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M Anwar Iqbal, Ph.D.

M Anwar Iqbal, Ph.D.

Contact

Office (585) 758-0494

Research Lab

Microarray Laboratory

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About Me

Faculty Appointments

Professor - Department of Pathology and Laboratory Medicine (SMD)

Credentials

Education

PhD | India-Osmania U, Gandhi Med Coll. Genetics. 1983

MS | India-Osmania U, Gandhi Med Coll. Genetics. 1976

BS | India-Osmania U, Gandhi Med Coll. Biology. 1974

Awards

Luminex Award. 2010 - 2011

Research

Dr. Iqbal's research is in the area of clinical and molecular cytogenetics. He has a particular interest in the application of cytogenetic and FISH testing in the diagnosis of neoplastic as well as genetic disorders. His interests include the molecular cytogenetics of renal cell carcinoma, small rou...
Dr. Iqbal's research is in the area of clinical and molecular cytogenetics. He has a particular interest in the application of cytogenetic and FISH testing in the diagnosis of neoplastic as well as genetic disorders. His interests include the molecular cytogenetics of renal cell carcinoma, small round cell tumors, the cytogenetics of leukemia and lymphomas, and prenatal cytogenetic diagnostics. He has special interest in cryptic rearrangements involving subtelomere regions of human chromosomes in genetic disorders and leukemia. Dr. Iqbal is actively involved in bringing microarray technology into use as the next cytogenomics tool to translate lab innovations into postnatal, prenatal and cancer diagnosis.

Publications

Journal Articles

Encompassing the COL1A1, and Two Additional Secondary Copy Number Variants in an Infant with Type I Osteogenesis Imperfecta: A Rare Case Report.

Numbere N; Weber DR; Porter G Jr; Iqbal MA.

2020; .

Diffuse astrocytoma with 3q26.2q29 duplication, 20p12.1p11.1 deletion and no recurrence over 25 years

Mahlon D Johnson; M. Anwar Iqbal; Ali Hussain;Webster Pilcher.

Interdisciplinary Neurosurgery. 2020; 100684.

Disruption of normal patterns of FOXF1 expression in a lethal disorder of lung development.

Laurie A Steiner; Michael Getman; Gillian M Schiralli; Lester, M; Anwar Iqbal; Philip Katzman; Przemyslaw Szafranski; Pawel Stankiewicz; S. Bhattacharya; Thomas Mariani; Gloria Pryhuber; Xin Lin; Jennifer L Young; David A Dean; Kristin Scheible.

Disruption of normal patterns of FOXF1 expression in a lethal disorder of lung development. 2019; 0:1–5.

Assessing copy number abnormalities and copy-neutral loss-of-heterozygosity across the genome as best practice in diagnostic evaluation of acute myeloid leukemia: An evidence-based review from the cancer genomics consortium (CGC) myeloid neoplasms working group.

Xu X, Bryke C, Sukhanova M, Huxley E, Dash DP, Dixon-Mciver A, Fang M, Griepp PT, Hodge JC, Iqbal A, Jeffries S, Kanagal-Shamanna R, Quintero-Rivera F, Shetty S, Slovak ML, Yenamandra A, Lennon PA, Raca G

Cancer genetics.. 2018 December 228-229 :218-235. Epub 10/06/2018.

Assessing copy number aberrations and copy neutral loss of heterozygosity across the genome as best practice: An evidence based review of clinical utility from the cancer genomics consortium (CGC) working group for myelodysplastic syndrome, myelodysplastic/myeloproliferative and myeloproliferative neoplasms.

Kanagal-Shamanna R, Hodge JC, Tucker T, Shetty S, Yenamandra A, Dixon-McIver A, Bryke C, Huxley E, Lennon PA, Raca G, Xu X, Jeffries S, Quintero-Rivera F, Greipp PT, Slovak ML, Iqbal MA, Fang M

Cancer genetics.. 2018 December 228-229 :197-217. Epub 10/10/2018.

Novel 1.3 Mb germline duplication in chromosome 8q21.11 by microarray comparative genomic hybridization plus single nucleotide polymorphism analysis in an adult patient with pancytopenia and urinary bladder complications.

