Professional Bio
Dr. Georas was born and grew up in Providence, Rhode Island. He graduated from Brown University with a B.S. in Applied Mathematics and Biology in 1983, and then attended Brown Medical School (M.D., 1987). After Internal Medicine internship and residency at Duke University Medical Center, Dr. Georas moved to Johns Hopkins University for a Fellowship in Pulmonary and Critical Care Medicine, which he completed in 1994. From 1994 to 2006, he was a faculty member of the Pulmonary & Critical Care Medicine Division at Johns Hopkins, conducting research in the Johns Hopkins Asthma & Allergy Center.
He rose to the rank of Associate Professor of Medicine and Director of Pulmonary Research. In July 2006, he moved to the University of Rochester Medical Center, where he served as Division Chief of Pulmonary & Critical Care Medicine until 2010. Dr. Georas directs a research group investigating mechanisms of immune cell activation in the lung in asthma and other diseases. He has authored numerous publications in this area, and has been invited to present his research at national and international meetings. He is active in peer review, and serves on numerous advisory panels and review groups for the NIH and other professional societies.
Research Bio
Dr. Georas is Professor of Medicine, Environmental Medicine. Microbiology and Immunology at the University of Rochester Medical Center. From 1994-2006, he was a faculty member at Johns Hopkins University in the Pulmonary & Critical Care Division with a joint appointment in the Division of Allergy & Clinical Immunology, and Department of Environmental Health Sciences. He moved to the University of Rochester in 2006. Dr. Georas directs a research group investigating mechanisms of immune cell activation in the lung. Current studies are aimed at defining molecular pathways by which allergens and particulate matter activate epithelial cells and dendritic cells, leading to generation of maladaptive allergen-specific immune responses in asthma.
A separate line of research is investigating how lysophosphatidic acid is generated in the lung, exploring the role of different LPA receptors in lung inflammation and immune responses. These studies should further our understanding of how the lung functions as an immune organ, with a long-term goal of alleviating the burden of immune-mediated lung diseases including asthma in susceptible human subjects.
2012 Apr 15
Emo J, Meednu N, Chapman TJ, Rezaee F, Balys M, Randall T, Rangasamy T, Georas SN. "Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation." Journal of immunology (Baltimore, Md. : 1950). 2012 Apr 15; 188(8):3784-90. Epub 2012 Mar 16. |
2011 Jul
Rangasamy T, Semenza GL, Georas SN. "What is hypoxia-inducible factor-1 doing in the allergic lung?" Allergy. 2011 Jul 0; 66(7):815-7. Epub 2011 Apr 11. |
2011 Jul
De Benedetto A, Slifka MK, Rafaels NM, Kuo IH, Georas SN, Boguniewicz M, Hata T, Schneider LC, Hanifin JM, Gallo RL, Johnson DC, Barnes KC, Leung DY, Beck LA. "Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis." The Journal of allergy and clinical immunology. 2011 Jul 0; 128(1):242-246.e5. Epub 2011 Apr 13. |
2011 Jun 15
Lin X, Sime PJ, Xu H, Williams MA, Larussa L, Georas SN, Guo J. "Yin yang 1 is a novel regulator of pulmonary fibrosis." American journal of respiratory and critical care medicine. 2011 Jun 15; 183(12):1689-97. Epub 2010 Dec 17. |
2011 Mar
De Benedetto A, Rafaels NM, McGirt LY, Ivanov AI, Georas SN, Cheadle C, Berger AE, Zhang K, Vidyasagar S, Yoshida T, Boguniewicz M, Hata T, Schneider LM, Hanifin JM, Gallo RL, Novak N, Weidinger S, Beaty TH, Leung DY, Barnes KC, Beck LA. "Tight junction defects in patients with atopic dermatitis." The Journal of allergy and clinical immunology. 2011 Mar 0; 127(3):773-86.e1-7. Epub 2010 Dec 15. |
