Juilee Thakar, Ph.D.

Juilee Thakar, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box CU420630
Rochester, NY 14642

Office: (585) 276-6925

Lab Information

Visit Lab Website »


Research Bio

Thakar lab uses systems biology approaches to identify immune signatures that can predict outcome of an immune response to infections or vaccinations. We are particularly interested in understanding dynamics of respiratory infections by single and multiple pathogens. We develop computational tools to model probable trajectories of the immune response which then allows us to identify parameters that can predict future outcomes of the disease. This has direct implications in early diagnosis. The models also reveal the mechanisms of pathogenesis. This work is based on multi-parameter datasets including gene expression, serum cytokine levels and known information about signaling and metabolic pathways.

Recent Journal Articles

Showing the 5 most recent journal articles. 27 available »

2015 Jul 29
Hartmann BM, Thakar J, Albrecht RA, Avey S, Zaslavsky E, Marjanovic N, Chikina M, Fribourg M, Hayot F, Schmolke M, Meng H, Wetmur J, GarcĂ­a-Sastre A, Kleinstein SH, Sealfon SC. "Human dendritic cell response signatures distinguish 1918, pandemic and seasonal H1N1 influenza viruses." Journal of virology. 2015 Jul 29; Epub 2015 Jul 29.
2015 Jan
Thakar J, Mohanty S, West AP, Joshi SR, Ueda I, Wilson J, Blevins TP, Tsang S, Trentalange M, Siconolfi B, Park K, Gill TM, Belshe RB, Kaech SM, Shadel GS, Kleinstein SH, Shaw AC. "Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination." Aging. 2015 Jan; 7(1):38-52.
2015
Khurana JK, Reeder JE, Shrimpton AE, Thakar J. "GESPA: classifying nsSNPs to predict disease association." BMC bioinformatics. 2015 16:228. Epub 2015 Jul 25.
2015
Thakar J, Hartmann BM, Marjanovic N, Sealfon SC, Kleinstein SH. "Comparative analysis of anti-viral transcriptomics reveals novel effects of influenza immune antagonism." BMC immunology. 2015 16(1):46. Epub 2015 Aug 14.
2014 Mar
Qian F, Thakar J, Yuan X, Nolan M, Murray KO, Lee WT, Wong SJ, Meng H, Fikrig E, Kleinstein SH, Montgomery RR. "Immune markers associated with host susceptibility to infection with West Nile virus." Viral immunology. 2014 Mar; 27(2):39-47.

Current Appointments

Assistant Professor - Department of Microbiology and Immunology (SMD) - Primary
Assistant Professor - Department of Biostatistics and Computational Biology (SMD)

Education

PhD | Bioinformatics | Germany-U Wurzburg2006
MSc | Microbiology | India-Univ of Pune, Pune2003
BSc | Microbiology | India-Univ of Pune, Pune2001

Post-Doctoral Training & Residency

Associate Research Scientist, Department of Pathology, Yale School of Medicine, USA 2013
Cancer Research Institute fellow, Department of Physics, Pennsylvania State University, USA 2010