Edward M. Schwarz, Ph.D.

Edward M. Schwarz, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester, NY 14642

Journal Articles

Showing all 205 journal articles available.

2014 Oct
Varrone JJ, de Mesy Bentley KL, Bello-Irizarry SN, Nishitani K, Mack S, Hunter JG, Kates SL, Daiss JL, Schwarz EM. "Passive immunization with anti-glucosaminidase monoclonal antibodies protects mice from implant-associated osteomyelitis by mediating opsonophagocytosis of Staphylococcus aureus megaclusters." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2014 Oct; 32(10):1389-96. Epub 2014 Jul 03.
2014 Jun
Papuga MO, Beck CA, Kates SL, Schwarz EM, Maloney MD. "Validation of GAITRite and PROMIS as high-throughput physical function outcome measures following ACL reconstruction." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2014 Jun; 32(6):793-801. Epub 2014 Feb 14.
2014 May
Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ. "Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment." Bone.. 2014 May; 62:79-89. Epub 2014 Feb 12.
2014 Apr
Inzana JA, Olvera D, Fuller SM, Kelly JP, Graeve OA, Schwarz EM, Kates SL, Awad HA. "3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration." Biomaterials.. 2014 Apr; 35(13):4026-34. Epub 2014 Feb 14.
2014 Mar 15
Bouta EM, Wood RW, Brown EB, Rahimi H, Ritchlin CT, Schwarz EM. "In vivo quantification of lymph viscosity and pressure in lymphatic vessels and draining lymph nodes of arthritic joints in mice." The Journal of physiology.. 2014 Mar 15; 592(Pt 6):1213-23. Epub 2014 Jan 13.
2014 Mar
Long T, Zhu Z, Awad HA, Schwarz EM, Hilton MJ, Dong Y. "The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice." Biomaterials.. 2014 Mar; 35(9):2752-9. Epub 2014 Jan 03.
2014 Mar
Nishitani K, Schwarz EM. "Regenerative medicine: Cartilage transplants hold promise for challenging bone defects." Nature reviews. Rheumatology.. 2014 Mar; 10(3):129-30. Epub 2014 Jan 14.
2014 Jan
Schwarz EM, Alt V, Kates SL. "The 1st International Consensus Meeting on Periprosthetic Joint Infection." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2014 Jan; 32 Suppl 1:S1.
2014
Dhillon RS, Zhang L, Schwarz EM, Boyce BF, Xie C. "The murine femoral bone graft model and a semiautomated histomorphometric analysis tool." Methods in molecular biology.. 2014 1130:45-59.
2013 Nov 20
Gedbjerg N, Larosa R, Hunter JG, Varrone JJ, Kates SL, Schwarz EM, Daiss JL. "Anti-glucosaminidase IgG in sera as a biomarker of host immunity against Staphylococcus aureus in orthopaedic surgery patients." The Journal of bone and joint surgery. American volume.. 2013 Nov 20; 95(22):e171.
2013 Sep
Ju Y, Li J, Xie C, Ritchlin CT, Xing L, Hilton MJ, Schwarz EM. "Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice." Genesis : the journal of genetics and development.. 2013 Sep; 51(9):667-75. Epub 2013 Jul 09.
2013 Mar
Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O'Keefe RJ, Schwarz EM. "PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2013 Mar; 28(3):586-97.
2013 Feb 22
Inzana JA, Maher JR, Takahata M, Schwarz EM, Berger AJ, Awad HA. "Bone fragility beyond strength and mineral density: Raman spectroscopy predicts femoral fracture toughness in a murine model of rheumatoid arthritis." Journal of biomechanics. 2013 Feb 22; 46(4):723-30. Epub 2012 Dec 20.
2013 Jan
Li J, Ju Y, Bouta EM, Xing L, Wood RW, Kuzin I, Bottaro A, Ritchlin CT, Schwarz EM. "Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow." Arthritis and rheumatism.. 2013 Jan; 65(1):130-8.
2013
Gao L, Sheu TJ, Dong Y, Hoak DM, Zuscik MJ, Schwarz EM, Hilton MJ, O'Keefe RJ, Jonason JH. "TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages." Journal of cell science.. 2013 126(Pt 24):5704-13. Epub 2013 Oct 21.
2013
Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA. "Cellular and molecular factors in flexor tendon repair and adhesions: a histological and gene expression analysis." Connective tissue research.. 2013 54(3):218-26. Epub 2013 Apr 15.
2013
Liu H, Schwarz EM, Xie C. "Dual differentiation-exogenous mesenchymal stem cell therapy for traumatic spinal cord injury repair in a murine hemisection model." Stem cells international. 2013 2013:928982. Epub 2013 Aug 20.
2012 Nov
Takahata M, Maher JR, Juneja SC, Inzana J, Xing L, Schwarz EM, Berger AJ, Awad HA. "Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk." Arthritis and rheumatism.. 2012 Nov; 64(11):3649-59.
2012 Jun 15
Moshkani S, Kuzin II, Adewale F, Jansson J, Sanz I, Schwarz EM, Bottaro A. "CD23+ CD21(high) CD1d(high) B cells in inflamed lymph nodes are a locally differentiated population with increased antigen capture and activation potential." The Journal of immunology : official journal of the American Association of Immunologists.. 2012 Jun 15; 188(12):5944-53. Epub 2012 May 16.
2012 Mar
Takahata M, Awad HA, O'Keefe RJ, Bukata SV, Schwarz EM. "Endogenous tissue engineering: PTH therapy for skeletal repair." Cell and tissue research.. 2012 Mar; 347(3):545-52. Epub 2011 May 31.
2012 Feb
Xie C, Schwarz EM, Sampson ER, Dhillon RS, Li D, O'Keefe RJ, Tyler W. "Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2012 Feb; 30(2):325-33. Epub 2011 Aug 01.
2012 Jan
Takahata M, Schwarz EM, Chen T, O'Keefe RJ, Awad HA. "Delayed short-course treatment with teriparatide (PTH(1-34)) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2012 Jan; 27(1):26-37.
2012 Jan
Chiu YH, Mensah KA, Schwarz EM, Ju Y, Takahata M, Feng C, McMahon LA, Hicks DG, Panepento B, Keng PC, Ritchlin CT. "Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP)." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2012 Jan; 27(1):79-92.
2012
Loiselle AE, Frisch BJ, Wolenski M, Jacobson JA, Calvi LM, Schwarz EM, Awad HA, O'Keefe RJ. "Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury." PloS one. 2012 7(7):e40602. Epub 2012 Jul 11.
