Ollivier Hyrien, PhD
Associate Professor of Biostatistics and Computational Biology Ph.D. (2001) University of Rennes I, France
Contact Information:
- University of Rochester
Dept of Biostatistics and Computational Biology
601 Elmwood Avenue Box 630
Rochester, New York 14642
Office: Saunders Research Building 4219
Phone: (585) 275-5303
Fax: (585) 273-1031
E-mail: Ollivier_Hyrien@urmc.rochester.edu
Research Interests
My research interests originate from the quantitative analysis of cellular systems. An example that motivated recent studies is oligodendrocytes (the myelin-forming cells of the central nervous system) and their progenitor cells cultured in vitro. Part of my work has been devoted to modeling the proliferation of cell populations using stochastic processes (such as branching processes). I am also involved in developing statistical methods to analyze data on cell kinetics generated by flow cytometry or clonal experiments. Simulation-based methods are of particular importance in this regard. Another area of interest is pharmacokinetics and pharmacodynamics modeling, and I am also currently involved in cancer-related collaborative studies.
Software
CFSE data (upcoming)
Selected References
- Godard, T, Fessard, V, Huet, S, Mourot, A, Deslandes, E, Pottier, D, Hyrien, O, Sichel, F, Gauduchon, P, and Poul, JM (1999). Comparative in vitro and in vivo assessment of genotoxic effects of etoposide and cholorotalonil by the comet assay. Mutation Research 444: 103-116.
- Hyrien, O, Klés, V, Concordet, D, Bonneu, M, Laurentie, M and Sanders, P (2001). Stochastic modeling in toxicokinetics, Application to the in vivo micronucleus assay. Mathematical Biosciences 169: 27-51.
- Klés, V, Hyrien, O, Poul, JM, and Sanders, P (2003). Application of pharmacokinetic/pharmacodynamic and stochastic modeling to 6-mercaptopurine micronucleus induction in mouse. Journal of Applied Toxicology 23:59-70.
- Baker, L, Hyrien, O and Ratka, A (2003). Contributions of morphine-3-glucuronide and morphine-6-glucoronide to differences in morphine analgesia in humans. American Journal of Pain Management 13:16-28.
- Hyrien, O, Mayer-Proschel, M, Noble, M and Yakovlev A (2005). A stochastic model to analyze clonal data on multi type cell populations. Biometrics 61:199-207.
- Hyrien, O, Mayer-Proschel, M, Noble, M and Yakovlev A (2005). Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture. Mathematical Biosciences 193:255-274.
- Chen, Y, Hyrien, O, Williams, J, Okunieff, P, Smudzin, T, Rubin, P (2005). IL-1a and IL-6: application to the predictive diagnostic testing of radiation pneumonitis. International Journal of Radiation Oncology, Biology, Physics 62(1):260-266.
- Hanin, L, Hyrien, O, Bedford J and Yakovlev A (2006). A comprehensive stochastic model of irradiated cell population in cell culture. Journal of Theoretical Biology 239(1):401-416.
- Hyrien, O, Ambeskovic, I, Mayer-Proschel, M, Noble, M and Yakovlev, A (2006). Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data. Theoretical Biology and Medical Modelling 3:21.
- Hyrien, O. (2007). A pseudo maximum likelihood estimator for discretely observed multitype Bellman-Harris branching processes, Journal of Statistical Planning and Inference, 137:1375-1388.
- Couderc, JP, McNitt, S, Hyrien, O, Vaglio, M, Xia, X, Polonsky, S, Moss, AJ, Zareba, W. (2007). Electrocardiographic Abnormalities of Repolarization Induced by Moxifloxacin: Improving the Detection of Subtle IKr-Inhibition. Drug Safety (in press).
- Dertinger, SD, Tsai, Y, Nowak, I, Hyrien, O., Sun, H, Bemis, JC, Torous, DK, Keng, P, Palis, J, and Chen, Y. (2007). Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry. Mutation Research (in press).
- Hyrien, O and Zand, MS (2007). A mixture model with dependent observations for the analysis of CFSE-labeling experiments. Journal of the American Statistical Association (in press).
