Richard T. Libby, Ph.D.

Richard T. Libby, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 659
Rochester, NY 14642

Journal Articles

Showing all 55 journal articles available.

2014 Nov 19
Mac Nair CE, Fernandes KA, Schlamp CL, Libby RT, Nickells RW. "Tumor necrosis factor alpha has an early protective effect on retinal ganglion cells after optic nerve crush." Journal of neuroinflammation. 2014 Nov 19; 11(1):194. Epub 2014 Nov 19.
2014 Sep
Fernandes KA, Harder JM, John SW, Shrager P, Libby RT. "DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury." Neurobiology of disease. 2014 Sep; 69:108-16. Epub 2014 May 27.
2014 Mar 1
Coleman JA, Zhu X, Djajadi HR, Molday LL, Smith RS, Libby RT, John SW, Molday RS. "Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival." Journal of cell science. 2014 Mar 1; 127(Pt 5):1138-49. Epub 2014 Jan 10.
2014 Feb
Strazzeri JM, Hunter JJ, Masella BD, Yin L, Fischer WS, Diloreto DA, Libby RT, Williams DR, Merigan WH. "Focal damage to macaque photoreceptors produces persistent visual loss." Experimental eye research. 2014 Feb; 119:88-96. Epub 2013 Dec 05.
2014
Huang L, Hu F, Xie X, Harder J, Fernandes K, Zeng XY, Libby R, Gan L. "Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice." PloS one. 2014 9(4):e94173. Epub 2014 Apr 15.
2014
Soto I, Howell GR, John CW, Kief JL, Libby RT, John SW. "DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation." PloS one. 2014 9(9):e107291. Epub 2014 Sep 10.
2013 Aug
Howell GR, Soto I, Libby RT, John SW. "Intrinsic axonal degeneration pathways are critical for glaucomatous damage." Experimental neurology. 2013 Aug; 246:54-61. Epub 2012 Jan 18.
2013 Jul
Fernandes KA, Harder JM, Kim J, Libby RT. "JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells." Experimental eye research. 2013 Jul; 112:106-17. Epub 2013 May 03.
2013 Jun 21
Jiang Y, Ding Q, Xie X, Libby R, Lefebvre V, Gan L. "Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells." The Journal of biological chemistry. 2013 Jun 21; 288(25):18429-38. Epub 2013 May 06.
2013 Jun
Howell GR, Libby RT. "Adding metabolomics to the toolbox for studying retinal disease." Investigative ophthalmology & visual science. 2013 Jun; 54(6):4260. Epub 2013 Jun 21.
2013 May 28
Zhou Y, Tanzie C, Yan Z, Chen S, Duncan M, Gaudenz K, Li H, Seidel C, Lewis B, Moran A, Libby RT, Kiernan AE, Xie T. "Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye." Proceedings of the National Academy of Sciences of the United States of America. 2013 May 28; 110(22):8966-71. Epub 2013 May 15.
2013 Jan
Harder JM, Libby RT. "Deficiency in Bim, Bid and Bbc3 (Puma) do not prevent axonal injury induced death." Cell death and differentiation. 2013 Jan; 20(1):182. Epub 2012 Sep 21.
2012 Aug
Harder JM, Ding Q, Fernandes KA, Cherry JD, Gan L, Libby RT. "BCL2L1 (BCL-X) promotes survival of adult and developing retinal ganglion cells." Molecular and cellular neurosciences. 2012 Aug; 51(1-2):53-9. Epub 2012 Jul 24.
2012 May
Fernandes KA, Harder JM, Fornarola LB, Freeman RS, Clark AF, Pang IH, John SW, Libby RT. "JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death." Neurobiology of disease. 2012 May; 46(2):393-401. Epub 2012 Feb 14.
2012 Apr 2
Howell GR, Soto I, Zhu X, Ryan M, Macalinao DG, Sousa GL, Caddle LB, Macnicoll KH, Barbay JM, Porciatti V, Anderson MG, Smith RS, Clark AF, Libby RT, John SW. "Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma." The Journal of clinical investigation. 2012 Apr 2; 122(4):1246-61. Epub 2012 Mar 19.
2012 Apr 1
Geng Y, Dubra A, Yin L, Merigan WH, Sharma R, Libby RT, Williams DR. "Adaptive optics retinal imaging in the living mouse eye." Biomedical optics express. 2012 Apr 1; 3(4):715-34. Epub 2012 Mar 15.
2012
Harder JM, Fernandes KA, Libby RT. "The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice." Scientific reports. 2012 2:530. Epub 2012 Jul 25.
