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Journal Clubs

The CMSR offers several Journal Clubs that are designed to be an integral component of graduate and post-doctoral training and education in the basic biomedical sciences. The Journal Clubs aim to provide trainees with a strong foundation and a broad grasp of current research questions and methodologies throughout the musculoskeletal biology field. The most recent advances in the fundamentals of osteoblast, osteoclast, and chondrocyte biology and the molecular mechanisms of musculoskeletal development and disease are presented and discussed.

The presenter(s) at each Journal Club meeting is a student or fellow and the paper to be discussed (not more than 6 months past publication) is chosen by the trainee in consultation with their faculty mentor. The paper is made available to all members of the CMSR a week in advance. During the meeting, the presenter(s) is responsible for providing enough background to bring the group up to speed on the specific topic and then moderates the group’s discussion of each figure and how it contributes to the overall conclusion(s) of the study. At least one faculty mentor is present at the meeting to observe and contribute if any clarification is necessary. Besides familiarizing the group with current literature, participants learn how to critically evaluate a study and envision novel experiments that might better address the hypothesis in question.

STEM CELLS in MUSCULOSKELETAL BIOLOGY
Room 1-8527, 11:30 am - 12:30 pm (Every Thursday)

December 13, 2018 - "Glucose metabolism induced by Bmp signaling is essential for murine skeletal development" View in Nature

November 29, 2018 - "Human tissue-specific MSCs demonstrate differential mitochondria transfer abilities that may determine their regenerative abilities​" View in Stem Cell Research & Therapy

November 15, 2018 - "Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation​" View in The Journal of Clinical Investigation

November 1, 2018 - "Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease" View in Science Direct

October 18, 2018 - "A dual role of cholesterol in osteogenic differentiation of bone marrow stromal cells"

October 4, 2018 - "Identification of the Human Skeletal Stem Cell" View in Cell

September 20, 2018 - "Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming" View in Science Direct

August 23, 2018 - "Deletion of the Transcription Factor PGC-1α in Mice Negatively Regulates Bone Mass" View in Calcified Tissue International

August 9, 2018 - "The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation" View in Science Direct

July 26, 2018 - "PGC-1a Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ" View in Cell

July 12, 2018 - "Understanding metabolic changes in aging bone marrow"

June 28, 2018 - "Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations"

June 14, 2018 - "Quiescence of human muscle stem cells is favored by culture on natural biopolymeric films" View in PubMed

May 31, 2018 - "Chromatin dynamics regulate mesenchymal stem cell lineage specification and differentiation to osteogenesis" View in Science Direct

May 17, 2018 - "Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia" View in Science Direct

May 3, 2018 - "Tyrosine kinase Fyn promotes osteoarthritis by activating the β-catenin pathway" View in British Medical Journals 

April 19, 2018 - "Mitochondrial Dysfunction Is an Acute Response of Articular Chondrocytes to Mechanical Injury" View in Journal of Orthopaedic Research

April 5, 2018 - "Vhl deletion in osteoblasts boosts cellular glycolysis and improves global glucose metabolism" View in The Journal of Clinical Investigation

March 22, 2018 - "Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis" View in Nature

February 22, 2018 - "Gpr177, a Novel Locus for Bone Mineral Density and Osteoporosis, Regulates Osteogenesis and Chondrogenesis in Skeletal Development" View in PubMed

February 8, 2018 - "Transcriptional Profiling of Quiescent Muscle Stem Cells In Vivo" View in Cell

January 11, 2018 - "Regulatory elements driving the expression of skeletal lineage reporters differ during bone development and adulthood" View article in The Bone Journal

January 25, 2018 - "Ontogenic Identification and Analysis of Mesenchymal Stromal Cell Populations during Mouse Limb and Long Bone Development" View article in PubMed

View more articles of the Stem Cells in Musculoskeletal Biology Journal Club

OSTEOARTHRITIS, FRACTURE HEALING AND THE IMPACT OF DIABETES ON THE SKELETON

February 8, 2018 - "Germinal Center B Cells Are Essential for Collagen - Induced Arthritis" View article in PubMed

January 24, 2018 - "Nanoindentation modulus of murine cartilage: a sensitive indicator of the initiation and progression of post-traumatic osteoarthritis" View article in PubMed

January 11, 2018 - "Inflammatory cytokines stabilize SOXC transcription factors to mediate the transformation of fibroblast - like synoviocytes in arthritic disease" View article in PubMed

January 4, 2018 - "Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes" View article in PubMed

November 30, 2017 - "Intermittent Fasting Promotes Wite Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota" View the article in PubMed

November 9, 2017 - "Effects of local delivery of BMP2, zoledronate and their combination on bone microarchitecture, biomechanics and bone turnover in osteoporotic rabbits" View article in PubMed

November 2, 2017 - "Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression" View article in PubMed

View more articles of the Osteoarthritis, Fracture Healing and the Impact of Diabetes on The Skeleton Journal Club