Martin S. Zand, M.D., Ph.D.

Martin S. Zand, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 675
Rochester, NY 14642

Office: (585) 275-7753
Fax: (585) 442-9201
Administrative: (585) 275-1593
Lab: (585) 275-7047

Professional Bio

Dr. Zand is a Professor of Medicine in the Division of Nephrology at the University of Rochester. He is the Director of the Rochester Center for Health Informatics, and co-director of the Center for Biodefense Immune Modeling.



Dr. Zand graduated from Northwestern University with an undergraduate degree in Biomedical Engineering, a PhD in Cell, Molecular and Structural Biology, and an MD. He completed his residency in Internal Medicine and Fellowship in Nephrology at Beth Israel Medical Center and Harvard University in Boston. He joined University of Rochester Medical Center faculty in July 1998 as Medical Director of the Kidney and Pancreas Transplant Programs, which he led until 2014, when he became Director of the Rochester Center for Health Informatics.

Dr. Zand has a clinical practice in Transplant Nephrology and Transplant Medicine, and sees patients with kidney and other solid organ transplants. He is an internationally recognized expert in B cell immunobiology in solid organ transplantation. He directs an active NIH funded research program in B cell immunobiology, vaccine biology, and computational modeling of immune responses. He leads the Rochester Center for Health Informatics, which is focused on using advanced data science methods to analyze population health data to create a "living healthcare laboratory" which improves community health and healthcare delivery.

Research Bio

My research is focused in two areas: Understanding how B cells respond to vaccines and organ transplants to produce antibodies, and using graph theory to understand how we can understand and improve population health and healthcare delivery. My groups use a similar core set of analytic methods in both areas, including high dimensional clustering methods, graph theory, differential equation and stochastic branching process modeling.



My laboratory studies how B cells and plasma cells participate in the adaptive immune response, through antibody production, antigen presentation, and modulation of immune responses by other immune cells. Our goal is to understand how B cell differentiation and antibody production is regulated if we are to enhance B cell anti-viral and vaccine responses, or to prevent transplant rejection. We use innovative mathematical modeling and statistical analyses to gain insights from complex and large experimental data sets. Our experiments often involve daily analysis of gene expression and cellular phenotypes from single subjects over 5-10 days after vaccination. The scientific questions we are focused on include:

1. What is the timing of B cell differentiation and antibody secretion, and how can we alter the molecular and cellular events to improve vaccine responses?
2. What are the molecular gene expression signatures of a successful B cell vaccine response?
3. How can we use mathematical models to create individualized treatment protocols for kidney transplant patients with antibody mediated rejection or allosensitization?

My Health Informatics Group uses advanced data science analytics to understand how people make their way through the healthcare system, and how larger factors such as employment, mental health, community engagement, and socio-economic status contribute to population health. We use network theory to investigate connections between these factors, and turn those insights into population health based research initiatives that we refer to as the "living healthcare laboratory". We collaborate with groups in the Institute for Data Science, the University of Rochester Medical Center, and numerous community and population health groups within the greater Rochester community.

Awards & Honors (National)

American Society of Transplant Physicians Young Investigator Award 1998

Awards & Honors (Local)

Technology Innovation Award - Cleveland Clinic 2006
Selected Participant-Woods Hole Marine Biology Laboratory 1986
Northwestern University Medical Scientist Training Program Scholarship 1985
Honors Program in Medical Education Scholarship | Northwestern University 1981 - 1992

Patents

Antigen Release Beads for a Quantitative ELISPOT or FLORISPOT Assay

United States Serial NO.: 12/298,626
Filed Date: April 30, 2007
Title: Analyte-Releasing Beads and Use Thereof in Quantitative Elispot or Fluorispot Assay
Invented by: Martin Zand, Alicia Henn, Miguel Brown

Recent Journal Articles

Showing the 5 most recent journal articles. 55 available »

2014
Egli A, Santer D, Barakat K, Zand M, Levin A, Vollmer M, Weisser M, Khanna N, Kumar D, Tyrrell L, Houghton M, Battegay M, O'Shea D. "Vaccine adjuvants--understanding molecular mechanisms to improve vaccines." Swiss medical weekly. 2014 144:w13940. Epub 2014 May 20.
2014
Miao H, Sangster MY, Livingstone AM, Hilchey SP, Zhang L, Topham DJ, Mosmann TR, Holden-Wiltse J, Perelson AS, Wu H, Zand MS. "Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection." PloS one. 2014 9(8):e104781. Epub 2014 Aug 29.
2013 Jul
Zand MS. "Tofacitinab in renal transplantation." Transplantation reviews (Orlando, Fla.). 2013 Jul; 27(3):85-9.
2013 Jun
Sangster MY, Baer J, Santiago FW, Fitzgerald T, Ilyushina NA, Sundararajan A, Henn AD, Krammer F, Yang H, Luke CJ, Zand MS, Wright PF, Treanor JJ, Topham DJ, Subbarao K. "B cell response and hemagglutinin stalk-reactive antibody production in different age cohorts following 2009 H1N1 influenza virus vaccination." Clinical and vaccine immunology : CVI. 2013 Jun; 20(6):867-76. Epub 2013 Apr 10.
2013
Henn AD, Wu S, Qiu X, Ruda M, Stover M, Yang H, Liu Z, Welle SL, Holden-Wiltse J, Wu H, Zand MS. "High-resolution temporal response patterns to influenza vaccine reveal a distinct human plasma cell gene signature." Scientific reports. 2013 3:2327.

Current Appointments

Professor - Department of Medicine, Nephrology (SMD) - Primary

Specialties

Internal Medicine - American Board of Internal Medicine
Nephrology - American Board of Internal Medicine

Education

MD | Medicine | Northwestern University Medical School1992
PhD | Cell, Molecular and Structural Biology | Northwestern University1990
BS | Medicine | Northwestern University1986
BS | Bioengineering | Northwestern University1985

Post-Doctoral Training & Residency

Fellowship at Beth Israel Hospital07/01/1995 - 06/30/1998
Residency in Internal Medicine at Beth Israel Hospital07/01/1992 - 06/30/1995
Internship in Internal Medicine at Beth Israel Hospital06/23/1992 - 06/30/1993