Juilee Thakar, Ph.D.

Contact Information

Biography

Research

Thakar lab uses systems biology approaches to identify immune signatures that can predict outcome of an immune response to infections or vaccinations. We develop computational tools to model probable trajectories of the immune response which then allows us to identify parameters that can predict future outcomes of the disease. This has direct implications in early diagnosis. The models also reveal the mechanisms of pathogenesis. This work is based on multi-parameter datasets including gene expression, serum cytokine levels and known information about signaling and metabolic pathways.

Credentials

Education

2001
BSc | India-Univ of Pune, Pune
Microbiology and Mathematics

2003
MSc with certificate | India-Univ of Pune, Pune
Microbiology and Computational Biology

2006
PhD | Germany-U Wurzburg
Bioinformatics

Post-doctoral Training & Residency

01/01/2011 - 10/31/2013
Associate Research Scientist, Department of Pathology, Yale School of Medicine, USA

05/01/2006 - 12/31/2010
Cancer Research Institute fellow, Department of Physics, Pennsylvania State University, USA

Awards

2016 - 2017
Novel Biostatistical and Epidemiologic Methods (NBEM) Awards
Sponsor: Clinical & Translational Science Institute
Location: University of Rochester Medical School

2015 - 2016
PhRMA research starter award in informatics
Sponsor: Pharmaceutical Research and Manufacturers of America

2014
Beutner Speaker
Location: Buffalo Immunology Conference

2008 - 2010
Cancer-Research-Institute fellowship
Sponsor: Cancer Research Institute fellowship

2007
Shankar Subramaniam award in systems biology research
Location: Pennsylvania State University

2001
The Association for the Study of Animal Behavior fellowship
Location: Edinburgh, UK and Pune, India

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Publications

Journal Articles

6/20/2023
Lazaro-Pena MI, Cornwell AB, Diaz-Balzac CA, Das R, Ward ZC, Macoretta N, Thakar J, Samuelson AV. "Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal aging and systemically regulates longevity from serotonergic and GABAergic neurons." eLife.. 2023 Jun 20; 12Epub 2023 Jun 20.

4/19/2023
Zhou T, Gilliam NJ, Li S, Spandau S, Osborn RM, Connor S, Anderson CS, Mariani TJ, Thakar J, Dewhurst S, Mathews DH, Huang L, Sun Y. "Generation and Functional Analysis of Defective Viral Genomes during SARS-CoV-2 Infection." mBio.. 2023 Apr 19; :e0025023. Epub 2023 Apr 19.

3/31/2023
Palshikar MG, Min X, Crystal A, Meng J, Hilchey SP, Zand MS, Thakar J. "Executable Network Models of Integrated Multiomics Data." Journal of proteome research.. 2023 Mar 31; Epub 2023 Mar 31.

Books & Chapters

2019
Chapter Title: BIOLOGICAL MONITORING
Book Title: Occupational Health and the Service Member
Author List: Timothy M. Mallon*, Richard Phipps, Juilee Thakar, Collynn Woeller, Dean P. Jones, Douglas I. Walker, Karan Uppal, Mark Utell and Thomas Thatcher
Edited By: Timothy M. Mallon
Published By: Office of The Surgeon General Borden Institute US Army Medical Department Center 2019

2018
Chapter Title: Developing Network Models of Multiscale Host Responses Involved in Infections and Diseases.
Book Title: Computational Cell Biology
Author List: Rohith Palli and Juilee Thakar
Edited By: Louise von Stechow and Alberto Santos Delgado
Published By: Springer Science and Humana Press 2018 in New York

2011
Chapter Title: Mathematical Models as Tools to Enable Infectious Diseases Research
Book Title: Emerging Trends in Antibacterial Discovery
Author List: Juilee Thakar and Eric Harvill
Edited By: Alita A. Miller and Paul F. Miller
Published By: Caister Academic Press 2011

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