Unlike cells within solid tissues, circulating lymphocytes and other leukocytes continuously migrate and relocate during the course of immune reactions. A subset of integrins (LFA-1, Mac-1, and VLA-4) are expressed on immune cells and play a major role in regulating recruitment of immuno-competent cells to normal or damaged and infected tissues. Under a wide range of pathologic conditions such as autoimmune disease, chronic inflammation, and transplantation rejection, integrin activations are mis-regulated resulting in abnormal leukocyte trafficking, and direct damage to the vasculature and the underlying host tissue.
Understanding how T cells and neutrophils home to and migrate within tissues is a major focus of our research.
- Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model. Neurobiol Aging. 35, 1286-92. (2014 Jun 01).
- Optogenetic control of chemokine receptor signal and T-cell migration. Proc Natl Acad Sci U S A. 111, 6371-6. (2014 Apr 29).
- MLK3 regulates fMLP-stimulated neutrophil motility. Mol Immunol. 58, 214-22. (2014 Apr 01).