Welcome to the Thakar Lab
Immune response to infections and vaccination depends on several factors including age, immunogenicity of the antigens, host genotype and host’s immune history.
The research focus of our lab is to delineate the effects of these factors using bioinformatics, systems biology and dynamic modeling tools. We typically integrate different datasets including gene expression, serum cytokine levels and known information about signaling and metabolic pathways.
Current Research Projects
- Human dendritic cell response signatures distinguish 1918, pandemic and seasonal H1N1 influenza viruses.J Virol. (2015 Jul 29).
- Comparative analysis of anti-viral transcriptomics reveals novel effects of influenza immune antagonism.BMC Immunol. 16, 46. (2015 Jan 01).
- GESPA: classifying nsSNPs to predict disease association.BMC Bioinformatics. 16, 228. (2015 Jan 01).