Hulin Wu, PhDDean's Professor of Biostatistics and Computational Biology
Professor of Medicine
Professor of Public Health Sciences
Chief, Division of Biomedical Modeling and Informatics
Director, Center for Biodefense Immune Modeling
Ph.D. (1994) Florida State University
Hulin Wu's Personal Website
- University of Rochester
Dept of Biostatistics and Computational Biology
601 Elmwood Avenue Box 630
Rochester, New York 14642
Office: Saunders Research Building 4132
Phone: (585) 275-6767
Fax: (585) 273-1031
My recent research interests include nonparametric regression methods and mixed-effects models for longitudinal data analysis, Bayesian and Monte Carlo filtering approaches for state-space models of biological systems, modeling HIV dynamics and AIDS clinical trials, pharmacokinetics and pharmacodynamics (PK/PD) modeling, and stochastic simulations and modeling of bioterrorist attacks. I am also expanding my research in the area of theoretical immunology.
I received my college education in engineering from the National University of Defense Technology, P.R. China (B.Sc., 1984; M.Sc., 1987). I earned my Ph.D. in statistics from Florida State University in 1994. After two years as a visiting Assistant Professor at the University of Memphis (TN), I joined Frontier Science & Technology Research Foundation in 1996 as a Senior Statistician to work for Statistical Data Analysis Center (SDAC), currently Center for Biostatistics in AIDS Research (CBAR), Harvard School of Public Health, where I became involved in AIDS clinical trials and HIV dynamic modeling. I served as the Head of Pharmacology/Dynamic Modeling Section at SDAC, Adults AIDS Clinical Trials Group (AACTG) from 1999-2002. I also held an Adjunct Lecturership position at the Department of Biostatistics, Harvard University from 2000-2003. I joined the Department of Biostatistics and Computational Biology, University of Rochester as Professor in 2003.
Since 1998, I have been awarded four research grants to develop statistical methods and mathematical models for HIV dynamics and AIDS clinical trials by NIH. I have advised 9 postdoctoral research fellows from 1998-2005, and most of them obtained academic or research positions at major Universities or Research Institutes after completing their postdoctoral training. I am currently leading a group of faculty and postdoc fellows to work on several NIH-sponsored projects related to modeling of infectious diseases and immune response that include HIV/AIDS and influenza virus.
Recently I received a grant (contract) totaling $10 million over 5 years to establish a Center for Biodefense Immune Modeling (CBIM) where I serve as the Director. I also serve as Chief of the newly established Division of Biomedical Modeling and Informatics (DBMI) in the Department of Biostatistics and Computational Biology.
I received the First Prize Student Paper Award from the Statistics and the Environment Section, American Statistical Association in 1993; the ENAR Student Paper Award from the Eastern North American Region of the Biometrics Society (ENAR) in 1994; the Ralph A. Bradley Award from Department of Statistics, Florida State University in 1994; the Young Investigator Award from the Epidemiology Section, American Statistical Association in 1995; and the Young Scientist Scholarship Fund Award from the International Workshop on HIV Drug Resistance and Treatment Strategies in 1997 and 1998. I served as a grant review member for several AIDS and Related Research sections and special emphasis panels, National Institutes of Health (NIH). I also served as a consultant for other NIH grant review sections and the National Science Foundation (NSF).
- Park, J-G. and Wu, H. (2004). Backfitting and Local Likelihood Methods for Nonparametric Mixed-Effects Models with Longitudinal Data (Technical Report 04/03).
- Liu, D., Niu, X-F. and Wu, H. (2005). Mixed-Effects State Space Models for Analysis of Longitudinal Dynamic Systems (Technical Report 05/07).
Wu, H., Xue, H., Kumar A. (2011). Numerical Algorithm-Based Estimation Methods for ODE Models via Penalized Spline Smoothing. Biometrics, accepted.
Wang, J., Zhang, G., Bambara, R., Li, D., Liang, H., Wu, H., Smith, H., Lowe, N., Demeter, L., and Dykes, C. (2011). Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)-resistant Virus is Stimulated by Efavirenz (EFV) During Early Stages of Infection. Journal of Virology, in press.
Lu, T., Liang, H., Li, H., Wu, H. (2011). High Dimensional ODEs Coupled with Mixed-Effects Modeling Techniques for Dynamic Gene Regulatory Network Identification. JASA, in press.
Miao, H., Jin, X., Perelson, A.S., Wu, H. (2011). Evaluation of Multitype Mathematical Models for CFSE-Labeling Experiment Data. Bulletin of Mathematical Biology, in press.
