Unlike cells within solid tissues, circulating lymphocytes and other leukocytes continuously migrate and relocate during the course of immune reactions. A subset of integrins (LFA-1, Mac-1, and VLA-4) are expressed on immune cells and play a major role in regulating recruitment of immuno-competent cells to normal or damaged and infected tissues. Under a wide range of pathologic conditions such as autoimmune disease, chronic inflammation, and transplantation rejection, integrin activations are mis-regulated resulting in abnormal leukocyte trafficking, and direct damage to the vasculature and the underlying host tissue.
Understanding how T cells and neutrophils home to and migrate within tissues is a major focus of our research.
- Neutrophil trails guide influenza-specific CD8⁺ T cells in the airways.Science. 349, aaa4352. (2015 Sep 04).
- Visualization of integrin Mac-1 in vivo.J Immunol Methods. (2015 Sep 02).
- TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.J Cell Biol. 209, 143-62. (2015 Apr 13).