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Alan Smrcka

Concepts (396)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of publications Most recent publication Publications by all authors Why?
GTP-Binding Protein gamma Subunits
19
2000
10
Why?
GTP-Binding Protein beta Subunits
19
2000
10
Why?
Type C Phospholipases
33
1991
34
Why?
GTP-Binding Proteins
28
1991
47
Why?
Isoenzymes
24
1992
144
Why?
Heterotrimeric GTP-Binding Proteins
10
2000
14
Why?
Phosphoinositide Phospholipase C
15
1991
9
Why?
Guanine Nucleotide Exchange Factors
8
2003
14
Why?
Signal Transduction
26
1992
313
Why?
Phospholipase C beta
18
1996
10
Why?
Protein Binding
22
1991
256
Why?
GTP-Binding Protein alpha Subunits
6
2005
6
Why?
Myocytes, Cardiac
6
2005
40
Why?
Peptides
10
2001
154
Why?
Receptors, G-Protein-Coupled
6
2004
41
Why?
Animals
61
1991
1031
Why?
Drug Evaluation, Preclinical
3
2006
65
Why?
Amino Acid Sequence
18
1993
319
Why?
Cardiomegaly
2
2005
36
Why?
Receptors, Adrenergic, beta
3
2005
35
Why?
Calcium Signaling
4
2006
52
Why?
Xanthenes
6
2006
8
Why?
Recombinant Proteins
20
1991
290
Why?
Myocardium
2
2007
119
Why?
Molecular Sequence Data
18
1993
404
Why?
Peptide Fragments
5
1993
144
Why?
Drug Design
2
2008
33
Why?
Enzyme Activation
19
1991
177
Why?
ras Proteins
3
2001
16
Why?
Binding Sites
10
1991
213
Why?
Protein Interaction Mapping
3
2005
19
Why?
Calcium
8
1991
208
Why?
Calcium-Calmodulin-Dependent Protein Kinase Type 2
2
2007
17
Why?
Molecular Targeted Therapy
1
2011
4
Why?
Cyclohexanes
4
2006
15
Why?
A Kinase Anchor Proteins
1
2011
4
Why?
Guanosine Triphosphate
3
1991
22
Why?
Chemotaxis, Leukocyte
3
1996
23
Why?
Nuclear Envelope
1
2011
14
Why?
Protein Subunits
6
2002
44
Why?
Cystamine
1
2010
4
Why?
Organoselenium Compounds
1
2010
6
Why?
Drug Delivery Systems
1
2011
55
Why?
Mice
21
1994
623
Why?
Chromatography, Affinity
5
1993
49
Why?
Neutrophils
5
1994
114
Why?
Muscle Proteins
1
2011
56
Why?
Phosphoric Diester Hydrolases
6
1991
29
Why?
Spodoptera
8
1996
12
Why?
Intracellular Signaling Peptides and Proteins
2
2006
73
Why?
Rats
15
1991
530
Why?
Kinetics
12
1991
349
Why?
Cell Migration Inhibition
1
2007
5
Why?
Cell Line
14
1991
375
Why?
GTP-Binding Protein alpha Subunits, Gi-Go
3
2000
13
Why?
Cyclic AMP
6
2005
89
Why?
Morphine
4
1999
38
Why?
Protein Structure, Tertiary
5
2004
163
Why?
Receptor, Parathyroid Hormone, Type 1
1
2005
9
Why?
Myocardial Contraction
1
2005
52
Why?
Hormones
2
1991
36
Why?
Mice, Knockout
9
1999
265
Why?
GTP-Binding Protein alpha Subunits, G12-G13
1
2004
2
Why?
Crystallography, X-Ray
3
2005
41
Why?
Humans
29
1992
1856
Why?
Sarcoplasmic Reticulum
3
2005
21
Why?
Models, Molecular
4
2004
102
Why?
Ligands
4
2009
116
Why?
Peptide Library
4
2002
21
Why?
Phospholipids
3
1996
52
Why?
Mutation
5
2001
340
Why?
Receptors, Opioid, mu
3
1999
15
Why?
Ribulose-Bisphosphate Carboxylase
2
1991
2
Why?
Insulin-Secreting Cells
2
2010
7
Why?
