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Labs and Centers
The Center for Neural Development and Disease (CNDD) at the University of Rochester Medical Center brings together faculty from diverse departments, including Neurology, Pediatrics, Biomedical Genetics, Biochemistry and Biophysics, Opthalmology, Emergency Medicine, and Neurobiology and Anatomy, to carry out research directed toward understanding how genes and environment build the human brain and modulate its function in health and disease
A research unit of the University of Rochester’s Department of Neurology, operates to foster multi-institutional academic research through the development, management, and reporting of hypothesis-driven, controlled clinical trials.
Single neuron recordings from awake monkey cerebral cortex have demonstrated the existence of neurons which are specifically activated during the viewing of optic flow fields. Our ongoing studies combine optic flow visual displays with real translational movement of the monkey using a room-sized, motorized sled. These studies are directed at characterizing the neuronal mechanisms of self-movement perception. Our human psychophysical studies are directed at analyzing the cortical operations involved in optic flow field perception. We are focusing on studies of perceptual involvement in the syndrome of visuospatial disorientation in Alzheimer's disease and other neurodegenerative disorders.
The Fields Center for FSHD and Neuromuscular Research represents the first concerted international effort to accelerate aggressive and innovative clinical and genetic research to find treatments for people with facioscapulohumeral muscular dystrophy (FSHD).
The Goldman Lab of the Center for Translational Neuromedicine focuses on the use of stem and progenitor cells for the treatment of neurodegenerative disorders such as Huntington's Disease, as well as for the treatment of glial diseases such as the pediatric leukodystrophies and multiple sclerosis. The lab also has a strong interest in the conversion of resident cells into brain cancers, and is board certified in neuro-oncology.
The Muscle Study Group (MSG), is a consortium of scientific investigators from academic and research centers who are committed to the cooperative planning, implementation, analysis and reporting of controlled clinical trials and of other research for muscle and other neuromuscular diseases.
As nationally recognized centers of excellence in muscular dystrophy, the Senator Paul D. Wellstone MDCRCs were charged with the task of establishing research programs focused on major questions about muscular dystrophy.
National Registry of Myotonic Dystrophy and Facioscapulohumeral Muscular Dystrophy Patients and Family Members
National Registry was developed to:
- Help people with Myotonic Dystrophy (DM) or Facioscapulohumeral Muscular Dystrophy (FSHD) participate in research on their disease
- Help investigators accomplish their research by connecting them with people who have DM or FSHD
- Encourage more research on these rare diseases
The University of Rochester is conducting a research study of antidepressant medication in patients with Parkinson’s disease (PD) at several medical centers throughout the United States and Canada.
Myotonia is a state of hyperexcitability in muscle fibers in which a voluntary contraction or electromechanical stimulation can provoke trains of repetitive action potentials. This causes delay in relaxation after a muscle contraction. The repetitive action potentials are generated by the muscle fibers, independent of any input from the motor neuron. Myotonia is caused by dysfunction of ion channels in the muscle membrane.