Kobie Lab

James Kobie, Ph.D.

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Ph.D. 2003
University of Arizonia

Research Assistant Professor
Division of Allergy/Immunology and Rheumatology

Research Overview

   Dr. Kobie's research interests include studying CD4 T cells and their contribution to the generation of effective anti-tumor immune responses and their translational applications for the development of cancer vaccines. He is also examining the effect of pregnancy and pregnancy-related factors on the differentiation of CD4 T cells. In collaboration with Dr. Inaki Sanz, he is studying the development of B cells that give rise to HIV specific antibodies capable of neutralizing a broad range of HIV isolates to elucidate strategies to generate effective HIV vaccines.

Select Publications

   Rebhahn, J.A., Bishop, C., Divekar, A.A., Jiminez-Garcia, J., Kobie, J.J., Lee, F.E., Maupin, G.M., Snyder_Cappione, J.E., Zaiss, D.M., Mossmann, T.R. "Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion." Comput Methods Programs Biomed. 2008 Oct:92(1):54-65. View article in PubMed.

   Kobie, J.J., Shah, R.R., Yang, L., Rebhahn, J.A., Fowell, D.J., Mossmann, T.R. "T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine." J Immunolo 2006 Nov 15;177(10):6780-6. View article in PubMed.

   Kobie, J.J., Wu, R.S., Kurt, R.A., Lou, S., Adelman, M.K., Whitesell, L.J., Ramanathapuram, L.V., Arteaga, C.L., Alporiaye, E.T. "Transforming growth factor beta inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines." Cance Res. 2003 Apr 15;63(8):1860-4. View article in PubMed.

   Ramanathspuram, L.V., Kobie, J.J., Bearss, D., Payne, C.M., Trevor, K.T., Akporiaye, E.T. "alpha-Tocopheryl succinate sensitizes established tumors to vaccination with nonmatured dendiritic cells." Cancer Immunol Immunother. 2004 Jul;53(7):580-8. View article in PubMed.

 

Contact

James Kobie, Ph.D.
University of Rochester
601 Elmwood Ave., Box 695
Rochester, NY 14642
Office: 585-275-6632
James_Kobie@urmc.
rochester.edu