Reyes Barron C, Evans AG, Miyamoto H, Zhang B, Iqbal MA

Clinical case reports.. 2018 October 6 (10):1947-1952. Epub 08/16/2018.

Combined comparative genomic hybridization and single-nucleotide polymorphism array detects cryptic chromosomal lesions in both myelodysplastic syndromes and cytopenias of undetermined significance.

Evans AG, Ahmad A, Burack WR, Iqbal MA

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2016 October 29 (10):1183-99. Epub 07/08/2016.

Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins.

Szafranski P, Gambin T, Dharmadhikari AV, Akdemir KC, Jhangiani SN, Schuette J, Godiwala N, Yatsenko SA, Sebastian J, Madan-Khetarpal S, Surti U, Abellar RG, Bateman DA, Wilson AL, Markham MH, Slamon J, Santos-Simarro F, Palomares M, Nevado J, Lapunzina P, Chung BH, Wong WL, Chu YW, Mok GT, Kerem E, Reiter J, Ambalavanan N, Anderson SA, Kelly DR, Shieh J, Rosenthal TC, Scheible K, Steiner L, Iqbal MA, McKinnon ML, Hamilton SJ, Schlade-Bartusiak K, English D, Hendson G, Roeder ER, DeNapoli TS, Littlejohn RO, Wolff DJ, Wagner CL, Yeung A, Francis D, Fiorino EK, Edelman M, Fox J, Hayes DA, Janssens S, De Baere E, Menten B, Loccufier A, Vanwalleghem L, Moerman P, Sznajer Y, Lay AS, Kussmann JL, Chawla J, Payton DJ, Phillips GE, Brosens E, Tibboel D, de Klein A, Maystadt I, Fisher R, Sebire N, Male A, Chopra M, Pinner J, Malcolm G, Peters G, Arbuckle S, Lees M, Mead Z, Quarrell O, Sayers R, Owens M, Shaw-Smith C, Lioy J, McKay E, de Leeuw N, Feenstra I, Spruijt L, Elmslie F, Thiruchelvam T, Bacino CA, Langston C, Lupski JR, Sen P, Popek E, Stankiewicz P

Human genetics.. 2016 May 135 (5):569-86. Epub 04/12/2016.

Recurrent Copy Number Variation Associated with Bronchopulmonary Dysplasia

Ahmad A; Battacharya S; Sridhar A; Iqbal MA and Mariani TJ.

Pediatr Res. 2016; 79((6)): 940-5.

Deletion 1q43 encompassing only CHRM3 in a patient with autistic disorder.

Petersen AK, Ahmad A, Shafiq M, Brown-Kipphut B, Fong CT, Anwar Iqbal M

European journal of medical genetics.. 2013 February 56 (2):118-22. Epub 12/16/2012.

Leukemia specific loss of heterozygosity of MHC in a CLL patient: disease state impacts timing of confirmatory typing.

Coppage M, Iqbal A, Ahmad A, Becker MW

Human immunology.. 2013 January 74 (1):41-4. Epub 10/17/2012.

A 0.7?Mb de novo duplication at 7q21.3 including the genes DLX5 and DLX6 in a patient with split-hand/split-foot malformation.

Velinov M, Ahmad A, Brown-Kipphut B, Shafiq M, Blau J, Cooma R, Roth P, Iqbal MA

American journal of medical genetics. Part A.. 2012 December 158A (12):3201-6. Epub 11/20/2012.

A 4.5 Mb terminal deletion of chromosome 12p helps further define a psychosis-associated locus.

Vargas H, Beldia G, Korosh W, Sudhalter V, Iqbal A, Sanchez-Lacay JA, Velinov M

European journal of medical genetics.. 2012 October 55 (10):573-6. Epub 06/02/2012.

Will a peripheral blood (PB) sample yield the same diagnostic and prognostic cytogenetic data as the concomitant bone marrow (BM) in myelodysplasia?

