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Juilee Thakar, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-6925

Research Labs

Faculty Appointments



Thakar lab uses systems biology approaches to identify immune signatures that can predict outcome of an immune response to infections or vaccinations. We are particularly interested in understanding dynamics of respiratory infections by single and multiple pathogens. We develop computational tools to model probable trajectories of the immune response which then allows us to identify parameters that can predict future outcomes of the disease. This has direct implications in early diagnosis. The models also reveal the mechanisms of pathogenesis. This work is based on multi-parameter datasets including gene expression, serum cytokine levels and known information about signaling and metabolic pathways.



BSc | India-Univ of Pune, Pune
Microbiology and Mathematics

MSc with certificate | India-Univ of Pune, Pune
Microbiology and Computational Biology

PhD | Germany-U Wurzburg

Post-doctoral Training & Residency

01/01/2011 - 10/31/2013
Associate Research Scientist, Department of Pathology, Yale School of Medicine, USA

05/01/2006 - 12/31/2010
Cancer Research Institute fellow, Department of Physics, Pennsylvania State University, USA


2016 - 2017
Novel Biostatistical and Epidemiologic Methods (NBEM) Awards
Sponsor: Clinical & Translational Science Institute
Location: University of Rochester Medical School

2015 - 2016
PhRMA research starter award in informatics
Sponsor: Pharmaceutical Research and Manufacturers of America

Beutner Speaker
Location: Buffalo Immunology Conference

2008 - 2010
Cancer-Research-Institute fellowship
Sponsor: Cancer Research Institute fellowship

Shankar Subramaniam award in systems biology research
Location: Pennsylvania State University

The Association for the Study of Animal Behavior fellowship
Location: Edinburgh, UK and Pune, India

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Journal Articles

Sarkar S, Piepenbrink MS, Basu M, Thakar J, Keefer MC, Hessell AJ, Haigwood NL, Kobie JJ. "IL-33 enhances the kinetics and quality of the antibody response to a DNA and protein-based HIV-1 Env vaccine." Vaccine.. 2019 Apr 17; 37(17):2322-2330. Epub 2019 Mar 27.

Cornwell AB, Llop JR, Salzman P, Thakar J, Samuelson AV. "The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan." Journal of visualized experiments : JoVE.. 2018 Jun 29; (136)Epub 2018 Jun 29.

Zhang Y, Thakar J, Topham DJ, Falsey AR, Zeng D, Qiu X. "Some equivalence relationships of regularized regressions". Mathematics for Applications. 2018; 7: 3-10.

Books & Chapters

Chapter Title: Mathematical Models as Tools to Enable Infectious Diseases Research
Book Title: Emerging Trends in Antibacterial Discovery
Author List: Juilee Thakar and Eric Harvill
Edited By: Alita A. Miller and Paul F. Miller
Published By: Caister Academic Press 2011

Chapter Title: Toward understanding the structure and function of cellular interaction networks
Book Title: Handbook of Large-Scale Random Networks
Author List: Juilee Thakar, Claire Christensen and Réka Albert
Edited By: Bella Bollobas, Robert Kozma and Dezso Miklos
Published By: Springer Verlag and Bolyai Mathematical Society 2009

Chapter Title: Boolean Networks in Inference and Dynamic Modeling of Biological Systems at the Molecular and Physiological Level
Book Title: Handbook on Biological Networks
Author List: Juilee Thakar and Réka Albert
Edited By: Stefano Boccaletti, Vito Latora and Yamir Moreno
Published By: World Scientific publishing group 2009