Minsoo Kim, Ph.D.

Minsoo Kim, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 609
Rochester, NY 14642

Administrative: (585) 273-1400
Lab: (585) 273-1435
Fax: (585) 273-2452
Office: (585) 276-3917

Research Bio

Unlike cells within solid tissues, circulating leukocytes relocate during the course of immune reactions and dynamically adhere and de-adhere to cells of the vasculature and to other immune cells, as well as to components of the extracellular matrix. A subset of integrins (LFA-1, Mac-1, and VLA4) are expressed on leukocytes and play a major role in regulating leukocyte adhesion and recruitment to damaged or infected tissues during inflammatory responses. The activity of integrins to bind ligands is dynamically and tightly regulated through conformational changes from inactive form to the active one that binds ligands with high affinity.

Under a wide range of pathologic conditions, these mechanisms of integrin activation are mis-regulated resulting in abnormal leukocyte trafficking, and direct damage to the vasculature and the underlying tissue making leukocyte integrins a promising therapeutic target for anti-inflammation therapy. Therefore, it would be critical to understand how integrins and their ligands bind to one another, the flow of conformational changes from one integrin domain to another, and the connections to other signaling molecules.
In order to visualize the conformational changes in integrin LFA-1 and its dynamic redistribution on the plasma membrane, we applied the quantitative imaging technique FRET (fluorescence resonance energy transfer) to living cells. Our current research focuses on integrin-mediated leukocyte migration during inflammation. By employing advanced imaging techniques including FRET, live cell imaging, 3D confocal-image reconstruction, IRM (interference reflection microscopy), and TIRFM (total internal reflection fluorescence microscopy), we are trying to improve our understanding of the supramolecular/architectural properties of leukocyte integrins with particular emphasis on their relationship with leukocyte migration. In addition, we are interested in visualizing dynamic interactions of intracellular signaling molecules and identifying new molecules that regulate integrin activation during the leukocyte chemotaxis.

Awards & Honors (National)

American Heart Association, Scientist Developmental Grant 2005
DDW Poster of Distinction 2001
DDW Poster of Distinction 2000
American Digestive Health Foundation Student Abstract Award 2000
Digestive Disease Week (DDW) Poster of Distinction 1999

Awards & Honors (Local)

Brown University Seed Fund Award (Co-investigator) 2007
Rhode Island Foundation, Medical Research Grant 2005
Honor student of 1992 by Korea University 1992

Recent Journal Articles

Showing the 5 most recent journal articles. 41 available »

2014 Jun 15
Stevenson C, de la Rosa G, Anderson CS, Murphy PS, Capece T, Kim M, Elliott MR. "Essential role of Elmo1 in Dock2-dependent lymphocyte migration." The Journal of immunology : official journal of the American Association of Immunologists. 2014 Jun 15; 192(12):6062-70. Epub 2014 May 12.
2014 Jun
Baik SH, Cha MY, Hyun YM, Cho H, Hamza B, Kim DK, Han SH, Choi H, Kim KH, Moon M, Lee J, Kim M, Irimia D, Mook-Jung I. "Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model." Neurobiology of aging. 2014 Jun; 35(6):1286-92. Epub 2014 Jan 08.
2014 Apr 29
Xu Y, Hyun YM, Lim K, Lee H, Cummings RJ, Gerber SA, Bae S, Cho TY, Lord EM, Kim M. "Optogenetic control of chemokine receptor signal and T-cell migration." Proceedings of the National Academy of Sciences of the United States of America. 2014 Apr 29; 111(17):6371-6. Epub 2014 Apr 14.
2014 Apr
Polesskaya O, Wong C, Lebron L, Chamberlain JM, Gelbard HA, Goodfellow V, Kim M, Daiss JL, Dewhurst S. "MLK3 regulates fMLP-stimulated neutrophil motility." Molecular immunology. 2014 Apr; 58(2):214-22. Epub 2014 Jan 03.
2014
Lerman YV, Lim K, Hyun YM, Falkner KL, Yang H, Pietropaoli AP, Sonnenberg A, Sarangi PP, Kim M. "Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin ?3?1-dependent." Blood. 2014 124(24):3515-23. Epub 2014 Oct 02.

Current Appointments

Associate Professor - Department of Microbiology and Immunology, Center for Vaccine Biology and Immunology (SMD) - Primary
Associate Professor - Department of Pharmacology and Physiology (SMD)

Education

PhD | Pharmacology | Ohio State University2001
BS | Genetic Engineering | Korea-Korea University1993

Post-Doctoral Training & Residency

Center for Blood Research, Harvard Medical School, Boston, MA 2004