Cherry AM, Slovak ML, Campbell LJ, Chun K, Eclache V, Haase D, Haferlach C, Hildebrandt B, Iqbal AM, Jhanwar SC, Ohyashiki K, Sole F, Vandenberghe P, VanDyke DL, Zhang Y, Dewald GW

Leukemia research.. 2012 July 36 (7):832-40. Epub 04/25/2012.

Radiation effects on human leptomeningeal cell response to cerebrospinal fluid and PDGF-BB.

Johnson MD, O'Connell M, Iqbal MA, Williams JP

International journal of radiation biology.. 2012 July 88 (7):547-55. Epub 05/25/2012.

Significance of genome-wide analysis of copy number alterations and UPD in myelodysplastic syndromes using combined CGH - SNP arrays.

Ahmad A, Iqbal MA

Current medicinal chemistry.. 2012 19 (22):3739-47. Epub 1900 01 01.

Microarray comparative genomic hybridization detection of copy number changes in desmoplastic melanoma and malignant peripheral nerve sheath tumor.

Pryor JG, Brown-Kipphut BA, Iqbal A, Scott GA

The American Journal of dermatopathology.. 2011 December 33 (8):780-5. Epub 1900 01 01.

ICF syndrome in Saudi Arabia: immunological, cytogenetic and molecular analysis.

Kaya N, Al-Muhsen S, Al-Saud B, Al-Bakheet A, Colak D, Al-Ghonaium A, Al-Dhekri H, Al-Mousa H, Arnaout R, Al-Owain M, Iqbal M

Journal of clinical immunology.. 2011 April 31 (2):245-52. Epub 12/01/2010.

High efficacy and low toxicity of APL induction with concurrent idarubicin/ATRA followed by a novel and simplified outpatient post-remission therapy using single doses of idarubicin and intermittent ATRA.

Aljurf M, Al Qurashi F, Al Mohareb F, Sahovic E, Al Sharif F, Al Zahrani H, Al Shanqeeti A, Owaidah T, Iqbal A, Zaidi SZ, Nurgat ZA, Sanz M, Chaudhri N

Medical oncology.. 2010 September 27 (3):702-7. Epub 08/08/2009.

Implementation of standardized international karyotype scoring practices is needed to provide uniform and systematic evaluation for patients with myelodysplastic syndrome using IPSS criteria: An International Working Group on MDS Cytogenetics Study.

Chun K, Hagemeijer A, Iqbal A, Slovak ML

Leukemia research.. 2010 February 34 (2):160-5. Epub 08/07/2009.

Renal failure associated with APECED and terminal 4q deletion: evidence of autoimmune nephropathy.

Al-Owain M, Kaya N, Al-Zaidan H, Bin Hussain I, Al-Manea H, Al-Hindi H, Kennedy S, Iqbal MA, Al-Mojalli H, Al-Bakheet A, Puel A, Casanova JL, Al-Muhsen S

Clinical & developmental immunology. 2010 2010 :586342. Epub 12/14/2010.

Interstitial del(20)(q11.2q12) - clinical and molecular cytogenetic characterization.

Iqbal MA, Al-Owain M

American journal of medical genetics. Part A.. 2007 August 15143A (16):1880-4. Epub 1900 01 01.

Isodicentric Philadelphia chromosomes in imatinib mesylate (Gleevec)-resistant patients.

Szych CM, Liesveld JL, Iqbal MA, Li L, Siebert S, Asmus C, O'Malley J, Lee A, Wang N

Cancer genetics and cytogenetics.. 2007 April 15174 (2):132-7. Epub 1900 01 01.

Cytogenetics, molecular and ultrastructural characteristics of biphenotypic acute leukemia identified by the EGIL scoring system.

Owaidah TM, Al Beihany A, Iqbal MA, Elkum N, Roberts GT

Leukemia.. 2006 April 20 (4):620-6. Epub 1900 01 01.

Y chromosome microdeletions in infertile men with idiopathic oligo- or azoospermia.

Hellani A, Al-Hassan S, Iqbal MA, Coskun S

Journal of experimental & clinical assisted reproduction. 2006 January 303 :1. Epub 01/30/2006.

Del(6)(p23) in two cases of de novo AML: A new recurrent primary chromosome abnormality.

