Haber Lab
Suzanne N. Haber, Ph.D.
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| View Dr. Haber's profile |
Professor:
- Department of Pharmacology & Physiology (SMD) - Primary
- Department of Neurobiology & Anatomy (SMD)
- Department of Brain & Cognitive Sciences (RC)
Affiliations:
- Cellular and Molecular Pharmacology and Physiology
- Interdepartmental Graduate Program in Neuroscience
Other:
Research Overview
Dr. Haber's laboratory investigates the neural network that underlies incentive-based learning and decision-making leading to the development of action plans. The cortico-basal ganglia system is at the center of this circuit and comprises a diverse group of structures involved in reward and motivation, cognition, and motor control. The consequence of basal ganglia dysfunction is emphasized in the range of diseases that involve it, including mental health disorders such as obsessive-compulsive disorder, drug abuse and addiction, and schizophrenia, and motor control disorders including Parkinson’s disease. One set of experiments in Dr. Haber's laboratory address the hypothesis that the cortico-basal ganglia network processes information through both parallel and integrative circuits. A second set of studies focus on the pathway trajectories from different prefrontal areas to their targets. A third set of experiments focus on which pathways and terminals fields are likely to be involved in the therapeutic effects of during deep brain stimulation (DBS). A fourth set of studies address the changes in terminal fields and white matter tracts during postnatal development. Movie of basal ganglia structures
Projects
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1) Organization of cortical and subcortical connectives: 1.1. Topographic and non-topographic cortico-striatal organization of terminal fields; 1.2. Cortico-subthalamic projections; 1.3 Cortico-thalamo-cortical circuits; 1.4 Habenular connections. Movie of monkey cortical-striatal projections. Movie of rat cortical-striatal projections. Movie of striatal-nigral spiral. |
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2) Rules the prefrontal cortical pathways use to get their targets. Movie of vmPFC cortical & subcortical pathways. Movie of OFC cortical & subcortical pathways. |
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3) Terminals and pathways effected during DBS. Movie of overview of deep brain stimulation. Movie of model of electrode in internal capsule. |
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4) Postnatal development of cortical conectivities and pathways |
Recent Publications
Lehman, J., Benjamin D. Greenberg, B.D. Cameron, C.M., Rasmussen, S. A., Haber, S. N. Rules ventral prefrontal cortical axons use to reach their targets: implications for DTI tractography and deep brain stimulation for psychiatric illness. 2006, J. Neurosci., 2011, 31(28):10392-10402.
Haber, S.N., Knutson, B., The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology Reviews, 2010, 35:4-26.
Greenberg BD, Rauch SL, Haber SN. Invasive Circuitry-Based Aerotherapeutics: Stereotactic Ablation and Deep Brain Stimulation for OCD. Neuropsychopharmacology Reviews, 2010, 35:317-336.
Haber, S.N., Calzavara, R., The cortico-basal ganglia integrative network: the role of the thalamus, 2009. Brain Research Bulletin, 78:69-74.
Suzanne N. Haber, Ph.D.
University of Rochester
School of Medicine and Dentistry
Box 711
601 Elmwood Avenue
Rochester, NY 14642
Telephone: 585 275-4538
Fax: 585-273-2652
Lab Members
