The Buckley lab is currently accepting applications for graduate students interested in viscoelasticity in connective tissues. For more information, please contact Professor Buckley.
Viscoelasticity in Connective Tissues
Confocal micrograph of articular cartilage under dynamic shear loading. The black stripes are photobleached lines used as markers to track time-dependent tissue deformation.
Tendon, ligament, cartilage and many other soft biological tissues serve predominantly mechanical functions. However, unlike steel, concrete and other elastic solids, these structurally complex materials exhibit a history- and time-dependent response to loading (i.e., viscoelasticity) that must be characterized in order to predict in vivo deformations and understand loss of mechanical function in the pathological state. Our lab is interested in evaluating changes in soft tissue viscoelastic properties across multiple length scales during processes including exercise, aging, injury and disease and identifying the specific biological and structural factors responsible for these alterations. To characterize viscoelasticity at the tissue, matrix and cellular levels, we combine simultaneous high-speed microscopy, force measurement and control of deformation on live tissue explants. Using our findings, we seek to devise strategies for assessing the efficacy of treatments or diagnosing damage based on viscoelastic measurements.
- Effects of enzymatic treatments on the depth-dependent viscoelastic shear properties of articular cartilage. J Orthop Res. 32, 1652-7. (2014 Dec 01).
- The Location- and Depth-Dependent Mechanical Response of the Human Cornea Under Shear Loading. Invest Ophthalmol Vis Sci. In press. (2014 Oct 30).
- Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature. 514, 92-7. (2014 Oct 02).