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Journal Clubs

The CMSR offers several Journal Clubs that are designed to be an integral component of graduate and post-doctoral training and education in the basic biomedical sciences. The Journal Clubs aim to provide trainees with a strong foundation and a broad grasp of current research questions and methodologies throughout the musculoskeletal biology field. The most recent advances in the fundamentals of osteoblast, osteoclast, and chondrocyte biology and the molecular mechanisms of musculoskeletal development and disease are presented and discussed.

The presenter(s) at each Journal Club meeting is a student or fellow and the paper to be discussed (not more than 6 months past publication) is chosen by the trainee in consultation with their faculty mentor. The paper is made available to all members of the CMSR a week in advance. During the meeting, the presenter(s) is responsible for providing enough background to bring the group up to speed on the specific topic and then moderates the group’s discussion of each figure and how it contributes to the overall conclusion(s) of the study. At least one faculty mentor is present at the meeting to observe and contribute if any clarification is necessary. Besides familiarizing the group with current literature, participants learn how to critically evaluate a study and envision novel experiments that might better address the hypothesis in question.

STEM CELLS in MUSCULOSKELETAL BIOLOGY
Zoom, 11:30 am - 12:30 pm (Every Other Thursday)

February 3, 2022 - Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss

December 2, 2021 - Senescent immune cells release grancalcin to promote skeletal aging

November 18, 2021 - Mitochondria transfer enhances proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cell and promotes bone defect healing

November 4, 2021 - Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells​

October 7, 2021 - Aged skeletal stem cells generate an inflammatory degenerative niche

September 23, 2021 - Nitric oxide modulates bone anabolism through regulation of osteoblast glycolysis and differentiation

August 26, 2021 - Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency​

August 12, 2021 - Arid1a regulates cell cycle exit of transit-amplifying cells by inhibiting the Aurka-Cdk1 axis in mouse incisor

July 29, 2021 - Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling

July 15, 2021 - Intercellular Interactions of an Adipogenic CXCL12-Expressing Stromal Cell Subset in Murine Bone Marrow

July 1, 2021 - Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis

June 17, 2021 - A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis

June 3, 2021 - Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss

May 20, 2021 - BMPR1A maintains skeletal stem cell properties in craniofacial development and craniosynostosis

April 29, 2021 - Osteogenic-differentiated mesenchymal stem cell-secreted extracellular matrix as a bone morphogenetic protein-2 delivery system for ectopic bone formation

April 15, 2021 - Immobilization after injury alters extracellular matrix and stem cell fate

April 1, 2021 - Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity

March 18, 2021 - Mtu1 defects are correlated with reduced osteogenic differentiation

March 4, 2021 - Allyl sulfide promotes osteoblast differentiation and bone density via reducing mitochondrial DNA release mediated Kdm6b/H3K27me3 epigenetic mechanism

February 18, 2021 - Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin

February 4, 2021 - Crosstalk between histone and DNA methylation mediates bone loss in hind limb unloadingView more articles of the Stem Cells in Musculoskeletal Biology Journal Club

BONE MARROW MICROENVIRONMENT 
Zoom, 4:00 pm - 5:00 pm (Every Thursday)

February 17, 2021 - Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF high neutrophils​

February 3, 2021 - Targeting Macrophages Sensitizes Chronic Lymphocytic Leukemia to Apoptosis and Inhibits Disease Progression​

January 13, 2021 - Myeloid-derived suppressor cell cytokine secretion as prognostic factor in myelodysplastic syndromes​

December 16, 2020 - Expression profile analysis of long non-coding RNA in acute myeloid leukemia by microarray and bioinformatics​

November 11, 2020 - Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche​

November 4, 2020 - Monocyte-Derived Leukemia-Associated Macrophages Facilitate Extramedullary Distribution of T-cell Acute Lymphoblastic Leukemia Cells

October 14, 2020 - Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia​

September 16, 2020 - VEGF-C protects the integrity of the bone marrow perivascular niche in mice

August 14, 2020 - Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance​

August 7, 2020 - Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells

July 30, 2020 - Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling​

July 23, 2020 - Repolarizing heterogeneous leukemia-associated macrophages with more M1 characteristics eliminates their pro-leukemic effects