2012
Farhat YM, Al-Maliki AA, Chen T, Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA. "Gene expression analysis of the pleiotropic effects of TGF-?1 in an in vitro model of flexor tendon healing." PloS one. 2012 7(12):e51411. Epub 2012 Dec 10.
2011 Nov
Myakishev-Rempel M, Kuper J, Mintz B, Hutchinson S, Voris J, Zavislan K, Offley S, Nardia FB, Yaseen Z, Yen T, Zavislan JM, Maloney MD, Schwarz EM. "Investigation of the peak action wavelength of light-activated gene transduction." Gene therapy.. 2011 Nov; 18(11):1043-51. Epub 2011 Apr 14.
2011 Sep 21
Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ. "Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis." Science translational medicine. 2011 Sep 21; 3(101):101ra93.
2011 Sep
Papuga MO, Kwok E, You Z, Rubery PT, Dougherty PE, Pryhuber G, Beck CA, Hilton MJ, Awad HA, Schwarz EM. "TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2011 Sep; 29(9):1367-74. Epub 2011 Mar 28.
2011 Aug
Yazici C, Takahata M, Reynolds DG, Xie C, Samulski RJ, Samulski J, Beecham EJ, Gertzman AA, Spilker M, Zhang X, O'Keefe RJ, Awad HA, Schwarz EM. "Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur." Molecular therapy : the journal of the American Society of Gene Therapy.. 2011 Aug; 19(8):1416-25. Epub 2011 Jan 04.
2011 Aug
Sampson ER, Beck CA, Ketz J, Canary KL, Hilton MJ, Awad H, Schwarz EM, Chen D, O'Keefe RJ, Rosier RN, Zuscik MJ. "Establishment of an index with increased sensitivity for assessing murine arthritis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2011 Aug; 29(8):1145-51. Epub 2011 Mar 03.
2011 Jun 1
Dhillon RS, Schwarz EM. "Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials." Journal of materials research. 2011 Jun 1; 4(6):1117-1131.
2011 Jun
Sampson ER, Martin BA, Morris AE, Xie C, Schwarz EM, O'Keefe RJ, Rosier RN. "The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2011 Jun; 26(6):1283-94.
2011 Apr 1
Varrone JJ, Li D, Daiss JL, Schwarz EM. "Anti-Glucosaminidase Monoclonal Antibodies as a Passive Immunization for Methicillin-Resistant Staphylococcus aureus (MRSA) Orthopaedic Infections." BoneKEy osteovision. 2011 Apr 1; 8:187-194.
2011 Apr
Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM, O'Keefe RJ. "EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2011 Apr; 26(4):792-802.
2011 Apr
Sampson ER, Amin V, Schwarz EM, O'Keefe RJ, Rosier RN. "The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2011 Apr; 29(4):623-32. Epub 2010 Oct 18.
2011 Mar 1
Reynolds DG, Takahata M, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA. "Teriparatide therapy enhances devitalized femoral allograft osseointegration and biomechanics in a murine model." Bone.. 2011 Mar 1; 48(3):562-70. Epub 2010 Oct 13.
2011 Feb
Jacobson JA, Yanoso Scholl L, Reynolds DG, Dadali T, Bradica G, Bukata S, Puzas JE, Zuscik MJ, Rosier R, O'Keefe RJ, Schwarz E, Awad H. "Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects." Tissue engineering. Part A. 2011 Feb; 17(3-4):389-98. Epub 2010 Oct 29.
2011
Li J, Zhou Q, Wood R, Kuzin I, Bottaro A, Ritchlin C, Xing L, Schwarz E. "CD23(+)/CD21(hi) B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice." Arthritis research & therapy. 2011 13(4):R138. Epub 2011 Aug 31.
2011
Bouta EM, Wood RW, Perry SW, Brown EB, Ritchlin CT, Xing L, Schwarz EM. "Measuring intranodal pressure and lymph viscosity to elucidate mechanisms of arthritic flare and therapeutic outcomes." Annals of the New York Academy of Sciences.. 2011 1240:47-52.
2010 Sep
Papuga MO, Proulx ST, Kwok E, You Z, Rubery PT, Dougherty PE, Hilton MJ, Awad HA, Schwarz EM. "Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2010 Sep; 28(9):1220-8.
2010 Aug
Gunnell LM, Jonason JH, Loiselle AE, Kohn A, Schwarz EM, Hilton MJ, O'Keefe RJ. "TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2010 Aug; 25(8):1784-97.
2010 Aug
Li TF, Gao L, Sheu TJ, Sampson ER, Flick LM, Konttinen YT, Chen D, Schwarz EM, Zuscik MJ, Jonason JH, O'Keefe RJ. "Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis." Arthritis and rheumatism.. 2010 Aug; 62(8):2359-69.
2010 Jun 1
Li J, Kuzin I, Moshkani S, Proulx ST, Xing L, Skrombolas D, Dunn R, Sanz I, Schwarz EM, Bottaro A. "Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy." The Journal of immunology : official journal of the American Association of Immunologists.. 2010 Jun 1; 184(11):6142-50. Epub 2010 Apr 30.
2010 Apr
Mensah KA, Ritchlin CT, Schwarz EM. "RANKL induces heterogeneous DC-STAMP(lo) and DC-STAMP(hi) osteoclast precursors of which the DC-STAMP(lo) precursors are the master fusogens." Journal of cellular physiology.. 2010 Apr; 223(1):76-83.
2010 Apr
Mensah KA, Mathian A, Ma L, Xing L, Ritchlin CT, Schwarz EM. "Mediation of nonerosive arthritis in a mouse model of lupus by interferon-alpha-stimulated monocyte differentiation that is nonpermissive of osteoclastogenesis." Arthritis and rheumatism.. 2010 Apr; 62(4):1127-37.
2010 Mar
Li D, Gromov K, Proulx ST, Xie C, Li J, Crane DP, Søballe K, O'Keefe RJ, Awad HA, Xing L, Schwarz EM. "Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw." Annals of the New York Academy of Sciences.. 2010 Mar; 1192:84-94.
2010
Yanoso-Scholl L, Jacobson JA, Bradica G, Lerner AL, O'Keefe RJ, Schwarz EM, Zuscik MJ, Awad HA. "Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering." Journal of biomedical materials research. Part A. 2010 95(3):717-26.
2010
Schwarz EM, Proulx ST, Ritchlin CT, Boyce BF, Xing L. "The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis." Advances in experimental medicine and biology. 2010 658:1-10.