Lee, Y. and Wu, H. (2011). MARS Approach for Global Sensitivity Analysis of Differential Equation Models with Applications to Dynamics of Influenza Infection. Bulletin of Mathematical Biology, in press.
Wu, H., Kumar, A., Miao, H., Holden-Wiltse, J., Mosmann, T.R., Livingstone, A.M., Belz, G.T., Perelson, A.S., Zand, M., Topham, D.J. (2011). Modeling of Influenza-Specific CD8+ T Cells During the Primary Response Indicates that the Spleen Is a Major Source of Effectors. Journal of Immunology, 187, 4474-4482.
Cao, J., Huang, J.Z., Wu, H. (2011). Penalized Nonlinear Least Squares Estimation of Time-Varying Parameters in Ordinary Differential Equations. Journal of Computational and Graphical Statistics (JCGS), in press.
Lartey, M., Sagoe, K.W., Yang, H., Kenu, E., Xexemeku, F., Oliver-Commey, J., Bioma, V., Seshie, M., Sagoe, A., Mingle, J., Flanigan, T.P., Wu, H., Kwara, A. (2011). Viral Decay Rates Are Similar in HIV-Infected Patients with and without TB Coinfection Treated with Efavirenz-containing Antiretroviral Therapy. Clinical Infectious Diseases, 52(4), 547-550.
Huang, Y., Wu, H., Holden-Wiltse, J., Acosta, P. (2011). A Dynamic Bayesian Nonlinear Mixed-Effects Model of HIV Response Incorporating Medication Adherence, Drug Resistance and Covariates. The Annals of Applied Statistics, 5(1), 551-577.
Liu, D., Lu, T., Niu, X.F., and Wu, H. (2011). Mixed-Effects State Space Models for Analysis of Longitudinal Dynamic Systems. Biometrics, 67, 476-485. NIHMSID 227412
Fang, Y., Wu, H., Zhu, L. (2011). A Two-Stage Estimation Method for Random Coefficient Differential Equation Models with Application to Longitudinal HIV Dynamic Data. Statistica Sinica, 21, 1145-1170. NIHMSID 339035
Miao, H., Xia, X., Perelson, A.S., Wu, H. (2011). On Identifiability of Nonlinear ODE Models and Applications in Viral Dynamics. SIAM Review, 53(1): 3-39.
Liang, H., Wu, H. (2010). Correction on “Parameter Estimation for Differential Equation Models Using a Framework of Measurement Error in Regression Models (JASA, 103, 1570-1583).” Journal of the American Statistical Association, 105, 1636.
Dykes, C., Wu, H., Sims, M., Holden-Wiltse, J., Demeter, L. (2010). Human Immunodeficiency Virus -1 (HIV-1) Harboring Protease Inhibitor Drug-Resistant Mutants Gives Discordant Results When Compared in Single-Cycle and Multiple-Cycle Fitness Assays. Journal of Clinical Microbiology, 48(11), 4035-4043.
Huang, Y., Wu, H., Acosta, P. (2010). Hierarchical Bayesian Inference for HIV Dynamic Differential Equation Models Incorporating Multiple Treatment Factors. Biometrical Journal, 52(4), 470-486.
Xue, H., Miao, H., Wu, H. (2010). Sieve Estimation of Constant and Time-Varying Coefficients in Nonlinear Ordinary Differential Equation Models by Considering Both Numerical Error and Measurement Error. Annals of Statistics, 38(4), 2351-87.
Wang, J., Liang, H., Bacheler, L., Wu, H., Deriziotis, K., Demeter, L.M., Dykes, C. (2010). The Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz Stimulates Replication of Human Immunodeficiency Virus Type 1 Harboring Certain Non-nucleoside Resistance Mutations, Virology, 402, 228-237.
Miao, H., Hollenbaugh, J.A., Zand, M., Holden-Wiltse, J., Mosmann, T.R., Perelson, A.S., Wu, H., Topham, D.J. (2010). Quantifying the Early Immune Response and Adaptive Immune Response Kinetics in Mice Infected by Influenza A Virus. Journal of Virology, 84, 6687-6698.
Ma, J., Dykes, C., Wu, T., Huang, Y., Demeter, L., Wu, H. (2010). vFitness: a web-based computing tool for improving estimation of in vitro HIV-1 fitness experiments. BMC Bioinformatics, 11:261.
Wood, R., Liang, H., Wu, H., Middelkoop, K., Oni, T., Rangaka, M.X., Wilkinson, R.J., Bekker, L.G., Lawn, S. D. (2010). Changing prevalence of TB infection with increasing age in high TB burden townships in South Africa. The International Journal of Tuberculosis and Lung Disease, 14, 406-412.