Peter G. Shrager, Ph.D.

Peter G. Shrager, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 603
Rochester, NY 14642

Journal Articles

Showing all 75 journal articles available.

2012
Einheber, S., Maurel, P., Meng, X., Rubin, M., Lam, I., Mohandas, N., An, X., Shrager, P., Kissil, J. and Salzer, J. "The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons." Glia. 2012; .
2011 Nov 30
Winters JJ, Ferguson CJ, Lenk GM, Giger-Mateeva VI, Shrager P, Meisler MH, Giger RJ. "Congenital CNS hypomyelination in the Fig4 null mouse is rescued by neuronal expression of the PI(3,5)P(2) phosphatase Fig4." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Nov 30; 31(48):17736-51.
2011
Winters, J., Lenk, G., Giger-Mateeva, V., Shrager, P., Meisler, M. and Giger, R..J. "Congenital CNS hypomyelination and reduced number of mature oligodendrocytes in the Fig4 null mouse." Journal of Neuroscience. 2011; .
2010 Sep 15
Raiker SJ, Lee H, Baldwin KT, Duan Y, Shrager P, Giger RJ. "Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Sep 15; 30(37):12432-45.
2010 Feb 25
Feinberg K, Eshed-Eisenbach Y, Frechter S, Amor V, Salomon D, Sabanay H, Dupree JL, Grumet M, Brophy PJ, Shrager P, Peles E. "A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier." Neuron. 2010 Feb 25; 65(4):490-502.
2010
Feinberg, K., Eshed-Eisenbach, Y., Frechter, S., Amor, V., Salomon, D., Sabanay, H., Dupree, J.L., Grumet, M., Brophy, P.J., Shrager, P., and Peles, E. "A glial signal consisting of Gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier." Neuron. 2010; : 1-14.
2010
Raiker, S.J., Lee, H., Duan, Y., Koelzer, K.T., Shrager, P. and Giger, R.J. "Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity." Journal of Neuroscience. 2010; 30: 12432-12445.
2008 Mar 12
Lee H, Raiker SJ, Venkatesh K, Geary R, Robak LA, Zhang Y, Yeh HH, Shrager P, Giger RJ. "Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Mar 12; 28(11):2753-65.
2008
Lee, H., Raiker, S., Venkatesh, K., Geary, R., Robak, L.A., Zhang, Y., Yeh, H.H., Shrager, P. and Giger, R.J. "Synaptic function for the Nogo-66 receptor NgR1: Regulation of dendritic spine morphology and activity-dependent synaptic strength." Journal of Neuroscience. 2008; : 2753-2765.
2007 Aug 27
Hedstrom KL, Xu X, Ogawa Y, Frischknecht R, Seidenbecher CI, Shrager P, Rasband MN. "Neurofascin assembles a specialized extracellular matrix at the axon initial segment." The Journal of cell biology. 2007 Aug 27; 178(5):875-86. Epub 2007 Aug 20.
2007
Hedstrom, K.L., Xu, X., Ogawa, Y., Frishnecht, R., Seidenbecher, C.I., Shrager, P. and Rasband, M.N. "Neurofascin assembles a specialized extracellular matrix at the axon initial segment." Journal of Cell Biology. 2007; 178: 875-886.
2006 May
Schafer DP, Custer AW, Shrager P, Rasband MN. "Early events in node of Ranvier formation during myelination and remyelination in the PNS." Neuron glia biology. 2006 May; 2(2):69-79.
2005 Sep 1
Taveggia C, Zanazzi G, Petrylak A, Yano H, Rosenbluth J, Einheber S, Xu X, Esper RM, Loeb JA, Shrager P, Chao MV, Falls DL, Role L, Salzer JL. "Neuregulin-1 type III determines the ensheathment fate of axons." Neuron. 2005 Sep 1; 47(5):681-94.
2005 Feb 15
Xu X, Shrager P. "Dependence of axon initial segment formation on Na+ channel expression." Journal of neuroscience research. 2005 Feb 15; 79(4):428-41.
2004 Apr 21
Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O'Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, Shrager P, Catterall WA, Isom LL. "Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Apr 21; 24(16):4030-42.
2003 Nov 5
Custer AW, Kazarinova-Noyes K, Sakurai T, Xu X, Simon W, Grumet M, Shrager P. "The role of the ankyrin-binding protein NrCAM in node of Ranvier formation." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Nov 5; 23(31):10032-9.