2010
Chiu YG, Shao T, Feng C, Mensah KA, Thullen M, Schwarz EM, Ritchlin CT. "CD16 (FcRgammaIII) as a potential marker of osteoclast precursors in psoriatic arthritis." Arthritis research & therapy. 2010 12(1):R14. Epub 2010 Jan 26.
2009 Oct
Tsutsumi R, Xie C, Wei X, Zhang X, Flick LM, Schwarz EM, O'Keefe RJ. "PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 Oct; 24(10):1753-62.
2009 Oct
Darowish M, Rahman R, Li P, Bukata SV, Gelinas J, Huang W, Flick LM, Schwarz EM, O'Keefe RJ. "Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation." Bone.. 2009 Oct; 45(4):661-8. Epub 2009 Jun 12.
2009 Sep
Guo R, Zhou Q, Proulx ST, Wood R, Ji RC, Ritchlin CT, Pytowski B, Zhu Z, Wang YJ, Schwarz EM, Xing L. "Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis." Arthritis and rheumatism.. 2009 Sep; 60(9):2666-76.
2009 Aug
Crane DP, Gromov K, Li D, Søballe K, Wahnes C, Büchner H, Hilton MJ, O'Keefe RJ, Murray CK, Schwarz EM. "Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2009 Aug; 27(8):1008-15.
2009 Aug
Xie C, Liang B, Xue M, Lin AS, Loiselle A, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X. "Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4." The American journal of pathology.. 2009 Aug; 175(2):772-85. Epub 2009 Jul 23.
2009 Jun
Loiselle AE, Bragdon GA, Jacobson JA, Hasslund S, Cortes ZE, Schwarz EM, Mitten DJ, Awad HA, O'Keefe RJ. "Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2009 Jun; 27(6):833-40.
2009 May
Reynolds DG, Shaikh S, Papuga MO, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA. "muCT-based measurement of cortical bone graft-to-host union." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 May; 24(5):899-907.
2009 Feb
Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ. "Reduced COX-2 expression in aged mice is associated with impaired fracture healing." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 Feb; 24(2):251-64.
2009
Mensah KA, Li J, Schwarz EM. "The emerging field of osteoimmunology." Immunologic research. 2009 45(2-3):100-13. Epub 2009 Jan 30.
2008 Oct
Tsutsumi R, Hock C, Bechtold CD, Proulx ST, Bukata SV, Ito H, Awad HA, Nakamura T, O'Keefe RJ, Schwarz EM. "Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 Oct; 26(10):1340-6.
2008 Oct
Yazici C, Yanoso L, Xie C, Reynolds DG, Samulski RJ, Samulski J, Yannariello-Brown J, Gertzman AA, Zhang X, Awad HA, Schwarz EM. "The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings." Biomaterials.. 2008 Oct; 29(28):3882-7. Epub 2008 Jun 30.
2008 Oct
Wu Q, Kim KO, Sampson ER, Chen D, Awad H, O'Brien T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ, Zuscik MJ, Rosier RN. "Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice." Arthritis and rheumatism.. 2008 Oct; 58(10):3132-44.
2008 Sep 1
Kaback LA, Soung do Y, Naik A, Geneau G, Schwarz EM, Rosier RN, O'Keefe RJ, Drissi H. "Teriparatide (1-34 human PTH) regulation of osterix during fracture repair." Journal of cellular biochemistry.. 2008 Sep 1; 105(1):219-26.
2008 Aug 22
Guo R, Yamashita M, Zhang Q, Zhou Q, Chen D, Reynolds DG, Awad HA, Yanoso L, Zhao L, Schwarz EM, Zhang YE, Boyce BF, Xing L. "Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins." The Journal of biological chemistry.. 2008 Aug 22; 283(34):23084-92. Epub 2008 Jun 19.
2008 Aug
Zhang X, Awad HA, O'Keefe RJ, Guldberg RE, Schwarz EM. "A perspective: engineering periosteum for structural bone graft healing." Clinical orthopaedics and related research.. 2008 Aug; 466(8):1777-87. Epub 2008 May 29.
2008 Aug
Mensah KA, Schwarz EM, Ritchlin CT. "Altered bone remodeling in psoriatic arthritis." Current rheumatology reports. 2008 Aug; 10(4):311-7.
2008 Jul
Proulx ST, Kwok E, You Z, Papuga MO, Beck CA, Shealy DJ, Calvi LM, Ritchlin CT, Awad HA, Boyce BF, Xing L, Schwarz EM. "Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast-enhanced magnetic resonance imaging." Arthritis and rheumatism.. 2008 Jul; 58(7):2019-29.
2008 Jun 5
Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH. "Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis." Oncogene.. 2008 Jun 5; 27(25):3605-14. Epub 2008 Jan 28.
2008 Jun
Hasslund S, Jacobson JA, Dadali T, Basile P, Ulrich-Vinther M, Søballe K, Schwarz EM, O'Keefe RJ, Mitten DJ, Awad HA. "Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 Jun; 26(6):824-33.
2008 May 9
Zhang Q, Guo R, Lu Y, Zhao L, Zhou Q, Schwarz EM, Huang J, Chen D, Jin ZG, Boyce BF, Xing L. "VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism." The Journal of biological chemistry.. 2008 May 9; 283(19):13491-9. Epub 2008 Mar 20.
2008 Apr 11
Yao Z, Xing L, Qin C, Schwarz EM, Boyce BF. "Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism." The Journal of biological chemistry.. 2008 Apr 11; 283(15):9917-24. Epub 2008 Feb 04.
2008 Mar
Anandarajah AP, Schwarz EM, Totterman S, Monu J, Feng CY, Shao T, Haas-Smith SA, Ritchlin CT. "The effect of etanercept on osteoclast precursor frequency and enhancing bone marrow oedema in patients with psoriatic arthritis." Annals of the rheumatic diseases.. 2008 Mar; 67(3):296-301. Epub 2007 Oct 29.
2008 Mar
Basile P, Dadali T, Jacobson J, Hasslund S, Ulrich-Vinther M, Søballe K, Nishio Y, Drissi MH, Langstein HN, Mitten DJ, O'Keefe RJ, Schwarz EM, Awad HA. "Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery." Molecular therapy : the journal of the American Society of Gene Therapy.. 2008 Mar; 16(3):466-73. Epub 2008 Jan 08.
2008 Feb
Xie C, Xue M, Wang Q, Schwarz EM, O'Keefe RJ, Zhang X. "Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation." The Journal of bone and joint surgery. American volume.. 2008 Feb; 90 Suppl 1:9-13.