2012
Zhu X, Libby RT, de Vries WN, Smith RS, Wright DL, Bronson RT, Seburn KL, John SW. "Mutations in a P-type ATPase gene cause axonal degeneration." PLoS genetics. 2012 8(8):e1002853. Epub 2012 Aug 09.
2011 Jul 1
Lopes VS, Gibbs D, Libby RT, Aleman TS, Welch DL, Lillo C, Jacobson SG, Radu RA, Steel KP, Williams DS. "The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65." Human molecular genetics. 2011 Jul 1; 20(13):2560-70. Epub 2011 Apr 14.
2011 Jun
Xi X, McMillan DH, Lehmann GM, Sime PJ, Libby RT, Huxlin KR, Feldon SE, Phipps RP. "Ocular fibroblast diversity: implications for inflammation and ocular wound healing." Investigative ophthalmology & visual science. 2011 Jun; 52(7):4859-65. Epub 2011 Jul 01.
2011 Apr
Yin L, Greenberg K, Hunter JJ, Dalkara D, Kolstad KD, Masella BD, Wolfe R, Visel M, Stone D, Libby RT, Diloreto D, Schaffer D, Flannery J, Williams DR, Merigan WH. "Intravitreal injection of AAV2 transduces macaque inner retina." Investigative ophthalmology & visual science. 2011 Apr; 52(5):2775-83. Epub 2011 Apr 25.
2011 Apr
Howell GR, Macalinao DG, Sousa GL, Walden M, Soto I, Kneeland SC, Barbay JM, King BL, Marchant JK, Hibbs M, Stevens B, Barres BA, Clark AF, Libby RT, John SW. "Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma." The Journal of clinical investigation. 2011 Apr; 121(4):1429-44. Epub 2011 Mar 07.
2011
Geng Y, Schery LA, Sharma R, Dubra A, Ahmad K, Libby RT, Williams DR. "Optical properties of the mouse eye." Biomedical optics express. 2011 2(4):717-38. Epub 2011 Feb 28.
2011
Harder JM, Libby RT. "BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina." Molecular neurodegeneration. 2011 6:50. Epub 2011 Jul 15.
2011
Howell GR, Walton DO, King BL, Libby RT, John SW. "Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data." BMC genomics. 2011 12:429. Epub 2011 Aug 24.
2010
Libby RT, Gould DB. "Endoplasmic reticulum stress as a primary pathogenic mechanism leading to age-related macular degeneration." Advances in experimental medicine and biology. 2010 664:403-9.
2010
Feng L, Xie ZH, Ding Q, Xie X, Libby RT, Gan L. "MATH5 controls the acquisition of multiple retinal cell fates." Molecular brain. 2010 3:36. Epub 2010 Nov 18.
2009 Nov
Bertram KM, Baglole CJ, Phipps RP, Libby RT. "Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration." American journal of physiology. Cell physiology. 2009 Nov; 297(5):C1200-10. Epub 2009 Sep 16.
2009 Apr 1
Ding Q, Chen H, Xie X, Libby RT, Tian N, Gan L. "BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Apr 1; 29(13):3992-4003.
2009
Scoles D, Gray DC, Hunter JJ, Wolfe R, Gee BP, Geng Y, Masella BD, Libby RT, Russell S, Williams DR, Merigan WH. "In-vivo imaging of retinal nerve fiber layer vasculature: imaging histology comparison." BMC ophthalmology. 2009 9:9. Epub 2009 Aug 23.
2008
Howell GR, Libby RT, John SW. "Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection." Progress in brain research. 2008 173:303-21.
2007
Howell GR, Libby RT, Jakobs TC, Smith RS, Phalan FC, Barter JW, Barbay JM, Marchant JK, Mahesh N, Porciatti V, Whitmore AV, Masland RH, John SW. "Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma." The Journal of cell biology. 2007 179(7):1523-37. Epub 2007 Dec 24.
2007
Howell GR, Libby RT, Marchant JK, Wilson LA, Cosma IM, Smith RS, Anderson MG, John SW. "Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1." BMC genetics. 2007 8:45. Epub 2007 Jul 03.
2007
Libby RT, Howell GR, Pang IH, Savinova OV, Mehalow AK, Barter JW, Smith RS, Clark AF, John SW. "Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model." BMC neuroscience. 2007 8:108. Epub 2007 Dec 19.
2006
Anderson MG, Libby RT, Mao M, Cosma IM, Wilson LA, Smith RS, John SW. "Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma." BMC biology. 2006 4:20. Epub 2006 Jul 07.