2003 Sep 15
Poliak S, Salomon D, Elhanany H, Sabanay H, Kiernan B, Pevny L, Stewart CL, Xu X, Chiu SY, Shrager P, Furley AJ, Peles E. "Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1." The Journal of cell biology. 2003 Sep 15; 162(6):1149-60. Epub 2003 Sep 08.
2002
Chen C, Bharucha V, Chen Y, Westenbroek RE, Brown A, Malhotra JD, Jones D, Avery C, Gillespie PJ, Kazen-Gillespie KA, Kazarinova-Noyes K, Shrager P, Saunders TL, Macdonald RL, Ransom BR, Scheuer T, Catterall WA, Isom LL. "Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits." Proceedings of the National Academy of Sciences of the United States of America. 2002 99(26):17072-7. Epub 2002 Dec 12.
2002
Chen, C; Bharucha, V; Chen, Y; Westenbroek, RE; Brown, A; Malhotra, JD; Jones, D; Avery, C; Gillespie, PJ; Kazen-Gillespie, KA; Kazarinova-Noyes, K; Shrager, P; Saunders, TL; Macdonald, RL; Ransom, BR; Scheuer, T; Catterall, WA,; Isom, LL. "Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta2-subunits." Proceedings of the National Academy of Sciences. 2002; 99: 17072-17077. Link
2002
Kazarinova-Noyes K, Shrager P. "Molecular constituents of the node of Ranvier." Molecular neurobiology. 2002 26(2-3):167-82.
2001 Oct 1
Kazarinova-Noyes K, Malhotra JD, McEwen DP, Mattei LN, Berglund EO, Ranscht B, Levinson SR, Schachner M, Shrager P, Isom LL, Xiao ZC. "Contactin associates with Na+ channels and increases their functional expression." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Oct 1; 21(19):7517-25.
2000 Oct
Harroch S, Palmeri M, Rosenbluth J, Custer A, Okigaki M, Shrager P, Blum M, Buxbaum JD, Schlessinger J. "No obvious abnormality in mice deficient in receptor protein tyrosine phosphatase beta." Molecular and cellular biology. 2000 Oct; 20(20):7706-15.
2000 May 15
Rasband MN, Shrager P. "Ion channel sequestration in central nervous system axons." The Journal of physiology. 2000 May 15; 525 Pt 1:63-73.
2000
Rasband, M.N.; Trimmer, J.S.; Peles, E.; Levinson, S.R.; Shrager, P. "K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve." Journal of Neurocytology. 2000; 28: 319-331. Link
1999 Sep 1
Rasband MN, Peles E, Trimmer JS, Levinson SR, Lux SE, Shrager P. "Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS." The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Sep 1; 19(17):7516-28.
1999 Jun 1
Weber P, Bartsch U, Rasband MN, Czaniera R, Lang Y, Bluethmann H, Margolis RU, Levinson SR, Shrager P, Montag D, Schachner M. "Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS." The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Jun 1; 19(11):4245-62.
1999 Jan 15
Vabnick I, Trimmer JS, Schwarz TL, Levinson SR, Risal D, Shrager P. "Dynamic potassium channel distributions during axonal development prevent aberrant firing patterns." The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Jan 15; 19(2):747-58.
1999
Poliak S, Gollan L, Martinez R, Custer A, Einheber S, Salzer JL, Trimmer JS, Shrager P, Peles E. "Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels." Neuron. 1999 24(4):1037-47.
1999
Rasband MN, Trimmer JS, Peles E, Levinson SR, Shrager P. "K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve." Journal of neurocytology. 1999 28(4-5):319-31.
1998 Oct
Vabnick I, Shrager P. "Ion channel redistribution and function during development of the myelinated axon." Journal of neurobiology. 1998 Oct; 37(1):80-96.
1998 Aug
Novakovic SD, Levinson SR, Schachner M, Shrager P. "Disruption and reorganization of sodium channels in experimental allergic neuritis." Muscle & nerve. 1998 Aug; 21(8):1019-32.
1998 Feb
Shrager P, Custer AW, Kazarinova K, Rasband MN, Mattson D. "Nerve conduction block by nitric oxide that is mediated by the axonal environment." Journal of neurophysiology. 1998 Feb; 79(2):529-36.
1998 Jan 1
Rasband MN, Trimmer JS, Schwarz TL, Levinson SR, Ellisman MH, Schachner M, Shrager P. "Potassium channel distribution, clustering, and function in remyelinating rat axons." The Journal of neuroscience : the official journal of the Society for Neuroscience. 1998 Jan 1; 18(1):36-47.