2008 Jan
Kaback LA, Soung do Y, Naik A, Smith N, Schwarz EM, O'Keefe RJ, Drissi H. "Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification." Journal of cellular physiology.. 2008 Jan; 214(1):173-82.
2008 Jan
Li D, Gromov K, Søballe K, Puzas JE, O'Keefe RJ, Awad H, Drissi H, Schwarz EM. "Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 Jan; 26(1):96-105.
2008
Eliseev,R. A.; Dong,Y. F.; Sampson,E.; Zuscik,M. J.; Schwarz,E. M.; O'Keefe,R. J.; Rosier,R. N.; Drissi,M. H.;. "Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis". Oncogene. 2008; .
2008
Hasslund,S.; Jacobson,J. A.; Dadali,T.; Basile,P.; Ulrich-Vinther,M.; Soballe,K.; Schwarz,E. M.; O'Keefe,R. J.; Mitten,D. J.; Awad,H. A.;. "Adhesions in a murine flexor tendon graft model: Autograft versus allograft reconstruction". J.Orthop.Res.. 2008; .
2008
Tsutsumi,R.; Hock,C.; Bechtold,C. D.; Proulx,S. T.; Bukata,S. V.; Ito,H.; A Awad,H.; Nakamura,T.; O'Keefe,R. J.; Schwarz,E. M.;. "Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT". J.Orthop.Res.. 2008; .
2008
Zhang Q, Guo R, Schwarz EM, Boyce BF, Xing L. "TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood." Arthritis research & therapy. 2008 10(2):R37. Epub 2008 Mar 27.
2008
Schwarz EM, . "What potential biologic treatments are available for osteolysis?" The Journal of the American Academy of Orthopaedic Surgeons.. 2008 16 Suppl 1:S72-5.
2008
Xie C, Ming X, Wang Q, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X. "COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing." Bone.. 2008 43(6):1075-83. Epub 2008 Aug 16.
2007 Nov
Proulx ST, Kwok E, You Z, Beck CA, Shealy DJ, Ritchlin CT, Boyce BF, Xing L, Schwarz EM. "MRI and quantification of draining lymph node function in inflammatory arthritis." Annals of the New York Academy of Sciences.. 2007 Nov; 1117:106-23. Epub 2007 Jul 23.
2007 Nov
Dong YF, Soung do Y, Chang Y, Enomoto-Iwamoto M, Paris M, O'Keefe RJ, Schwarz EM, Drissi H. "Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner." Molecular endocrinology.. 2007 Nov; 21(11):2805-20. Epub 2007 Aug 07.
2007 Nov
Boyce BF, Yao Z, Zhang Q, Guo R, Lu Y, Schwarz EM, Xing L. "New roles for osteoclasts in bone." Annals of the New York Academy of Sciences.. 2007 Nov; 1116:245-54.
2007 Sep
Zuscik MJ, Ma L, Buckley T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ. "Lead induces chondrogenesis and alters transforming growth factor-beta and bone morphogenetic protein signaling in mesenchymal cell populations." Environmental health perspectives.. 2007 Sep; 115(9):1276-82.
2007 Aug
Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. "Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2007 Aug; 22(8):1260-70.
2007 Aug
Awad HA, Zhang X, Reynolds DG, Guldberg RE, O'Keefe RJ, Schwarz EM. "Recent advances in gene delivery for structural bone allografts." Tissue engineering. 2007 Aug; 13(8):1973-85.
2007 Jun 22
Yamashita T, Yao Z, Li F, Zhang Q, Badell IR, Schwarz EM, Takeshita S, Wagner EF, Noda M, Matsuo K, Xing L, Boyce BF. "NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1." The Journal of biological chemistry.. 2007 Jun 22; 282(25):18245-53. Epub 2007 May 07.
2007 Mar
Xie C, Reynolds D, Awad H, Rubery PT, Pelled G, Gazit D, Guldberg RE, Schwarz EM, O'Keefe RJ, Zhang X. "Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering." Tissue engineering. 2007 Mar; 13(3):435-45.
2007
Reynolds DG, Hock C, Shaikh S, Jacobson J, Zhang X, Rubery PT, Beck CA, O'keefe RJ, Lerner AL, Schwarz EM, Awad HA. "Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts." Journal of biomechanics. 2007 40(14):3178-86. Epub 2007 May 23.
2007
Schwarz EM, Ritchlin CT. "Clinical development of anti-RANKL therapy." Arthritis research & therapy. 2007 9 Suppl 1:S7.
2007
Zhang Q, Lu Y, Proulx ST, Guo R, Yao Z, Schwarz EM, Boyce BF, Xing L. "Increased lymphangiogenesis in joints of mice with inflammatory arthritis." Arthritis research & therapy. 2007 9(6):R118.
2007
Proulx ST, Kwok E, You Z, Papuga MO, Beck CA, Shealy DJ, Ritchlin CT, Awad HA, Boyce BF, Xing L, Schwarz EM. "Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography." Arthritis and rheumatism.. 2007 56(12):4024-37.
2006 Oct
Robertson G, Xie C, Chen D, Awad H, Schwarz EM, O'Keefe RJ, Guldberg RE, Zhang X. "Alteration of femoral bone morphology and density in COX-2-/- mice." Bone.. 2006 Oct; 39(4):767-72. Epub 2006 May 30.
2006 Jul 28
Li TF, Chen D, Wu Q, Chen M, Sheu TJ, Schwarz EM, Drissi H, Zuscik M, O'Keefe RJ. "Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes." The Journal of biological chemistry.. 2006 Jul 28; 281(30):21296-304. Epub 2006 May 10.
2006 Jul
Dong YF, Soung do Y, Schwarz EM, O'Keefe RJ, Drissi H. "Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor." Journal of cellular physiology.. 2006 Jul; 208(1):77-86.
2006 Jul
Boyce BF, Schwarz EM, Xing L. "Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory bone disease." Current opinion in rheumatology. 2006 Jul; 18(4):427-32.
2006 Jun
Wood RW, Baggs RB, Schwarz EM, Messing EM. "Initial observations of reduced uroflow in transgenic adenocarcinoma of murine prostate." Urology.. 2006 Jun; 67(6):1324-8.
2006 May 10
Nishio Y, Dong Y, Paris M, O'Keefe RJ, Schwarz EM, Drissi H. "Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene." Gene.. 2006 May 10; 372:62-70. Epub 2006 Mar 29.
2006 Apr 28
Yao Z, Li P, Zhang Q, Schwarz EM, Keng P, Arbini A, Boyce BF, Xing L. "Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression." The Journal of biological chemistry.. 2006 Apr 28; 281(17):11846-55. Epub 2006 Feb 06.
