Principal Investigator

Photo of Minsoo Kim
Minsoo Kim, Ph.D. University of Rochester work Rochester NY p +1-585-276-3917

Contact

Kim Lab University of Rochester work KMRB 3-9858 601 Elmwood Ave Rochester NY 14642 p +1-585-273-1435

Affiliations

Overview

Live FRET image (VLA-4 activation) on TIRFM

Total integrin LFA-1 (red) and active LFA-1 (green) staining on human T cell

Inflammation caused by tissue damage or injury characterized by redness, heat, swelling, and pain is a necessary and beneficial process for the survival of the host as a defense reaction. One of major inflammatory responses is leukocytes (white blood cells) transmigration through blood vessel endothelium and accumulation at the site of injury. The primary objective of inflammation is to localize and eradicate the pathogens and irritants, and repair the surrounding tissue. However, inflammation sometime can cause autoimmune diseases or systemic inflammatory reactions by hypersensitive response. Since the one of ultimate goals of inflammation research is to develop methods to control inflammation by modulating and blocking hyperactive leukocyte infiltration into tissues, the roles of integrins, cell surface adhesion molecules involved in leukocyte migration, have been investigated.

Recent Publications

    1. Lefort CT
    2. Hyun YM
    3. Schultz JB
    4. Law FY
    5. Waugh RE
    6. Knauf PA
    7. Kim M
    (2009 Nov 05). Outside-in signal transmission by conformational changes in integrin Mac-1. J Immunol. 183, 6460-8.Abstract on PubMed
    1. Hyun YM
    2. Chung HL
    3. McGrath JL
    4. Waugh RE
    5. Kim M
    (2009 Jun 22). Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1. J Immunol. 183, 359-69.Abstract on PubMed
    1. Elphick GF
    2. Sarangi PP
    3. Hyun YM
    4. Hollenbaugh JA
    5. Ayala A
    6. Biffl WL
    7. Chung HL
    8. Rezaie AR
    9. McGrath JL
    10. Topham DJ
    11. Reichner JS
    12. Kim M
    (2009 Apr 24). Recombinant human activated protein C inhibits integrin-mediated neutrophil migration. Blood. 113, 4078-85.Abstract on PubMed

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