Pertussis Toxin
5
1994
25
Why?
Nuclear Proteins
1
2005
139
Why?
Cloning, Molecular
8
1991
183
Why?
Binding, Competitive
3
2000
109
Why?
HL-60 Cells
3
2006
28
Why?
Transfection
10
1993
237
Why?
G-Protein-Coupled Receptor Kinase 2
2
2006
6
Why?
Phosphatidylinositol 4,5-Diphosphate
6
1991
15
Why?
Gene Expression Regulation, Enzymologic
4
1997
104
Why?
Mutagenesis, Site-Directed
4
1994
126
Why?
Phosphatidylinositol 3-Kinases
8
1994
67
Why?
rap GTP-Binding Proteins
2
2006
4
Why?
Sequence Homology, Amino Acid
3
2001
156
Why?
Cross-Linking Reagents
3
1998
38
Why?
Transducin
3
1995
7
Why?
Lipid Bilayers
1
1996
16
Why?
Guanosine Diphosphate
3
1991
9
Why?
Analgesics
2
2006
47
Why?
Models, Biological
5
1993
410
Why?
Computer Simulation
2
2006
134
Why?
rho GTP-Binding Proteins
2
2004
16
Why?
Insects
3
1997
11
Why?
Baculoviridae
5
1993
23
Why?
Glutathione Transferase
2
2000
45
Why?
Recombinant Fusion Proteins
3
1996
189
Why?
Cells, Cultured
6
2003
447
Why?
Cyanobacteria
2
1991
2
Why?
Enzyme-Linked Immunosorbent Assay
3
2002
224
Why?
HEK293 Cells
2
2010
16
Why?
Dimerization
2
2004
92
Why?
Heart Failure
2
2005
106
Why?
Phosphatidylinositol Phosphates
5
1991
6
Why?
N-Formylmethionine Leucyl-Phenylalanine
3
1996
14
Why?
COS Cells
3
2001
73
Why?
Phosphotransferases (Alcohol Group Acceptor)
5
1994
19
Why?
Guanosine 5'-O-(3-Thiotriphosphate)
7
1992
8
Why?
Macromolecular Substances
8
1991
92
Why?
Proto-Oncogene Proteins
2
2000
113
Why?
Mitogen-Activated Protein Kinases
2
2003
68
Why?
Cell Membrane
4
1993
170
Why?
GTP-Binding Protein alpha Subunits, Gq-G11
2
2000
9
Why?
Amino Acid Substitution
2
2000
68
Why?
Gene Expression Regulation
5
1999
277
Why?
Hydrolysis
6
1991
57
Why?
Phosphatidylinositol Diacylglycerol-Lyase
6
1991
10
Why?
Surface Plasmon Resonance
1
2011
10
Why?
Sugar Alcohols
1
1991
3
Why?
Pentosephosphates
1
1991
3
Why?
Aluminum Compounds
1
1991
7
Why?
Adenylate Cyclase
3
1994
24
Why?
GTP-Binding Protein alpha Subunits, Gs
1
2010
5
Why?
Venoms
1
2010
2
Why?
Mass Spectrometry
1
2011
57
Why?
Receptors, Glucagon
1
2010
3
Why?
Esters
1
2010
20
Why?
Suppressor of Cytokine Signaling Proteins
1
2010
9
Why?
Adenosine Diphosphate Ribose
3
1996
10
Why?
Organ Specificity
1
2011
104
Why?
Chromatography, Ion Exchange
5
1991
36
Why?
Lysophospholipids
3
2004
19
Why?
Substrate Specificity
2
1991
90
Why?
Glucagon
1
2010
31
Why?
Hepatocytes
1
2010
42
Why?
Nitrogen Isotopes
1
2009
4
Why?
Quantum Theory
1
2009
7
Why?
Proline-Rich Protein Domains
1
2009
4
Why?
Mice, Inbred ICR
2
2006
34
Why?
Rats, Sprague-Dawley
2
2006
257
Why?
Tryptophan
1
2009
21
Why?
Mammals
3
1996
47
Why?
Hyperalgesia
1
2009
3
Why?
rhoA GTP-Binding Protein
1
2009
11
Why?
Pain Threshold
1
2009
11
Why?
Protein Structure, Secondary
2
2005
54
Why?
