Principal Investigator

Mark Raymond Buckley, Ph.D. University of Rochester work Box 270168 Rochester NY 14627-0168 office: Goergen Hall 317 p (585) 276-4195

Contact

Buckley Lab University of Rochester work Goergen Hall 321 Rochester NY 14627-0168

Affiliations

Viscoelasticity in Connective Tissues

Confocal micrograph of articular cartilage under dynamic shear loading. The black stripes are photobleached lines used as markers to track time-dependent tissue deformation.

Mechanics plays a key role in the onset, progression and treatment of several diseases that affect cartilage, tendon, cornea, sclera and other connective tissues. The Buckley lab is interested in evaluating pathology-associated mechanical changes in these tissues and using our findings to develop novel diagnostic tools and therapeutic strategies. We characterize the viscoelastic (i.e., rate- and time-dependent) mechanical response of connective tissues in vivo and in viable explants across multiple length scales using image-guided mechanical testing methods. Our current focus is on diseases of the musculoskeletal system (e.g., osteoarthritis and tendinopathy) and diseases of the eye (e.g., keratoconus and glaucoma) with significant public health impacts.


Current Research Projects

Recent Publications

    1. Freedman BR
    2. Zuskov A
    3. Sarver JJ
    4. Buckley MR
    5. Soslowsky LJ
    (2015 Mar 13). Evaluating changes in tendon crimp with fatigue loading as an ex vivo structural assessment of tendon damage.J Orthop Res.
    1. Kuchenbaecker KB
    2. Ramus SJ
    3. Tyrer J
    4. Lee A
    5. Shen HC
    6. Beesley J
    7. Lawrenson K
    8. McGuffog L
    9. Healey S
    10. Lee JM
    11. Spindler TJ
    12. Lin YG
    13. Pejovic T
    14. Bean Y
    15. Li Q
    16. Coetzee S
    17. Hazelett D
    18. Miron A
    19. Southey M
    20. Terry MB
    21. Goldgar DE
    22. Buys SS
    23. Janavicius R
    24. Dorfling CM
    25. van Rensburg EJ
    26. Neuhausen SL
    27. Ding YC
    28. Hansen TV
    29. Jønson L
    30. Gerdes AM
    31. Ejlertsen B
    32. Barrowdale D
    33. Dennis J
    34. Benitez J
    35. Osorio A
    36. Garcia MJ
    37. Komenaka I
    38. Weitzel JN
    39. Ganschow P
    40. Peterlongo P
    41. Bernard L
    42. Viel A
    43. Bonanni B
    44. Peissel B
    45. Manoukian S
    46. Radice P
    47. Papi L
    48. Ottini L
    49. Fostira F
    50. Konstantopoulou I
    51. Garber J
    52. Frost D
    53. Perkins J
    54. Platte R
    55. Ellis S
    56. EMBRACE
    57. Godwin AK
    58. Schmutzler RK
    59. Meindl A
    60. Engel C
    61. Sutter C
    62. Sinilnikova OM
    63. GEMO Study Collaborators
    64. Damiola F
    65. Mazoyer S
    66. Stoppa-Lyonnet D
    67. Claes K
    68. De Leeneer K
    69. Kirk J
    70. Rodriguez GC
    71. Piedmonte M
    72. O'Malley DM
    73. de la Hoya M
    74. Caldes T
    75. Aittomäki K
    76. Nevanlinna H
    77. Collée JM
    78. Rookus MA
    79. Oosterwijk JC
    80. Breast Cancer Family Registry
    81. Tihomirova L
    82. Tung N
    83. Hamann U
    84. Isaccs C
    85. Tischkowitz M
    86. Imyanitov EN
    87. Caligo MA
    88. Campbell IG
    89. Hogervorst FB
    90. HEBON
    91. Olah E
    92. Diez O
    93. Blanco I
    94. Brunet J
    95. Lazaro C
    96. Pujana MA
    97. Jakubowska A
    98. Gronwald J
    99. Lubinski J
    100. Sukiennicki G
    101. Barkardottir RB
    102. Plante M
    103. Simard J
    104. Soucy P
    105. Montagna M
    106. Tognazzo S
    107. Teixeira MR
    108. KConFab Investigators
    109. Pankratz VS
    110. Wang X
    111. Lindor N
    112. Szabo CI
    113. Kauff N
    114. Vijai J
    115. Aghajanian CA
    116. Pfeiler G
    117. Berger A
    118. Singer CF
    119. Tea MK
    120. Phelan CM
    121. Greene MH
    122. Mai PL
    123. Rennert G