Iqbal MA; Al-Omar HM; Owaidah T; Al-Humaidan H; Bhuiyan ZA; Sahovic E.

Eur J Haematol. 2006; 77: 245-250.

Complex de novo cryptic subtelomeric rearrangements in a fetus with multiple ultrasonographic abnormalities and a normal karyotype at amniocentesis.

Iqbal MA, Ramadan S, Ali FA, Kurdi W

Prenatal diagnosis.. 2005 December 25 (12):1142-9. Epub 1900 01 01.

Trisomy 4 as the sole karyotypic abnormality in a case of acute biphenotypic leukemia with T-lineage markers in minimally differentiated acute myelocytic leukemia.

Al-Qurashi FH, Owaidah T, Iqbal MA, Aljurf M

Cancer genetics and cytogenetics.. 2004 April 1150 (1):66-9. Epub 1900 01 01.

Cytogenetics and etiology of ambiguous genitalia in 120 pediatric patients.

Al-Mutair A, Iqbal MA, Sakati N, Ashwal A

Annals of Saudi medicine.. 2004 24 (5):368-72. Epub 1900 01 01.

Monitoring of donor/recipient T-cell engraftment kinetics in myeloablative allogeneic stem cell transplantation using short tandem repeat amplification from cell lysates.

Boumah CE, Meyer B, Aljurf M, Bertilsson PA, Pyle RH, Al-Hussein KA, Iqbal A, Gyger M

Leukemia & lymphoma.. 2002 June 43 (6):1281-7. Epub 1900 01 01.

Extramedullary myeloid cell tumours localised to the mediastinum: a rare clinicopathological entity with unique karyotypic features.

Nounou R, Al-Zahrani H H, Ajarim DS, Martin J, Iqbal A, Naufal R, Stuart R, Roberts G, Gyger M

Journal of clinical pathology.. 2002 March 55 (3):221-5. Epub 1900 01 01.

Tumor necrosis factor-alpha and interleukin-10 secretion in precursor B cell acute lymphoblastic leukemia: functional significance of interleukin-12

Raziuddin S; Iqbal MA; Khalil S; Siraj AK; Butt AI; Al-Sedairy S.

Lab Hematol. 2002; 8: 59-69.

FISH analysis in chromophobe renal-cell carcinoma.

Iqbal MA, Akhtar M, Ulmer C, Al-Dayel F, Paterson MC

Diagnostic cytopathology.. 2000 January 22 (1):3-6. Epub 1900 01 01.

Cytogenetic diagnosis of fragile X syndrome: study of 305 suspected cases in Saudi Arabia.

Iqbal MA, Sakati N, Nester M, Ozand P

Annals of Saudi medicine.. 2000 20 (3-4):214-7. Epub 1900 01 01.

Use of FISH technique in the diagnosis of chromosomal syndromes.

Iqbal MA, Ulmer C, Sakati N

Eastern Mediterranean health journal = La revue de sante? de la Me?diterrane?e orientale = al-Majallah al-s?ih?h?i?yah li-sharq al-mutawassit?.. 1999 November 5 (6):1218-24. Epub 1900 01 01.

Fine-needle aspiration biopsy diagnosis of small round cell tumors of childhood: A comprehensive approach.

Akhtar M, Iqbal MA, Mourad W, Ali MA

Diagnostic cytopathology.. 1999 August 21 (2):81-91. Epub 1900 01 01.

Use of FISH analysis for diagnosis of renal cell carcinoma subtypes.

Iqbal MA, Akhtar M, Al Dayel F, Ulmer C, Paterson MC

Annals of Saudi medicine.. 1999 19 (6):495-500. Epub 1900 01 01.

Genetics of small round cell tumors of children.

Akhtar M, Iqbal MA

Annals of Saudi medicine.. 1998 18 (4):311-7. Epub 1900 01 01.

The use of an all oral chemotherapy (idarubicin and etoposide) in the treatment of acute myeloid leukaemia in the elderly: a report of toxicity and efficacy.

Jackson GH, Taylor PR, Iqbal A, Galloway MJ, Turner G, Haynes A, Hamilton PJ, Russell N, Proctor SJ

Leukemia.. 1997 August 11 (8):1193-6. Epub 1900 01 01.

