Unlike cells within solid tissues, circulating lymphocytes and other leukocytes continuously migrate and relocate during the course of immune reactions. A subset of integrins (LFA-1, Mac-1, and VLA-4) are expressed on immune cells and play a major role in regulating recruitment of immuno-competent cells to normal or damaged and infected tissues. Under a wide range of pathologic conditions such as autoimmune disease, chronic inflammation, and transplantation rejection, integrin activations are mis-regulated resulting in abnormal leukocyte trafficking, and direct damage to the vasculature and the underlying host tissue.
Understanding how T cells and neutrophils home to and migrate within tissues is a major focus of our research.
- Role of β1 integrin in tissue homing of neutrophils during sepsis. Shock. 38, 281-7. (2012 Aug 01).
- Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. J Exp Med. 209, 1349-62. (2012 Jul 02).
- Opposing roles for RhoH GTPase during T-cell migration and activation. Proc Natl Acad Sci U S A. 109, 10474-9. (2012 Jun 26).