July 16, 2020 - Inflammation-driven activation of JAK/STAT signaling reversibly accelerates acute myeloid leukemia in vitro​

June 18, 2020 - PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

June 11, 2020 - Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner

June 4, 2020 - Codelivery of Ponatinib and SAR302503 by Active Bone-Targeted Polymeric Micelles for the Treatment of Therapy-Resistant Chronic Myeloid Leukemia

May 28, 2020 - Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia

May 14, 2020 - Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

May 7, 2020 - Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

April 30, 2020 - Mesenchymal stem cells suppress leukemia via macrophage- mediated functional restoration of bone marrow microenvironment

April 23, 2020 - Erythropoietin inhibits osteoblast function in myelodysplastic syndromes via the canonical Wnt pathway

April 16, 2020 - Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche

CARTILAGE
Zoom, 9:00 am - 10:00 am (Every Other Monday)

July 26, 2021 - MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway​

June 28, 2021 - Comparative evaluation of isogenic mesodermal and ectomesodermal chondrocytes from human iPSCs for cartilage regeneration

June 14, 2021 - WNT3A-loaded exosomes enable cartilage repair​

May 24, 2021 - Lysosomal dysfunction in osteoarthritis and aged cartilage triggers apoptosis in chondrocytes through BAX mediated release of Cytochrome c

May 10, 2021 - Does Pain at an Earlier Stage of Chondropathy Protect Female Mice Against Structural Progression After Surgically Induced Osteoarthritis?

April 26, 2021 - Mechanical stress determines the configuration of TGFβ activation in articular cartilage​

April 5, 2021 - A dysfunctional TRPV4-GSK3β pathway prevents osteoarthritic chondrocytes from sensing changes in extracellular matrix viscoelasticity​

March 22, 2021 - Nuclear stiffness decreases with disruption of the extracellular matrix in living tissues

March 8, 2021 - Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation

February 22, 2021 - Targeting cartilage EGFR pathway for osteoarthritis treatment

February 1, 2021 - STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway

January 11, 2021 - Bromodomain-containing-protein-4 and cyclin-dependent-kinase 9 inhibitors interact synergistically in vitro and combined treatment reduces post-traumatic osteoarthritis severity in mice

December 14, 2020 - Suppressing mitochondrial respiration is critical for hypoxia tolerance in the fetal growth plate

November 30, 2020 - FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis

November 16, 2020 - Human osteoarthritis cartilage-derived stromal cells activate joint degeneration through TGF-beta lateral signaling

November 2, 2020 - Mechano-activated biomolecule release in regenerating load-bearing tissue microenvironments

October 19, 2020 - IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis

October 5, 2020 - Synovial cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis

September 21, 2020 - Articular cartilage regeneration by activated skeletal stem cells

August 31, 2020 - SIRT1 directly activates autophagy in human chondrocytes

August 17, 2020 - A proteomic atlas of senescence-associated secretomes for aging biomarker development

July 27, 2020 - Hypoxia impacts human MSC response to substrate stiffness during chondrogenic differentiation

July 13, 2020 - Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis

June 15, 2020 - Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2

June 1, 2020 - Senescence cell–associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers

May 11, 2020 - Identification of Chondrocyte Genes and Signaling Pathways in Response to Acute Joint Inflammation

April 27, 2020 - Inhibition of TET1 prevents the development of osteoarthritis and reveals the 5hmC landscape that orchestrates pathogenesis

April 13, 2020 - Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation

March 30, 2020 - Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk

March 9, 2020 - Lipid availability determines fate of skeletal progenitor cells via SOX9

BONE BIOLOGY
Zoom, 4:00 pm - 5:00 pm (Every Other Thursday)

January 28, 2021 - Chronic inflammation in the etiology of disease across the life span

January 13, 2021 - Regulation of lymphatic function and injury by nitrosative stress in obese mice

July 8, 2020 - High-Dose TGF-β1 Impairs Mesenchymal Stem Cell-Mediated Bone Regeneration via Bmp2 Inhibition

June 24, 2020 - TGF-b type 2 receptor–mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis

June 10, 2020 - ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

May 27, 2020 - Blockade of only TGF-b 1 and 2 is sufficient to enhance the efficacy of vaccine and PD-1 checkpoint blockade immunotherapy

