Juilee Thakar, Ph.D.

Juilee Thakar, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box CU420630
Rochester, NY 14642

Lab Information

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Research Bio

Thakar lab uses systems biology approaches to identify immune signatures that can predict outcome of an immune response to infections or vaccinations. We are particularly interested in understanding dynamics of respiratory infections by single and multiple pathogens. We develop computational tools to model probable trajectories of the immune response which then allows us to identify parameters that can predict future outcomes of the disease. This has direct implications in early diagnosis. The models also reveal the mechanisms of pathogenesis. This work is based on multi-parameter datasets including gene expression, serum cytokine levels and known information about signaling and metabolic pathways.

Recent Journal Articles

Showing the 5 most recent journal articles. 23 available »

2014 Mar
Qian F, Thakar J, Yuan X, Nolan M, Murray KO, Lee WT, Wong SJ, Meng H, Fikrig E, Kleinstein SH, Montgomery RR. "Immune markers associated with host susceptibility to infection with West Nile virus." Viral immunology. 2014 Mar; 27(2):39-47.
2014
Albert R, Thakar J. "Boolean modeling: a logic-based dynamic approach for understanding signaling and regulatory networks and for making useful predictions." Wiley interdisciplinary reviews. Systems biology and medicine. 2014 6(5):353-69.
2013 Nov
Thakar J, Schmid S, Duke JL, GarcĂ­a-Sastre A, Kleinstein SH. "Overcoming NS1-mediated immune antagonism involves both interferon-dependent and independent mechanisms." Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2013 Nov; 33(11):700-8. Epub 2013 Jun 17.
2013 Oct
Yaari G, Bolen CR, Thakar J, Kleinstein SH. "Quantitative set analysis for gene expression: a method to quantify gene set differential expression including gene-gene correlations." Nucleic acids research. 2013 Oct; 41(18):e170. Epub 2013 Aug 05.
2013 Mar 6
Lass S, Hudson PJ, Thakar J, Saric J, Harvill E, Albert R, Perkins SE. "Generating super-shedders: co-infection increases bacterial load and egg production of a gastrointestinal helminth." Journal of the Royal Society, Interface. 2013 Mar 6; 10(80):20120588. Epub 2012 Dec 19.

Current Appointments

Assistant Professor - Department of Microbiology and Immunology (SMD) - Primary
Assistant Professor - Department of Biostatistics and Computational Biology (SMD)

Education

PhD | Bioinformatics | Germany-U Wurzburg2006
MSc | Microbiology | India-Univ of Pune, Pune2003
BSc | Microbiology | India-Univ of Pune, Pune2001

Post-Doctoral Training & Residency

Associate Research Scientist, Department of Pathology, Yale School of Medicine, USA 2013
Cancer Research Institute fellow, Department of Physics, Pennsylvania State University, USA 2010