Krystel Huxlin, Ph.D.

Krystel Huxlin, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 659
Rochester, NY 14642

Research Bio

One of our goals is to understand the cellular basis and psychophysical characteristics of visual perceptual plasticity in adulthood. We are particularly interested in contrasting the plastic potential of intact visual systems with the visual plasticity that can be attained by adult visual systems that have sustained permanent damage at different levels of their hierarchical organization. One avenue of research we are currently pursuing is to use anatomical tools, molecular biology, visual psychophysics, virtual reality and functional imaging (fMRI) to characterize changes at the cellular and systems levels that are key to the recovery of visual functions after brain damage in adulthood. We have recently begun applying this knowledge to patients with visual cortical damage following stroke, tumor or trauma with the ultimate goal of developing behavioral and pharmacological strategies to promote visual recovery following such damage.

Another area of research in the Huxlin lab deals with corneal wound healing and physiological optics. This work is intended to provide new insights into the biological causes and perceptual consequences of increased optical aberrations in the eye following manipulations or the ocular surface, including laser refractive surgery and corneal transplantation. Using anterior segment optical coherence tomography, in vivo confocal imaging, wavefront sensing, histology, cell culture and molecular biology, we are beginning to understand the relationship between different aspects of ocular wound healing and optical quality in the eye. This knowledge is essential for the ultimate development of both intra- and post-operative strategies to improve the optical outcome of ocular surgeries and wounds. In collaboration with Dr. Wayne Knox, we are also developing a revolutionary new refractive method called IRIS (for Intra-tissue Refractive Index Shaping). IRIS uses a low-energy, high-repetition rate femtosecond laser to non-invasively alter the refractive index and optical properties of different ocular tissues. Our initial work has focused on the cornea and lens, but we are now beginning to use IRIS to customize and correct aberrations in implanted IOLs. Because it does not cause tissue damage or cell death, IRIS offers great promise as a novel tool to non-invasively customize refractive power and higher order aberration correction without the side effects normally induced by wound healing.

Recent Journal Articles

Showing the 5 most recent journal articles. 49 available »

2014 Aug 27
Das A, Tadin D, Huxlin KR. "Beyond blindsight: properties of visual relearning in cortically blind fields." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Aug 27; 34(35):11652-64.
2014 May
Jeon KI, Kulkarni A, Woeller CF, Phipps RP, Sime PJ, Hindman HB, Huxlin KR. "Inhibitory effects of PPAR? ligands on TGF-?1-induced corneal myofibroblast transformation." The American journal of pathology. 2014 May; 184(5):1429-45. Epub 2014 Mar 17.
2014
Savage D.E.; Brooks D.R.; DeMagistris M.; Xu L.; MacRae S.; Ellis J.D.; Knox W.H.; Huxlin K.R. "First Demonstration of Ocular Refractive Change Using Blue-IRIS in Live Cats". Investigative Ophthalmology and Vision Science. 2014; 55(7): 4603-4612. Link
2013
Huxlin KR, Hindman HB, Jeon KI, B├╝hren J, Macrae S, Demagistris M, Ciufo D, Sime PJ, Phipps RP. "Topical rosiglitazone is an effective anti-scarring agent in the cornea." PloS one. 2013 8(8):e70785. Epub 2013 Aug 05.
2013
Weis AJ, Huxlin KR, Callan CL, Demagistris MA, Hindman HB. "Keratocyte apoptosis and not myofibroblast differentiation mark the graft/host interface at early time-points post-DSAEK in a cat model." PloS one. 2013 8(9):e75623. Epub 2013 Sep 30.

Current Appointments

Professor - Department of Ophthalmology (SMD) - Primary
Professor - Department of Neurobiology and Anatomy (SMD)
Professor - Center for Visual Science A&S (RC)

Education

PhD | Neuroscience | Australia-U Sydney Fac Med1994
BS | Neuroscience | Australia-U Sydney Fac Med1991