Edward M. Schwarz, Ph.D.

Edward M. Schwarz, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester, NY 14642

Research Bio

Dr. Schwarz is Professor of Orthopaedics and Associate Director of the
Center for Musculoskeletal Research at URMC. His laboratory focuses on
finding solutions to bone loss due to conditions such as rheumatoid
arthritis, infections, tumors that spread to bone, and bone destruction near
the implants used in reconstructive surgery.



Several genes are known to turn on the healing process in bone. Dr.
Schwarz's group loads these genes into harmless virus particles. The
particles are coated onto experimental bone implants to deliver therapeutic
genes to the area of reconstruction, thus improving bone healing. The
cartilage that lines joints in mice can be encouraged to heal more
completely when virus particles deliver therapeutic genes too.

An additional interest of Dr. Schwarz's lab is the use of magnetic resonance
imaging (MRI) and high resolution computed tomography (CT) scans to
visualize the formation of new blood vessels as patients heal.

Awards & Honors (Local)

J.R. Neff Award, Musculoskeletal Research Foundation 2007
Orthopaedic Research Society's Kappa Delta Young Investigator Award 2005
Orthopaedic Research Society's Harris Award 2003
New Investigator Research Award, The Association of Bone & Joint Surgeons . 1999
University of Rochester Nominee for the Sinshimmer Award. 1999
University of Rochester Nominee for the Elison Award. 1999

Recent Journal Articles

Showing the 5 most recent journal articles. 208 available »

2015 Jun
Farnsworth CW, Shehatou CT, Maynard R, Nishitani K, Kates SL, Zuscik MJ, Schwarz EM, Daiss JL, Mooney RA. "A Humoral Immune Defect Distinguishes the Response to Staphylococcus aureus Infections in Mice with Obesity and Type 2 Diabetes from That in Mice with Type 1 Diabetes." Infection and immunity. 2015 Jun; 83(6):2264-74. Epub 2015 Mar 23.
2015 Apr 28
Kuzin II, Bouta EM, Schwarz EM, Bottaro A. "TNF signals are dispensable for the generation of CD23+ CD21/35-high CD1d-high B cells in inflamed lymph nodes." Cellular immunology. 2015 Apr 28; Epub 2015 Apr 28.
2015 Apr
Bouta EM, Banik PD, Wood RW, Rahimi H, Ritchlin CT, Thiele RG, Schwarz EM. "Validation of power Doppler versus contrast-enhanced magnetic resonance imaging quantification of joint inflammation in murine inflammatory arthritis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2015 Apr; 30(4):690-4.
2015 Mar 26
Nishitani K, Sutipornpalangkul W, de Mesy Bentley KL, Varrone JJ, Bello-Irizarry SN, Ito H, Matsuda S, Kates SL, Daiss JL, Schwarz EM. "Quantifying the natural history of biofilm formation in vivo during the establishment of chronic implant-associated Staphylococcus aureus osteomyelitis in mice to identify critical pathogen and host factors." Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2015 Mar 26; Epub 2015 Mar 26.
2015 Mar
Zhang M, Feigenson M, Sheu TJ, Awad HA, Schwarz EM, Jonason JH, Loiselle AE, O'Keefe RJ. "Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength." Bone. 2015 Mar; 72:92-100. Epub 2014 Nov 29.

Current Appointments

Director - Center for Musculoskeletal Research - Primary Administrative
Richard and Margaret Burton Distinguished Professor in Orthopaedics - Department of Orthopaedics (SMD)
Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD) - Primary
Professor - Department of Microbiology and Immunology (SMD)

Education

PhD | Immunology, All Other | Einstein College Medicine1993
MA | Immunology, All Other | Einstein College Medicine1990
BS | Biology | Worcester Polytech Inst1988

Post-Doctoral Training & Residency

Laboratory of Inder M. Verma, Ph.D., Laboratory of Genetics The Salk Institute, La Jolla, California, Concentrations: Gene Therapy, NFkB Signal, Transduction, Transgenic Mice. 1997
Training - Pre-doctoral Fellow, Laboratory of Barry R. Bloom, Ph.D., Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York 1993
Training - Summer Student - Laboratory of Carl Shilkraut, Ph.D., Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 0
Training - Undergraduate Research Laboratory of Donald J. Tipper, Ph.D., Department of Microbiology & Molecular Genetics, University of Massachusetts Medical School, Worcester, Massachusetts 1988
Training - Summer Student - Laboratory of Fritz Herz, Ph.D., Department of Pathology, Montefiore Medical Center, Bronx, New York 0