Welcome to the Thakar Lab
Immune response to infections and vaccination depends on several factors including age, immunogenicity of the antigens, host genotype and host’s immune history.
The research focus of our lab is to delineate the effects of these factors using bioinformatics, systems biology and dynamic modeling tools. We typically integrate different datasets including gene expression, serum cytokine levels and known information about signaling and metabolic pathways.
Current Research Projects
- Competitive SWIFT cluster templates enhance detection of aging changes.Cytometry A. 89, 59-70. (2016 Jan 01).
- Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses.J Virol. 89, 10190-205. (2015 Oct 01).
- Diversity in Compartmental Dynamics of Gene Regulatory Networks: The Immune Response in Primary Influenza A Infection in Mice.PLoS One. 10, e0138110. (2015 Jan 01).