Research Bio
Dr. Steven A. Goldman is the Edward and Alma Vollertsen Rykenboer Professor of Neurology. He is Chief of the Department's Division of Cell and Gene Therapy, and Co-Director of Rochester's Center for Translational Neuromedicine. Goldman is Emeritus Chairman of the Department, and holds additional appointments as a Professor of Neurosurgery, and as the Dean Zutes Chair in Biology of the Aging Brain. Goldman moved to Rochester in 2003 from the Weill Medical College of Cornell University, where he was the Nathan Cummings Professor of Neurology, and Attending Neurologist at New York Presbyterian Hospital.
A summa cum laude graduate of the University of Pennsylvania, he obtained his PhD with Fernando Nottebohm at the Rockefeller University in 1983, and his MD from Cornell in 1984. Dr. Goldman interned in Medicine and did his residency in Neurology under Fred Plum at New York Hospital-Cornell, and Jerome Posner at the Memorial Sloan-Kettering Cancer Center, before joining the Cornell faculty. Dr. Goldman is interested in cell genesis and neural regeneration in the adult brain, with a focus on the use of neural stem and progenitor cells in treating demyelinating and neurodegenerative diseases. His lab focuses on the use of stem and progenitor cells for the treatment of neurodegenerative disorders such as Huntington's Disease, as well as for the treatment of glial diseases such as the pediatric leukodystrophies and multiple sclerosis He also has a strong interest in the conversion of resident cells into brain cancers, and is board certified in neuro-oncology. He has published over 200 papers in his field, over 100 as first or senior author. Dr. Goldman is a recipient of the Jacob Javits Neuroscience Investigator Award of the NIH, and has been elected to the Association of American Physicians and American Society for Clinical Investigation, as well as the American Neurological Association. Dr. Goldman remains active clinically, with subspecialty interests in stroke, myelin disease and neuro-oncology, and he is the program director for Rochester's neuro-oncology fellowship. He serves on standing committees of the NIH, and is a voting member of the FDA Cellular, Tissue and Gene Therapy Advisory Committee. His work is supported by NIH/NINDS, the Mathers and Adelson Foundations, the Department of Defense, CHDI, the National MS Society, NYSTEM, and Biogen Idec.
| Jacob Javits Neurosci. Investigator Award (NIH) |
2002 - 2009 |
| Human Frontiers Scientific Program award |
1998 - 2001 |
| National Multiple Sclerosis Soc. Invest. Award |
1997 - 2007 |
| American Paralysis Association Award |
1993 - 1994 |
| Irma T. Hirschl Career Scientist Award |
1993 - 1997 |
| FIRST Award | NIH/NINDS |
1992 - 1997 |
| Cornell Scholar in Biomedical Science |
1988 - 1991 |
| Clinical Invest. Development Award | HIH/NINDS |
1988 - 1993 |
| Mathers Charitable Foundation Awards |
1988 - 1997 |
| Medical Scientist Training Program | USPHS |
1978 - 1984 |
| Phi Beta Kappa | University of Pennsylvania |
1977 |
| Mayor's Scholar | City of Philadelphia |
1974 - 1978 |
| Senatorial Scholar | State of Pennsylvania |
1974 - 1978 |
| Benjamin Franklin Scholar, U. of Pennsylvania |
1974 - 1978 |
2013 Jun 3
Chen Z, Ye R, Goldman SA. "Testosterone modulation of angiogenesis and neurogenesis in the adult songbird brain." Neuroscience. 2013 Jun 3; 239:139-48. Epub 2013 Jan 03. |
2013 Apr 3
Guo H, Zhao Z, Yang Q, Wang M, Bell RD, Wang S, Chow N, Davis TP, Griffin JH, Goldman SA, Zlokovic BV. "An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway." The Journal of neuroscience : the official journal of the Society for
Neuroscience. 2013 Apr 3; 33(14):6181-90. |
2013 Mar 7
Han X, Chen M, Wang F, Windrem M, Wang S, Shanz S, Xu Q, Oberheim NA, Bekar L, Betstadt S, Silva AJ, Takano T, Goldman SA, Nedergaard M. "Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice." Cell stem cell. 2013 Mar 7; 12(3):342-53. |
2013 Feb 7
Wang S, Bates J, Li X, Schanz S, Chandler-Militello D, Levine C, Maherali N, Studer L, Hochedlinger K, Windrem M, Goldman SA. "Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination." Cell stem cell. 2013 Feb 7; 12(2):252-64. |
2012 Oct 26
Goldman SA, Nedergaard M, Windrem MS. "Glial progenitor cell-based treatment and modeling of neurological disease." Science (New York, N.Y.). 2012 Oct 26; 338(6106):491-5. |