2005 Nov
Whitmore AV, Libby RT, John SW. "Glaucoma: thinking in new ways-a rĂ´le for autonomous axonal self-destruction and other compartmentalised processes?" Progress in retinal and eye research. 2005 Nov; 24(6):639-62.
2005 Oct 24
Jakobs TC, Libby RT, Ben Y, John SW, Masland RH. "Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice." The Journal of cell biology. 2005 Oct 24; 171(2):313-25.
2005 Jul
Kitamoto J, Libby RT, Gibbs D, Steel KP, Williams DS. "Myosin VI is required for normal retinal function." Experimental eye research. 2005 Jul; 81(1):116-20.
2005 Jul
Libby RT, Li Y, Savinova OV, Barter J, Smith RS, Nickells RW, John SW. "Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage." PLoS genetics. 2005 Jul; 1(1):17-26. Epub 2005 Jul 25.
2005 Mar 22
Anderson MG, Libby RT, Gould DB, Smith RS, John SW. "High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma." Proceedings of the National Academy of Sciences of the United States of America. 2005 Mar 22; 102(12):4566-71. Epub 2005 Mar 09.
2005
Libby RT, Gould DB, Anderson MG, John SW. "Complex genetics of glaucoma susceptibility." Annual review of genomics and human genetics. 2005 6:15-44.
2005
Libby RT, Anderson MG, Pang IH, Robinson ZH, Savinova OV, Cosma IM, Snow A, Wilson LA, Smith RS, Clark AF, John SW. "Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration." Visual neuroscience. 2005 22(5):637-48.
2004 Sep 1
Libby RT, Lillo C, Kitamoto J, Williams DS, Steel KP. "Myosin Va is required for normal photoreceptor synaptic activity." Journal of cell science. 2004 Sep 1; 117(Pt 19):4509-15. Epub 2004 Aug 17.
2004
Gibbs D, Azarian SM, Lillo C, Kitamoto J, Klomp AE, Steel KP, Libby RT, Williams DS. "Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes." Journal of cell science. 2004 117(Pt 26):6473-83. Epub 2004 Nov 30.
2003 Mar 7
Libby RT, Smith RS, Savinova OV, Zabaleta A, Martin JE, Gonzalez FJ, John SW. "Modification of ocular defects in mouse developmental glaucoma models by tyrosinase." Science. 2003 Mar 7; 299(5612):1578-81.
2003 Feb 3
Warner CL, Stewart A, Luzio JP, Steel KP, Libby RT, Kendrick-Jones J, Buss F. "Loss of myosin VI reduces secretion and the size of the Golgi in fibroblasts from Snell's waltzer mice." The EMBO journal. 2003 Feb 3; 22(3):569-79.
2003
Libby RT, Kitamoto J, Holme RH, Williams DS, Steel KP. "Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration." Experimental eye research. 2003 77(6):731-9.
2002 Jan
Kros CJ, Marcotti W, van Netten SM, Self TJ, Libby RT, Brown SD, Richardson GP, Steel KP. "Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations." Nature neuroscience. 2002 Jan; 5(1):41-7.
2001 Mar
Libby RT, Steel KP. "Electroretinographic anomalies in mice with mutations in Myo7a, the gene involved in human Usher syndrome type 1B." Investigative ophthalmology & visual science. 2001 Mar; 42(3):770-8.
2000 Sep 1
Libby RT, Champliaud MF, Claudepierre T, Xu Y, Gibbons EP, Koch M, Burgeson RE, Hunter DD, Brunken WJ. "Laminin expression in adult and developing retinae: evidence of two novel CNS laminins." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Sep 1; 20(17):6517-28.
2000
Libby RT, Brunken WJ, Hunter DD. "Roles of the extracellular matrix in retinal development and maintenance." Results and problems in cell differentiation. 2000 31:115-40.
2000
Libby RT, Steel KP. "The roles of unconventional myosins in hearing and deafness." Essays in biochemistry. 2000 35:159-74.
1999 Nov 1
Libby RT, Lavallee CR, Balkema GW, Brunken WJ, Hunter DD. "Disruption of laminin beta2 chain production causes alterations in morphology and function in the CNS." The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Nov 1; 19(21):9399-411.
1997
Libby RT, Xu Y, Selfors LM, Brunken WJ, Hunter DD. "Identification of the cellular source of laminin beta2 in adult and developing vertebrate retinae." The Journal of comparative neurology. 1997 389(4):655-67.
1996 Jul
Libby RT, Hunter DD, Brunken WJ. "Developmental expression of laminin beta 2 in rat retina. Further support for a role in rod morphogenesis." Investigative ophthalmology & visual science. 1996 Jul; 37(8):1651-61.