Krystel Huxlin, PhD
- Professor - Department of Ophthalmology (SMD) - Primary Appointment
- Professor - Department of Neurobiology and Anatomy (SMD)
- Professor - Department of Brain / Cognitive Science (RC)
- Professor - Center for Visual Science (RC)
- PhD | Neuroscience | Australia-U Sydney Fac Med (1994)
Dr. Huxlin directs the research efforts of two separate laboratories at Flaum Eye Institute. In the visual training and rehabilitation lab, the goal is to understand the cellular basis and psychophysical characteristics of visual perceptual plasticity in adulthood. Of particular interest is contrasting the plastic potential of intact visual systems with the visual plasticity that can be attained by adult visual systems that have sustained permanent damage at different levels of their hierarchical organization. One avenue of research currently being pursued is to use anatomical tools, molecular biology, visual psychophysics, virtual reality and functional imaging (fMRI) to characterize changes at the cellular and systems levels that are key to the recovery of visual functions after brain damage in adulthood. The laboratory has recently begun applying this knowledge to patients with visual cortical damage following stroke, tumor or trauma with the ultimate goal of developing behavioral and pharmacological strategies to promote visual recovery following such damage.
The second laboratory deals with corneal wound healing and physiological optics. This work is intended to provide new insights into the biological causes and perceptual consequences of increased optical aberrations in the eye following manipulations or the ocular surface, including laser refractive surgery and corneal transplantation. Using anterior segment optical coherence tomography, in vivo confocal imaging, wavefront sensing, histology, cell culture and molecular biology, we are beginning to understand the relationship between different aspects of ocular wound healing and optical quality in the eye. This knowledge is essential for the ultimate development of both intra- and post-operative strategies to improve the optical outcome of ocular surgeries and wounds. The laboratory is also developing a revolutionary new refractive method called IRIS (for Intra-tissue Refractive Index Shaping). IRIS uses a low-energy, high-repetition rate femtosecond laser to non-invasively alter the refractive index and optical properties of different ocular IOLs. Because it does not cause tissue damage or cell death, IRIS offers great promise as a novel tool to non-invasively customize refractive power and higher order aberration correction without the side effects normally induced by wound healing.
Selected Publications (Visual Training & Rehabilitation Lab)
- Martin, T., Das, A. and Huxlin, K.R. (2012) Visual cortical activity reflects faster accumulation of information during motion discrimination in cortically blind fields. Brain 135 (Pt 11) :3440-3452.
- Das, A., DeMagistris, M. and Huxlin, K.R. (2012) Different properties of visual relearning after damage to early versus higher-level visual cortical areas. Journal of Neuroscience 32(16): 5414 – 5425. Cover illustration.
- Iorizzo, D. Riley M.E., Hayhoe M. and Huxlin K.R. (2011) Differential impact of partial cortical blindness on gaze strategies when sitting and walking - an immersive virtual reality study. Vision Research, 51: 1173-1184.
Selected Publications (Cornea Lab)
- Xu L, Knox W.H. and Huxlin K.R. (2011) Exogenous and endogenous two-photon absorption for Intra-tissue Refractive Index Shaping (IRIS) in live corneal tissue [Invited], Optical Materials Express, Vol. 1, Issue 7, pp. 1159-1164, http://dx.doi.org/10.1364/OME.1.001159.
- Xu, L., Knox, W.H., DeMagistris, M., Wang, N. and Huxlin, K.R. (2011) Non-invasive Intra-tissue Refractive Index Shaping (IRIS) of the cornea with blue femtosecond laser light. IOVS 52: 8148 - 8155.
- Cui, L., Huxlin, K.R., Xu, L., MacRae S. and Knox, W.H. (2011) High-resolution, non-invasive two-photon fluorescence measurement of molecular concentrations corneal tissue. IOVS 52 (5): 2556 - 2564.
- Bühren, J., Nagy, L.J., Yoon, G., MacRae, S., Kohnen, T. and Huxlin, K.R. (2010) The effect of the asphericity of myopic laser ablation profiles on the induction of wavefront aberrations. IOVS 51(5): 2805 – 2812. PMCID: PMC2862885.
- 5. Hindman, H.B., Swanton, J., Phipps, R.P., Sime, P.J. and Huxlin, K.R. (2010) Differences in the TGFbeta-induced pro-fibrotic response of anterior and posterior corneal keratocytes in vitro. IOVS 51(4): 1935 – 1942. PMCID: PMC2846206.
Krystel Huxlin, Ph.D.
University of Rochester
School of Medicine and Dentistry 601 Elmwood Ave., Box 659
Rochester, NY 14642
Visual Training & Rehabilitation Lab Contacts
Aaron Levi, B.S.
Michael Melnick, Grad Student
Matt Cavanaugh, Grad Student
Cornea Lab Contacts
Kye-Im Jeon, Ph.D.
Corneal Wound Healing
Margaret DeMagistris, B.S.
Daniel Savage, Grad Student
Noah Elkins, Grad Student
Former Lab Members
Tim Martin, Ph.D.
Jens Bühren, M.D.
Meghan Riley, M.S.
Lana Nagy, B.S.
Ferhina Ali, B.S.
Ryan Bisbey, M.D.
Emily Brandon, B.S.
Brad Feldman, M.D.
Micki Flynn, B.S.
Krista Gigone, M.S.
Shawn Kenner, B.S.
Brian Kraftschik, B.S.
Jason Lyons, M.D.
Tracy Price, M.S.
Jennifer Swanton, B.S.
Nadan Wang, M.S
Jennifer Williams, B.S.
Danielle Shaked, B.A.
Emily Nash, B.A.