Randall Lab

Troy Randall, Ph.D.

Division of Allergy/Immunology and
Rheumatology

Professor of Microbiology and Immunology
Professor of Medicine

Research Overview

Pulmonary immunity to viruses, tumors and allergens. One of the major projects in my lab is to determine how local lymphoid tissues develop and function in the respiratory tract in response to respiratory viruses, lung tumors and allergens. We find that, although naïve mice lack detectable lymphoid areas in their lungs, organized lymphoid tissues can be formed in response to either infection or inflammmation. continued

Recent Publications

Moyron-Quiroz JE; Rangel-Moreno J; Kusser K; Hartson L; Sprague F; Goodrich S; Woodland DL; Lund FE; Randall TD. "Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity." Nat Med. 2004;10(9):927-34. View article in PubMed.

Moyron-Quiroz JE; Rangel-Moreno J; Hartson L; Kusser K; Tighe MP; Klonowski KD; Lefrançois L; Cauley LS; Harmsen AG; Lund FE; Randall TD. "Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organs." Immunity. 2006;25(4):643-5. View article in PubMed.

Carragher DM; Kaminski DA; Moquin A; Hartson L; Randall TD. "A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virus." J Immunol. 2008;181(6):4168-76. View article in PubMed.

Rangel-Moreno J; Moyron-Quiroz JE; Carragher DM; Kusser K; Hartson L; Moquin A; Randall TD. "Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigens." Immunity. 2009;30(5):731-43. View article in PubMed.

Ballesteros-Tato, A., Leon, B., Lund, F.E., Randall, T.D. "Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8(+) T cell responses to influenza." Nat Immunol. 2010;11(3):216-24. View article in PubMed.

The combined labs of Troy Randall and Fran Lund

LundRand lab picture