Minsoo Kim, Ph.D.

Minsoo Kim, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 609
Rochester, NY 14642

Administrative: (585) 273-1400
Lab: (585) 273-1435
Fax: (585) 273-2452
Office: (585) 276-3917

Research Bio

Unlike cells within solid tissues, circulating leukocytes relocate during the course of immune reactions and dynamically adhere and de-adhere to cells of the vasculature and to other immune cells, as well as to components of the extracellular matrix. A subset of integrins (LFA-1, Mac-1, and VLA4) are expressed on leukocytes and play a major role in regulating leukocyte adhesion and recruitment to damaged or infected tissues during inflammatory responses. The activity of integrins to bind ligands is dynamically and tightly regulated through conformational changes from inactive form to the active one that binds ligands with high affinity.

Under a wide range of pathologic conditions, these mechanisms of integrin activation are mis-regulated resulting in abnormal leukocyte trafficking, and direct damage to the vasculature and the underlying tissue making leukocyte integrins a promising therapeutic target for anti-inflammation therapy. Therefore, it would be critical to understand how integrins and their ligands bind to one another, the flow of conformational changes from one integrin domain to another, and the connections to other signaling molecules.
In order to visualize the conformational changes in integrin LFA-1 and its dynamic redistribution on the plasma membrane, we applied the quantitative imaging technique FRET (fluorescence resonance energy transfer) to living cells. Our current research focuses on integrin-mediated leukocyte migration during inflammation. By employing advanced imaging techniques including FRET, live cell imaging, 3D confocal-image reconstruction, IRM (interference reflection microscopy), and TIRFM (total internal reflection fluorescence microscopy), we are trying to improve our understanding of the supramolecular/architectural properties of leukocyte integrins with particular emphasis on their relationship with leukocyte migration. In addition, we are interested in visualizing dynamic interactions of intracellular signaling molecules and identifying new molecules that regulate integrin activation during the leukocyte chemotaxis.

Awards & Honors (National)

American Heart Association, Scientist Developmental Grant 2005
DDW Poster of Distinction 2001
DDW Poster of Distinction 2000
American Digestive Health Foundation Student Abstract Award 2000
Digestive Disease Week (DDW) Poster of Distinction 1999

Awards & Honors (Local)

University of Rochester School of Medicine and Dentistry Trainee Academic Mentoring Award 2015
Brown University Seed Fund Award (Co-investigator) 2007
Rhode Island Foundation, Medical Research Grant 2005
Honor student of 1992 by Korea University 1992

Recent Journal Articles

Showing the 5 most recent journal articles. 46 available »

2015 Sep 4
Lim K, Hyun YM, Lambert-Emo K, Capece T, Bae S, Miller R, Topham DJ, Kim M. "Neutrophil trails guide influenza-specific CD8? T cells in the airways." Science. 2015 Sep 4; 349(6252):aaa4352.
2015 Sep 2
Lim K, Hyun YM, Lambert-Emo K, Topham DJ, Kim M. "Visualization of integrin Mac-1 in vivo." Journal of immunological methods. 2015 Sep 2; Epub 2015 Sep 02.
2015 Apr 13
Na BR, Kim HR, Piragyte I, Oh HM, Kwon MS, Akber U, Lee HS, Park DS, Song WK, Park ZY, Im SH, Rho MC, Hyun YM, Kim M, Jun CD. "TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse." The Journal of cell biology. 2015 Apr 13; 209(1):143-62.
2015 Jan 17
Haynes-Gimore N, Banach M, Brown E, Dawes R, Edholm ES, Kim M, Robert J. "Semi-solid tumor model in Xenopus laevis/gilli cloned tadpoles for intravital study of neovascularization, immune cells and melanophore infiltration." Developmental biology. 2015 Jan 17; Epub 2015 Jan 17.
Lerman YV, Kim M. "Neutrophil migration under normal and sepsis conditions." Cardiovascular & hematological disorders drug targets. 2015 15(1):19-28.

Current Appointments

Associate Professor - Department of Microbiology and Immunology, Center for Vaccine Biology and Immunology (SMD) - Primary
Associate Professor - Department of Pharmacology and Physiology (SMD)


PhD | Pharmacology | Ohio State University2001
BS | Genetic Engineering | Korea-Korea University1993

Post-Doctoral Training & Residency

Center for Blood Research, Harvard Medical School, Boston, MA 2004