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Journal Clubs

The CMSR offers several Journal Clubs that are designed to be an integral component of graduate and post-doctoral training and education in the basic biomedical sciences. The Journal Clubs aim to provide trainees with a strong foundation and a broad grasp of current research questions and methodologies throughout the musculoskeletal biology field. The most recent advances in the fundamentals of osteoblast, osteoclast, and chondrocyte biology and the molecular mechanisms of musculoskeletal development and disease are presented and discussed.

The presenter(s) at each Journal Club meeting is a student or fellow and the paper to be discussed (not more than 6 months past publication) is chosen by the trainee in consultation with their faculty mentor. The paper is made available to all members of the CMSR a week in advance. During the meeting, the presenter(s) is responsible for providing enough background to bring the group up to speed on the specific topic and then moderates the group’s discussion of each figure and how it contributes to the overall conclusion(s) of the study. At least one faculty mentor is present at the meeting to observe and contribute if any clarification is necessary. Besides familiarizing the group with current literature, participants learn how to critically evaluate a study and envision novel experiments that might better address the hypothesis in question.

STEM CELLS in MUSCULOSKELETAL BIOLOGY
Room 1-8527, 11:30 am - 12:30 pm (Every Other Thursday)

February 21, 2019 - "A Novel Single Pulsed Electromagnetic Field Stimulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells and Bone Repair​" View in PLOS ONE

February 7, 2019 - "Gain Fat—Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis" View in Cancer Cell

January 24, 2019 - "Mesenchymal Stem Cells Shift Mitochondrial Dynamics and Enhance Oxidative Phosphorylation in Recipient Cells" View in Frontiers in Physiology

January 10, 2019 - "Simvastatin alleviates bone resorption in apical periodontitis possibly by inhibition of​ mitophagy-related osteoblast apoptosis" View in the International Endodontic Journal

December 13, 2018 - "Glucose metabolism induced by Bmp signaling is essential for murine skeletal development" View in Nature

November 29, 2018 - "Human tissue-specific MSCs demonstrate differential mitochondria transfer abilities that may determine their regenerative abilities​" View in Stem Cell Research & Therapy

November 15, 2018 - "Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation​" View in The Journal of Clinical Investigation

November 1, 2018 - "Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease" View in Science Direct

October 18, 2018 - "A dual role of cholesterol in osteogenic differentiation of bone marrow stromal cells"

October 4, 2018 - "Identification of the Human Skeletal Stem Cell" View in Cell

September 20, 2018 - "Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming" View in Science Direct

View more articles of the Stem Cells in Musculoskeletal Biology Journal Club

OSTEOARTHRITIS, FRACTURE HEALING AND THE IMPACT OF DIABETES ON THE SKELETON

February 8, 2018 - "Germinal Center B Cells Are Essential for Collagen - Induced Arthritis" View article in PubMed

January 24, 2018 - "Nanoindentation modulus of murine cartilage: a sensitive indicator of the initiation and progression of post-traumatic osteoarthritis" View article in PubMed

January 11, 2018 - "Inflammatory cytokines stabilize SOXC transcription factors to mediate the transformation of fibroblast - like synoviocytes in arthritic disease" View article in PubMed

January 4, 2018 - "Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes" View article in PubMed

November 30, 2017 - "Intermittent Fasting Promotes Wite Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota" View the article in PubMed

November 9, 2017 - "Effects of local delivery of BMP2, zoledronate and their combination on bone microarchitecture, biomechanics and bone turnover in osteoporotic rabbits" View article in PubMed

November 2, 2017 - "Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression" View article in PubMed

View more articles of the Osteoarthritis, Fracture Healing and the Impact of Diabetes on The Skeleton Journal Club