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Juilee Thakar, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-6925

Research Labs

Biography

Research

Thakar lab uses systems biology approaches to identify immune signatures that can predict outcome of an immune response to infections or vaccinations. We are particularly interested in understanding dynamics of respiratory infections by single and multiple pathogens. We develop computational tools to model probable trajectories of the immune response which then allows us to identify parameters that can predict future outcomes of the disease. This has direct implications in early diagnosis. The models also reveal the mechanisms of pathogenesis. This work is based on multi-parameter datasets including gene expression, serum cytokine levels and known information about signaling and metabolic pathways.

Credentials

Faculty Appointments

Education

2001
BSc | India-Univ of Pune, Pune
Microbiology and Mathematics

2003
MSc with certificate | India-Univ of Pune, Pune
Microbiology and Computational Biology

2006
PhD | Germany-U Wurzburg
Bioinformatics

Awards

2016 - 2017
Novel Biostatistical and Epidemiologic Methods (NBEM) Awards
Sponsor: Clinical & Translational Science Institute
Location: University of Rochester Medical School

2015 - 2016
PhRMA research starter award in informatics
Sponsor: Pharmaceutical Research and Manufacturers of America

2014
Beutner Speaker
Location: Buffalo Immunology Conference

2008 - 2010
Cancer-Research-Institute fellowship
Sponsor: Cancer Research Institute fellowship

2007
Shankar Subramaniam award in systems biology research
Location: Pennsylvania State University

2001
The Association for the Study of Animal Behavior fellowship
Location: Edinburgh, UK and Pune, India

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Publications

Journal Articles

11/15/2017
Mariani TJ, Qiu X, Chu CY, Wang L, Thakar J, Holden-Wiltse J, Corbett A, Topham DJ, Falsey AR, Caserta MT, Walsh EE. "Association of Dynamic Changes in the CD4 T-Cell Transcriptome With Disease Severity During Primary Respiratory Syncytial Virus Infection in Young Infants." The Journal of infectious diseases.. 2017 Nov 15; 216(8):1027-1037.

10/2017
Connor R, Jones LD, Qiu X, Thakar J, Maggirwar SB. "Frontline Science: c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection." Journal of leukocyte biology.. 2017 Oct 0; 102(4):953-964. Epub 2017 Jun 29.

7/1/2017
Zhang Y, Topham DJ, Thakar J, Qiu X. "FUNNEL-GSEA: FUNctioNal ELastic-net regression in time-course gene set enrichment analysis." Bioinformatics.. 2017 Jul 1; 33(13):1944-1952.

Books & Chapters

2011
Chapter Title: Mathematical Models as Tools to Enable Infectious Diseases Research
Book Title: Emerging Trends in Antibacterial Discovery
Author List: Juilee Thakar and Eric Harvill
Edited By: Alita A. Miller and Paul F. Miller
Published By: Caister Academic Press2011

2009
Chapter Title: Toward understanding the structure and function of cellular interaction networks
Book Title: Handbook of Large-Scale Random Networks
Author List: Juilee Thakar, Claire Christensen and Réka Albert
Edited By: Bella Bollobas, Robert Kozma and Dezso Miklos
Published By: Springer Verlag and Bolyai Mathematical Society2009

2009
Chapter Title: Boolean Networks in Inference and Dynamic Modeling of Biological Systems at the Molecular and Physiological Level
Book Title: Handbook on Biological Networks
Author List: Juilee Thakar and Réka Albert
Edited By: Stefano Boccaletti, Vito Latora and Yamir Moreno
Published By: World Scientific publishing group2009

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