2006 Apr
Maloney MD, Goater JJ, Parsons R, Ito H, O'Keefe RJ, Rubery PT, Drissi MH, Schwarz EM. "Safety and efficacy of ultraviolet-a light-activated gene transduction for gene therapy of articular cartilage defects." The Journal of bone and joint surgery. American volume.. 2006 Apr; 88(4):753-61.
2006 Apr
Schwarz EM, Looney RJ, Drissi MH, O'Keefe RJ, Boyce BF, Xing L, Ritchlin CT. "Autoimmunity and bone." Annals of the New York Academy of Sciences.. 2006 Apr; 1068:275-83.
2006 Apr
O'Keefe RJ, Tiyapatanaputi P, Xie C, Li TF, Clark C, Zuscik MJ, Chen D, Drissi H, Schwarz E, Zhang X. "COX-2 has a critical role during incorporation of structural bone allografts." Annals of the New York Academy of Sciences.. 2006 Apr; 1068:532-42.
2006 Feb 17
Kaneki H, Guo R, Chen D, Yao Z, Schwarz EM, Zhang YE, Boyce BF, Xing L. "Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts." The Journal of biological chemistry.. 2006 Feb 17; 281(7):4326-33. Epub 2005 Dec 22.
2006 Feb 1
Anandarajah AP, Schwarz EM. "Anti-RANKL therapy for inflammatory bone disorders: Mechanisms and potential clinical applications." Journal of cellular biochemistry.. 2006 Feb 1; 97(2):226-32.
2006 Jan 1
Eliseev RA, Schwarz EM, Zuscik MJ, O'Keefe RJ, Drissi H, Rosier RN. "Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB." Experimental cell research.. 2006 Jan 1; 312(1):40-50. Epub 2005 Nov 02.
2006 Jan
Looney RJ, Schwarz EM, Boyd A, O'Keefe RJ. "Periprosthetic osteolysis: an immunologist's update." Current opinion in rheumatology. 2006 Jan; 18(1):80-7.
2006 Jan
Li TF, Darowish M, Zuscik MJ, Chen D, Schwarz EM, Rosier RN, Drissi H, O'Keefe RJ. "Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2006 Jan; 21(1):4-16. Epub 2005 Sep 19.
2006
Xie,C.; Reynolds,D.; Awad,H.; Rubery,P. T.; Pelled,G.; Gazit,D.; Guldberg,R. E.; Schwarz,E. M.; O'keefe,R. J.; Zhang,X.;. "Structural Bone Allograft Combined with Genetically Engineered Mesenchymal Stem Cells As a Novel Platform for Bone Tissue Engineering". Tissue Eng.. 2006; .
2006
Xie,C.; Reynolds,D.; Awad,H.; Rubery,P. T.; Pelled,G.; Gazit,D.; Guldberg,R. E.; Schwarz,E. M.; O'keefe,R. J.; Zhang,X.;. "Structural Bone Allograft Combined with Genetically Engineered Mesenchymal Stem Cells As a Novel Platform for Bone Tissue Engineering". Tissue Eng.. 2006; .
2005 Nov
Soloviev A, Schwarz EM, Darowish M, O'Keefe RJ. "Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: a role for free radicals, NFkappaB, and TNFalpha." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2005 Nov; 23(6):1258-65. Epub 2005 Jun 09.
2005 Sep
Wang Y, Belflower RM, Dong YF, Schwarz EM, O'Keefe RJ, Drissi H. "Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 Sep; 20(9):1624-36. Epub 2005 May 23.
2005 Sep
Zhang Q, Badell IR, Schwarz EM, Boulukos KE, Yao Z, Boyce BF, Xing L. "Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2." Arthritis and rheumatism.. 2005 Sep; 52(9):2708-18.
2005 Sep
Boyce BF, Li P, Yao Z, Zhang Q, Badell IR, Schwarz EM, O'Keefe RJ, Xing L. "TNF-alpha and pathologic bone resorption." The Keio journal of medicine. 2005 Sep; 54(3):127-31.
2005 Aug 1
Dong Y, Drissi H, Chen M, Chen D, Zuscik MJ, Schwarz EM, O'Keefe RJ. "Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta." Journal of cellular biochemistry.. 2005 Aug 1; 95(5):1057-68.
2005 Aug
Koefoed M, Ito H, Gromov K, Reynolds DG, Awad HA, Rubery PT, Ulrich-Vinther M, Soballe K, Guldberg RE, Lin AS, O'Keefe RJ, Zhang X, Schwarz EM. "Biological effects of rAAV-caAlk2 coating on structural allograft healing." Molecular therapy : the journal of the American Society of Gene Therapy.. 2005 Aug; 12(2):212-8.
2005 Jul
Mandelin J, Liljeström M, Li TF, Ainola M, Hukkanen M, Salo J, Santavirta S, Konttinen YT. "Pseudosynovial fluid from loosened total hip prosthesis induces osteoclast formation." Journal of biomedical materials research. Part B, Applied biomaterials. 2005 Jul; 74(1):582-8.
2005 Jul
Wei X, Zhang X, Zuscik MJ, Drissi MH, Schwarz EM, O'Keefe RJ. "Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 Jul; 20(7):1136-48. Epub 2005 Feb 14.
2005 Jun
Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM. "Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency." Environmental health perspectives.. 2005 Jun; 113(6):749-55.
2005 Apr 15
Gordon AH, O'Keefe RJ, Schwarz EM, Rosier RN, Puzas JE. "Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone." Cancer research.. 2005 Apr 15; 65(8):3209-17.
2005 Apr
Smith N, Dong Y, Lian JB, Pratap J, Kingsley PD, van Wijnen AJ, Stein JL, Schwarz EM, O'Keefe RJ, Stein GS, Drissi MH. "Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development." Journal of cellular physiology.. 2005 Apr; 203(1):133-43.
2005 Apr
Mandelin J, Li TF, Hukkanen M, Liljeström M, Salo J, Santavirta S, Konttinen YT. "Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K." The Journal of rheumatology.. 2005 Apr; 32(4):713-20.
2005 Mar 18
Clark CA, Schwarz EM, Zhang X, Ziran NM, Drissi H, O'Keefe RJ, Zuscik MJ. "Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation." Biochemical and biophysical research communications.. 2005 Mar 18; 328(3):764-76.
2005 Mar
Ito H, Koefoed M, Tiyapatanaputi P, Gromov K, Goater JJ, Carmouche J, Zhang X, Rubery PT, Rabinowitz J, Samulski RJ, Nakamura T, Soballe K, O'Keefe RJ, Boyce BF, Schwarz EM. "Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy." Nature medicine.. 2005 Mar; 11(3):291-7. Epub 2005 Feb 13.