Oxidation-Reduction
1
2010
124
Why?
Mitochondrial Proteins
1
2009
26
Why?
Morphine Dependence
1
2008
3
Why?
Protein Kinase C-epsilon
1
2008
9
Why?
Benzylamines
1
2008
9
Why?
Detergents
2
1996
25
Why?
Drug Tolerance
1
2008
26
Why?
Insulin
2
1994
129
Why?
Static Electricity
1
2008
17
Why?
Peptide Mapping
1
2008
27
Why?
Phosphorylation
3
1996
224
Why?
Multiprotein Complexes
1
2008
11
Why?
CHO Cells
2
2005
65
Why?
Magnetic Resonance Spectroscopy
1
2009
74
Why?
Membrane Proteins
2
1991
233
Why?
Protein Conformation
1
2009
123
Why?
Calcium Channels, L-Type
1
2008
15
Why?
Consensus Sequence
2
2003
39
Why?
Calcium-Binding Proteins
1
2008
49
Why?
Cercopithecus aethiops
3
1996
67
Why?
Protein Kinase Inhibitors
1
2008
59
Why?
Dendritic Cells
1
2009
60
Why?
Protein Transport
1
2008
101
Why?
Cricetinae
2
2005
130
Why?
Sulfonamides
1
2008
74
Why?
Mice, Inbred C57BL
3
2005
318
Why?
Ryanodine Receptor Calcium Release Channel
1
2008
21
Why?
Retinal Rod Photoreceptor Cells
1
2007
7
Why?
Cell-Free System
1
2007
34
Why?
Dose-Response Relationship, Drug
3
2000
431
Why?
Sepharose
1
2007
13
Why?
Electric Stimulation
1
2007
101
Why?
Retinal Cone Photoreceptor Cells
1
2007
9
Why?
Edema
1
2007
67
Why?
Evoked Potentials
1
2006
44
Why?
Nephrotic Syndrome
1
2006
16
Why?
Liposomes
1
2007
38
Why?
Structure-Activity Relationship
2
1994
124
Why?
beta-Adrenergic Receptor Kinases
1
2006
8
Why?
Transduction, Genetic
1
2006
65
Why?
Molecular Structure
1
2006
67
Why?
Mitochondria
1
2009
100
Why?
Isoproterenol
1
2005
47
Why?
Cysteine
2
1996
52
Why?
Heparin
1
2007
87
Why?
Surface Properties
1
2005
63
Why?
Software
1
2006
92
Why?
Phosphoproteins
2
2000
86
Why?
Sequence Deletion
2
2001
88
Why?
Caveolae
1
2004
3
Why?
Catalytic Domain
1
2004
27
Why?
Myocardial Ischemia
1
2006
62
Why?
Astrocytes
1
2007
62
Why?
MAP Kinase Signaling System
1
2005
56
Why?
Adenosine Diphosphate
1
2004
30
Why?
Phosphatidylinositols
3
1992
17
Why?
Endocytosis
1
2004
38
Why?
Protein Prenylation
2
1996
3
Why?
src-Family Kinases
1
2004
30
Why?
Sphingosine
1
2004
16
Why?
cdc42 GTP-Binding Protein
1
2003
3
Why?
Biotinylation
1
2003
7
Why?
Restriction Mapping
2
1993
74
Why?
Inflammation
1
2007
208
Why?
Receptor Protein-Tyrosine Kinases
1
2004
40
Why?
Cattle
6
1991
176
Why?
Chromatography, Gel
2
1993
61
Why?
Genetic Vectors
2
1993
139
Why?
Male
8
1991
1553
Why?
Mitogen-Activated Protein Kinase 3
1
2003
37
Why?
Mitogen-Activated Protein Kinase 1
1
2003
36
Why?
Mice, Transgenic
3
2007
209
Why?
Bacteriophage M13
1
2002
8
Why?
RNA, Messenger
2
2005
394
Why?
Virulence Factors, Bordetella
3
1994
22
Why?
Endothelial Cells
1
2004
80
Why?
Coliphages
1
2001
11
Why?
Point Mutation
2
1996
122
Why?
Brain
4
1992
305
Why?
GTP Phosphohydrolases
3
1991
21
Why?
RGS Proteins
1
2000
4
Why?
