Photomicrograph of a hepatitis lesion in the liver of influenza infected mice. Cytotoxic CD8 T cells (red) and hepatocyte nuclei (green)
The David H. Smith Center for Vaccine Biology and Immunology (CBVI) was formed in 1998 as part of the Aab Institute of Biomedical Sciences. Research in the Center is focused on basic research into immunological mechanisms with a long time goal of helping to design the next generation of vaccines. Investigators in the Center have research areas that focus on many areas of immunology, including T cell activation and differentiation, T cell memory and homing, MHC class II -restricted antigen presentation, T cell responses to pathogenic organisms and T cell-mediated autoimmunity. These varied research programs seek to dissect key regulatory events that control protective and pathogenic immune responses.
Tim Mosmann, Ph.D., director of the David H. Smith Center for Vaccine Biology and Immunology at the Medical Center recently gave a presention at a 2011 independently organized TEDx Rochester event. Dr. Mosmann's talk starts by explaining the complexity behind the immune system. Then goes on to tell how we're being overwhelmed by new data on that subject and how best to handle that overload.
Hematoxylin & eosin staining of the influenza infected mouse lung tissue
The research programs in the Center is highly synergistic among the faculty within the Center and with investigators in other Centers and departments. Research and education in the Center build on strong faculty and graduate programs in Immunology, Microbiology and Virology, and Infectious Diseases at the University of Rochester Medical Center. The Center occupies 31,500 square feet of exceptional research space on the top floor of the Arthur Kornberg Medical Research Building at the University of Rochester Medical Center. In addition, faculty throughout the Medical Center, including those in the new research building, share state-of-the-art core facilities, which are housed in the new research building and elsewhere.
