Steve N. Georas, M.D.

Steve N. Georas, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 692
Rochester, NY 14642

Office: (585) 275-4861
Fax: (585) 273-1114
Lab: (585) 276-3238
Administrative: (585) 275-4861

Lab Information

Our lab consists of a collaborative group of technicians, students and post-doctoral fellows studying cell activation in asthma and lung inflammation. Interested candidates are encouraged to apply.

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Professional Bio

Dr. Georas was born and grew up in Providence, Rhode Island. He graduated from Brown University with a B.S. in Applied Mathematics and Biology in 1983, and then attended Brown Medical School (M.D., 1987). After Internal Medicine internship and residency at Duke University Medical Center, Dr. Georas moved to Johns Hopkins University for a Fellowship in Pulmonary and Critical Care Medicine, which he completed in 1994. From 1994 to 2006, he was a faculty member of the Pulmonary & Critical Care Medicine Division at Johns Hopkins, conducting research in the Johns Hopkins Asthma & Allergy Center.

He rose to the rank of Associate Professor of Medicine and Director of Pulmonary Research. In July 2006, he moved to the University of Rochester Medical Center, where he served as Division Chief of Pulmonary & Critical Care Medicine until 2010. Dr. Georas directs a research group investigating mechanisms of immune cell activation in the lung in asthma and other diseases. He has authored numerous publications in this area, and has been invited to present his research at national and international meetings. He is active in peer review, and serves on numerous advisory panels and review groups for the NIH and other professional societies.

Research Bio

Dr. Georas is Professor of Medicine, Environmental Medicine. Microbiology and Immunology at the University of Rochester Medical Center. From 1994-2006, he was a faculty member at Johns Hopkins University in the Pulmonary & Critical Care Division with a joint appointment in the Division of Allergy & Clinical Immunology, and Department of Environmental Health Sciences. He moved to the University of Rochester in 2006. Dr. Georas directs a research group investigating mechanisms of immune cell activation in the lung. Current studies are aimed at defining molecular pathways by which allergens and particulate matter activate epithelial cells and dendritic cells, leading to generation of maladaptive allergen-specific immune responses in asthma.

A separate line of research is investigating how lysophosphatidic acid is generated in the lung, exploring the role of different LPA receptors in lung inflammation and immune responses. These studies should further our understanding of how the lung functions as an immune organ, with a long-term goal of alleviating the burden of immune-mediated lung diseases including asthma in susceptible human subjects.

Patents

Over-Trimethylation of 27-Lysine on Histone 3 in Human Idiopathic Pulmonary Fibrosis and Silica Mouse Model

United States Serial NO.: 13/126,875
Filed Date: November 2, 2009
Title: Methods of Diagnosing and Treating Fibrosis
Invented by: Xin Lin, Jia Guo, Steve Georas, Patricia Sime

Recent Journal Articles

Showing the 5 most recent journal articles. 74 available »

2014 May
Rezaee F, Georas SN. "Breaking barriers. New insights into airway epithelial barrier function in health and disease." American journal of respiratory cell and molecular biology.. 2014 May; 50(5):857-69.
2014 Feb 1
Knowlden S, Georas SN. "The autotaxin-LPA axis emerges as a novel regulator of lymphocyte homing and inflammation." The Journal of immunology : official journal of the American Association of Immunologists.. 2014 Feb 1; 192(3):851-7.
2014
Abdolahi A, Georas SN, Thomas Brenna J, Cai X, Thevenet-Morrison K, Phipps RP, Lawrence P, Mousa SA, Block RC. "The effects of aspirin and fish oil consumption on lysophosphatidylcholines and lysophosphatidic acids and their correlates with platelet aggregation in adults with diabetes mellitus." Prostaglandins, leukotrienes, and essential fatty acids.. 2014 90(2-3):61-8. Epub 2013 Dec 18.
2014
Georas SN, Upham J. "Environmental exposures and innate immunity in the lung." Journal of environmental immunology and toxicology.. 2014 2(1):1-3.
2014
Knowlden SA, Capece T, Popovic M, Chapman TJ, Rezaee F, Kim M, Georas SN. "Regulation of T Cell Motility In Vitro and In Vivo by LPA and LPA2." PloS one. 2014 9(7):e101655. Epub 2014 Jul 08.

Current Appointments

Professor - Department of Medicine, Pulmonary Diseases and Critical Care (SMD) - Primary
Professor - Department of Environmental Medicine (SMD)
Professor - Department of Microbiology and Immunology (SMD)

Specialties

Internal Medicine - American Board of Internal Medicine
Pulmonary Disease - American Board of Internal Medicine
Critical Care Medicine - American Board of Internal Medicine

Education

M.D. | Medicine | Brown Univ Bio/Med Sciences1987
B.S. | Applied Math / Biology | Brown University1983

Post-Doctoral Training & Residency

Fellowship in Pulmonary Diseases & Critical Care at Johns Hopkins University School of Medicine07/01/1990 - 06/30/1994
Residency in Internal Medicine at Duke University Medical Center07/01/1988 - 06/30/1990
Internship in Internal Medicine at Duke University School of Medicine07/01/1987 - 06/30/1988