Jennifer L. Nayak, M.D.

Jennifer L. Nayak, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 690
Rochester, NY 14642

Office: (585) 275-9477

Research Bio

My current research interests involves:

• Understanding factors controlling immunodominance following secondary infection with a heterosubtypic strain of influenza virus using a mouse model.
• Examining how memory and naïve CD4 T cells compete during sequential exposure to different strains of influenza virus in humans, who have exposure to multiple strains of influenza over a lifetime
• Understanding how pre-existing CD4 T cells directed against influenza influence the ability of B cells to respond to influenza vaccination
• Studying whether increases in the CD4 T cell response following vaccination correlate with the magnitude of the neutralizing antibody response and whether the specificity of the responding CD4 T cells impacts the production of neutralizing antibodies.

Awards & Honors (National)

Phi Beta Kappa National Honor Society 1999
Golden Key National Honor Society 1999

Awards & Honors (Local)

Rush Rhees Scholarship 1996 - 2000

Recent Journal Articles

Showing the 5 most recent journal articles. 10 available »

2015 May 1
Nayak JL, Richards KA, Yang H, Treanor JJ, Sant AJ. "Effect of influenza A(H5N1) vaccine prepandemic priming on CD4+ T-cell responses." The Journal of infectious diseases. 2015 May 1; 211(9):1408-17. Epub 2014 Nov 06.
Kennedy BS; Weimer AC; Bedard B; Nayak JL; Sacheli D; Ricci J;, Meyer DD; and Hubbard D. "Menningitis in a school-aged child due to Haemophilus influenza type E during the post-conjugate vaccine era. Vaccines. 2014; 2: 107-111". Vaccines. 2014; 2: 107-111.
2013 Aug 1
Nayak JL, Alam S, Sant AJ. "Cutting edge: Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to hemagglutinin." The Journal of immunology : official journal of the American Association of Immunologists. 2013 Aug 1; 191(3):1001-5. Epub 2013 Jun 21.
2013 Jan 15
Nayak JL, Fitzgerald TF, Richards KA, Yang H, Treanor JJ, Sant AJ. "CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine." The Journal of infectious diseases. 2013 Jan 15; 207(2):297-305. Epub 2012 Nov 12.
2012 Aug
Nayak JL, Sant AJ. "Loss in CD4 T-cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host." Immunology. 2012 Aug; 136(4):425-36.


Pediatric Infectious Diseases - American Board of Pediatrics
Pediatrics - American Board of Pediatrics


MD | Medicine | Univ at Buffalo SUNY School of Medicine & Biomedical Sciences2004
BS | Arts & Sciences | University of Rochester2000
Fellowship | Pediatrics Infectious Diseases | University of Rochester, Golisano Children's Hospital at StrongAttended 2007 - 2010
Pediatric Residency Training | University of Rochester, Golisano Children's Hospital at StrongAttended 2004 - 2007

Post-Doctoral Training & Residency

Fellowship in Pediatric Infectious Disease at University of Rochester Medical Center07/21/2007 - 07/21/2010
Residency in Pediatrics at University of Rochester Medical Center07/01/2005 - 07/20/2007
Internship in Pediatrics at University of Rochester Medical Center07/01/2004 - 06/30/2005