Principal Investigator

Mark Raymond Buckley, Ph.D. University of Rochester work Box 270168 Rochester NY 14627-0168 office: Goergen Hall 317 p 585-276-4195 mark.buckley@rochester.edu

Contact

Buckley Lab University of Rochester work Goergen Hall 321 Rochester NY 14627-0168

Affiliations

Biomedical Engineering

The Buckley lab is currently accepting applications for graduate students interested in viscoelasticity in connective tissues. For more information, please contact Professor Buckley.

Viscoelasticity in Connective Tissues

Confocal micrograph of articular cartilage under dynamic shear loading. The black stripes are photobleached lines used as markers to track time-dependent tissue deformation.

Tendon, ligament, cartilage and many other soft biological tissues serve predominantly mechanical functions. However, unlike steel, concrete and other elastic solids, these structurally complex materials exhibit a history- and time-dependent response to loading (i.e., viscoelasticity) that must be characterized in order to predict in vivo deformations and understand loss of mechanical function in the pathological state. Our lab is interested in evaluating changes in soft tissue viscoelastic properties across multiple length scales during processes including exercise, aging, injury and disease and identifying the specific biological and structural factors responsible for these alterations. To characterize viscoelasticity at the tissue, matrix and cellular levels, we combine simultaneous high-speed microscopy, force measurement and control of deformation on live tissue explants. Using our findings, we seek to devise strategies for assessing the efficacy of treatments or diagnosing damage based on viscoelastic measurements.

Department of Biomedical Engineering BME

Recent Publications

1. Dunkman AA
2. Buckley MR
3. Mienaltowski MJ
4. Adams SM
5. Thomas SJ
6. Satchell L
7. Kumar A
8. Pathmanathan L
9. Beason DP
10. Iozzo RV
11. Birk DE
12. Soslowsky LJ
(2013 Jan 01). Decorin expression is important for age-related changes in tendon structure and mechanical properties. Matrix Biol. 32, 3-13.
1. Chandler EM
2. Seo BR
3. Califano JP
4. Andresen Eguiluz RC
5. Lee JS
6. Yoon CJ
7. Tims DT
8. Wang JX
9. Cheng L
10. Mohanan S
11. Buckley MR
12. Cohen I
13. Nikitin AY
14. Williams RM
15. Gourdon D
16. Reinhart-King CA
17. Fischbach C
(2012 Jun 19). Implanted adipose progenitor cells as physicochemical regulators of breast cancer. Proc Natl Acad Sci U S A. 109, 9786-91.
1. Chen T
2. Buckley M
3. Cohen I
4. Bonassar L
5. Awad HA
(2012 May 01). Insights into interstitial flow, shear stress, and mass transport effects on ECM heterogeneity in bioreactor-cultivated engineered cartilage hydrogels. Biomech Model Mechanobiol. 11, 689-702.

See all »