Edward M. Schwarz, Ph.D.

Edward M. Schwarz, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester, NY 14642

Research Bio

Dr. Schwarz is Professor of Orthopaedics and Associate Director of the
Center for Musculoskeletal Research at URMC. His laboratory focuses on
finding solutions to bone loss due to conditions such as rheumatoid
arthritis, infections, tumors that spread to bone, and bone destruction near
the implants used in reconstructive surgery.



Several genes are known to turn on the healing process in bone. Dr.
Schwarz's group loads these genes into harmless virus particles. The
particles are coated onto experimental bone implants to deliver therapeutic
genes to the area of reconstruction, thus improving bone healing. The
cartilage that lines joints in mice can be encouraged to heal more
completely when virus particles deliver therapeutic genes too.

An additional interest of Dr. Schwarz's lab is the use of magnetic resonance
imaging (MRI) and high resolution computed tomography (CT) scans to
visualize the formation of new blood vessels as patients heal.

Awards & Honors

J.R. Neff Award, Musculoskeletal Research Foundation 2007
Orthopaedic Research Society's Kappa Delta Young Investigator Award 2005
Orthopaedic Research Society's Harris Award 2003
New Investigator Research Award, The Association of Bone & Joint Surgeons . 1999
University of Rochester Nominee for the Sinshimmer Award. 1999
University of Rochester Nominee for the Elison Award. 1999

Recent Journal Articles

Showing the 5 most recent journal articles. 192 available »

2013 Mar
Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O'Keefe RJ, Schwarz EM. "PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2013 Mar 0; 28(3):586-97.
2013 Feb 22
Inzana JA, Maher JR, Takahata M, Schwarz EM, Berger AJ, Awad HA. "Bone fragility beyond strength and mineral density: Raman spectroscopy predicts femoral fracture toughness in a murine model of rheumatoid arthritis." Journal of biomechanics. 2013 Feb 22; 46(4):723-30. Epub 2012 Dec 20.
2013 Jan
Li J, Ju Y, Bouta EM, Xing L, Wood RW, Kuzin I, Bottaro A, Ritchlin CT, Schwarz EM. "Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow." Arthritis and rheumatism. 2013 Jan 0; 65(1):130-8.
2013
Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA. "Cellular and molecular factors in flexor tendon repair and adhesions: a histological and gene expression analysis." Connective tissue research. 2013 54(3):218-26. Epub 2013 Apr 15.
2012 Nov
Takahata M, Maher JR, Juneja SC, Inzana J, Xing L, Schwarz EM, Berger AJ, Awad HA. "Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk." Arthritis and rheumatism. 2012 Nov 0; 64(11):3649-59.

Current Appointments

Director - Center for Musculoskeletal Research - Primary Administrative
Richard and Margaret Burton Distinguished Professor in Orthopaedics - Department of Orthopaedics (SMD)
Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD) - Primary
Professor - Department of Biomedical Engineering (SMD)
Professor - Department of Medicine, Allergy/Immunology and Rheumatology (SMD)
Professor - Department of Microbiology and Immunology (SMD)
Professor - Department of Pathology and Laboratory Medicine (SMD)
Professor - Department of Urology (SMD)

Education

PhD | Immunology, All Other | Einstein College Medicine1993
MA | Immunology, All Other | Einstein College Medicine1990
BS | Biology | Worcester Polytech Inst1988

Post-Doctoral Training & Residency

Laboratory of Inder M. Verma, Ph.D., Laboratory of Genetics The Salk Institute, La Jolla, California, Concentrations: Gene Therapy, NFkB Signal, Transduction, Transgenic Mice. 1997
Training - Pre-doctoral Fellow, Laboratory of Barry R. Bloom, Ph.D., Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York 1993
Training - Summer Student - Laboratory of Carl Shilkraut, Ph.D., Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 0
Training - Undergraduate Research Laboratory of Donald J. Tipper, Ph.D., Department of Microbiology & Molecular Genetics, University of Massachusetts Medical School, Worcester, Massachusetts 1988
Training - Undergraduate Research Laboratory of Donald J. Tipper, Ph.D., Department of Microbiology & Molecular Genetics, University of Massachusetts Medical School, Worcester, Massachusetts 1988
Training - Undergraduate Research Laboratory of Donald J. Tipper, Ph.D., Department of Microbiology & Molecular Genetics, University of Massachusetts Medical School, Worcester, Massachusetts 1988
Training - Undergraduate Research Laboratory of Donald J. Tipper, Ph.D., Department of Microbiology & Molecular Genetics, University of Massachusetts Medical School, Worcester, Massachusetts 1988
Training - Summer Student - Laboratory of Fritz Herz, Ph.D., Department of Pathology, Montefiore Medical Center, Bronx, New York 0