2005 Feb
Yu S, Zhang X, He Z, Liu Y. "[Corrosiveness of Ti-Fe-Mo-Mn-Nb-Zr alloys in various pH lactic acids]." Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. 2005 Feb; 22(1):91-4.
2005 Jan 1
Li TF, O'Keefe RJ, Chen D. "TGF-beta signaling in chondrocytes." Frontiers in bioscience : a journal and virtual library. 2005 Jan 1; 10:681-8. Epub 2005 Jan 01.
2005
Andela VB, Schwarz EM, O'Keefe RJ, Puzas EJ, Rosenblatt JD, Rosier RN. "A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival." FEBS letters.. 2005 579(30):6814-20. Epub 2005 Nov 28.
2005
Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN. "Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase." Journal of cellular biochemistry.. 2005 96(6):1262-73.
2005
Zhang X, Xie C, Lin AS, Ito H, Awad H, Lieberman JR, Rubery PT, Schwarz EM, O'Keefe RJ, Guldberg RE. "Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 20(12):2124-37. Epub 2005 Aug 08.
2005
Xing L, Schwarz EM, Boyce BF. "Osteoclast precursors, RANKL/RANK, and immunology." Immunological reviews. 2005 208:19-29.
2004 Nov
Tiyapatanaputi P, Rubery PT, Carmouche J, Schwarz EM, O'keefe RJ, Zhang X. "A novel murine segmental femoral graft model." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Nov; 22(6):1254-60.
2004 Nov
Anandarajah AP, Schwarz EM. "Dynamic exercises in patients with rheumatoid arthritis." Annals of the rheumatic diseases.. 2004 Nov; 63(11):1359-61.
2004 Oct 15
Li TF, Zuscik MJ, Ionescu AM, Zhang X, Rosier RN, Schwarz EM, Drissi H, O'Keefe RJ. "PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling." Experimental cell research.. 2004 Oct 15; 300(1):159-69.
2004 Sep 10
Li TF, Dong Y, Ionescu AM, Rosier RN, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. "Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway." Experimental cell research.. 2004 Sep 10; 299(1):128-36.
2004 Sep
Ritchlin CT, Schwarz EM, O'Keefe RJ, Looney RJ. "RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis." Journal of musculoskeletal & neuronal interactions. 2004 Sep; 4(3):276-84.
2004 Aug
Leung YY, Schwarz EM, Silvers CR, Messing EM, Wood RW. "Uroflow in murine urethritis." Urology.. 2004 Aug; 64(2):378-82.
2004 Jul
Ferguson CM, Schwarz EM, Puzas JE, Zuscik MJ, Drissi H, O'Keefe RJ. "Transforming growth factor-beta1 induced alteration of skeletal morphogenesis in vivo." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Jul; 22(4):687-96.
2004 Jul
Ulrich-Vinther M, Duch MR, Søballe K, O'Keefe RJ, Schwarz EM, Pedersen FS. "In vivo gene delivery to articular chondrocytes mediated by an adeno-associated virus vector." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Jul; 22(4):726-34.
2004 May 15
Zuscik MJ, Baden JF, Wu Q, Sheu TJ, Schwarz EM, Drissi H, O'Keefe RJ, Puzas JE, Rosier RN. "5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes." Journal of cellular biochemistry.. 2004 May 15; 92(2):316-31.
2004 May
Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ. "Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation." Bone.. 2004 May; 34(5):809-17.
2004 Mar
Ionescu AM, Drissi H, Schwarz EM, Kato M, Puzas JE, McCance DJ, Rosier RN, Zuscik MJ, O'Keefe RJ. "CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter." Journal of cellular physiology.. 2004 Mar; 198(3):428-40.
2004 Feb
Li P, Schwarz EM, O'Keefe RJ, Ma L, Boyce BF, Xing L. "RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2004 Feb; 19(2):207-13.
2004 Feb
Yu S, Zhang X, He Z, Gao Z, Wang C. "[The influence of Ce on microstructures and mechanics performances of Ti-Fe-Mo-Mn-Nb-Zr alloys]." Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. 2004 Feb; 21(1):102-6.
2004 Jan
Bukata SV, Gelinas J, Wei X, Rosier RN, Puzas JE, Zhang X, Schwarz EM, Song XY, Griswold DE, O'Keefe RJ. "PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Jan; 22(1):6-12.
2004 Jan
Ito H, Goater JJ, Tiyapatanaputi P, Rubery PT, O'Keefe RJ, Schwarz EM. "Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells." Gene therapy.. 2004 Jan; 11(1):34-41.
2004 Jan
Li P, Schwarz EM, O'Keefe RJ, Ma L, Looney RJ, Ritchlin CT, Boyce BF, Xing L. "Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice." Arthritis and rheumatism.. 2004 Jan; 50(1):265-76.
2004
Schwarz EM, O'Keefe RJ, Looney RJ. "Bone implant interface, osteolysis and potential therapies." Journal of musculoskeletal & neuronal interactions. 2004 4(4):390-2.
2004
Guldberg RE, Oest M, Lin AS, Ito H, Chao X, Gromov K, Goater JJ, Koefoed M, Schwarz EM, O'Keefe RJ, Zhang X. "Functional integration of tissue-engineered bone constructs." Journal of musculoskeletal & neuronal interactions. 2004 4(4):399-400.
2003 Nov
Schwarz EM, Campbell D, Totterman S, Boyd A, O'Keefe RJ, Looney RJ. "Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: a 1-year clinical pilot of etanercept vs. placebo." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 Nov; 21(6):1049-55.
2003 Oct
Andela VB, Pirri M, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosenblatt JD, Rosier RN. "The mevalonate synthesis pathway as a therapeutic target in cancer." Clinical orthopaedics and related research.. 2003 Oct; (415 Suppl):S59-66.
2003 Oct
Andela VB, Gordon AH, Zotalis G, Rosier RN, Goater JJ, Lewis GD, Schwarz EM, Puzas JE, O'Keefe RJ. "NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone." Clinical orthopaedics and related research.. 2003 Oct; (415 Suppl):S75-85.
2003 Sep
Li X, Ionescu AM, Schwarz EM, Zhang X, Drissi H, Puzas JE, Rosier RN, Zuscik MJ, O'Keefe RJ. "Smad6 is induced by BMP-2 and modulates chondrocyte differentiation." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 Sep; 21(5):908-13.