1997 Oct 15
Vabnick I, Messing A, Chiu SY, Levinson SR, Schachner M, Roder J, Li C, Novakovic S, Shrager P. "Sodium channel distribution in axons of hypomyelinated and MAG null mutant mice." Journal of neuroscience research. 1997 Oct 15; 50(2):321-36.
1996 Aug 15
Vabnick I, Novakovi? SD, Levinson SR, Schachner M, Shrager P. "The clustering of axonal sodium channels during development of the peripheral nervous system." The Journal of neuroscience : the official journal of the Society for Neuroscience. 1996 Aug 15; 16(16):4914-22.
1996 Aug 1
England JD, Levinson SR, Shrager P. "Immunocytochemical investigations of sodium channels along nodal and internodal portions of demyelinated axons." Microscopy research and technique. 1996 Aug 1; 34(5):445-51.
1996 Jun
Novakovic SD, Deerinck TJ, Levinson SR, Shrager P, Ellisman MH. "Clusters of axonal Na+ channels adjacent to remyelinating Schwann cells." Journal of neurocytology. 1996 Jun; 25(6):403-12.
1995 Oct
Tzoumaka EE, Novakovi? SD, Levinson SR, Shrager P. "Na+ channel aggregation in remyelinating mouse sciatic axons following transection." Glia. 1995 Oct; 15(2):188-94.
1995 Aug 28
Shrager P, Novakovic SD. "Control of myelination, axonal growth, and synapse formation in spinal cord explants by ion channels and electrical activity." Brain research. Developmental brain research. 1995 Aug 28; 88(1):68-78.
1995 Jan 1
Dugandzija-Novakovi? S, Shrager P. "Survival, development, and electrical activity of central nervous system myelinated axons exposed to tumor necrosis factor in vitro." Journal of neuroscience research. 1995 Jan 1; 40(1):117-26.
1995 Jan
Dugandzija-Novakovi? S, Koszowski AG, Levinson SR, Shrager P. "Clustering of Na+ channels and node of Ranvier formation in remyelinating axons." The Journal of neuroscience : the official journal of the Society for Neuroscience. 1995 Jan; 15(1 Pt 2):492-503.
1994 Aug 15
Wu JV, Shrager P. "Resolving three types of chloride channels in demyelinated Xenopus axons." Journal of neuroscience research. 1994 Aug 15; 38(6):613-20.
1993 Aug 13
Shrager P. "Axonal coding of action potentials in demyelinated nerve fibers." Brain research. 1993 Aug 13; 619(1-2):278-90.
1993
Wu JV, Rubinstein CT, Shrager P. "Single channel characterization of multiple types of potassium channels in demyelinated Xenopus axons." The Journal of neuroscience : the official journal of the Society for Neuroscience. 1993 13(12):5153-63.
1991 Oct
Shen L, Shrager P, Girsch SJ, Donaldson PJ, Peracchia C. "Channel reconstitution in liposomes and planar bilayers with HPLC-purified MIP26 of bovine lens." The Journal of membrane biology. 1991 Oct; 124(1):21-32.
1991 Jan 1
Hines M, Shrager P. "A computational test of the requirements for conduction in demyelinated axons." Restorative neurology and neuroscience. 1991 Jan 1; 3(2):81-93.
1991
Hines, M.; Shrager, P. "A computational test of the requirements for conduction in demyelinated axons." Restorative Neurology and Neuroscience. 1991; 3: 81-93. Link
1990 Aug 6
Rubinstein CT, Shrager P. "Remyelination of nerve fibers in the transected frog sciatic nerve." Brain research. 1990 Aug 6; 524(2):303-12.
1990 May
Shrager P, Rubinstein CT. "Optical measurement of conduction in single demyelinated axons." The Journal of general physiology. 1990 May; 95(5):867-89.
1989 Mar 27
Shrager P. "Sodium channels in single demyelinated mammalian axons." Brain research. 1989 Mar 27; 483(1):149-54.
1988 Oct
Shrager P. "Ionic channels and signal conduction in single remyelinating frog nerve fibres." The Journal of physiology. 1988 Oct; 404:695-712.
1988
Shrager, P.; Custer, A.W.; Kazarinova, K.; Rasband, M.N.; Mattson, D. "Nerve conduction block by nitric oxide that is mediated by the axonal environment." Journal of Neurophysiology. 1988; 79: 529-536. Link
1988
Rasband, M.N.; Trimmer, J.S.; Schwarz, T.L.; Levinson, S.R.; Ellisman, M.H.; Schachner, M.; Shrager, P. "Potassium channel distribution, clustering, and function in remyelinating rat axons." Journal of Neuroscience. 1988; 18: 36-47. Link
1987 Nov
Shrager P. "The distribution of sodium and potassium channels in single demyelinated axons of the frog." The Journal of physiology. 1987 Nov; 392:587-602.
