He has authored or co-authored a variety of papers and chapters on the assessment and treatment of sleep disorders and published more than 55 empirical or theoreetical papers on sleep related topics. He is also on the editorial boards of SLEEP and Journal_of_Sleep Research.

In addition to his academic endeavors, he has served as Assistant Director of Training for the SRS (1996-2000) and as the founding editor of the SRS & AASM Training Opportunities in Sleep Research and Sleep Medicine Manual. Dr. Perlis was a founding member of the American Academy of Sleep Medicine Presidential Committee on Behavioral Sleep Medicine, the section chair for Behavioral Sleep Medicine (2003-2004), and is the coordinator of the Early Career Faculty Development Group (aka the Junior Faculty in Sleep Research Interest Group).