Escherichia coli
3
1991
143
Why?
Protein-Serine-Threonine Kinases
1
2003
105
Why?
Histidine
1
2000
42
Why?
Molecular Weight
2
1991
154
Why?
Trypsin
1
2000
63
Why?
GTP-Binding Protein alpha Subunit, Gi2
1
2000
3
Why?
Enzyme Inhibitors
2
1996
216
Why?
Mutagenesis
1
2001
74
Why?
Chemotactic Factors
1
2000
14
Why?
Receptors, Complement
2
1996
10
Why?
Enkephalins
1
1999
14
Why?
Potassium Channels
1
2001
33
Why?
Carrier Proteins
1
2003
177
Why?
Receptors, Cell Surface
1
2000
115
Why?
Neurons, Afferent
1
1999
48
Why?
Base Sequence
2
1994
371
Why?
Drug Interactions
2
2008
111
Why?
Muscle, Smooth, Vascular
1
2003
59
Why?
Reaction Time
2
2008
81
Why?
Receptors, Muscarinic
2
1992
16
Why?
Pain Measurement
2
2008
98
Why?
Antigens, CD
2
1996
128
Why?
Leukemia, Promyelocytic, Acute
2
1993
16
Why?
Sequence Alignment
1
1998
114
Why?
Chemotaxis
2
2003
20
Why?
Energy Transfer
1
1996
19
Why?
Tumor Cells, Cultured
3
1993
233
Why?
Receptors, Peptide
1
1996
4
Why?
Receptors, Immunologic
1
1996
36
Why?
Spectrometry, Fluorescence
1
1996
59
Why?
Pain
1
1999
191
Why?
Protein-Tyrosine Kinases
1
1996
77
Why?
Aluminum
2
1991
17
Why?
Disease Models, Animal
2
2006
349
Why?
Time Factors
3
2000
896
Why?
Fluorides
2
1991
35
Why?
Magnesium Chloride
1
1993
7
Why?
Liver
3
1991
248
Why?
Azides
1
1991
17
Why?
Swine
3
1994
95
Why?
Fabaceae
1
1991
2
Why?
GTP-Binding Protein Regulators
1
2011
1
Why?
Fluorescence Resonance Energy Transfer
1
2011
18
Why?
Plants, Medicinal
1
1991
15
Why?
Vasopressins
1
1991
21
Why?
Protein Structure, Quaternary
1
2011
18
Why?
Molecular Dynamics Simulation
1
2011
4
Why?
Protein Multimerization
1
2011
17
Why?
8-Bromo Cyclic Adenosine Monophosphate
1
2010
16
Why?
Thapsigargin
1
2010
18
Why?
Eye Proteins
1
2011
26
Why?
Water
1
2011
85
Why?
Immunoglobulin G
1
1993
191
Why?
Gluconeogenesis
1
2010
22
Why?
Staurosporine
1
2009
24
Why?
Periaqueductal Gray
1
2009
5
Why?
Drug Administration Routes
1
2009
10
Why?
Moths
3
1993
16
Why?
Exploratory Behavior
1
2009
15
Why?
Ovalbumin
1
2009
32
Why?
Cyclic AMP-Dependent Protein Kinases
1
2010
62
Why?
Xenopus
1
2010
37
Why?
RNA, Small Interfering
1
2010
116
Why?
DNA
2
1991
262
Why?
Somatostatin
1
2009
15
Why?
Immunoprecipitation
1
2009
57
Why?
Plasmids
1
1991
122
Why?
Luciferases
1
2009
70
Why?
Inositol Phosphates
1
2008
19
Why?
Cell Culture Techniques
1
2009
74
Why?
Naloxone
1
2008
22
Why?
Cricetulus
1
2008
39
Why?
Kidney
2
1996
223
Why?
Disease Progression
1
2010
244
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2010
243
Why?
Carbachol
1
2007
30
Why?
Behavior, Animal
1
2008
77
Why?
Cell Movement
1
2009
163
Why?
Genes, Recessive
1
2006
33
Why?
Vision, Ocular
1
2007
34
Why?
Nucleotides
1
2006
22
Why?
Zebrafish
1
2006
17
Why?
Homozygote
1
2006
68
Why?
