Edward M. Schwarz, Ph.D.

Edward M. Schwarz, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester, NY 14642

Research Bio

Dr. Schwarz is Professor of Orthopaedics and Associate Director of the
Center for Musculoskeletal Research at URMC. His laboratory focuses on
finding solutions to bone loss due to conditions such as rheumatoid
arthritis, infections, tumors that spread to bone, and bone destruction near
the implants used in reconstructive surgery.

Several genes are known to turn on the healing process in bone. Dr.
Schwarz's group loads these genes into harmless virus particles. The
particles are coated onto experimental bone implants to deliver therapeutic
genes to the area of reconstruction, thus improving bone healing. The
cartilage that lines joints in mice can be encouraged to heal more
completely when virus particles deliver therapeutic genes too.

An additional interest of Dr. Schwarz's lab is the use of magnetic resonance
imaging (MRI) and high resolution computed tomography (CT) scans to
visualize the formation of new blood vessels as patients heal.

Awards & Honors (Local)

J.R. Neff Award, Musculoskeletal Research Foundation 2007
Orthopaedic Research Society's Kappa Delta Young Investigator Award 2005
Orthopaedic Research Society's Harris Award 2003
New Investigator Research Award, The Association of Bone & Joint Surgeons . 1999
University of Rochester Nominee for the Sinshimmer Award. 1999
University of Rochester Nominee for the Elison Award. 1999

Recent Journal Articles

Showing the 5 most recent journal articles. 213 available »

2015 Nov 20
Sheyn D, Shapiro G, Tawackoli W, Jun DS, Koh Y, Kang KB, Su S, Da X, Ben-David S, Bez M, Yalon E, Antebi B, Avalos P, Stern T, Zelzer E, Schwarz EM, Gazit Z, Pelled G, Bae HM, Gazit D. "PTH induces systemically administered mesenchymal stem cells to migrate to and regenerate spine injuries." Molecular therapy : the journal of the American Society of Gene Therapy. 2015 Nov 20; Epub 2015 Nov 20.
2015 Oct 23
Chen Y, Hallab NJ, Liao YS, Narayan V, Schwarz EM, Xie C. "Antioxidant impregnated ultra-high molecular weight polyethylene wear debris particles display increased bone remodeling and a superior osteogenic: Osteolytic profile vs. conventional UHMWPE particles in a murine calvaria model." Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2015 Oct 23; Epub 2015 Oct 23.
2015 Sep
Nishitani K, Sutipornpalangkul W, de Mesy Bentley KL, Varrone JJ, Bello-Irizarry SN, Ito H, Matsuda S, Kates SL, Daiss JL, Schwarz EM. "Quantifying the natural history of biofilm formation in vivo during the establishment of chronic implant-associated Staphylococcus aureus osteomyelitis in mice to identify critical pathogen and host factors." Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2015 Sep; 33(9):1311-9. Epub 2015 May 18.
2015 Sep
Nishitani K, Beck CA, Rosenberg AF, Kates SL, Schwarz EM, Daiss JL. "A Diagnostic Serum Antibody Test for Patients With Staphylococcus aureus Osteomyelitis." Clinical orthopaedics and related research. 2015 Sep; 473(9):2735-49. Epub 2015 May 27.
2015 Sep
Xie C, Li Y, Li Q, Chen Y, Yao J, Yin G, Bi Q, O'Keefe RJ, Schwarz EM, Tyler W. "Increased Insulin mRNA Binding Protein-3 Expression Correlates with Vascular Enhancement of Renal Cell Carcinoma by Intravenous Contrast-CT and is Associated with Bone Metastasis." Journal of bone oncology. 2015 Sep; 4(3):69-76. Epub 2015 Sep 12.

Current Appointments

Director - Center for Musculoskeletal Research - Primary Administrative
Richard and Margaret Burton Distinguished Professor in Orthopaedics - Department of Orthopaedics (SMD)
Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD) - Primary
Professor - Department of Biomedical Engineering (SMD)
Professor - Department of Medicine, Allergy/Immunology and Rheumatology (SMD)
Professor - Department of Microbiology and Immunology (SMD)
Professor - Department of Pathology and Laboratory Medicine (SMD)
Professor - Department of Urology (SMD)


PhD | Immunology, All Other | Einstein College Medicine1993
MA | Immunology, All Other | Einstein College Medicine1990
BS | Biology | Worcester Polytech Inst1988

Post-Doctoral Training & Residency

Laboratory of Inder M. Verma, Ph.D., Laboratory of Genetics The Salk Institute, La Jolla, California, Concentrations: Gene Therapy, NFkB Signal, Transduction, Transgenic Mice. 1997
Training - Pre-doctoral Fellow, Laboratory of Barry R. Bloom, Ph.D., Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York 1993
Training - Summer Student - Laboratory of Carl Shilkraut, Ph.D., Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 0
Training - Undergraduate Research Laboratory of Donald J. Tipper, Ph.D., Department of Microbiology & Molecular Genetics, University of Massachusetts Medical School, Worcester, Massachusetts 1988
Training - Summer Student - Laboratory of Fritz Herz, Ph.D., Department of Pathology, Montefiore Medical Center, Bronx, New York 0