectomized rats" View article in PubMed

December 17, 2015 - "Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density" View article in PubMed

December 10, 2015 - "The alarmins S100A8/A9 induce canonical Wnt signaling in murine knee joints; implications for osteoarthritis" View article in PubMed

October 22, 2015 - "Chronic superantigen exposure induces systemic inflammation, elevated bloodstream endotoxin and abnormal glucose tolerance in rabbits: possible role in diabetes" View article in PubMed

October 15, 2015 - "Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture" View article in PubMed

October 1, 2015 - " Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation" View article in PubMed

September 24, 2015 - "Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice" View article in PubMed

September 17, 2015 - "Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis" View article in PubMed

September 10, 2015 - "Intermittent Parathryoid Hormone Enhances Cancellous Osseointegration of a Novel Murine tibial Implant" View article in PubMed

September 3, 2015 - "Intermittent PTHrP (1-34) exposure augments chondrogenesis and reduces hypertrophy of mesenchymal stromal cells" View article in PubMed

August 27, 2015 - "PTH [1-34]-induced alterations of the subchondral bone provoke early osteoarthritis" View article in PubMed

August 20, 2015 - "Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification" View article in PubMed

July 30, 2015 - "The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment" View article in PubMed

July 23, 2015 - "IKKB in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5" View article in PubMed

July 16, 2015 - "Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation" View article in PubMed

View more articles of the Osteoarthritis, Fracture Healing and the Impact of Diabetes on The Skeleton Journal Club