Skip to main content
Explore URMC



Journal Clubs

The CMSR offers several Journal Clubs that are designed to be an integral component of graduate and post-doctoral training and education in the basic biomedical sciences. The Journal Clubs aim to provide trainees with a strong foundation and a broad grasp of current research questions and methodologies throughout the musculoskeletal biology field. The most recent advances in the fundamentals of osteoblast, osteoclast, and chondrocyte biology and the molecular mechanisms of musculoskeletal development and disease are presented and discussed.

The presenter(s) at each Journal Club meeting is a student or fellow and the paper to be discussed (not more than 6 months past publication) is chosen by the trainee in consultation with their faculty mentor. The paper is made available to all members of the CMSR a week in advance. During the meeting, the presenter(s) is responsible for providing enough background to bring the group up to speed on the specific topic and then moderates the group’s discussion of each figure and how it contributes to the overall conclusion(s) of the study. At least one faculty mentor is present at the meeting to observe and contribute if any clarification is necessary. Besides familiarizing the group with current literature, participants learn how to critically evaluate a study and envision novel experiments that might better address the hypothesis in question.

Room 1-8527, 10:00 am - 11:00 am (Every Other Thursday)


January 22, 2018 - "Ontogenic Identification and Analysis of Mesenchymal Stromal Cell Populations during Mouse Limb and Long Bone Development" View article in PubMed

September 21, 2017 - "Heypothalamic stem cells control ageing speed partly through exosomal miRNAs" View article in Nature

August 24, 2017 - "Correction of a pathogenic gene mutation in human embryos" View article in Nature

August 10, 2017 - "Modulation of oxidative phosphorylation and redox homeostasis in mitochondrial NDUFS4 deficiency via mesenchymal stem cells" View article in Stem Cell Research & Therapy

July 13, 2017 - "Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy" View article in Cell

June 29, 2017 - "Postnatal Calvarial Skeletal Stem Cells Expressing PRX1 Reside Exclusively in the Calvarial Sutures and Are Required for Bone Regeneration" View article in PubMed

June 15, 2017 - "Leptin-receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis" View article in Nature

May 4, 2017 - "MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells" View article in Nature

April 20, 2017 - "Adipocyte Accumulation in Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration" View article in Science Direct

March 30, 2017 - "Tumor-homing cytotoxic human induced neural stem cells for cancer therapy" View article in Science Translational Medicine

March 16, 2017 - "Tumor-homing cytotoxic human induced neural stem cells for cancer therapy" View article in Science Translational Medicine

March 2, 2017 - " Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells in Vivo" View article in Cell Stem Cell

February 16, 2017 - "Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate" View article in Science Direct

February 2, 2017 - "Wnt/β-catenin signaling in osteoblasts regulates global energy metabolism" View article in Science Direct

January 17, 2017 - "Oxidative status predicts quality in human mesenchymal stem cells" View article in BioMed Central 

November 10, 2016 - "The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are independent and Mechanistically Distinct" View article in PubMed

October 27, 2016 - "Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response" View article in Cell

October 13, 2016 - "Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs)" View article here

September 29, 2016 - "NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice" View article in Science

August 25, 2016 - "Transcriptome sequencing wide functional analysis of human mesenchymal stem cells in response to TLR4 ligand" View article in Nature

August 11, 2016 - "Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells" View article in PubMed

July 28, 2016 - "Asymmetric division of clonal muscle stem cells coordinates muscle regeneration in vivo" View article in PubMed

July 14, 2016 - "No Identical "Mesenchymal Stem Cells" at Different Times and Sites: Human Committed Progenitors of Distinct Origin and Differentiation Potential Are Incorporated as Adventitial Cells in Microvessels" View article in Cell

June 2, 2016 - "Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program" View article in Science Direct

May 5, 2016"Mitotic History reveals distinct stem cell populations and their contributions to hematopoiesis" View article in Cell

April 7, 2016 - "Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation" View article in PubMed

March 10, 2016 - "Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation" View article in Science Direct

February 25, 2016 - "A predictive computational framework for direct reprogramming between human cell types" View article in Nature

