Unlike cells within solid tissues, circulating lymphocytes and other leukocytes continuously migrate and relocate during the course of immune reactions. A subset of integrins (LFA-1, Mac-1, and VLA-4) are expressed on immune cells and play a major role in regulating recruitment of immuno-competent cells to normal or damaged and infected tissues. Under a wide range of pathologic conditions such as autoimmune disease, chronic inflammation, and transplantation rejection, integrin activations are mis-regulated resulting in abnormal leukocyte trafficking, and direct damage to the vasculature and the underlying host tissue.
Understanding how T cells and neutrophils home to and migrate within tissues is a major focus of our research.
Minsoo Kim to serve as member of the Atherosclerosis and Inflammation of the Cardiovascular Systems Study Section, Center for Scientific Review
- TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.J Cell Biol. 209, 143-62. (2015 Apr 13).
- Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin α3β1-dependent.Blood. 124, 3515-23. (2014 Dec 04).
- Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model.Neurobiol Aging. 35, 1286-92. (2014 Jun 01).