Gene Expression
1
2010
291
Why?
Receptor, Anaphylatoxin C5a
2
1996
1
Why?
Blotting, Western
3
1991
275
Why?
Gene Targeting
1
2006
51
Why?
Photic Stimulation
1
2007
58
Why?
Models, Genetic
1
2006
90
Why?
Methylation
2
1995
36
Why?
Endothelin-1
1
2005
19
Why?
Genotype
1
2007
175
Why?
Gene Library
1
2006
50
Why?
Rats, Wistar
1
2006
75
Why?
DNA, Complementary
2
1996
139
Why?
Mutation, Missense
1
2006
59
Why?
Asthma
1
2009
97
Why?
Protein Isoforms
1
2005
86
Why?
Dynamin II
1
2004
1
Why?
Caveolins
1
2004
6
Why?
Caveolin 1
1
2004
12
Why?
Anoxia
1
2006
85
Why?
Second Messenger Systems
1
2004
19
Why?
Thrombin
1
2005
41
Why?
Extracellular Signal-Regulated MAP Kinases
1
2004
32
Why?
Albumins
1
2004
33
Why?
Sialoglycoproteins
1
2004
31
Why?
Complement C5a
1
2003
1
Why?
Cell Proliferation
1
2007
227
Why?
Cell Polarity
1
2003
24
Why?
Fluorescent Dyes
1
2004
115
Why?
Apoptosis
1
2009
265
Why?
Fibroblasts
1
2005
179
Why?
Actins
1
2003
112
Why?
Precipitin Tests
2
1991
81
Why?
Receptor, Muscarinic M2
1
2000
3
Why?
Electrophoresis, Polyacrylamide Gel
2
1991
167
Why?
Infant
1
2006
464
Why?
Immunoglobulin lambda-Chains
1
2000
11
Why?
Skin Ulcer
1
2000
8
Why?
Chemokine CCL4
1
2000
16
Why?
Neutrophil Infiltration
1
2000
17
Why?
Macrophage Inflammatory Proteins
1
2000
17
Why?
Peritonitis
1
2000
28
Why?
Endothelium, Vascular
1
2004
139
Why?
Superoxides
1
2000
36
Why?
Child, Preschool
1
2006
554
Why?
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
1
1999
7
Why?
Female
2
2006
1643
Why?
Ganglia, Spinal
1
1999
21
Why?
Receptors, Opioid, delta
1
1999
7
Why?
Receptors, Opioid, kappa
1
1999
7
Why?
Membrane Potentials
1
1999
99
Why?
Calcium Channels
1
1999
52
Why?
Child
1
2006
749
Why?
Lung
1
2004
232
Why?
Genistein
1
1996
12
Why?
Isoflavones
1
1996
10
Why?
Esterases
1
1996
7
Why?
Receptors, Formyl Peptide
1
1996
4
Why?
Cytosol
1
1997
79
Why?
Enzymes, Immobilized
1
1996
7
Why?
Phosphatidylcholines
1
1996
28
Why?
Micelles
1
1995
8
Why?
Rhodopsin
1
1995
3
Why?
B-Lymphocytes
1
2000
134
Why?
Glutamic Acid
1
1996
66
Why?
Adenylate Cyclase Toxin
1
1994
4
Why?
Androstadienes
1
1994
25
Why?
Indicators and Reagents
1
1994
79
Why?
Calmodulin
1
1994
34
Why?
Sensitivity and Specificity
1
1997
427
Why?
Polymerase Chain Reaction
1
1996
279
Why?
Magnesium
1
1993
69
Why?
Protein Processing, Post-Translational
1
1994
78
Why?
DNA Primers
1
1994
208
Why?
Gene Transfer Techniques
1
1993
59
Why?
Lipid Metabolism
1
1992
50
Why?
Bradykinin
1
1991
12
Why?
Immune Sera
1
1991
56
Why?
Receptors, Vasopressin
1
1991
5
Why?
Adenosine Triphosphate
1
1994
121
Why?
Affinity Labels
1
1991
17
Why?
Photochemistry
1
1991
17
Why?
Receptors, Angiotensin
1
1991
10
Why?
Angiotensin II
1
1991
31
Why?
Rats, Inbred Strains
1
1991
170
Why?

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