Michael O'Banion, M.D., Ph.D.

Michael O'Banion, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 603
Rochester, NY 14642

Office: (585) 275-5185
Lab: (585) 273-2149
Fax: (585) 756-5334

Professional Bio

EDUCATION:



1976 – 1980 University of Illinois, College of Liberal Arts and Sciences - B.S. with honors in Biology (summa cum laude). Research training with Dr. Sue Carter-Porges, Department of Neural and Behavioral Biology.
1980 – 1987 University of Illinois, College of Liberal Arts and Sciences - M.S., Ph.D. in Microbiology.
1980 – 1987 University of Illinois, School of Medicine, Urbana, Illinois - M.D. with honors.
1987 – 1990 Postdoctoral Fellow, Departments of Medicine and Biochemistry, University of Rochester School of Medicine & Dentistry.

FACULTY APPOINTMENTS:

1990 – 1991 Instructor and Fellow, Departments of Medicine and Biochemistry, University of Rochester School of Medicine & Dentistry
1991 – 1997 Assistant Professor, Departments of Neurology and of Neurobiology and Anatomy, University of Rochester School of Medicine & Dentistry
1997 – 2000 Associate Professor, Departments of Neurology and of Neurobiology and Anatomy, University of Rochester School of Medicine & Dentistry
2000 – Present Associate Professor (Tenured in 2002), Departments of Neurobiology and Anatomy and of Neurology, University of Rochester School of Medicine & Dentistry

HONORS, AWARDS AND FELLOWSHIPS:

1977 – 1980 Edmund J. James Scholar
1980 Phi Kappa Phi (Honorary Society)
1980 B.S. with honors (summa cum laude); Bronze Tablet Recipient
1980 University of Illinois Life Sciences Predoctoral Fellowship
1982 Excellence in Undergraduate Teaching Award
1984 Otto Saphir Memorial Award in Pathology
1984 Alpha Omega Alpha (Honorary Medical Society)
1986 University of Illinois College of Medicine Predoctoral Fellowship
1987 M.D. with honors; Valedictorian Address, Medical School Commencement
1987 Lange Book Award
1988 Proficiency in Pediatrics Book Award
1987 – 1989 NIH Postdoctoral Training Fellow in Endocrinology and Metabolism, University of Rochester
1988 – 1991 Wilmot Cancer Research Postdoctoral Fellowship, University of Rochester
1990 – 1991 New York State Health Research Council Postdoctoral Fellowship for Diabetes Research
1996 – 1999 George W. Corner Dean's Teaching Scholar
1998 Graduate Student Society Faculty Teaching Award

Research Bio

RESEARCH: Neuroinflammation in CNS Injury and Alzheimer's Disease.



Twenty years ago evidence from epidemiological studies and investigations of human brain pathology suggested the hypothesis that innate immune activation of the brain, a term now referred to as neuroinflammation, might contribute to the pathogenesis of Alzheimer's and other brain diseases. Based on our pioneering work in the area of cyclooxygenase-2 and inflammation, we initiated a research program that focuses on understanding the role of neuroinflammation in Alzheimer's and other neurodegenerative diseases. Studies conducted in the laboratory with human brain tissue, neuronal cell culture models and mouse models of acute injury and neurodegeneration have pointed to a prominent role for specific proinflammatory cytokines and bioactive prostaglandins in promoting neuroinflammation. Interestingly, our current work in Alzheimer's disease has revealed a potential protective role for neuroinflammation and has led to a focus on the influence of glial expressed cytokines and infiltrating peripheral cells on brain pathology, utilizing genetic and pharmacological approaches in a variety of mouse models. In complementary work, we also have active preclinical projects in the area of brain radiation injury, a critical problem for individuals receiving radiotherapy for brain tumors or bone marrow transplantation. The main goal is to understand the role of neuroinflammation and oxidative stress in promoting injury and to determine whether therapeutic interventions targeting these processes can alleviate late radiation effects, including cognitive changes

RECENT PUBLICATIONS:

Cherry, J.D., B. Liu, J.L. Frost, C.A. Lemere, J.P. Williams, J.A. Olschowka and M.K. O'Banion. 2012. Galactic cosmic radiation leads to cognitive impairment and increased Ab plaque accumulation in a mouse model of Alzheimer's disease. PLOS ONE 7:e53275. PMCID in process.

Dilmanian, F.A., A.L. Jenkins, J. Olschowka, Z. Zhong, J.Y. Park, N.R. Desnoyers, S. Sobotka, G.R. Fois, C.R. Messina, M. Morales, S.D. Hurley, L.A. Trojanczyk, S. Ahmad, N. Shahrabi, P.K. Coyle, A.G. Meek and M.K. O'Banion. 2012. X-ray microbeam irradiation of the contusion-injured rat spinal cord temporarily improves hind-limb function. Rad. Res. Dec 5 [Epub ahead of print]. PMCID in process.

