Lund Lab
Frances Lund, Ph.D.
Division of Allergy/Immunology and Rheumatology
Professor of Microbiology and Immunology
Professor of Medicine
Research Focus:
- Role of cytokine-producing B cells in infection, autoimmune disease and cancer.
- Regulation of inflammation, oxidative stress and metabolic fitness by extracellular nucleotides.
Research Overview:
My laboratory studies the mechanism(s) that control inflammation in response to infectious, allergic and autoimmune diseases. In one project, we are characterizing the antibody independent roles that B cells play in infection, autoimmune disease and cancer. We previously showed that B cells can produce different arrays of cytokines, depending on the environment in which the B cells were originally primed. These cytokine-producing “effector” B cells regulate the early innate immune response and also modulate T cell-mediated immune responses to pathogens. continued
Five Relevant Publications
Shi, S., Partida-Sánchez, S., Misra, R.S., Tighe, M, Borchers, M., Lee, J.J. Simon, M., Lund F.E. 2007. Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes. J. Exp. Med. 204:2. View article in PubMed.
Partida-Sanchez, S., Gasser, A., Fliegert, R., Sandoval-Montes, C., Shi, G., Bhagat, H., Guse, A.H., Walseth, T.F., Lund, F.E. 2007. Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction. J. Immunol. 179:7827-7839.706-2718. View article in PubMed.
Rangel-Moreno, J., Carragher, D.M., Misra, R.S., Kusser, K., Hartson, L., Moquin, A., Lund, F.E., Randall, T.D. 2008. B cells promote resistance to heterosubtypic strains of influenza via multiple mechanisms. J. Immunol. 180:454-463. View article in PubMed.
Wojciechowski, W., Harris, D.P., Sprague, F., Mousseau, B., Makris, M., Kusser, K., Honjo, T., Mohrs, K., Mohrs, M., Randall, T.D., and Lund, F.E. 2009. Cytokine-Producing Effector B Cells Regulate Type 2 Immunity to H. polygyrus. Immunity. 30:421-433. View article in PubMed.
Lund, F.E. and Randall, T.D. 2010. Effector and regulatory B cells: modulators of CD4 T cell immunity. Nature Rev. Immunol. 10:236-47. View article in PubMed.
The Combined Labs of Fran Lund and Troy Randall
Contact
Frances Lund, Ph.D.
University of Rochester
601 Elmwood Ave., Box 695
Rochester, NY 14642
Office: 585-276-4612
Frances_Lund@urmc.
rochester.edu
Lab Members
