Latest Grants & Awards
Wei Hsu, Ph.D.
Professsor of Biomedical Genetics in the Center for Oral Biology
Professor of Oncology in the Center for Oral Biology
Stem Cell-mediated Craniofacial Skeletogenesis in Health and Disease
The objective of this proposal is to identify and characterize the stem cells responsible for calvarial morphogenesis in health and disease.
Jose Lemos, Ph.D. (Co-PI)
Associate Professor of Microbiology in the Center for Oral Biology
Jacqueline Abranches, Ph.D. (Co-PI)
Research Associate Professor of Microbiology in the Center for Oral Biology
Intracellular Invasion by Streptococcus mutans: Significance in Disease
The goals of this application are to conduct the functional analysis of the collagen-binding protein Cnm and to characterize the role of Cnm in host-bacteria interactions. To achieve these goals, we propose to use in vitro approaches to further characterize, genetically and biochemically, Cnm and its associated proteins, an ex vivo adhesion model to examine the role of Cnm in the colonization of heart tissues, and an in vivo rabbit endocarditis model to conclusively demonstrate the contribution of Cnm to the pathogenesis of infective endocarditis.
Catherine Ovitt, Ph.D.
Associate Professor of Biomedical Genetics in the Center for Oral Biology
A Genetic Model for Salivary Gland Adenoid Cystic Carcinoma
Wilmot Cancer Center
The major goal of this proposal is to develop a model that can be used for the molecular investigation of adenoid cystic carcinoma (ACC) of the salivary gland. The second-most common of all salivary gland malignancies, ACC is an aggressive cancer, with very poor prognosis.