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Journal Clubs

The CMSR offers several Journal Clubs that are designed to be an integral component of graduate and post-doctoral training and education in the basic biomedical sciences. The Journal Clubs aim to provide trainees with a strong foundation and a broad grasp of current research questions and methodologies throughout the musculoskeletal biology field. The most recent advances in the fundamentals of osteoblast, osteoclast, and chondrocyte biology and the molecular mechanisms of musculoskeletal development and disease are presented and discussed.

The presenter(s) at each Journal Club meeting is a student or fellow and the paper to be discussed (not more than 6 months past publication) is chosen by the trainee in consultation with their faculty mentor. The paper is made available to all members of the CMSR a week in advance. During the meeting, the presenter(s) is responsible for providing enough background to bring the group up to speed on the specific topic and then moderates the group’s discussion of each figure and how it contributes to the overall conclusion(s) of the study. At least one faculty mentor is present at the meeting to observe and contribute if any clarification is necessary. Besides familiarizing the group with current literature, participants learn how to critically evaluate a study and envision novel experiments that might better address the hypothesis in question.

STEM CELLS in MUSCULOSKELETAL BIOLOGY
Room 1-8527, 11:30 am - 12:30 pm (Every Other Thursday)

December 12, 2019 - "Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer"

November 14, 2019 - "Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin"

October 31, 2019 - "Molecular architecture of lineage allocation and tissue organization in early mouse embryo"

October 17, 2019 - "Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects"

October 10, 2019 - "Mediation of the Acute Stress Response by the Skeleton"

September 5, 2019 - "17β-Estradiol Directly Lowers Mitochondrial Membrane Microviscosity and Improves Bioenergetic Function in Skeletal Muscle"

August 22, 2019 - "Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate"

August 8, 2019 - "Transcriptional profiling of intramembranous and endochondral ossification after fracture in mice"

July 25, 2019 - "Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping"

July 11, 2019 - "The bone marrow microenvironment at single-cell resolution"

June 27, 2019 - "Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility"

June 13, 2019 - "The extracellular domain of epithelial cell adhesion molecule (EpCAM) enhances multipotency of mesenchymal stem cells through EGFR–LIN28–LET7 signaling"

May 23, 2019 - "L-Carnitine Reduces Oxidative Stress and Promotes Cells Differentiation and Bone Matrix Proteins Expression in Human Osteoblast-Like Cells"

May 2, 2019 - "Changes in characteristics of periodontal ligament stem cells in spheroid culture"

April 18, 2019 - "Curcumin pretreatment protects against hypoxia/reoxgenation injury via improvement of mitochondrial function, destabilization of HIF-1α and activation of Epac1-Akt pathway in rat bone marrow mesenchymal stem cells​"

April 4, 2019 - "A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate"

March 28, 2019 - "Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells"

March 7, 2019 - "Periarticuar mesenchymal progenitors initiate and contribute to secondary ossification center formation during mouse long bone development"

February 21, 2019 - "A Novel Single Pulsed Electromagnetic Field Stimulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells and Bone Repair​"

February 7, 2019 - "Gain Fat—Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis"

January 24, 2019 - "Mesenchymal Stem Cells Shift Mitochondrial Dynamics and Enhance Oxidative Phosphorylation in Recipient Cells"

January 10, 2019 - "Simvastatin alleviates bone resorption in apical periodontitis possibly by inhibition of​ mitophagy-related osteoblast apoptosis"

December 13, 2018 - "Glucose metabolism induced by Bmp signaling is essential for murine skeletal development"

November 29, 2018 - "Human tissue-specific MSCs demonstrate differential mitochondria transfer abilities that may determine their regenerative abilities​"

November 15, 2018 - "Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation​"

November 1, 2018 - "Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease"

October 18, 2018 - "A dual role of cholesterol in osteogenic differentiation of bone marrow stromal cells"

October 4, 2018 - "Identification of the Human Skeletal Stem Cell"

September 20, 2018 - "Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming"

View more articles of the Stem Cells in Musculoskeletal Biology Journal Club

OSTEOARTHRITIS, FRACTURE HEALING AND THE IMPACT OF DIABETES ON THE SKELETON

February 8, 2018 - "Germinal Center B Cells Are Essential for Collagen - Induced Arthritis"

January 24, 2018 - "Nanoindentation modulus of murine cartilage: a sensitive indicator of the initiation and progression of post-traumatic osteoarthritis"

January 11, 2018 - "Inflammatory cytokines stabilize SOXC transcription factors to mediate the transformation of fibroblast - like synoviocytes in arthritic disease"

January 4, 2018 - "Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes"

November 30, 2017 - "Intermittent Fasting Promotes Wite Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota"

November 9, 2017 - "Effects of local delivery of BMP2, zoledronate and their combination on bone microarchitecture, biomechanics and bone turnover in osteoporotic rabbits"

November 2, 2017 - "Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression"

View more articles of the Osteoarthritis, Fracture Healing and the Impact of Diabetes on The Skeleton Journal Club