February 11, 2016 - "Distinct EMT programs control normal mammary stem cells and tumor-initiating cells" View article in PubMed

January 28, 2016 - "Direct measurement of local oxygen concentration in the bone marrow of live animals" View article in PubMed

December 3, 2015 - "Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs" View article in PubMed

November 19, 2015 - "Multiparameter Analysis of Human Bone Marrow Stromal Cells Identifies Distinct Immunomodulatory and Differentiation-Competent Subtypes" View article in PubMed

November 5, 2015 - "Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging" View article in PubMed

September 10, 2015 - "CD49f Acts as an Inflammation Sensor to Regulate Differentiation, Adhesion, and Migration of Human Mesenchymal Stem Cells" View article in PubMed

August 27, 2015 - "Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness" View article in PubMed

August 13, 2015 - "Establishing criteria for human mensenchymal stem cell potency" View article in PubMed

July 30, 2015 - "Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation" View article in PubMed

June 25, 2015 - "Systemic infusion of mesenchymal stem cells improves cell-based bone regeneration via upregulation of regulatory T cells" View article in PubMed

View more articles of the Mesenchymal Stem Cell Journal Club

Room 1-8527, 11:00 am - 12:00 pm (Every Thursday)


February 8, 2018 - "Germinal Center B Cells Are Essential for Collagen - Induced Arthritis" View article in PubMed

January 24, 2018 - "Nanoindentation modulus of murine cartilage: a sensitive indicator of the initiation and progression of post-traumatic osteoarthritis" View article in PubMed

January 11, 2018 - "Inflammatory cytokines stabilize SOXC transcription factors to mediate the transformation of fibroblast - like synoviocytes in arthritic disease" View article in PubMed

January 4, 2018 - "Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes" View article in PubMed

November 30, 2017 - "Intermittent Fasting Promotes Wite Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota" View the article in PubMed

November 9, 2017 - "Effects of local delivery of BMP2, zoledronate and their combination on bone microarchitecture, biomechanics and bone turnover in osteoporotic rabbits" View article in PubMed

November 2, 2017 - "Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression" View article in PubMed

October 26, 2017 - "Regional Differences Between Perisynovial and Infrapatellar Adipose Tissue Depots and Their Response to Class II and Class III Obesity in Patients with Osteoarthritis." View article in PubMed

August 31, 2017 - "Knee osteoarthritis has doubled in prevalence since the mid-20th century." View article in PubMed

August 17, 2017- "Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs" View article in PubMed

August 10,2017 - "Mechanoresponsive stem cells to target cancer metastases through biophysical cues" View article in PubMed

August 3, 2017 - "Impact Insertion of Osteochondral Grafts: Interference Fit and Central Graft Reduction Affect Biomechanics and Cartilage Damage" View article in PubMed

July 20, 2017 - "Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells" View article in PubMed

July 13, 2017 - "Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis" View article in PubMed

June 29, 2017 - "Beyond Sequencing: Population Analysis in an Era of Mass Spe" View webinar

June 22, 2017 - "FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging." View article in PubMed

June 15, 2017 - "Joint morphogenetic cells in the adult mammalian synovium" View article in PubMed

June 8, 2017 - "Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties" View article in Nature

June 1, 2017 - "Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug." View article in PubMed

May 11, 2017 - "Exogenous fibroblast growth factor 9 attenuates cartilage degradation and aggravates osteophyte formation in post-traumatic osteoarthritis" View article in PubMed

May 4, 2017 - "Post-Traumatic Osteoarthritis in Mice Following Mechanical Injury to the Synovial Joint" View article in PubMed

April 27, 2017 - "Differences in sensitivity to microstructure between cyclic - and impact-based microindentation of the human cortical bone." View article in PubMed

March 30, 2017 - "Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice." View article in PubMed

March 9, 2017 - "Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease" View article in PubMed

February 16, 2017 - "Assessment of collagen quality associated with non-enzymatic cross-links in human bone using Fourier-transform infrared imagining" View article in PubMed

February 9, 2017 - "Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity" View article in PubMed

February 2, 2017 - "Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage" View article in Arthritis & Rheumatology

January 19, 2017 - "Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes." View article in PubMed