FISHing genes and chromosomes from human cells.

Iqbal A

Annals of Saudi medicine.. 1997 July 17 (4):391-4. Epub 1900 01 01.

A case of presumptive monosomy 21 re-diagnosed as unbalanced t(5p;21q) by FISH and review of literature.

Iqbal MA, Ahmed MZ, Wu D, Sakati N

American journal of medical genetics.. 1997 May 1670 (2):174-8. Epub 1900 01 01.

Cytogenetic findings in renal cell carcinoma.

Iqbal MA, Akhtar M, Ali MA

Human pathology.. 1996 September 27 (9):949-54. Epub 1900 01 01.

Cytogenetic characterization of sarcomas of bone and soft tissues.

Iqbal AM, Akhtar M, Ali MA

Annals of Saudi medicine.. 1995 November 15 (6):622-7. Epub 1900 01 01.

A human adult Wilms' tumor. Histologic, ultrastructural, and cytogenetic analysis.

Sherwood JB, Bard R, Bhargava M, Burns ER, Iqbal MA

Cancer genetics and cytogenetics.. 1989 October 142 (1):35-42. Epub 1900 01 01.

Replication program of active and inactive multigene families in mammalian cells.

Hatton KS, Dhar V, Brown EH, Iqbal MA, Stuart S, Didamo VT, Schildkraut CL

Molecular and cellular biology.. 1988 May 8 (5):2149-58. Epub 1900 01 01.

Partial duplication 16q: report of two affected siblings resulting from a maternal translocation and literature review.

Hahm SY, Chitayat D, Iqbal MA, Cho S, Nitowsky HM

Clinical genetics.. 1987 May 31 (5):343-8. Epub 1900 01 01.

Replication of proto-oncogenes early during the S phase in mammalian cell lines.

Iqbal MA, Chinsky J, Didamo V, Schildkraut CL

Nucleic acids research.. 1987 January 1215 (1):87-103. Epub 1900 01 01.

Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon.

Brown EH, Iqbal MA, Stuart S, Hatton KS, Valinsky J, Schildkraut CL

Molecular and cellular biology.. 1987 January 7 (1):450-7. Epub 1900 01 01.

Ring chromosome 6: report of a patient and literature review.

Chitayat D, Hahm SY, Iqbal MA, Nitowsky HM

American journal of medical genetics.. 1987 January 26 (1):145-51. Epub 1900 01 01.

Coordinate replication of members of the multigene family of core and H1 human histone genes.

Iqbal MA, Plumb M, Stein J, Stein G, Schildkraut CL

Proceedings of the National Academy of Sciences of the United States of America.. 1984 December 81 (24):7723-7. Epub 1900 01 01.

Increased sister chromatid exchanges in human cell lines characterized by monosomy X or structural abnormalities of the X chromosome.

Iqbal MA, Martin AO, Simpson JL

Human genetics.. 1984 68 (3):205-8. Epub 1900 01 01.

Ultrasonic induction of sister chromatid exchanges in human lymphocytes.

Haupt M, Martin AO, Simpson JL, Iqbal MA, Elias S, Dyer A, Sabbagha RE

Human genetics.. 1981 59 (3):221-6. Epub 1900 01 01.

Finger and palmar ridge counts in diabetes mellitus

Iqbal MA; Sahay BK and Ahuja YR.

Acta Anthropogenetics. 1978; 2: 35-38.

Combined CGH-SNP Array Detects Cryptic Chromosomal Lesions in Both MDS and Cytopenias of Undetermined Significance

Evans AG*; Ahmad A*; Burack RW and Iqbal MA.

Modern Pathology. .

The coordinate replication of the human B-globin gene domain reflects its transcriptional activity and nuclease hypersensitivity

Dhar V; Mager D; Iqbal MA and Schildkraut CL.

Molec. Cellar Biol. 8: 4958-4965.

Fingertip and palmar patterns in duodenal ulcer

Habibullah CM; Mujahid; Iqbal MA and Ishaq M.

Hum. Hered. 32: 432-434.