2003 Sep
Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ. "ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2003 Sep; 18(9):1593-604.
2003 Aug 1
Ionescu AM, Schwarz EM, Zuscik MJ, Drissi H, Puzas JE, Rosier RN, O'Keefe RJ. "ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation." Experimental cell research.. 2003 Aug 1; 288(1):198-207.
2003 Aug
Li P, Schwarz EM. "The TNF-alpha transgenic mouse model of inflammatory arthritis." Springer seminars in immunopathology. 2003 Aug; 25(1):19-33.
2003 Jul
Flick LM, Weaver JM, Ulrich-Vinther M, Abuzzahab F, Zhang X, Dougall WC, Anderson D, O'Keefe RJ, Schwarz EM. "Effects of receptor activator of NFkappaB (RANK) signaling blockade on fracture healing." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 Jul; 21(4):676-84.
2003 Jun
Li X, Schwarz EM, Zuscik MJ, Rosier RN, Ionescu AM, Puzas JE, Drissi H, Sheu TJ, O'Keefe RJ. "Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5." Endocrinology.. 2003 Jun; 144(6):2514-23.
2003 May 8
Andela VB, Gingold BI, Souza MD, O'Keefe RJ, Puzas EJ, Schwarz EM, Rosier RN. "Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB." Cancer letters.. 2003 May 8; 194(1):37-43.
2003 Mar
Ritchlin CT, Haas-Smith SA, Li P, Hicks DG, Schwarz EM. "Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis." The Journal of clinical investigation.. 2003 Mar; 111(6):821-31.
2003 Jan 3
Sheu TJ, Schwarz EM, Martinez DA, O'Keefe RJ, Rosier RN, Zuscik MJ, Puzas JE. "A phage display technique identifies a novel regulator of cell differentiation." The Journal of biological chemistry.. 2003 Jan 3; 278(1):438-43. Epub 2002 Oct 25.
2003
Drissi MH, Li X, Sheu TJ, Zuscik MJ, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. "Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes." Journal of cellular biochemistry.. 2003 90(6):1287-98.
2003
Huang W, O'Keefe RJ, Schwarz EM. "Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation." Arthritis research & therapy. 2003 5(1):R49-59. Epub 2002 Nov 12.
2003
Huang W, Drissi MH, O'Keefe RJ, Schwarz EM. "A rapid multiparameter approach to study factors that regulate osteoclastogenesis: demonstration of the combinatorial dominant effects of TNF-alpha and TGF-ss in RANKL-mediated osteoclastogenesis." Calcified tissue international.. 2003 73(6):584-93. Epub 2003 Oct 02.
2003
Ulrich-Vinther M, Maloney MD, Schwarz EM, Rosier R, O'Keefe RJ. "Articular cartilage biology." The Journal of the American Academy of Orthopaedic Surgeons.. 2003 11(6):421-30.
2003
Puzas JE, O'Keefe RJ, Schwarz EM, Zhang X. "Pharmacologic modulators of fracture healing: the role of cyclooxygenase inhibition." Journal of musculoskeletal & neuronal interactions. 2003 3(4):308-12; discussion 320-1.
2002 Sep 20
Andela VB, Sheu TJ, Puzas EJ, Schwarz EM, O'Keefe RJ, Rosier RN. "Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB." Biochemical and biophysical research communications.. 2002 Sep 20; 297(2):237-41.
2002 Sep
Zuscik MJ, O'Keefe RJ, Gunter TE, Puzas JE, Schwarz EM, Rosier RN. "Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Sep; 20(5):1079-90.
2002 Aug
Ulrich-Vinther M, Carmody EE, Goater JJ, S balle K, O'Keefe RJ, Schwarz EM. "Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis." The Journal of bone and joint surgery. American volume.. 2002 Aug; 84-A(8):1405-12.
2002 Aug
Ulrich-Vinther M, Maloney MD, Goater JJ, Søballe K, Goldring MB, O'Keefe RJ, Schwarz EM. "Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes." Arthritis and rheumatism.. 2002 Aug; 46(8):2095-104.
2002 Jul
Soloviev A, Schwarz EM, Kuprash DV, Nedospasov SA, Puzas JE, Rosier RN, O'Keefe RJ. "The role of p105 protein in NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Jul; 20(4):714-22.
2002 Jul
Zuscik MJ, Pateder DB, Puzas JE, Schwarz EM, Rosier RN, O'Keefe RJ. "Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Jul; 20(4):811-8.
2002 Jun 10
Zuscik MJ, D'Souza M, Ionescu AM, Gunter KK, Gunter TE, O'Keefe RJ, Schwarz EM, Puzas JE, Rosier RN. "Growth plate chondrocyte maturation is regulated by basal intracellular calcium." Experimental cell research.. 2002 Jun 10; 276(2):310-9.
2002 Jun
Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ. "Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair." The Journal of clinical investigation.. 2002 Jun; 109(11):1405-15.
2002 Jun
O'Keefe RJ. "Determination of responsiveness in biological systems is dependent on highly sensitive quantitative measures." Annals of the New York Academy of Sciences.. 2002 Jun; 961:206.
2002 May
Yin G, Liu W, An P, Li P, Ding I, Planelles V, Schwarz EM, Min W. "Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis." Molecular therapy : the journal of the American Society of Gene Therapy.. 2002 May; 5(5 Pt 1):547-54.
2002 May
Sheu TJ, Schwarz EM, O'Keefe RJ, Rosier RN, Puzas JE. "Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 May; 17(5):915-22.
2002 May
Carmody EE, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. "Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles." Arthritis and rheumatism.. 2002 May; 46(5):1298-308.
2002 Apr
Andela VB, Rosenblatt JD, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosier RN. "Synergism of aminobisphosphonates and farnesyl transferase inhibitors on tumor metastasis." Clinical orthopaedics and related research.. 2002 Apr; (397):228-39.
2002 Mar
Good CR, O'Keefe RJ, Puzas JE, Schwarz EM, Rosier RN. "Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors." Journal of surgical oncology. 2002 Mar; 79(3):174-9.
2002 Mar
Goater JJ, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. "Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Mar; 20(2):169-73.
2002 Feb
Childs LM, Paschalis EP, Xing L, Dougall WC, Anderson D, Boskey AL, Puzas JE, Rosier RN, O'Keefe RJ, Boyce BF, Schwarz EM. "In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 Feb; 17(2):192-9.
2002 Jan
Pateder DB, Sheu TJ, O'Keefe RJ, Puzas JE, Schwarz EM, Constine LS, Okunieff P, Rosier RN. "Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes." Radiation research.. 2002 Jan; 157(1):62-8.
