Email this pageSanz Lab
The Team
Igñacio Sanz, M.D., Professor of Medicine, Microbiology & Immunology
James Kobie, Ph.D., Research Assistant Professsor of Medicine
Chungwen, Wei, Ph.D. Research Assistant Professor of Medicine
Katie Gall, Health Project Coordinator
Scott Jenks, Ph.D., Post-doctoral Fellow
Sunil Keshetti, M.D. Health Project Coordinator
Nataly Manjarrez-Orduno, Ph.D, Post-doctoral Fellow
Elides Marin, Technician
Elise Palmer, Research Assistant
Tam Quach, Graduate Student
Christopher Richardson, Graduate Student
Mustimbo Roberts, Graduate Student
James Roger, D.D.S. Instructor of Dentistry, Center for Oral Biology
Bo Zheng, Technician
Dr. Sanz's Research Interests
Dr. Sanz's current research interests and efforts are focused on examining human B cell development, function and tolerance. He is also exploring the use of B cell depletion in the treatment of autoimmune diseases and is attempting to identify new biomarkers for Sjogrens syndrome. He is also co-director of the Rochester Center for the Biodefense of Immunocomprimised Populations and director of the Rochester NIH Autoimmune Center of Excellence. The Rochester ACE has made further investigations into the pathogenesis of systemic lupus erythematosis possible.
Dr. Sanz has served as a mentor for many students in the past and continues to mentor future scientists in his lab.
Funding
Dr. Sanz is funded through the NIH, Amgen, Immunex, Centocor, Bristol-Meyuers Squibb, National Psoriasis Fund, American College of Rheumatology, Corrona, and Abbot.
Relevant Publications
- Sanz, I., Wei, C., Lee, P.E.-H, and Anolik, J. Phenotypic and functional heterogeneity of human memory B cells. Seminars in Immunology 20(2008)67-82.
- Anolik J.H., Ravikumar, R., Banard, J., Owen, TJ., Almudevar, A., Milner, E.C.B., Miller, C.H., Dutcher, P.O., Hadley, J.A., and Sanz, I. Cutting Edge: Anti-Tumor Necrosis Factor Therapy in Rheumatoid Arthritis Inhibits Memory B Lymphocytes via Effects on Lymphoid Germinal Centers and Follic8lar Dendritic Cell Networks. J Immunol 180 (2008):688-692.
- Wei, C.; Anolik, JH.; Cppione, A.; Zheng, B.; Pugh-Bernard, A.; Brooks, J.; Lee, EH.; Milner, EC.; Sanz, I. "A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus." Journal of Immunology 178 (2007): 6624.
- Anolik, JA.; Barnard, J.; Owen, T.; Zheng, B.; Kemshetti, S.; Looney, RJ.; Sanz, I. "Delayed memory B cell recovery in peripheral blood and lymphoid tissue in SLE after B cell depletion therapy." Arthritis and Rheumatism 56 (2007): 3044-3056.
- Cappione,A.,3rd; Anolik,J. H.; Pugh-Bernard,A.; Barnard,J.; Dutcher,P.; Silverman,G.; Sanz,I. "Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus." The Journal of Clinical Investigation 115 (2005): 3205,3216.
- Looney,R. J.; Anolik,J. H.; Campbell,D.; Felgar,R. E.; Young,F.; Arend,L. J.; Sloand,J. A.; Rosenblatt,J.; Sanz,I. "B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab." Arthritis and Rheumatism 50 (2004): 2580,2589.
- Anolik,J. H.; Barnard,J.; Cappione,A.; Pugh-Bernard,A. E.; Felgar,R. E.; Looney,R. J.; Sanz,I. "Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosu.s. Arthritis and Rheumatism 50 (2004): 3580,3590.
Dr. Kobie's Research Interests
Dr. Kobie is co-director of the of the Rochester Center for the Biodefense of Immunocompromised Populations.
Dr. Kobie’s research interest include studying CD4 T cells and their contribution to the generation of effective anti-tumor immune responses and their translational applications for the development of cancer vaccines. He is also examining the effect of pregnancy and pregnancy-related factors on the differentiation of CD4 T cells. In collaboration with Dr. Iñaki Sanz he is studying the development of B cells that give rise to HIV specific antibodies capable of neutralizing a broad range of HIV isolates to elucidate strategies to generate effective HIV vaccines.
Funding
Dr. Kobie receives his funding from the NIH including the NIAID and the NCI.
Relevant Publications
- Wang, J.E., Kobie, J.J., Zhang, L., Cochran, M., Mosmann, T.R., Ritchlin, C.T., and Quataert, S.A. An 11-color Flow Cytometric Assay for Identifying, Phenotyping, and Assessing Endocytic Ability of Peripheral Blood Dendritic Cell Subsets in A Single Platform. J. Imm. Methods (2008)
- Kyu, S.Y., Kobie, J.J., Zand, M.S., Topham, D.J., Quataert, S.A., Sanz, I., and Lee, F.E. Frequencies of Human Influenza-Specific Antibody Secreting Cells or Plasmablasts post Vaccination from Fresh and Frozen PBMC. J Imm. Methods. (2008)
- Rebhahn, J.A., Bishop, C., Divekar, A., Jiminez-Garcia, K., Kobie, J.J., Lee, F.E., Maupin, G.M., Snyder-Cappione, J.E., Zaiss, D.M., and Mosmann, T.R. Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion. Computer Methods and Programs in Biomedicine. 92, 54-65 (2008)
- Kobie, J. J., Shah, P.R., Yang, L., Rebhahn, J.A., Fowell, D.J., and Mosmann, T.R.. T regulatory and primed uncommitted CD4 T cells express CD73 which suppresses effector CD4 T cells by converting 5’AMP to adenosine. J Immunol. 177, 6780-6 (2006)
- Kobie, J. J., Wu, R. S., Kurt, R. A., Lou, S., Adelman, M. K. , Whitesell, L. J., Ramanathapuram, L. V., Arteaga, C. L., and Akporiaye, E. T.. TGF-b inhibits the antigen presenting functions and anti-tumor activity of dendritic cell vaccines. Cancer Research. 63, 1860-1864 (2003)
Complete list of Dr. Kobie's publications
Dr. Wei's Research Interests
Dr. Wei's current research interests include the study of human B cell development and anergy through immunophenotyping utilizing polychromatic flow cytometry, gene expression profiling and functional analysis.
Relevant Publications
Wei, C., Saller, D.N. and Sutherland, J.W.H. (2001) Detection and quantitation by homogeneous PCR of cell-free fetal DNA in maternal plasma. Clin. Chem. 47:336-338.
Brown, D.M., Fisher, T., Wei, C., Frelinger, J.G. and Lord, E.M. (2001) Tumors can act as adjuvants for humoral immunity. Immunology 102:486-497.
Huggins, J., Pellegrin, T., Felgar, R.E., Wei, C., Brown, M., Zheng, B., Milner, E.C.B., Bernstein, S.H., Sanz, I. and Zand M.S. (2007) CpG DNA activation and plasma-cell differentiation of CD27- naïve human B cells. Blood 109:1611-1619.
Wei, C., Anolik, J., Cappione, A., Zheng, B., Pugh-Bernard, A., Brooks, J., Lee, E-H., Milner, E.C.B., and Sanz, I. (2007) A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus. J. Immunol. 178:6624-6633.
Sanz, I., Wei, C., Lee, F.E., Anolik, J. (2008) Phenotypic and functional heterogeneity of human memory B cells. Semin. Immunol. 20:67-82.
Complete listing of Dr. Wei's publications
