B Paige Lawrence, Ph.D.

B Paige Lawrence, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Office: (585) 275-1974
Lab: (585) 275-2013
Fax: (585) 276-0239

Research Bio

Environmental signaling, immune function, and cellular development
Environmental signals influence the behavior of cells throughout the body. In some cases this is part of normal physiology, but in other instances environmental signals cue cells to work aberrantly. When this occurs, pathology generally ensues, leading to poorer health. For many chemicals from our environment the mechanisms by which they perturb physiology are largely unknown, and determining these mechanisms forms the basis of most of our research. We have several interrelated projects currently underway.



The aryl hydrocarbon receptor (AhR)
The AhR is a ligand-activated transcription factor that mediates many environmental signals. Its normal function in the body is unknown, but numerous exogenous chemicals bind to AhR, affecting gene expression and cell function. A major focus of our research is to delineate the mechanisms by which the AhR regulates the development and function of the immune system. To accomplish this, we often use influenza viruses, as they are common human pathogens, and because humans exposed to pollutants that bind AhR often have more respiratory illness. We often use the pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) because it binds the AhR with very high affinity and causes sustained activation. This makes it a powerful research tool, as we can probe AhR-regulated pathways by exploiting the knowledge gained when they are perturbed. Also, TCDD represents a large group of highly toxic chemicals found throughout the world, and daily low-level exposure to them has been linked to impairment of the immune, reproductive, and endocrine systems. Current projects seek to understand AhR's normal role in, and how pollutants impact, the immune system and developing organs, and include the following projects:
• The role of AhR in immune response to respiratory viral infection
• The role of AhR in programming the developing immune system
• The role of the AhR in mammary gland differentiation and lactogenesis
There is now compelling evidence that developmental exposures to chemicals from our environment lead to disease later in life, and our interest in how environmental signals alter the developing immune system extends beyond AhR and dioxin. We have two additional funded projects in this area.

Neonatal oxygen supplementation and respiratory viral infection
In collaboration with Dr. Michael O'Reilly, we are studying the effects of neonatal oxygen supplementation on pulmonary immune function. Premature infants are often given high oxygen supplementation, which has substantially reduced premature infant mortality. However, even as adolescents, these infants exhibit reduced lung function and are more likely to be re-hospitalized due to respiratory viral infection. Using a mouse model, we are currently determining how neonatal high oxygen treatment disrupts the response to respiratory viral infection. Moreover, we are integrating our research findings with studies of immune responses in infected children who were born prematurely, which we hope will help us identify novel therapeutic opportunities for improving the health of children born prematurely.

Developmental immunotoxicity of bisphenol A (BPA)
BPA is used in the manufacture of polycarbonate plastics and epoxy resins, and is one of the highest volume chemicals produced worldwide. Existing but very limited data indicate that maternal exposure adversely impacts the developing immune system, and this is a cause for concern. Yet, our current inadequate understanding of BPA's developmental immunotoxicity fetters progress toward comprehensive assessment of the human health effects of BPA. To address this we have started a new project in which we will conduct the most detailed analysis to-date of the impact of the BPA on immune system development and function in the context of animal models of human diseases, such as asthma, influenza, and inflammatory bowel disease.

Awards & Honors (National)

Service Recognition Award for Excellence in Mentoring | Women in Toxicology Special Interest Group of the Society of Tox 2007
Outstanding Young Investigator Award | Immunotoxicology Specialty Section, Society of Toxicology 2006
Independent Scientist Award (K02) | NIH 2004
National Research Service Award (NRSA) Postdoctoral Fellowship | NIEHS, NIH 1995
Phi Beta Kappa, Skidmore College Chapter 1986

Awards & Honors (Local)

Faculty Mentoring Award | University of Rochester 2012
Advisor Excellence Award | Graduate & Professional Student Association | Washington State University 2003
Periclean Honor Society | Honorary Society for academic excellence | Skidmore College 1986
Charlotte W. Fahey Prize for academic achievement in the field of Chemistry 1986

Recent Journal Articles

Showing the 5 most recent journal articles. 63 available »

2015 Aug 1
Boule LA, Winans B, Lambert K, Vorderstrasse BA, Topham DJ, Pavelka MS, Lawrence BP. "Activation of the aryl hydrocarbon receptor during development enhances the pulmonary CD4+ T-cell response to viral infection." American journal of physiology. Lung cellular and molecular physiology. 2015 Aug 1; 309(3):L305-13. Epub 2015 Jun 12.
2015 May 1
Winans B, Nagari A, Chae M, Post CM, Ko CI, Puga A, Kraus WL, Lawrence BP. "Linking the aryl hydrocarbon receptor with altered DNA methylation patterns and developmentally induced aberrant antiviral CD8+ T cell responses." The Journal of immunology : official journal of the American Association of Immunologists. 2015 May 1; 194(9):4446-57. Epub 2015 Mar 25.
2015
Sundar IK, Ahmad T, Yao H, Hwang JW, Gerloff J, Lawrence BP, Sellix MT, Rahman I. "Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD." Scientific reports. 2015 4:9927. Epub 2015 Apr 29.
2014 Nov
Sifkarovski J, Grayfer L, De Jesús Andino F, Paige Lawrence B, Robert J. "Negative effects of low dose atrazine exposure on the development of effective immunity to FV3 in Xenopus laevis." Developmental and comparative immunology. 2014 Nov; 47(1):52-8. Epub 2014 Jun 28.
2014 Nov
Boule LA, Winans B, Lawrence BP. "Effects of developmental activation of the AhR on CD4+ T-cell responses to influenza virus infection in adult mice." Environmental health perspectives. 2014 Nov; 122(11):1201-8. Epub 2014 Jul 22.

Current Appointments

Professor - Department of Environmental Medicine (SMD) - Primary
Professor - Department of Microbiology and Immunology (SMD)

Education

PhD | Biochemistry, Molecular and Cell Biology | Cornell University1993
BA | Biology, Chemistry | Skidmore College1986

Post-Doctoral Training & Residency

Toxicology Program and Dept. Environmental and Molecular Toxicology, Oregon State University 1997