2002 Jan
Mungo DV, Zhang X, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. "COX-1 and COX-2 expression in osteoid osteomas." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Jan; 20(1):159-62.
2002
Looney RJ, Boyd A, Totterman S, Seo GS, Tamez-Pena J, Campbell D, Novotny L, Olcott C, Martell J, Hayes FA, O'Keefe RJ, Schwarz EM. "Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear." Arthritis research. 2002 4(1):59-63. Epub 2001 Oct 03.
2002
Huang W, Schwarz EM. "Mechanisms of bone resorption and new bone formation in spondyloarthropathies." Current rheumatology reports. 2002 4(6):513-7.
2001 Sep
Pateder DB, Ferguson CM, Ionescu AM, Schwarz EM, Rosier RN, Puzas JE, O'Keefe RJ. "PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signaling." Journal of cellular physiology.. 2001 Sep; 188(3):343-51.
2001 Jul
Pollice PF, Rosier RN, Looney RJ, Puzas JE, Schwarz EM, O'Keefe RJ. "Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components." The Journal of bone and joint surgery. American volume.. 2001 Jul; 83-A(7):1057-61.
2001 Jun
Pateder DB, Eliseev RA, O'Keefe RJ, Schwarz EM, Okunieff P, Constine LS, Puzas JE, Rosier RN. "The role of autocrine growth factors in radiation damage to the epiphyseal growth plate." Radiation research.. 2001 Jun; 155(6):847-57.
2001 Apr 13
Ionescu AM, Schwarz EM, Vinson C, Puzas JE, Rosier R, Reynolds PR, O'Keefe RJ. "PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling." The Journal of biological chemistry.. 2001 Apr 13; 276(15):11639-47. Epub 2001 Jan 02.
2001 Apr
Zhang X, Morham SG, Langenbach R, Young DA, Xing L, Boyce BF, Puzas EJ, Rosier RN, O'Keefe RJ, Schwarz EM. "Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2001 Apr; 16(4):660-70.
2001 Feb
Childs LM, Goater JJ, O'Keefe RJ, Schwarz EM. "Efficacy of etanercept for wear debris-induced osteolysis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2001 Feb; 16(2):338-47.
2001 Jan
Grimsrud CD, Romano PR, D'Souza M, Puzas JE, Schwarz EM, Reynolds PR, Roiser RN, O'Keefe RJ. "BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2001 Jan; 19(1):18-25.
2001
Puzas JE, Landeau JM, Tallents R, Albright J, Schwarz EM, Landesberg R. "Degradative pathways in tissues of the temporomandibular joint. Use of in vitro and in vivo models to characterize matrix metalloproteinase and cytokine activity." Cells, tissues, organs. 2001 169(3):248-56.
2001
Childs LM, Goater JJ, O'Keefe RJ, Schwarz EM. "Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysis." The Journal of bone and joint surgery. American volume.. 2001 83-A(12):1789-97.
2000 Nov
Schwarz EM, Benz EB, Lu AP, Goater JJ, Mollano AV, Rosier RN, Puzas JE, Okeefe RJ. "Quantitative small-animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2000 Nov; 18(6):849-55.
2000 Oct
Schwarz EM. "The adeno-associated virus vector for orthopaedic gene therapy." Clinical orthopaedics and related research.. 2000 Oct; (379 Suppl):S31-9.
2000 Sep
Chi H, Yang X, Kingsley PD, O'Keefe RJ, Puzas JE, Rosier RN, Shears SB, Reynolds PR. "Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo." Molecular and cellular biology.. 2000 Sep; 20(17):6496-507.
2000 Jun 1
Li P, Sanz I, O'Keefe RJ, Schwarz EM. "NF-kappa B regulates VCAM-1 expression on fibroblast-like synoviocytes." The Journal of immunology : official journal of the American Association of Immunologists.. 2000 Jun 1; 164(11):5990-7.
2000 May 1
Pateder DB, Rosier RN, Schwarz EM, Reynolds PR, Puzas JE, D'Souza M, O'Keefe RJ. "PTHrP expression in chondrocytes, regulation by TGF-beta, and interactions between epiphyseal and growth plate chondrocytes." Experimental cell research.. 2000 May 1; 256(2):555-62.
2000 May
Schwarz EM, Lu AP, Goater JJ, Benz EB, Kollias G, Rosier RN, Puzas JE, O'Keefe RJ. "Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2000 May; 18(3):472-80.
2000 Apr
Goater J, Müller R, Kollias G, Firestein GS, Sanz I, O'Keefe RJ, Schwarz EM. "Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis." The Journal of rheumatology.. 2000 Apr; 27(4):983-9.
2000
Andela VB, Schwarz EM, Puzas JE, O'Keefe RJ, Rosier RN. "Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB." Cancer research.. 2000 60(23):6557-62.
2000
Schwarz EM, Looney RJ, O'Keefe RJ. "Anti-TNF-alpha therapy as a clinical intervention for periprosthetic osteolysis." Arthritis research. 2000 2(3):165-8. Epub 2000 Mar 27.
2000
Ferguson CM, Schwarz EM, Reynolds PR, Puzas JE, Rosier RN, O'Keefe RJ. "Smad2 and 3 mediate transforming growth factor-beta1-induced inhibition of chondrocyte maturation." Endocrinology.. 2000 141(12):4728-35.
1994 Aug
Scully SP, Mott MP, Temple HT, O'Keefe RJ, O'Donnell RJ, Mankin HJ. "Late recurrence of giant-cell tumor of bone. A report of four cases." The Journal of bone and joint surgery. American volume.. 1994 Aug; 76(8):1231-3.

Books

2003
Schwarz, E.M.. "Signal Transduction in Rheumatic Diseases". Kelley's Textbook of Rheumatology. : W.B. Saunders Company, 2003.
2003
Schwarz, E.M.. "Biologic Agents as Antiresorptive Therapy". Molecular Biology in Orthopaedics. Rosier, R.N. & Evans, C.H.. : American Academy of Orthopaedic Surgeons: 241, 2003.
2001
Wright. T.M. Goodman, S.B., Schwarz, E.M.. Implant Wear in Total Joint Replacement. : American Academy of Orthopaedic Surgeons, 2001.
2000
O'Keefe, R.J. and Schwarz, E.M.. Current Opinion in Orthopedics. : Lippincott Williams & Wilkins, 2000.
2000
O'Keefe, R. J., Puzas, J.E. and Schwarz, E.M.. Current Opinion in Orthopedics. : Lippicott Williams & Wilkins, 2000.