1987 Feb
Shrager P, Chiu SY, Ritchie JM, Zecevic D, Cohen LB. "Optical recording of action potential propagation in demyelinated frog nerve." Biophysical journal. 1987 Feb; 51(2):351-5.
1985 Feb
Shrager P, Chiu SY, Ritchie JM. "Voltage-dependent sodium and potassium channels in mammalian cultured Schwann cells." Proceedings of the National Academy of Sciences of the United States of America. 1985 Feb; 82(3):948-52.
1985
Chiu SY, Shrager P, Ritchie JM. "Loose patch clamp recording of ionic currents in demyelinated frog nerve fibers." Brain research. 1985 359(1-2):338-42.
1985
Shrager, P.; S.Y. Chiu; J.M. Ritchie. "Voltage-dependent sodium and potassium channels in mammalian cultured Schwann cells." Proceedings of the National Academy of Sciences USA. 1985; 82: 948-952. Link
1984
Chiu SY, Schrager P, Ritchie JM. "Neuronal-type Na+ and K+ channels in rabbit cultured Schwann cells." Nature. 1984 311(5982):156-7.
1983 Aug
Shrager P, Starkus JC, Lo MV, Peracchia C. "The periaxonal space of crayfish giant axons." The Journal of general physiology. 1983 Aug; 82(2):221-44.
1982 Apr 1
Shrager P, Lo MV. "Influence of ionic current on Na+ channel gating in crayfish giant axon." Nature. 1982 Apr 1; 296(5856):450-2.
1981 Jul
Lo MV, Shrager P. "Block and inactivation of sodium channels in nerve by amino acid derivatives. I. Dependence on voltage and sodium concentration." Biophysical journal. 1981 Jul; 35(1):31-43.
1981 Jul
Lo MV, Shrager P. "Block and inactivation of sodium channels in nerve by amino acid derivatives. II. Dependence on temperature and drug concentration." Biophysical journal. 1981 Jul; 35(1):45-57.
1981 Mar
Bean BP, Shrager P, Goldstein DA. "Modification of sodium and potassium channel gating kinetics by ether and halothane." The Journal of general physiology. 1981 Mar; 77(3):233-53.
1978 Nov
Starkus JG, Shrager P. "Modification of slow sodium inactivation in nerve after internal perfusion with trypsin." The American journal of physiology. 1978 Nov; 235(5):C238-44.
1977 Feb
Shrager P. "Slow sodium inactivation in nerve after exposure to sulhydryl blocking reagents." The Journal of general physiology. 1977 Feb; 69(2):183-202.
1976 Apr
Jaimovich E, Venosa RA, Shrager P, Horowicz P. "Density and distribution of tetrodotoxin receptors in normal and detubulated frog sartorius muscle." The Journal of general physiology. 1976 Apr; 67(4):399-416.
1975
Shrager P. "Specific chemical groups involved in the control of ionic conductance in nerve." Annals of the New York Academy of Sciences. 1975 264:293-303.
1974
Shrager P. "Ionic conductance changes in voltage clamped crayfish axons at low pH." The Journal of general physiology. 1974 64(6):666-90.
1973 Aug 9
Shrager P, Profera C. "Inhibition of the receptor for tetrodotoxin in nerve membranes by reagents modifying carboxyl groups." Biochimica et biophysica acta. 1973 Aug 9; 318(1):141-6.
1972
Shrager P, Tosteson DC, Lauf PK. "Biochemical characterization of a lipid-dependent membrane protein antigen in HK sheep red cells." Biochimica et biophysica acta. 1972 290(1):186-99.
1969 Aug
Shrager PG, Macey RI, Strickholm A. "Internal perfusion of crayfish, giant axons: action of tannic acid, DDT, and TEA." Journal of cellular physiology. 1969 Aug; 74(1):77-90.
1969 Aug
Shrager PG, Strickholm A, Macey RI. "Chemical modification of crayfish axons by protein crosslinking aldehydes." Journal of cellular physiology. 1969 Aug; 74(1):91-100.
1969 Jul
Strickholm A, Wallin BG, Shrager P. "The pH dependency of relative ion permeabilities in the crayfish giant axon." Biophysical journal. 1969 Jul; 9(7):873-83.
1964
Shrager, P.; Susskind, C. "Electronics and the blind." Advances in Electronics and Electron Physics. 1964; 20: 261-301. Link

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