January 5, 2017 - "Early, focal changes in cartilage cellularity and structure following surgically induced meniscal destabilization in the mouse." View article in PubMed

December 15, 2016 - "Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury" View article here

October 6, 2016 - "Hyperelastic "bone": A highly, versatile, growth factor-free, osteogenerative, scalable, and surgically friendly biomaterial" View article here

September 8, 2016 - "Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage"  View article here

September 1,2016 - "Defining the consequences of genetic variation on a proteome-wide scale" View article in PubMed

August 25, 2016 - "Interaction of HIF1α and β-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice" View article here

August 18, 2016 - "Peptide - siRNA nanocomplexes targeting NF - kB subunit p65 suppress nascent experimental arthritis" View article in JCI

August 11,2016 - "Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis" View article in JCI

August 4,2016 - "Genome-wide associate study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility gene" View article in Science Direct

July 28, 2016 - "Reduction of friction by recombinant human proteoglycan 4 in IL-1α stimulated bovine cartilage explantsView article in Pubmed

July 21, 2016 - "Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest" View pdf article here

July 14, 2016 - "Network Analysis Implicates Alpha-Synuclein (Snca) in the Regulation of Ovariectomy-Induced Bone Loss" View article in PubMed

July 7, 2016 - "Protein related to DAN and cerberus (PRDC) inhibits osteoblastic differentiation and its suppression promotes osteogenesis in vitro." View article in PubMed

June 30, 2016 - "CCL20/CCR6 Signaling Regulates Bone Mass Accrual in Mice" View pdf article here

June 23, 2016 - "Sepsis- Induced Osteoblast Ablation Causes Immunodeficiency" View pdf article here

June 2, 2016 - "Bone marrow lesions detected by specific combination of MRI sequences are associated with severity of osteochondral degeneration" View article in PubMed

May 26, 2016 - "A predictive computational framework for direct reprogramming between human cell types." View article in PubMed

May 12, 2016 - "Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis." View article in PubMed

May 5, 2016 - "NOTCH signaling in skeletal progenitors is critical for fracture repair." View article in PubMed

April 28, 2016 - "Sex steroid deficiency-associated bone loss in microbiota dependent and prevented by probiotics." View article in PubMed

April 21, 2016 - "Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis" View article in PubMed

February 25, 2016 - "Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term" View article in PubMed

February 11, 2016 - "Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro" View article in PubMed

February 4, 2016 - "Fibrin accumulation secondary to loss of plasmin-mediated fibrinolysis drives inflammatory osteoporosis in mice" View article in PubMed

January 28, 2016 - "Vitamin D prevents articular cartilage erosion by regulating collagen II turnover through TGF-B1 in ovariectomized rats" View article in PubMed

December 17, 2015 - "Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density" View article in PubMed

December 10, 2015 - "The alarmins S100A8/A9 induce canonical Wnt signaling in murine knee joints; implications for osteoarthritis" View article in PubMed

October 22, 2015 - "Chronic superantigen exposure induces systemic inflammation, elevated bloodstream endotoxin and abnormal glucose tolerance in rabbits: possible role in diabetes" View article in PubMed

October 15, 2015 - "Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture" View article in PubMed

October 1, 2015 - " Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation" View article in PubMed

September 24, 2015 - "Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice" View article in PubMed

September 17, 2015 - "Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis" View article in PubMed

September 10, 2015 - "Intermittent Parathryoid Hormone Enhances Cancellous Osseointegration of a Novel Murine tibial Implant" View article in PubMed

September 3, 2015 - "Intermittent PTHrP (1-34) exposure augments chondrogenesis and reduces hypertrophy of mesenchymal stromal cells" View article in PubMed

August 27, 2015 - "PTH [1-34]-induced alterations of the subchondral bone provoke early osteoarthritis" View article in PubMed

August 20, 2015 - "Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification" View article in PubMed

July 30, 2015 - "The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment" View article in PubMed

July 23, 2015 - "IKKB in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5" View article in PubMed

July 16, 2015 - "Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation" View article in PubMed

View more articles of the Osteoarthritis, Fracture Healing and the Impact of Diabetes on The Skeleton Journal Club