Wu, M.D., A.M. Hein, M.J. Moravan, S.S. Shaftel, J.A. Olschowka and M.K. O'Banion. 2012. Adult murine hippocampal neurogenesis is inhibited by sustained IL-1? and not rescued by voluntary running. Brain Behav. Immun. 26:292-300. PMCID: PMC3258353

Matousek, S.B., S. Ghosh, S.S. Shaftel, S. Kyrkanides, J.A. Olschowka and M.K. O'Banion. 2012. Chronic IL-1?-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration. J. Neuroimmune Pharmacol. 7:156-164. PMCID: PMC3302720

Hein, A. M., T. J. Zarcone, D. B. Parfitt, S. B. Matousek, D. M. Carbonari, J. A. Olschowka and M. K. O'Banion. 2012. Behavioral, structural and molecular changes following long-term hippocampal IL-1? overexpression in transgenic mice. J. Neuroimmune Pharmacol. 7:145-155. PMCID: PMC3214690

Kyrkanides S., R.H. Tallents, J.N. Miller, M.E. Olschowka, R. Johnson, M. Yang, J.A. Olschowka, S.M. Brouxhon and M.K. O'Banion. 2011. Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice. J. Neuroinflammation 8:112. PMCID: PMC3179730

Moravan, M.J., D.A. Olschowka, J.P. Williams and M.K. O'Banion. 2011. Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain. Radiat. Res. 176:459-473. PMCID: PMC3191189.

Awards & Honors (Local)

Graduate Student Society Faculty Teaching Award 1998
George W. Corner Dean's Teaching Scholar 1996 - 1999
Proficiency in Pediatrics Book Award 1988
M.D. with honors; Valedictorian Address 1987
Lange Book Award 1987
Otto Saphir Memorial Award in Pathology 1984
Alpha Omega Alpha (Honorary Medical Society) 1984
Excellence in Undergraduate Teaching Award 1982
Phi Kappa Phi (Honorary Society) 1980
B.S. with honors (summa cum laude); Bronze Tablet Recipient 1980
Edmund J. James Scholar 1977 - 1980

Recent Journal Articles

Showing the 5 most recent journal articles. 105 available »

2013 Aug
Wu MD, Montgomery SL, Rivera-Escalera F, Olschowka JA, Kerry O'Banion M. "Sustained IL-1? expression impairs adult hippocampal neurogenesis independent of IL-1 signaling in nestin+ neural precursor cells." Brain, behavior, and immunity. 2013 Aug; 32:9-18. Epub 2013 Mar 16.
2013 Jun 15
"Monoclonal antibody against the ectodomain of E-cadherin (DECMA-1) suppresses breast carcinogenesis: involvement of the HER/PI3K/Akt/mTOR and IAP pathways." Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 Jun 15; 19(12):3234-46. Epub 2013 Apr 25.
2012 Oct 1
Dilmanian FA, Rusek A, Fois GR, Olschowka J, Desnoyers NR, Park JY, Dioszegi I, Dane B, Wang R, Tomasi D, Lee H, Hurley SD, Coyle PK, Meek AG, O'Banion MK. "Interleaved carbon minibeams: an experimental radiosurgery method with clinical potential." International journal of radiation oncology, biology, physics. 2012 Oct 1; 84(2):514-9. Epub 2012 Feb 17.
2012 Mar
Hein AM, Zarcone TJ, Parfitt DB, Matousek SB, Carbonari DM, Olschowka JA, O'Banion MK. "Behavioral, structural and molecular changes following long-term hippocampal IL-1? overexpression in transgenic mice." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2012 Mar; 7(1):145-55. Epub 2011 Jul 12.
2012 Mar
Hein AM, O'Banion MK. "Neuroinflammation and cognitive dysfunction in chronic disease and aging." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2012 Mar; 7(1):3-6. Epub 2012 Jan 18.

Current Appointments

Interim Chair - Department of Neurobiology and Anatomy (SMD) - Primary Administrative
Professor - Department of Neurobiology and Anatomy (SMD) - Primary

Education

PhD | Microbiology | Univ of Illinois-Urbana1987
MD | Medicine | Univ of Illinois Coll Medicine1987
BS | Biology | Univ of Illinois-Urbana1980

Post-Doctoral Training & Residency

New York State Health Research Council Fellowship for Diabetes Research. 1991
Wilmot Cancer Research Postdoctoral Fellowship, University of Rochester. 1991
Postdoctoral Fellow, Departments of Medicine and Biochemistry, University of Rochester School of Medicine. Trained with Dr. D. A. Young. 1990