Steven A. Goldman, M.D., Ph.D.

Steven A. Goldman, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 645
Rochester, NY 14642

Office: (585) 275-9550
Fax: (585) 276-2298
Administrative: (585) 273-2717

Research Bio

Dr. Steven A. Goldman is the URMC Distinguished Professor of Neuroscience and Neurology. He is Chief of the Department's Division of Cell and Gene Therapy, and Co-Director of Rochester's Center for Translational Neuromedicine. Goldman is Emeritus Chairman of the Department, and holds additional appointments as a Professor of Neurosurgery, and as the Dean Zutes Chair in Biology of the Aging Brain. Dr. Goldman moved to Rochester in 2003 from the Weill Medical College of Cornell University, where he was the Nathan Cummings Professor of Neurology, and Attending Neurologist at New York Presbyterian Hospital.

A summa cum laude graduate of the University of Pennsylvania, he obtained his PhD with Fernando Nottebohm at the Rockefeller University in 1983, and his MD from Cornell in 1984. Dr. Goldman interned in Medicine and did his residency in Neurology under Fred Plum at New York Hospital-Cornell, and Jerome Posner at the Memorial Sloan-Kettering Cancer Center, before joining the Cornell faculty. Dr. Goldman is interested in cell genesis and neural regeneration in the adult brain, with a focus on the use of neural stem and progenitor cells in treating demyelinating and neurodegenerative diseases. His lab focuses on the use of stem and progenitor cells for the treatment of neurodegenerative disorders such as Huntington's Disease, as well as for the treatment of glial diseases such as the pediatric leukodystrophies and multiple sclerosis He also has a strong interest in the conversion of resident cells into brain cancers, and is board certified in neuro-oncology. He has published over 200 papers in his field, over 100 as first or senior author. Dr. Goldman is a recipient of the Jacob Javits Neuroscience Investigator Award of the NIH, and has been elected to the Association of American Physicians and American Society for Clinical Investigation, as well as the American Neurological Association. Dr. Goldman remains active clinically, with subspecialty interests in stroke, myelin disease and neuro-oncology, and he is the program director for Rochester's neuro-oncology fellowship. He serves on standing committees of the NIH, and is a voting member of the FDA Cellular, Tissue and Gene Therapy Advisory Committee. His work is supported by NIH/NINDS, the Mathers and Adelson Foundations, the Department of Defense, CHDI, the National MS Society, NYSTEM, and Biogen Idec.

Awards & Honors (Local)

Jacob Javits Neurosci. Investigator Award (NIH) 2002 - 2009
Human Frontiers Scientific Program award 1998 - 2001
National Multiple Sclerosis Soc. Invest. Award 1997 - 2007
American Paralysis Association Award 1993 - 1994
Irma T. Hirschl Career Scientist Award 1993 - 1997
FIRST Award | NIH/NINDS 1992 - 1997
Cornell Scholar in Biomedical Science 1988 - 1991
Clinical Invest. Development Award | HIH/NINDS 1988 - 1993
Mathers Charitable Foundation Awards 1988 - 1997
Medical Scientist Training Program | USPHS 1978 - 1984
Phi Beta Kappa | University of Pennsylvania 1977
Mayor's Scholar | City of Philadelphia 1974 - 1978
Senatorial Scholar | State of Pennsylvania 1974 - 1978
Benjamin Franklin Scholar, U. of Pennsylvania 1974 - 1978

Patents

Human-Glial Chimeric Mouse Brains for Assessment of in vivo Responses of Human Glial Cells to Injury, Inflammation, and Toxicants

United States Serial NO.: 12/015,372
Filed Date: January 16, 2008
Title: Non-Human Animals With Human-Glial Chimeric Brains
Invented by: Steven Goldman, Martha Windrem
Optimized Cell Preparations for Allogeneic Repair of Injured Human White Matter

