Neil Blumberg, M.D.

Neil Blumberg, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 608
Rochester, NY 14642

Office: (585) 275-3189
Fax: (585) 273-3002

Research Bio

Blood transfusions are known to be broadly immunomodulatory and are associated with substantially poorer clinical outcomes in surgical and cancer patients, and better outcomes in solid organ allograft recipients. Our laboratory and clinical group has been interested for the last twenty years in the disparate effects of autologous and allogeneic transfusions on immune function, as well as the potential benefits of removing allogeneic white cells and stored supernatant plasma from blood components before transfusions.



Our studies demonstrated that patients receiving leukocyte-reduced allogeneic blood transfusions for leukemia, and those receiving leukocyte-reduced allogeneic or autologous transfusions during surgical procedures, experienced reduced morbidity and mortality compared with patients receiving unmodified allogeneic transfusions. We were the first to document that one likely mechanism for these benefits is that allogeneic transfusions promote type 2 (Th2) cellular immunity and down regulate type 1 (Th1) immunity. Leukoreduction or use of autologous transfusions reduces these immunologic effects. We also have pioneered clinical outcomes and cost-effectiveness analyses in the study of transfusion immunomodulation.

Transfusions, however, can also promote inflammatory processes. Platelet transfusions are associated with a dose dependent increase in multi-organ failure syndrome in surgical patients. Work done in collaboration with Dr. Rick Phipps's laboratory has shown that stored platelet transfusion supernatant promotes cellular secretion of PGE2 , IL6 and IL8 in vitro through a soluble CD40L dependent mechanism. Current investigations include clinical and laboratory studies of the effects of stored platelet supernatant CD40L on clinical outcomes and in vitro immunologic function. We are also exploring the possible use of autologous stored platelet supernatant for immunotherapeutic use.

Awards & Honors (National)

Editorial Board Member | BLOOD | Washington, DC 2008 - 2012
Co-Chair REDS III and Chair REDS II Data Monitoring Committee | NIH-National Heart, Lung and Blood Institute | Bethesda, MD 2005 - 2018
Editorial Board Member | TRANSFUSION | Washington, DC 1990 - Present
National Merit Scholarship Program | National Merit Scholarship Program 1966 - 1970

Awards & Honors (Local)

NIH Medical Scientist Training Grant Fellowship 1971 - 1974
BS, Yale, Magna cum laude 1970
Phi Beta Kappa 1969

Patents

Peroxisome Proliferator-Activated Receptor (PPAR) Expression in Human Body Fluids, Platelets and Secretions

United States Serial NO.: 10/576,824
Filed Date: October 22, 2004
Title: Peroxisome Proliferator-Activated Receptor Gamma (PPARy) and/or Retinoic Acid Receptor (RXR) Agonst To Inhibit Platelet Functions
Invented by: Richard Phipps, Patricia Sime, Neil Blumberg

Recent Journal Articles

Showing the 5 most recent journal articles. 218 available »

2014 Jun
Spinelli SL, Lannan KL, Casey AE, Croasdell A, Curran TM, Henrichs KF, Pollock SJ, Milne GA, Refaai MA, Francis CW, Phipps RP, Blumberg N. "Isoprostane and isofuran lipid mediators accumulate in stored red blood cells and influence platelet function in vitro." Transfusion.. 2014 Jun; 54(6):1569-79. Epub 2013 Nov 05.
2014 Apr 2
Rohde JM, Dimcheff DE, Blumberg N, Saint S, Langa KM, Kuhn L, Hickner A, Rogers MA. "Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis." JAMA : the journal of the American Medical Association.. 2014 Apr 2; 311(13):1317-26.
2014 Mar
Glance LG, Mukamel DB, Blumberg N, Fleming FJ, Hohmann SF, Dick AW. "Association between surgical resident involvement and blood use in noncardiac surgery." Transfusion.. 2014 Mar; 54(3):691-700. Epub 2013 Jul 25.
2014 Jan 7
Blumberg N. "ABO mismatched platelet transfusions in trauma patients." CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.. 2014 Jan 7; 186(1):63.
2014 Jan
Glance LG, Blumberg N, Eaton MP, Lustik SJ, Osler TM, Wissler R, Zollo R, Karcz M, Feng C, Dick AW. "Preoperative thrombocytopenia and postoperative outcomes after noncardiac surgery." Anesthesiology.. 2014 Jan; 120(1):62-75.

Current Appointments

Professor - Department of Pathology and Laboratory Medicine (SMD) - Primary

Specialties

Clinical Pathology/Laboratory Medicine - American Board of Pathology

Education

MD | Medicine | Yale University Sch Medicine1975
BS | Molecular Biophysics and Biochemistry | Yale University1970

Post-Doctoral Training & Residency

Residency in Laboratory Medicine at Yale University -New Haven Hospital07/01/1976 - 06/30/1978
Internship in Laboratory Medicine at Yale University -New Haven Hospital09/01/1975 - 06/30/1976