Department of Obstetrics & Gynecology

Clinical Research in Ob/Gyn

The faculty of Obstetrics and Gynecology regularly conduct clinical research on new devices and medications that may assist in the future health of women. Scroll down to see what we're studying and how you can participate.

Studies for Pregnant Women

Comparison of gabapentin and ondansetron in the treatment of hyperemesis gravidarum

About the study: Double-blind clinical trial enrolling pregnant women who have received intravenous fluids and have not had much benefit with previous treatments for nausea and vomiting.  Study participants will be randomly assigned to take gabapentin (Neurontin) or ondansetron (Zofran).  Click here for more information.
Enrolling: Yes
PI: Loralei Thornburg, MD
Contact: Heather Fiore, MS Ed, RD, CDE 585-275-9165

Prenatally Diagnosed Lower Urinary Tract Obstruction (LUTO) with Normal Amniotic Fluid
About the Study: The purpose of this study is to determine whether infants who had normal amniotic fluid volume, but enlarged bladders and kidneys before birth, suffer renal injury before birth and develop renal insufficiency or failure before birth or during the first two years of life. Participants are not compensated.
Enrolling? Yes
PI: Tulin Ozcan, MD

Sources of Fetal Iron During Pregnancy (Prelabeled Iron study)

About the Study: Study is enrolling only women who are less than 16 weeks into their pregnancy, single gestation, between 15-35 years of age, and who do not smoke. Compensation is $160 in Wal-Mart gift cards. Participants must be receiving care through URMC Midwifery practice.
Enrolling? Yes
PI: Eva Pressman, MD; Kimberly O'Brien, PhD
Contact: Melissa Miller 585-410-0119

Study Title: Vitamin D and Infection during Pregnancy

About the Study: Study is enrolling only young women who are 13-18 years of age and do not smoke. Participants must be receiving care through the RAMP clinic. Compensation is $125 in gift cards ($90 Wal-Mart, $35 CVS pharmacy). In addition, we are also offering to print and frame a baby picture for those who are interested.
Enrolling? Yes
PI: Eva Pressman, MD; Kimberly O'Brien, PhD
Contact: Melissa Miller 585-410-0119

Studies of Polycystic Ovarian Syndrome

PCOS Study: The Use of an MMP Inhibitor, doxycycline, to reduce ovarian androgen production and restore normal cycling in women with Polycystic Ovarian Syndrome

About the Study: We are recruiting women ages 18-40 with irregular menstrual cycles for a 24 week study looking at the effects of 12 weeks of study medicine on menstrual cycles and hormones. Payment up to $230.00 for completion of study.
Enrolling? Yes
PI: Kathleen Hoeger, MD, MPH; Stephen Hammes, MD
Contact: Lynda Kochman, RN, CCRC  585-275-4149, 585-273-2995
pcos_research@urmc.rochester.edu

Prenatal androgens and PCOS

About the Study: We are recruiting women with polycystic ovary syndrome (PCOS) for a study on whether  PCOS might be related to hormones circulating in mothers’ bodies during pregnancy. The study involves a one-time visit similar to a gynecological exam. Blood draw optional.  Payment up to $40.00 for completion of study.
Enrolling? Yes
PI: Emily Barrett, PhD
Contact: Lynda Kochman, RN, CCRC  585-275-4149, 585-273-2995
pcos_research@urmc.rochester.edu

Studies of Vulvadynia and Pelvic Pain

Localized Provoked Vulvodynia Pathogenesis

About the Study: We are planning to enroll 30 women between 18 and 50 who meet Friedrich’s Criteria for localized provoked vulvodynia with 30 controls between 18 and 50 years old, negative Friedrich’s criteria, and planned surgical procedure to lower genital tract. Both groups will undergo biopsy of the vulva. Both groups will be compensated.
Enrolling? Yes
PI: David Foster, MD
Contact: Sarah Caveglia 585-275-3160

A Controlled Trial of Gabapentin in Vulvodynia: Biological Correlates of Response

About the Study: We are enrolling women with diagnosed vulvodynia will undergo 6 weeks of therapy with either drug or placebo, a week of no drug and then another 6 weeks of therapy with either drug or placebo. Extensive testing for pain will be done at the peak of medication or placebo levels. Patients are compensated for participation.
Enrolling? Yes
PI: David Foster, MD
Contact: Sarah Caveglia 585-275-3160
www.hopeformypain.org

A current list of open clinical trials at the University of Rochester is available here.