United States Serial NO.: 12/990,874
Filed Date: May 7, 2009
Title: Treating Myelin Diseases With Optimized Cell Preparations
Invented by: Steven Goldman, Fraser Sim
CD24 as a Brain Tumor Stem Cell Marker as a Diagnostic and Therapeutic Target in Primary Neural and Glial Tumors of the Brain

United States Serial NO.: 12/809,491
Filed Date: December 22, 2008
Title: CD24 as a Brain Tumor Stem Cell Marker as a Diagnostic and Therapeutic Target in Primary Neural and Glial Tumors of the Brain
Invented by: Steven Goldman, Fraser Sim, Romane Auvergne
Isolating and Purifying Neuronal Stem Cells for Enrichment and Therapeutic Applications

United States Serial NO.: 09/282,239
Filed Date: March 31, 1999
Title: A Method for Isolating and Purifying Oligodendrocytes and Oligodendrocyte Progenitor Cells
Invented by: Steven Goldman, Su Wang
Isolating and Purifying Neuronal Stem Cells for Enrichment and Therapeutic Applications

United States Serial NO.:
Filed Date: January 1, 1899
Title: A Method for Isolating and Purifying Oligodendrocytes and Oligodendrocyte Progenitor Cells
Invented by: Steven Goldman, Su Wang
Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells

United States Serial NO.: 13/527,099
Filed Date: June 19, 2012
Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells
Invented by: Steven Goldman
Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells

United States Serial NO.: 12/111,839
Filed Date: April 9, 2008
Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells
Invented by: Steven Goldman
Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells

United States Serial NO.: 10/368,810
Filed Date: February 14, 2003
Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells
Invented by: Steven Goldman
Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells

United States Serial NO.: 2,476,376
Filed Date: February 14, 2003
Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
Invented by: Steven Goldman

Recent Journal Articles

Showing the 5 most recent journal articles. 143 available »

2014 Nov 17
Kondo Y, Windrem MS, Zou L, Chandler-Militello D, Schanz SJ, Auvergne RM, Betstadt SJ, Harrington AR, Johnson M, Kazarov A, Gorelik L, Goldman SA. "Human glial chimeric mice reveal astrocytic dependence of JC virus infection." The Journal of clinical investigation. 2014 Nov 17; Epub 2014 Nov 17.
2014 Oct 19
Xavier AL, Menezes JR, Goldman SA, Nedergaard M. "Fine-tuning the central nervous system: microglial modelling of cells and synapses." Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2014 Oct 19; 369(1654):20130593.
2014 Aug 22
Fox IJ, Daley GQ, Goldman SA, Huard J, Kamp TJ, Trucco M. "Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease." Science. 2014 Aug 22; 345(6199):1247391.
2014 Apr
Goldman SA, Osorio J. "So many progenitors, so little myelin." Nature neuroscience. 2014 Apr; 17(4):483-5.
2013 Jun 27
Auvergne RM, Sim FJ, Wang S, Chandler-Militello D, Burch J, Al Fanek Y, Davis D, Benraiss A, Walter K, Achanta P, Johnson M, Quinones-Hinojosa A, Natesan S, Ford HL, Goldman SA. "Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes." Cell reports. 2013 Jun 27; 3(6):2127-41. Epub 2013 May 30.

Current Appointments

Co-Director - Center for Translational Neuromedicine - Primary Administrative
Dean Zutes Chair in Biology of the Aging Brain - Department of Neurology, Center for Translational Neuromedicine (SMD)
URMC Distinguished Professor in Neurosciences - Department of Dean's Office, SMD (SMD)
Professor - Department of Neurology, Center for Translational Neuromedicine (SMD) - Primary
Professor - Department of Neurosurgery (SMD)

Specialties

Neurology - American Board of Psychiatry and Neurology

Education

MD | Medicine | Cornell Univ Medical College1984
PhD | Neurobiology | Rockefeller University1983
BA | Biology | Univ of Pennsylvania1978

Post-Doctoral Training & Residency

Residency in Neurology at Cornell University Medical College07/01/1985 - 6/1988
Internship in Internal Medicine at Cornell University Medical College07/01/1984 - 6/1985