May 13, 2020 - Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine

April 29, 2020 - Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin

April 15, 2020 - TGF-β Signaling in Cellular Senescence and Aging-Related Pathology

April 1, 2020 - Cells exhibiting strong p16-INK4a promoter activation in vivo display features of senescence

March 11, 2020 - Periosteal cells are a major source of soft callus in bone fracture

February 26, 2020 - M1 macrophages accelerate renal glomerular endothelial cell senescence through reactive oxygen species accumulation in streptozotocin-induced diabetic mice

February 12, 2020 - Senolytics improve physical function and increase lifespan in old age

January 29, 2020 - Senolytic therapies for healthy longevity

January 15, 2020 - An Essential Role for Senescent Cells in Optimal Wound Healing
through Secretion of PDGF-AA​

SINGLE CELL RNA SEQ/TRANSCRIPTOMICS
Zoom, 2:00 pm - 3:00 pm, (Every Other Thursday) 

May 12, 2022 - Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence

April 28, 2022 - Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis

April 14, 2022 - Museum of Spatial Transcriptomics​

March 31, 2022 - Inference and analysis of cell-cell communication using CellChat

March 10, 2022 - T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10

February 24, 2022 - Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

February 10, 2022 - SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation

January 20, 2022 - Single-cell sequencing of immune cells from anticitrullinated peptide antibody positive and negative rheumatoid arthritis

January 6, 2022 - Parallel single cell multi-omics analysis of neonatal skin reveals transitional fibroblast states that restricts differentiation into distinct fates.

December 16, 2021 - Synovial tissue from sites of joint pain in knee osteoarthritis patients exhibits a differential phenotype with distinct fibroblast subsets

December 2, 2021 - Presentation by H. Mark Kenney on his experience in designing, performing, and analyzing scRNAseq and spatial transcriptomics experiments

November 11, 2021 - Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch

October 14, 2021 - Computational reconstruction of the signalling networks surrounding implanted biomaterials from single-cell transcriptomics​

September 30, 2021 - Single cell and spatial transcriptomics in human tendon disease indicate dysregulated immune homeostasis​

September 2, 2021 - Combined single-cell and spatial transcriptomics reveals the molecular, cellular and spatial bone marrow niche organization

August 19, 2021 - Single-cell transcriptomic atlas of primate cardiopulmonary aging​

August 5, 2021 - Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis​

July 22, 2021 - Specification of axial identity by Hoxa2 distinguishes between a phenotypic and molecular ground state in mouse cranial neural crest cells

July 8, 2021 - Comparison of the major cell populations among osteoarthritis, Kashin–Beck disease and healthy chondrocytes by single-cell RNA-seq analysis 

June 24, 2021 - Subchondral bone length in knee osteoarthritis: A deep learning derived imaging measure and its association with radiographic and clinical outcomes

June 10, 2021 - Heterogeneity of murine periosteum progenitors involved in fracture healing

May 27, 2021 - Spatiotemporal single-cell RNA sequencing of developing chicken hearts identifies interplay between cellular differentiation and morphogenesis​

May 13, 2021 - IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation

April 29, 2021 - A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

April 15, 2021 - A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature

April 1, 2021 - Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

March 18, 2021 - Novel Lineage-Tracing System to Identify Site-Specific Ectopic Bone Precursor Cells​

March 4, 2021 - Discovery of a periosteal stem cell mediating intramembranous bone formation

February 18, 2021 - Decoding myofibroblast origins in human kidney fibrosis

February 4, 2021 - Single-cell characterization and metabolic profiling of in vitro cultured human skeletal progenitors with enhanced in vivo bone forming capacity

January 21, 2021 - Distinct fibroblast subsets drive inflammation and damage in arthritis

January 7, 2021 - Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers

December 17, 2020 - Notch signaling drives synovial fibroblast identity and arthritis pathology

December 3, 2020 - The changing mouse embryo transcriptome at whole tissue and single-cell resolution

November 12, 2020 - Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming

October 29, 2020 - Transcriptional profiling of intramembranous and endochondral ossification after fracture in mice

October 15, 2020 - Single-cell RNA-seq analysis identifies meniscus progenitors and reveals the progression of meniscus degeneration

 

View more articles of archived Journal Clubs