Xinping Zhang, B.Med., Ph.D.

Xinping Zhang, B.Med., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester, NY 14642

Office: (585) 275-7928
Lab: (585) 273-4255

Lab Information

The Center for Musculoskeletal Research houses nearly 70 MD and PhD researchers and graduate and post-doctoral students. This team has been the top orthopaedics lab in the United States since 2006.

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Research Bio

Dr. Zhang's research centers on finding ways to "revitalize, " or reactivate the healing processes of bone. When people suffer massive bone loss due to traumatic injury or a tumor, bone grafts are used to restore the shape and strength of the bone. Even when a bone graft from the patient's own body is used, healing and strengthening are sometimes never complete.

By studying how our body's cells mature to become bone-forming cells, Dr. Zhang hopes to find ways to turn the process of healing on so that the entire bone graft will heal after surgery.



Adult mesenchymal stem cells (MSCs) have enormous potential for bone tissue repair and regeneration. Our research has been focused on understanding the molecular and cellular mechanisms that control the activation, proliferation and differentiation of mesenchymal stem cells during skeletal repair. We are particularly interested in the periosteal stem cells that play key roles in repair and regeneration. Our current program has integrated the following topics:
1) Molecular signals that control mesenchymal stem cell differentiation.
2) Mechanism of skeletal repair and regeneration
3) Stem cell therapy and bone tissue engineering for repair and reconstruction of large segmental defects.

Awards & Honors (Local)

MTF J.R. Neff Award 2008
Orthopaedic Research Society New Investigator Recognition Award | Chicago, IL 2005
Orthopaedic Research Society Travel Fellowship Award | Chicago, IL 2002

Recent Journal Articles

Showing the 5 most recent journal articles. 48 available »

2009 Oct
Tsutsumi, R; Xie, C; Wei, X; Zhang, X; Flick, LM; Schwarz, EM; O'Keefe, RJ. "PGE2 Signaling Through the EP4 Receptor on Fibroblasts Upregulates RANKL and Stimulates Osteolysis". J Bone Miner Res. 2009; 24(10): 1753-62. Link
2009
Naik A; Xie, C; Kingsley, P; Zuscik, MJ; Schwarz, EM; Awad, H; Guldberg, R; Drissi, H; Puzas, E; Boyce, B; Zhang, X; O'Keefe, RJ. "Reduced COX-2 expression in aged mice is associated with impaired fracture healing". Journal of Bone & Mineral Research. 2009; 24(2): 251-64. Link
2009
Xie, C; Liang, B; Xue, M; Lin, ASP; Loiselle, A; Schwarz, EM; Guldberg, RE; O'Keefe, RJ; Zhang, X. "Rescue of Impaired Fracture Healing in Cox-2-/- mice via Activation of Prostaglandin E2 Receptor Subtype 4". The American Journal of Pathology. 2009; 175(2): 772-85. Link
2009
Clark, CA; Li, TF; Kim, KO; Drissi, H; Zuscik, MJ; Zhang, X; O'Keefe, RJ. "Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation". J. Orthop. Res.. 2009; 27(6): 785-92. Link
2009
Xie, C., Liang, B., Xue, M., Lin, ASP., Loiselle, A. Schwarz, EM, Guildberg, RE., O'Keefe, RJ, Zhang, X. "Rescue of impaired fracture healing in COX-2 mice via activation of prostaglandin E2 receptor subtype 4." The American Journal of Pathology. 2009; 175(2): 772-85. Link

Current Appointments

Associate Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD) - Primary

Education

PhD, | Biochemistry | University of Rochester School of Medicine & Dentistry1999
MS, | Biochemistry | China-Shanghai Medical University1993
MD | Medicine | China-Shanghai Medical University1990