    124. Mulligan AM
    125. Tchatchou S
    126. Andrulis IL
    127. Glendon G
    128. Toland AE
    129. Jensen UB
    130. Kruse TA
    131. Thomassen M
    132. Bojesen A
    133. Zidan J
    134. Friedman E
    135. Laitman Y
    136. Soller M
    137. Liljegren A
    138. Arver B
    139. Einbeigi Z
    140. Stenmark-Askmalm M
    141. Olopade OI
    142. Nussbaum RL
    143. Rebbeck TR
    144. Nathanson KL
    145. Domchek SM
    146. Lu KH
    147. Karlan BY
    148. Walsh C
    149. Lester J
    150. Australian Cancer Study (Ovarian Cancer Investigators)
    151. Australian Ovarian Cancer Study Group
    152. Hein A
    153. Ekici AB
    154. Beckmann MW
    155. Fasching PA
    156. Lambrechts D
    157. Van Nieuwenhuysen E
    158. Vergote I
    159. Lambrechts S
    160. Dicks E
    161. Doherty JA
    162. Wicklund KG
    163. Rossing MA
    164. Rudolph A
    165. Chang-Claude J
    166. Wang-Gohrke S
    167. Eilber U
    168. Moysich KB
    169. Odunsi K
    170. Sucheston L
    171. Lele S
    172. Wilkens LR
    173. Goodman MT
    174. Thompson PJ
    175. Shvetsov YB
    176. Runnebaum IB
    177. Dürst M
    178. Hillemanns P
    179. Dörk T
    180. Antonenkova N
    181. Bogdanova N
    182. Leminen A
    183. Pelttari LM
    184. Butzow R
    185. Modugno F
    186. Kelley JL
    187. Edwards RP
    188. Ness RB
    189. du Bois A
    190. Heitz F
    191. Schwaab I
    192. Harter P
    193. Matsuo K
    194. Hosono S
    195. Orsulic S
    196. Jensen A
    197. Kjaer SK
    198. Hogdall E
    199. Hasmad HN
    200. Azmi MA
    201. Teo SH
    202. Woo YL
    203. Fridley BL
    204. Goode EL
    205. Cunningham JM
    206. Vierkant RA
    207. Bruinsma F
    208. Giles GG
    209. Liang D
    210. Hildebrandt MA
    211. Wu X
    212. Levine DA
    213. Bisogna M
    214. Berchuck A
    215. Iversen ES
    216. Schildkraut JM
    217. Concannon P
    218. Weber RP
    219. Cramer DW
    220. Terry KL
    221. Poole EM
    222. Tworoger SS
    223. Bandera EV
    224. Orlow I
    225. Olson SH
    226. Krakstad C
    227. Salvesen HB
    228. Tangen IL
    229. Bjorge L
    230. van Altena AM
    231. Aben KK
    232. Kiemeney LA
    233. Massuger LF
    234. Kellar M
    235. Brooks-Wilson A
    236. Kelemen LE
    237. Cook LS
    238. Le ND
    239. Cybulski C
    240. Yang H
    241. Lissowska J
    242. Brinton LA
    243. Wentzensen N
    244. Hogdall C
    245. Lundvall L
    246. Nedergaard L
    247. Baker H
    248. Song H
    249. Eccles D
    250. McNeish I
    251. Paul J
    252. Carty K
    253. Siddiqui N
    254. Glasspool R
    255. Whittemore AS
    256. Rothstein JH
    257. McGuire V
    258. Sieh W
    259. Ji BT
    260. Zheng W
    261. Shu XO
    262. Gao YT
    263. Rosen B
    264. Risch HA
    265. McLaughlin JR
    266. Narod SA
    267. Monteiro AN
    268. Chen A
    269. Lin HY
    270. Permuth-Wey J
    271. Sellers TA
    272. Tsai YY
    273. Chen Z
    274. Ziogas A
    275. Anton-Culver H
    276. Gentry-Maharaj A
    277. Menon U
    278. Harrington P
    279. Lee AW
    280. Wu AH
    281. Pearce CL
    282. Coetzee G
    283. Pike MC
    284. Dansonka-Mieszkowska A
    285. Timorek A
    286. Rzepecka IK
    287. Kupryjanczyk J
    288. Freedman M
    289. Noushmehr H
    290. Easton DF
    291. Offit K
    292. Couch FJ
    293. Gayther S
    294. Pharoah PP
    295. Antoniou AC
    296. Chenevix-Trench G
    297. Consortium of Investigators of Modifiers of BRCA1 and BRCA2
    (2015 Feb 01). Identification of six new susceptibility loci for invasive epithelial ovarian cancer.Nat Genet. 47, 164-71.
    1. Sloan SR
    2. Khalifa YM
    3. Buckley MR
    (2014 Dec 01). The location- and depth-dependent mechanical response of the human cornea under shear loading.Invest Ophthalmol Vis Sci. 55, 7919-24.