Flaum Eye Institute / Research / Labs / Kiernan Lab / Publications Recent Publications Brown RMNelson JCZhang HKiernan AEGroves AK Notch-mediated lateral induction is necessary to maintain vestibular prosensory identity during inner ear development.; Developmental biology; Vol 462(1). 2020 Jun 01. Steevens ARGlatzer JCKellogg CCLow WCSanti PAKiernan AE SOX2 is required for inner ear growth and cochlear nonsensory formation prior to sensory development.; Development (Cambridge, England). 2019 May 31. Johnson KRGagnon LHTian CLongo-Guess CMLow BEWiles MVKiernan AE Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear Development in Mice.; Genetics; Vol 208(3). 2018 Mar. Rausch RLLibby RTKiernan AE Trabecular meshwork morphogenesis: A comparative analysis of wildtype and anterior segment dysgenesis mouse models.; Experimental eye research. 2018 Feb 13. Rausch RLLibby RTKiernan AE Ciliary margin-derived BMP4 does not have a major role in ocular development.; PloS one; Vol 13(5). 2018. Steevens ARSookiasian DLGlatzer JCKiernan AE SOX2 is required for inner ear neurogenesis.; Scientific reports; Vol 7(1). 2017 Jun 22. Fernandes KAHarder JMWilliams PARausch RLKiernan AENair KSAnderson MGJohn SWHowell GRLibby RT Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.; Experimental eye research; Vol 141. 2015 Dec. Deng MLuo XJPan LYang HXie XLiang GHuang LHu FKiernan AEGan L LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 34(30). 2014 Jul 23. Savoy-Burke GGilels FAPan WPratt DQue JGan LWhite PMKiernan AE Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells.; PloS one; Vol 9(9). 2014. Pan WJin YChen JRottier RJSteel KPKiernan AE Ectopic expression of activated notch or SOX2 reveals similar and unique roles in the development of the sensory cell progenitors in the mammalian inner ear.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 33(41). 2013 Oct 9. Zhou YTanzie CYan ZChen SDuncan MGaudenz KLi HSeidel CLewis BMoran ALibby RTKiernan AEXie T Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye.; Proceedings of the National Academy of Sciences of the United States of America; Vol 110(22). 2013 May 28. Kiernan AE Notch signaling during cell fate determination in the inner ear.; Seminars in cell & developmental biology; Vol 24(5). 2013 May. Steffes GLorente-Cánovas BPearson SBrooker RHSpiden SKiernan AEGuénet JLSteel KP Mutanlallemand (mtl) and Belly Spot and Deafness (bsd) are two new mutations of Lmx1a causing severe cochlear and vestibular defects.; PloS one; Vol 7(11). 2012. Pan WJin YStanger BKiernan AE Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear.; Proceedings of the National Academy of Sciences of the United States of America; Vol 107(36). 2010 Sep 7. Kiernan AELi RHawes NLChurchill GAGridley T Genetic background modifies inner ear and eye phenotypes of jag1 heterozygous mice.; Genetics; Vol 177(1). 2007 Sep. Kiernan AE The paintfill method as a tool for analyzing the three-dimensional structure of the inner ear.; Brain research; Vol 1091(1). 2006 May 26. Kiernan AEXu JGridley T The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear.; PLoS genetics; Vol 2(1). 2006 Jan. Kiernan AECordes RKopan RGossler AGridley T The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.; Development (Cambridge, England); Vol 132(19). 2005 Oct. Kiernan AEPelling ALLeung KKTang ASBell DMTease CLovell-Badge RSteel KPCheah KS Sox2 is required for sensory organ development in the mammalian inner ear.; Nature; Vol 434(7036). 2005 Apr 21. Hulander MKiernan AEBlomqvist SRCarlsson PSamuelsson EJJohansson BRSteel KPEnerbäck S Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice.; Development (Cambridge, England); Vol 130(9). 2003 May. Kiernan AEErven AVoegeling SPeters JNolan PHunter JBacon YSteel KPBrown SDGuénet JL ENU mutagenesis reveals a highly mutable locus on mouse Chromosome 4 that affects ear morphogenesis.; Mammalian genome : official journal of the International Mammalian Genome Society; Vol 13(3). 2002 Mar. Alavizadeh AKiernan AENolan PLo CSteel KPBucan M The Wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects.; Developmental biology; Vol 234(1). 2001 Jun 01. Kiernan AEAhituv NFuchs HBalling RAvraham KBSteel KPHrabé de Angelis M The Notch ligand Jagged1 is required for inner ear sensory development.; Proceedings of the National Academy of Sciences of the United States of America; Vol 98(7). 2001 Mar 27. Tsai HHardisty RERhodes CKiernan AERoby PTymowska-Lalanne ZMburu PRastan SHunter AJBrown SDSteel KP The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti.; Human molecular genetics; Vol 10(5). 2001 Mar 01. Brigande JVKiernan AEGao XIten LEFekete DM Molecular genetics of pattern formation in the inner ear: do compartment boundaries play a role?; Proceedings of the National Academy of Sciences of the United States of America; Vol 97(22). 2000 Oct 24. Kiernan AESteel KP Mouse homologues for human deafness.; Advances in oto-rhino-laryngology; Vol 56. 2000. Kiernan AEZalzman MFuchs HHrabe de Angelis MBalling RSteel KPAvraham KB Tailchaser (Tlc): a new mouse mutation affecting hair bundle differentiation and hair cell survival.; Journal of neurocytology; Vol 28(10-11). 1999 Oct. Kiernan AENunes FWu DKFekete DM The expression domain of two related homeobox genes defines a compartment in the chicken inner ear that may be involved in semicircular canal formation.; Developmental biology; Vol 191(2). 1997 Nov 15. Kiernan AEFekete DM In vivo gene transfer into the embryonic inner ear using retroviral vectors.; Audiology & neuro-otology; Vol 2(1-2). 1997 Jan.